Journal of Young Pharmacists
Volume 9, Issue 2
· pp. 140–302 · 31 articles
- Volume
- 9
- Issue
- 2
- Published
- Pages
- 140–302
- Articles
- 31
- Sections
- 4
- ISSN
- Print - 0975-1483 | Online - 0975-1505
- Journal
- JYP
In this issue
Review Article
- Review
Comparison of Adverse Effects of Newer Atypical Antipsychotics: An Evidence Based Review
Kharadi Dhruvika Gaurang, Shah Agam Rajendra, Ganguly Barna
pp. 140–144 · DOI: 10.5530/jyp.2017.9.29 · Published
Aim:To Compare the safety of asenapine and iloperidone as per informa tion available in public domain. Method:In addition to their USFDA ap proved prescribing information, literature on these two drugs from Pubmed indexe…
- Review
Highly Cited Publications Output by India in Clinical Pharmacology during 2000-14: A Scientometric Assessment
K K Mueen Ahmed, S.M. Dhawan, B. M. Gupta, Madhu Bansal
pp. 145–157 · DOI: 10.5530/jyp.2017.9.30 · Published
Objectives:The main objective of this research is to identify highly cited papers in clinical pharmacology and to analyze their publication and citation data to study their citation characteristics, and understand what r…
Original Artcile
- Article
Design, Synthesis and Characterization of Benzothiazole Analogues as Promising Pharmacological Agents
Katharigatta Narayanaswamy Venugopala
pp. 158–161 · DOI: 10.5530/jyp.2017.9.31 · Published
Objective: Benzothiazole moiety containing various functional groups are found to have broad spectrum of biological activity and diverse chemical reactivity. The various pharmacological properties shown by the benzothia …
- Article
3D QSAR Studies on Some 5-(1H-Indol-5-yl)-1, 3, 4-Thiadiazol-2 Amines as Potential PIM-1 Inhibitors
Panche Tulesh Kumar, Ghode Piyush, Jain Sanmati Kumar
pp. 162–167 · DOI: 10.5530/jyp.2017.9.32 · Published
Objective:Proviral integration site for moloney murine leukemia virus (PIM) kinases are among the contemporary targets for cancer chemotherapy as they play a pivotal role in inhibition of apoptosis and oncogenic signalin…
- Article
In-Silico Screening of Flavonoids Targeted for Death Receptors in Cancer by Using Hex Molecular Docking
Vaithiyalingam Jagannathan Vishnuvarthan, Karunanidhi Santhanam Lakshmi, Ammayappan Rajam Srividya
pp. 168–171 · DOI: 10.5530/jyp.2017.9.33 · Published
Objective: Docking is one of the major tools in the drug development process, here we have selected certain flavonoid molecules such as Formononetin, Tangeritin, Myricetin and Kaempferol and we docked against Death Recep…
- Article
Synthesis of Chitosan-Graft- HPβCD Copolymer by Novel One Pot Technique and its Application for Solubility Enhancement of Efavirenz
Aarti Belgamwar, Shagufta Khan, Lalit Rathi
pp. 172–176 · DOI: 10.5530/jyp.2017.9.34 · Published
Objective: To enhance solubility of efavirenz by using chitosan-graft-HPβCD copolymer synthesized by novel one pot technique. Methodology: Poor aqueous solubility and limited bioavailability is the major problem for more…
- Article
Application of Experimental Design to Develop a Robust RP-TLC/ Densitometry Method for Quantification of Phthalates in Person al Care Products
Jayaseelan Kavitha, Karunanidhi Santhana Lakshmi
pp. 177–182 · DOI: 10.5530/jyp.2017.9.35 · Published
Objective:A rapid, simple and economic RP-TLC/Densitometry method for the simultaneous quantification of Phthalates, namely Dimethyl Phthalate (DMP), Diethyl Phthalate (DEP) and Di-n-butyl Phthalate (DBP) in Personal car…
- Article
Co-crystallization: A Tool to Enhance Solubility and Dissolution Rate of Simvastatin
Iyan Sopyan, Achmad Fudholi, Muchtaridi Muchtaridi, Ika Puspita Sari
pp. 183–186 · DOI: 10.5530/jyp.2017.9.36 · Published
