FTIR and Raman Spectroscopic Investigations of a Norfloxacin/Carbopol934 Polymeric Suspension
Sahoo S1★, Chakraborti CK1, Behera PK2, Mishra SC3★ Corresponding author
- 1Department of Pharmaceutics, Kanak Manjari Institute of Pharmaceutical Sciences, INDIA.
- 2School of Chemistry, Sambalpur University, Jyoti Bihar, INDIA.
- 3Metallurgical and Materials Engineering Department, National Institute of Technology, Rourkela, Orissa, INDIA.
CORRESPONDENCE
Sahoo S
Department of Pharmaceutics, Kanak Manjari Institute of Pharmaceutical Sciences, INDIA.
Volume 4, Issue 3 · pp. 138–145 · PUBLISHED · DOI: 10.4103/0975-1483.10017
ABSTRACT
Till now very few formulations are available from which the drug is uniformly absorbed, so that the safe and effective blood level of norfloxacin could be maintained for a prolonged period. To fulfill this requirement, a controlled release mucoadhesive suspension was prepared by using a mucoadhesive carbopol934 polymer. The chemical interaction between norfloxacin and the polymer in formulation (prepared by an ultrasonication method) has been studied by FTIR and Raman spectroscopy. From the spectral interpretation, it has been found that in formulation, the carboxylic groups of norfloxacin and hydroxyl groups of carbopol934 undergo chemical interaction, leading to esterification and hydrogen bonding. The formation of micellies due to esterification and hydrogen bonding causes more drug entrapment and a stable formulation. From this it can be concluded that the formulation of norfloxacin may give a better controlled release and mucoadhesive action in the gastrointestinal tract. Hence, carbopol934 could be considered as an effective carrier for norfloxacin.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
S, S., CK, C., PK, B., & SC, M. (). FTIR and Raman Spectroscopic Investigations of a Norfloxacin/Carbopol934 Polymeric Suspension. Journal of Young Pharmacists, 4(3), 138–145. https://doi.org/10.4103/0975-1483.10017