Effect of a Disintegration Mechanism on Wetting, Water Absorption, and Disintegration Time of Orodispersible Tablets
Pabari RM1, Ramtoola Z1★★ Corresponding author
- 1School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephens Green, Dublin 2, IRELAND.
CORRESPONDENCE
Ramtoola Z
School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephens Green, Dublin 2, IRELAND.
Volume 4, Issue 3 · pp. 157–163 · PUBLISHED · DOI: 10.4103/0975-1483.10021
ABSTRACT
The aim of this study was to evaluate the influence of disintegration mechanism of various types of disintegrants on the absorption ratio (AR), wetting time (WT), and disintegration time (DT) of orodispersible tablets (ODTs). ODTs were prepared by direct compression using mannitol as filler and disintegrants selected from a range of swellable, osmotic, and porous disintegrants. Tablets formed were characterized for their water AR, WT, and DT. The porosity and mechanical strength of the tablets were also measured. Results show that the DT of formulated ODTs was directly related to the WT and was a function of the disintegration mechanism of the disintegrant used. The lowest WT and DT were observed for tablets formulated using the osmotic disintegrant sodium citrate and these tablets also showed the lowest AR and porosity. The wetting and disintegration of tablets containing the highly swellable disintegrant, sodium starch glycollate, was slowest despite their high-water AR and high tablet porosity. Rapid wetting and disintegration of ODTs were therefore not necessarily related to the porosity of the tablets.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
RM, P., & Z, R. (). Effect of a Disintegration Mechanism on Wetting, Water Absorption, and Disintegration Time of Orodispersible Tablets. Journal of Young Pharmacists, 4(3), 157–163. https://doi.org/10.4103/0975-1483.10021