Volume 17, Issue 4

Yachita Rajwadwala, Priyanka Patil, Nidhi Chauhan, Umesh Upadhyay

pp. 752–762 · DOI: 10.5530/jyp.20250046 · 2025

Diabetic Kidney Disease (DKD) is a leading cause of End-Stage Renal Disease (ESRD) worldwide, contributing substantially to morbidity and mortality among patients with Type 2 Diabetes Mellitus (T2DM). Its pathogenesis in…

Lakshman Ram, Mohammed Fayaz Sadiqbasha, Hariharan Murugadoss, Rishi Tushaar Vadlamannati, Hubert Igno Castus, Sarumathy Sundararajan

pp. 763–769 · DOI: 10.5530/jyp.20251770 · 2025

Alcohol Use Disorder (AUD) presents a significant challenge, with limited efficacy and adherence to current FDA-approved treatments. This comprehensive review analyzes the spectrum of pharmacological management for AUD. …

Ragesh Gurumoorthy, Karthik Thiyagarajan, Santhosh Kumar Ganesan

pp. 770–776 · DOI: 10.5530/jyp.20251751 · 2025

Blood transfusion is one of the key practices in making sure that the safety of the patients remains intact; however, traditional systems are being faced with a substantial number of challenges, such as underreporting ut…

Bhishmani Tarare, Sadhana Misar, Vinay Kumar, Mohnish Gokhale

pp. 790–796 · DOI: 10.5530/jyp.20250082 · 2025

Background:Ferroptosis is an iron-dependent, regulated form of cell death characterized by lipid peroxidation and oxidative stress, distinct from apoptosis and necrosis. It has emerged as a key therapeutic target in canc…

Alindam Ghosh, Arpan Sen, Avik Dutta, Soumya Sunder Ghora, Saurav Guchhait, Susobhan Das, Faruk Alam, Mrinmoy Nag, Sindhuja Sengupta, Prithviraj Chakraborty

pp. 797–809 · DOI: 10.5530/jyp.20250069 · 2025

Immunological receptor signaling maintains homeostasis and prevents infections. Significant immune system changes like immunosenescence decrease innate and adaptive immunity. This lowers resistance to cancer, autoimmune …

Jenita Varshini Anthony Raj, Priyadharshini Ananthathandavan, Safreen Rumana Sella Babu, Harinipriya Arunagiri

pp. 810–815 · DOI: 10.5530/jyp.20250007 · 2025

PPIs are the most popular medications used in treatment of gastric diseases based on acids, and they turn out to be the strongest agents to suppress the acids. But extended use has been associated with hypochlorhydria an…

Piyali Khamkat, Soumen Singh, Bramhajit Chatterjee, Sangita Banerjee, Siddheswar Maiti, Sayandip Mandal, Bikram Chowdhury, Md Mehedi Hasan

pp. 816–823 · DOI: 10.5530/jyp.20250008 · 2025

Emulgel is a blend of gel and emulsion that improves drug penetration across the epidermal barrier and facilitates efficient skin diffusion, particularly for drugs that are poorly soluble in water. It is a potent, thermo…

Paras Monga, Rina Das, Bimal Kumar Agrawal, Dinesh Kumar Mehta

pp. 824–832 · DOI: 10.5530/jyp.20250040 · 2025

Children who binge eating are at a higher risk of becoming overweight. The Metabolic Syndrome (MetS) significantly predicts Type 2 diabetes and coronary heart disease in obese children and adolescents. The accumulation o…

Gummalla Vijayamma, S. Nirmala

pp. 833–840 · DOI: 10.5530/jyp.20250087 · 2025

The integration of Analytical Quality by Design (AQbD) with Green Analytical Chemistry (GAC) represents a transformative approach in High-Performance Liquid Chromatography (HPLC) method development and validation. This r…

Anamika Dey, Nagarajan Janaki Sankarachari Krishnan, Shenthilnathan Sivakumar, Sarvesh Ravichandran, Mullaiadhavan Bharathi, Pavalan Krishnan

pp. 777–783 · DOI: 10.5530/jyp.20250075 · 2025

This study provides an overview of the green analytical methods in pharmaceutical impurity profiling with focus on regulatory compliance, effectiveness, and environmental impact. We address recent trends in spectroscopic…

