Sustain-Release of Various Drugs from Leucaena Leucocephala Polysaccharide
Jeevanandham S1★, Sekar M1, Dhachinamoorthi D2, Muthukumaran M1, Sriram N1, Joysaruby J1★ Corresponding author
- 1Department of Pharmaceutics, Santhiram College of Pharmacy, INDIA.
- 2QIS College of Pharmacy, Andhra Pradesh, INDIA.
CORRESPONDENCE
Jeevanandham S
Department of Pharmaceutics, Santhiram College of Pharmacy, INDIA.
Volume 2, Issue 1 · pp. 15–20 · PUBLISHED · DOI: 10.4103/0975-1483.62207
ABSTRACT
This study examines the sustained release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water-insoluble (indomethacin) drugs from Leucaena leucocephala seed Gum isolated from Leucaena leucocephala kernel powder. It further investigates the effect of incorporation of diluents like microcrystalline cellulose and lactose on release of caffeine and partial cross-linking of the gum (polysaccharide) on release of acetaminophen. Applying exponential equation, the mechanism of release of soluble drugs was found to be anomalous. The insoluble drug showed near case II or zero-order release mechanism. The rate of release was in the decreasing order of caffeine, acetaminophen, theophylline, salicylic acid and indomethacin. An increase in release kinetics of drug was observed on blending with diluents. However, the rate of release varied with type and amount of blend in the matrix. The mechanism of release due to effect of diluents was found to be anomalous. The rate of release of drug decreased on partial cross-linking and the mechanism of release was found to be super case II.
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S, J., M, S., D, D., M, M., N, S., & J, J. (). Sustain-Release of Various Drugs from Leucaena Leucocephala Polysaccharide. Journal of Young Pharmacists, 2(1), 15–20. https://doi.org/10.4103/0975-1483.62207