Objective : The aim of this study was to explore co-crystallization to enhance the solubility of simvastatin (SV) as a drug of choice for hypercholesterolemia using saccharin (Sacch) as co-former. Methods: Molecular mode…
- Article
Formulation and Optimization of Piroxicam Orodispersible Tablets by Central Composite Design
E. Bhargav, C.Surya Prakash Reddy, C. Sowmya, C. Haranath, K. Arshad Ahmed Khan, K. Rajesh, B. Srinath
pp. 187–191 · DOI: 10.5530/jyp.2017.9.37 · Published
Objective:The present work was designed to formulate and optimize Orodispersible tablets of Piroxicam using QbD approach. The central composite design tool was used to evaluate the scientific understanding of input and o…
- Article
Formulation and Optimization of Controlled Release 5-Fluoro uracil Tablets for Colonic Delivery
Moumita Das, Bijaya Ghosh, Swapnoleena Sen, L. K. Ghosh
pp. 192–196 · DOI: 10.5530/jyp.2017.9.38 · Published
Objective:Formulations were developed for targeted controlled delivery of 5-fluorouracil at the colonic site.Methods:Probable dose for drug loading in the tablets and duration of drug release at the colon was determined.…
- Article
Reliable and Sensitive Stability Indicating – Liquid Chromatographic Method for Determination of Azilsartan Medoxomil and Characterization of Common Hydrolytic Degradation Product
Ramalingam Peraman, SubbaRao Dakinedi, Rajesh Reddy Kadiri, Lavanya malineni
pp. 197–202 · DOI: 10.5530/jyp.2017.9.39 · Published
Objective:The objective of the proposed method was to develop an accurate, rapid and cost-effective stability indicating a reversed phase high-performance liquid chromatographic method for the determination of azilsartan…
- Article
Application of SeDeM ODT Expert System in Formulation Development of Orodispersible Tablets of Antihyperlipidemic Agent
Fatima Sanjeri Dasankoppa, Vinuta Mallikarjun Sajjanar, Hasanpasha Sholapur, N.G. Nanjundaswamy, Kiran Ashok Kubasad, Pooja Mohan Walvekar
pp. 203–208 · DOI: 10.5530/jyp.2017.9.40 · Published
Background:Rosuvastatin calcium exhibits poor oral bioavailability due to extensive pre-systemic metabolism. Orodispersible tablets (ODTs) were prepared that disintegrate rapidly in oral mucosa thus preventing pre- syste…
- Article
Improved Anticancer Activity of Meloxicam Hydrogels in K562 and HL60 Cell Lines
Manish Kumar Thimmaraju, Khaggeswar Bheemanapally, Rajkumar Dharavath, Lavanya Kakarla, Mahendran Botlagunta
pp. 209–213 · DOI: 10.5530/jyp.2017.9.41 · Published
Objective: The aim of the present study is to prepare poloxamer based formulations of meloxicam to evaluate various parameters like pH stability, drug release and in vitro anticancer activities in cell lines with an inte…
- Article
Effect of Garcinia Imberti Bourd Against Candida Isolates in Rootcanal Infection
Srikrishnan Rajendran Sri Ramkumar, Natesan Sivakumar, Jaya Balaji Mano Christaine Angelo
pp. 214–217 · DOI: · Published
Background:Many research works are being carried out in preparing intra canal medicaments using herbal plants since it is safe as well as containing a better therapeutic value. The present study was designed to evaluate …
- Article
Utility of Isatin Semicarbazones in Mammary Carcinoma Cells - A Proof of Concept Study
Sathianarayanan s, Amrutha B Chittethu, Asha Jose, Ranganathan Balasubramanian, Saranya TS, Asha Asokan Manakadan
pp. 218–223 · DOI: 10.5530/jyp.2017.9.43 · Published
Objective:The present study was aimed to determine cytotoxic and apoptotic activity of isatin semicarbazones against mammary carcinoma. Methodology: The preparation of these target compounds involved substitution at the …
- Article
Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk e-Saghir, A Traditional Preparation, and Its Ingredients
