Spasmolytic Activity of Fruits of Tamarindus indica L.
Ali N1★, Shah SWA1★ Corresponding author
- 1Department of Pharmacy, University of Malakand, Chakdara, Dir (Lower). Khyber Pakhtunkhwa, PAKISTAN.
CORRESPONDENCE
Ali N
Department of Pharmacy, University of Malakand, Chakdara, Dir (Lower). Khyber Pakhtunkhwa, PAKISTAN.
Volume 2, Issue 3 · pp. 261–264 · PUBLISHED · DOI: 10.4103/0975-1483.66805
ABSTRACT
Objective:To study the possible effects of methanolic extract of fruits of Tamarindus indica on rabbit’s jejunum preparations. Materials and Methods:The study was carried out on rabbit’s jejunum preparations. Methanolic extract of fruits of T. indica was applied in different doses. Potassium chloride (KCl 80 mM)-induced contractions were relaxed by the extract. For determination of possible mode of action of relaxing effects, calcium chloride curves were constructed in decalcified tissues using K+ normal and followed by K+ rich solution. The curves were then compared with verapamil. Results:Relaxant effects on KCl-induced contractions were prominent at a concentration of 5.0-10.0 mg/ml (P<0.05). A right shift at a concentration of 3.0 mg/ml (EC50 ± SEM = 1.98 ± 0.03) and 10.0 mg/ml (EC50 ± SEM = 1.79 ± 0.05) versus control (EC50 ± SEM = 2.33 ± 0.058) resembled the effects of verapamil on the calcium chloride curves. Conclusion: The results confirmed its possible mode of relaxing effects i.e. through calcium channel blockade.
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N, A., & SWA, S. (). Spasmolytic Activity of Fruits of Tamarindus indica L.. Journal of Young Pharmacists, 2(3), 261–264. https://doi.org/10.4103/0975-1483.66805