Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies
Liza Pratiwi1★, Achmad Fudholi2, Ronny Martien2, Suwidjiyo Pramono3★ Corresponding author
- 1Department of Pharmaceutical Technology, Faculty of Medical, Tanjungpura University, Pontianak, INDONESIA.
- 2Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, INDONESIA.
- 3Department of Pharmacy Biology, Faculty of of Pharmacy, Gadjah Mada University, Yogyakarta, INDONESIA.
CORRESPONDENCE
Liza Pratiwi
Department of Pharmaceutical Technology, Faculty of Medical, Tanjungpura University, Pontianak, INDONESIA.
Received: 04-12-2016; Revised: 17-03-2017; Accepted: 07-04-2017.
Volume 9, Issue 3 · pp. 341–346 · PUBLISHED · DOI: 10.5530/jyp.2017.9.68
ABSTRACT
Objective: Purpose of this research was to get the optimum formulation of Self-Nanoemulsifying Drug Delivery System (SNEDDS) of mangosteen peels and to evaluate the permeation ability of active substances in the formulation.Method: Oil phase solubility of ethanol extract, ethyl acetate extract, ethyl acetate fraction, n-hexane fraction and residue of the mangosteen peels was tested with virgin coconut oil (VCO). The formulation was designed with a simplex lattice design using Design Expert software and the permeation was tested using Franz diffusion cell.Results: Based on the results of simplex lattice design methods obtained that the optimum formulation of SNEDDS was the composition of VCO, Tween 80, PEG 400 at a ratio of 1:6,95:2,05. The results of permeation test in vitro using Franz Diffusion cell indicated that the obtained SNEDDS ethyl acetate fraction of mangosteen peels that is 96.9223% higher than without prepara tion SNEDDS was 18,9426 % on hour-8. The optimum physical evaluation SNEDDS optimum values obtained involved drug loading of 125mg/5 mL SNEDDS, the transmittance value of 92%, emulsification time of 65 seconds, pH of 6.35, particle size 20 nm, zeta potential -12,40 and stable for three months. Conclusion:SNEDDS can improve the diffusion rate of mangosteen peels as a model poorly water soluble drug.Various samples of mangosteen peels were screened as candidates for SNEDDS on the basis of solubility of the active compound in oils, surfactants, and co-surfactants. Simplex lattice design methods can be used to obtain optimum formulation on SNEDDS.
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Pratiwi, L., Fudholi, A., Martien, R., & Pramono, S. (). Self-nanoemulsifying Drug Delivery System (Snedds) for Topical Delivery of Mangosteen Peels (Garcinia Mangostana L.,): Formulation Design and In vitro Studies. Journal of Young Pharmacists, 9(3), 341–346. https://doi.org/10.5530/jyp.2017.9.68