Zarrin Sarhadynejad, Abbas Pardakhty, Ali Mandegary, Suleiman Afsharypuor, Fariba Sharififar
pp. 224–229 · DOI: 10.5530/jyp.2017.9.44 · Published
Objective: Quality control and standardization of traditional preparations ensure their safe, pure and efficient prescription. Zereshk-e-Saghir (ZES), a folk remedy, has been recommended as a hepatoprotective agent in Tr…
- Article
A Comparative Study on Anti-diabetic Effects of Aqueous Trigonella foenum graecum, Hibiscus cannabinus Linn, and Cicer arietinum extracts on Alloxan Induced Diabetic Male Albino Rats
Kailash S. Chadchan, Swastika N. Das, Jameel G. Jargar, Kusal K. Das
pp. 230–233 · DOI: 10.5530/jyp.2017.9.45 · Published
Objective: To compare anti-diabetic effect between the different aqueous extracts of green leafy plants locally available in North Karnataka region of India on alloxan induced diabetic male albino rats. Materials and Met…
- Article
Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats
Sai Sruthi Kaveripakam, Sreedevi Adikay, Gandhimathi Retnasamy
pp. 234–238 · DOI: : 10.5530/jyp.2017.9.46 · Published
Objective:The present study was designed to evaluate the anti-obesity efficacy of ethanol extract of roots of Stereospermum suaveolens on high fat fed obese rats. Methodology:Ethanol extract of roots was prepared by hot …
- Article
Comparative Experimental Studies of Calcium Channel Agonists and Antagonists against Ovariectomy Induced Osteoporosis In Rats
Vijay R. Chidrawar, Krishnapriya Pegalapati, Pavani Ade, Abdulkhaliq J. Alsalman, Shruti Shiromwar
pp. 239–245 · DOI: 10.5530/jyp.2017.9.47 · Published
Background: Ca2+ channels and calcium signalling appears to play a critical role in the differentiation and functions of osteoclasts and osteoblasts and L-types voltage dependent calcium channels (VDCC) are expressed on …
- Article
Effect of Anti-stress Activity of Fluoxetine on Restrained Stress Induced Male Albino Rats in Hematological Parameters and Whole Brain Histopathology
Rohini S. Kori, Ravindranath H. Aladkatti, S.D. Desai, Kusal K.Das
pp. 246–250 · DOI: 10.5530/jyp.2017.9.48 · Published
Objective: In this study we investigated the effect of Fluoxetine, a selective serotonin reuptake inhibitor, on the gravimetry, hematology and whole brain histopathology in the restrained stressed male albino rats. Metho…
- Article
Protective Cardiorenal Effects Of Tropaeolum majus L. In Rats With Renovascular Hypertension
Arquimedes Gasparotto Junior, Thiago Bruno Lima Prando, Karimi Sater Gebara, Francielly Mourão Gasparotto, Francislaine Apareci da dos Reis Lívero, Dênis Pires de Lima, Roberto da Silva Gomes, Emerson Luiz Botelho Lourenço
pp. 251–257 · DOI: 10.5530/jyp.2017.9.49 · Published
Background:Tropaeolum majus L. (Tropaeolaceae) is an important medicinal plant belonging to the Tropaeolaceae family, which has 80 species distributed in South and Central America. In Brazil, it is distributed practicall…
- Article
Awareness of Custom Officers on Counterfeit Pharmaceutical Products And The Roles Of Pharmacy Enforcement Officers
Chuo Yew Ting, Hiram Ting, Yee Chang Soh, Abu Hassan AAJ, Kah Seng Lee
pp. 258–262 · DOI: 10.5530/jyp.2017.9.50 · Published
Background: Counterfeit pharmaceutical products (CPP) is a lucrative business for illegal operators who constantly try to smuggle their products into Malaysia. Full understanding of the roles and duties of pharmacy enfor…
- Article
Knowledge, Attitude and Practice of Resident Doctors for use of Generic Medicines at a Tertiary care Hospital
Kamejaliya Dinesh Zaverbhai, Kapadia Jigar Dilipkumar, Desai Chetna Kalpan, Desai Mira Kiran
