Assessment of Dissolution Profile of Marketed Aceclofenac Formulations
Soni T1, Chotai N2★★ Corresponding author
- 1Department of Pharmaceutics, Anand Pharmacy College, Sardar Patel University, Anand, Gujarat, INDIA.
- 2AR College of Pharmacy, Sardar Patel University, Vallabh-Vidyanagar, Gujarat, INDIA.
CORRESPONDENCE
Chotai N
AR College of Pharmacy, Sardar Patel University, Vallabh-Vidyanagar, Gujarat, INDIA.
Volume 2, Issue 1 · pp. 21–26 · PUBLISHED · DOI: 10.4103/0975-1483.62208
ABSTRACT
Statistical comparison of dissolution profiles under a variety of conditions relating to formulation characteristics, lot-to-lot, and brand-to-brand variation attracts interest of pharmaceutical scientist. The objective of this work is to apply several profile comparison approaches to the dissolution data of five-marketed aceclofenac tablet formulations. Model-independent approaches including ANOVA-based procedures, ratio test procedure, and pair wise procedure. The ratio test includes percentage, area under the curve, mean dissolution time, while the pair wise procedure includes difference factor (f1), similarity factor (f2), and Rescigno index. In the model-dependent approach, zero order, first order, Hixson-Crowell, Higuchi, and Weibull models were applied to the utilization of fit factors. All the approaches were applicable and useful. ANOVA with multiple comparison tests was found to be sensitive and discriminating for comparing the profiles. Weibull parameters were more sensitive to the difference between two release kinetic data in terms of curve shape and level.
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T, S., & N, C. (). Assessment of Dissolution Profile of Marketed Aceclofenac Formulations. Journal of Young Pharmacists, 2(1), 21–26. https://doi.org/10.4103/0975-1483.62208