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A Comparative Study on Anti-diabetic Effects of Aqueous Trigonella foenum graecum, Hibiscus cannabinus Linn, and Cicer arietinum extracts on Alloxan Induced Diabetic Male Albino Rats

Kailash S. Chadchan1, Swastika N. Das1★, Jameel G. Jargar2, Kusal K. Das3★ Corresponding author

  1. 1Department of Chemistry, B.L.D.E.A’s College of Engineering and Technology, Vijayapur -586103, (Affiliated to Visvesvaraya Technological University, Belagavi) Karnataka, INDIA.
  2. 2Department of Physiology, Al Ameen Medical College, Vijayapur, Karnataka, INDIA.
  3. 3Department of Physiology, Shri B.M. Patil Medical College, Hospital and Research Centre, BLDE University, Vijayapur -586103, Karnataka, INDIA.

CORRESPONDENCE

Swastika N. Das

Department of Chemistry, B.L.D.E.A’s College of Engineering and Technology, Vijayapur -586103, (Affiliated to Visvesvaraya Technological University, Belagavi) Karnataka, INDIA.

drswastika@yahoo.com

Received: 28-05-2016; Revised: 30-07-2016; Accepted: 21-08-2016.

Volume 9, Issue 2 · pp. 230–233 · PUBLISHED · DOI: 10.5530/jyp.2017.9.45

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ABSTRACT

Objective: To compare anti-diabetic effect between the different aqueous extracts of green leafy plants locally available in North Karnataka region of India on alloxan induced diabetic male albino rats. Materials and Methods:The preparation of aqueous extracts, preliminary phytochemical analysis and toxicity screening test of 3 aqueous extracts was done by using standard protocol. To study anti-diabetic activity experimental rats were divided into f ive groups viz. Group I (Control), Group II (Diabetic, Alloxan monohydrate, 15mg/100g bwt, i.p.), Group III (Diabetic with Trigonella foenum graecum), Group IV (Diabetic with Hibiscus cannabinus Linn) and Group V (Diabetic with Cicer arietinum). All above extracts were supplemented with same dose i.e. 12.5mg/100g bwt, orally. The blood glucose levels were evaluated in all the above experimental groups after acute (OGTT) and sub chronic (2 weeks) supplementation. Results: Our results depicts statistically signi f icant decreased blood glucose level in Group III rats after both acute and sub chronic supplementation whereas in Group IV rats only after sub chronic supplementation when compared with Group II rats. But, Group V rats not showed any significant change in both acute as well as sub chronic exposure when compared with Group II rats. Conclusion:Trigonella foenum graecum and Hibiscus cannabinus Linn. leaves may be used as a dietary supplement in diabetic patients.

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    Chadchan, K. S., Das, S. N., Jargar, J. G., & Das, K. K. (). A Comparative Study on Anti-diabetic Effects of Aqueous Trigonella foenum graecum, Hibiscus cannabinus Linn, and Cicer arietinum extracts on Alloxan Induced Diabetic Male Albino Rats. Journal of Young Pharmacists, 9(2), 230–233. https://doi.org/10.5530/jyp.2017.9.45