pp. 263–266 · DOI: 10.5530/jyp.2017.9.51 · Published
Objective:To assess knowledge, attitude and practice of resident doctors regarding generic medicines at a tertiary care teaching hospital. Method:This cross sectional study was conducted in 296 resident doctors of a tert…
- Article
Use of Social Media for Seeking Health Related Information – An Exploratory Study
Navya Bhaskaran, Manish Kumar, Manthan Dilipkumar Janodia
pp. 267–271 · DOI: 10.5530/jyp.2017.9.52 · Published
Introduction: Social Media (SM) is evolving and more number of people are experiencing benefits of SM. Though use of social media is beneficial, it has to be carefully calibrated when used for sharing health information.…
- Article
Assessment of Factors Associated with Low Adherence to Pharmacotherapy in Elderly Patients
Naveen Thekkemelathil Roy, Manjusha Sajith, Madhu Pankaj Bansode
pp. 272–276 · DOI: 10.5530/jyp.2017.9.53 · Published
Objective: To assess factors associated with low adherence to pharmacotherapy in elderly patients. Methods:A prospective cross sectional observational study was conducted in Bharati Hospital and Research Centre, Pune ove…
- Article
Evaluation of Clinical Efficacy of Metformin Therapy in Polycystic Ovary Syndrome
Chandran Jaganmohan, Mani Vannan, Ashraf Ali, Parasuraman S
pp. 277–279 · DOI: 10.5530/jyp.2017.9.54 · Published
Objective:To evaluate the metformin efficacy in Polycystic Ovary Syndrome (PCOS), intent to regulate the menstrual cycle and achieving pregnancy rate (live birth, stillbirth) in infertile women with PCOS proportions expe…
- Article
Extents of Generic Prescribing in Hospitals and Community Pharmacies for Diabetic and Hypertensive Outpatients in Eastern Region of Saudi Arabia
Promise Madu Emeka, Anas Al Ahmed
pp. 280–283 · DOI: 10.5530/jyp.2017.9.55 · Published
Objective: As population increase, Healthcare resources are stretched and the need to reduce prescription drug spending becomes obvious. The aim of this study was to evaluate the levels of generic prescribing in place of…
- Article
Frequencies of Genetic Polymorphisms of the Cholesterol and Statin Metabolic Pathway Genes among Healthy South Indian Tamil Population
Chandrasekaran Indumathi, Annan Sudarsan Arun Kumar, Adithan Surendiran, Steven Aibor Dkhar
pp. 284–289 · DOI: 10.5530/jyp.2017.9.56 · Published
Background:Indians are genetically predisposed to Coronary Artery Disease (CAD), hence it is worth studying the effect of genetic polymorphisms which affect CAD development including Low- Density Lipoprotein Cholesterol …
- Article
In vitro and In silico Approaches to Study the Bioactivity of Citrus limon Leaf Extracts
Raji P, Antony V Samrot, Divya Dharani, Boniface Alexander
pp. 290–295 · DOI: antonysamrot@gmail.com · Published
Aim: To study the bioactivity of Citrus limon leaf extracts through in vitro and in silico approaches. Methodology: In this study, the leaves of Citrus limon were subjected to solvent extraction using ethyl acetate and e…
Short communication
- Communication
In vivo Study of Tetraprenyltoluquinone, An Anticancer Compounds from Garcinia cowa Roxb
Fatma Sri Wahyuni, Lim Siang Hui, Johnson Stanslas, Nordin Hj Lajis, Dachriyanus d
pp. 296–298 · DOI: 10.5530/jyp.2017.9.58 · Published
Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were tr…
Case Report
- Article
Subdural Hematoma and Delirium case evaluation in elderly patients
Abdalla Al-Khateeb, Muaed Jamal Alomar
pp. 299–302 · DOI: 10.5530/jyp.2017.9.59 · Published
Objective: A common and serious acute neuropsychiatric syndrome with core features of inattention and global cognitive dysfunction called delirium can be associated with subdural haematoma (SBD) following a minor trauma …