Rajesh Balam, Priyanka Mahesh, Kinjal Gandhi, Swathi Ganesha Poojary, Ajith Chandran, Anoop Narayanan Vadakkepushpakath

pp. 784–789 · DOI: 10.5530/jyp.20250104 · 2025

The pharmaceutical industry is currently welcoming a digital revolution known as Pharma 4.0, which builds upon the principles of Industry 4.0 to improve product quality, operational efficiency, and compliance. This trans…

Ashwini Kumar Patil, Brugupati Pandey, Bharat Patil, Aboli Patil, Rupali Bawa

pp. 841–846 · DOI: 10.5530/jyp.20250015 · 2025

Background:Charak Samhita mentions Truptighna Mahakashaya as a group of herbs effective in treating Kaphaja disorders, commonly seen in children with loss of appetite and Kapha dominance. However, traditional formulation…

Farhan Alshammari

pp. 847–854 · DOI: 10.5530/jyp.20250009 · 2025

Objectives:This study aimed to conduct a comprehensive strategic evaluation of Saudi Arabia’s pharmaceutical industry in relation to pharmacy education, with a focus on industrial localization, regulatory capacity, and c…

Harsha Prashant Kavale, Vijay Jagdish Upadhye

pp. 855–863 · DOI: 10.5530/jyp.20250081 · 2025

Background:Microbial bioload control in clean rooms is critical for ensuring pharmaceutical product quality. Regular monitoring and effective disinfection practices are essential to minimize contamination risks. This stu…

Nithyananth Muniswamy, Sankar Veintramuthu, Malathi Sellappan

pp. 864–876 · DOI: 10.5530/jyp.20250096 · 2025

Background:For driver-negative Non-Small Cell Lung Cancer (NSCLC), platinum-based chemotherapy remains standard; however, carboplatin efficacy is limited by poor tumour delivery and dose-limiting toxicity. In this study,…

Nurjamal Hoque, Ananta Choudhury, Deepraj Datta

pp. 877–886 · DOI: 10.5530/jyp.20250155 · 2025

Background:The efficacy of the anticancer agent palbociclib can be limited by its conventional release profile. Developing nano-formulations presents a viable approach to modulate its delivery for improved therapeutic ou…

Ravali Ravi, Sowmiya Raju, Siena Jasmine Chinnappan, Abhimanyu K. Singh, Rakesh Sarma, Joseva Sankar

pp. 887–901 · DOI: 10.5530/jyp.20250134 · 2025

Background:Pyrazoline derivatives have significant medicinal use for their diverse pharmacological activities. Zebrafish embryos are mostly used in toxicity studies due to its transparency, rapid development and genetic …

Kishori Prasanna Sutar, Utkarsh Shashtri, Vinayak Patil, Atharv Milind Lad, Nagaprajwal Anantha Araga, Gangayya Wakkundmath

pp. 902–908 · DOI: 10.5530/jyp.20250249 · 2025

Background:Schizophrenia is a persistent neuropsychiatric condition that requires precise drug delivery to the brain for effective treatment. Amisulpride, a second-generation antipsychotic, has low oral bioavailability a…

Chandana Ganesha, Mohammad Ali, Bharathi Doddla Raghunathanaidu

pp. 909–913 · DOI: 10.5530/jyp.20250041 · 2025

Background:Diabetes mellitus causes ovarian granulosa cells to undergo oxidative stress, inflammation, and apoptosis, all of which have a negative impact on female reproductive health. Although there are currently few tr…

Dighe Santosh Bhausaheb, Jadhav Shweta Shantaram, Bhawar Sanjay Balasaheb, Ghogare Rajshree Dadasaheb, Patole Varsha Aniket, Patil Samrudhi Santosh

pp. 914–921 · DOI: 10.5530/jyp.20250150 · 2025

Background:Olanzapine an atypical antipsychotic, is known to cause metabolic side effects such as weight gain, hyperlipidemia and oxidative stress, contributing to the development of metabolic syndrome. Caralluma fimbria…