Volume 9, Issue 4

Chidambaram Ramasamy, Subramani Parusuraman

pp. 451–452 · DOI: 10.5530/jyp.2017.9.88

One of the health related topics, which is consistently receiving attention in recent years, is antibiotic misuse. Interestingly, there is a high-profile report claiming that antibiotic consumption could trigger obesity …

Saurabh Singh, Khushboo Gupta, Kavita Nitish Garg, Neeraj Kumar Fuloria, Shivkanya Fuloria, Teerthesh Jain

pp. 453–456 · DOI: 10.5530/jyp.2017.9.89

Cardiovascular disease trends, complications, and associated therapeutics, impact the dental health and treatment. Such patients require special consideration with regard to when and which dental treatment is appropriate…

Imalia Nurachma Ayuningtyas, Maesya Rahmawati, Sutriyo s, Abdul Mun’im

pp. 457–462 · DOI: 10.5530/jyp.2017.9.90

Introduction: Gnetum gnemon L. (Melinjo) is popular in Indonesia as a source of nutrition. Its seeds contain trans-resveratrol, which has been shown to have multiple pharmacological activities. The application of ionic l…

Nadhir N.A. Jafar, Ibtihial M Abdul Mahdi, Mahmoud Hussein Hadwan, Ameer A, Alameri

pp. 463–467 · DOI: 10.5530/jyp.2017.9.91

Objective: 4-methoxy-N, N-dimethyl-6-(phenylthio) pyrimidin-2-amine, 4-(benzo[d]thiazol-2-ylthio)-6-methoxy-N,N-dimethylpyrimidin-2-amine, 4-(4-(1,2,3-selenadiazol-4-yl)phenoxy)-6-methoxy-N,N 2-amine and 4-(4-(1,2,3-thia…

Mohd Syafwan Soffian, Irfan Mohamad, Zeehaida Mohamed, Rosdan Salim

pp. 468–474 · DOI: 10.5530/jyp.2017.9.92

Background: Kaffir lime (Citrus hystrix D.C) has been used for a long time in agricultural and alternative medicine. Kaffir lime leaf (KLL) had been proved effective against certain fungi that could infect human body. Ob…

Muhammad Yusuf, Ade Rizqi Ridwan Firdaus, Unang Supratman

pp. 475–479 · DOI: 10.5530/jyp.2017.9.93

Objectives: This study aimed to predict the binding pose of bufadienolides from Kalanchoe pinnata on Na+/K+-ATPase using molecular docking in comparison with a known inhibitor, and to determine the important functional g…

Rathinasabapathy Pushpalatha, Subramanian Selvamuthukumar, Duraisamy Kilimozhi

pp. 480–485 · DOI: 10.5530/jyp.2017.9.94

Object: To compare the molecular activity of curcumin and resveratrol on selected breast cancer protein receptors and to investigate their combination for synergism against human breast cancer MCF-7 cell line. Method: Cu…

Islamudin Ahmad, Arry Yanuar, Kamarza Mulia, Abdul Mun’im

pp. 486–490 · DOI: 10.5530/jyp.2017.9.95

Objective: The aims of the study was to explore the application effect of ionic liquid as a green solvent in the polyphenolics content extraction from Peperomia pellucida (L.) Kunth herbs using 1-butyl-3-methyl imidazoli…

Mohammad Hossein Morowvat, Younes Ghasemi

pp. 496–501 · DOI: 10.5530/jyp.2017.9.97

Objective: Chlamydomonas reinhardtii, the most commonly studied model organism in microalgal kingdom, is known to be a rich lipid producer. Methods: Here, a naturally isolated C. reinhardtii strain was cultivated phototr…

Jayashri Gajananrao Mahore, Bhavana Bhikhubai Rohit, Sanjeevani Shekhar Deshkar

pp. 502–506 · DOI: 10.5530/jyp.2017.9.98

Objective: Vaginitis is a very common gynaecological problem in women of all age groups resulted in millions of visit to physician. Decrease in vaginal Lactobacilli is one of the reasons of Bacterial vaginitis. Approach …

Jayashri Gajananarao Mahore, Suvarna Dinkarrao Suryawanshi, Satish Vasudeo Shirolkar, Sanjeevani Shekhar Deshkar

pp. 507–512 · DOI: 10.5530/jyp.2017.9.99

Objective: The purpose of this study was to developed microemulsion based gel formulation for topical delivery of dapsone with an objective to increase the solubility and skin permeability of the drug for treatment of ac…

Revathi Mannam, Indira Muzib Yallamalli

pp. 513–518 · DOI: 10.5530/jyp.2017.9.100

Background: Hydralazine hydrochloride (HZH) is a drug candidate used to treat pulmonary arterial hypertension. Extreme variability in oral dosing, bioavailability of 31%, variable half-life of 3 to 7 h and molecular weig…

Sravanthi Mulagada, Srinivasa Rao Baratam

pp. 519–524 · DOI: 10.5530/jyp.2017.9.101 · 2017

Objective: Ondansetron is an anti-emetic drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves in the gastrointestinal tract. So the rate of dissolution and therefore its bioavailabilit…

Afrasim Moin, Talib Hussain, DV Gowda

pp. 525–536 · DOI: 10.5530/jyp.2017.9.102

Background: To prepare and characterize modified Poly(acrylamide-grafted- Ghatti gum). To formulate and evaluate using this grafted polymer pH-sensitive hydrogel beads of diclofenac sodium for enteric delivery. Methods: …

Khaggeswar Bheemanapally, Manish Kumar Thimmaraju, Sagar Kasagoni, Prathyusha Thatikonda, Swathi Akula, Kranthi Raj Kodamala, Lavanya Kakarla, Sridhar Babu Gummadi, Harishankar Nemani, Mahendran Botlagunta

pp. 537–544 · DOI: 10.5530/jyp.2017.9.103

Background: DDX3 is the human RNA helicase and enhanced expression of DDX3 protein was found in several cancers including leukemia. Statin family of drugs shown to inhibit the growth of acute myeloid leukemia cells. Obje…

Shrishail Kashinath Nimbal, Basavaraj Chanabasappa Koti

pp. 545–549 · DOI: 10.5530/jyp.2017.9.104

Background: Doxorubicin is a Anthracycline derivative and has proven efficacy in various malignancies. It is the most effective cytotoxic agent in current use. The clinical usefulness is limited due to its cardiac toxici…

Pavana Pamu, Manoharan Shanmugam, Sethupathy Subramanian

pp. 550–554 · DOI: 10.5530/jyp.2017.9.105

Objective: Traditionally, Tephrosia purpurea Linn. (Fabaceae) is known to possess medicinal values in treating diabetes and other endocrine disorders. In this experiment, authors evaluated the beneficial role of Tephrosi…

Elsa Trinovita, Sutriyo s, Fadlina Chany Saputri, Abdul Mun’im

pp. 555–558 · DOI: 10.5530/jyp.2017.9.106

Objective: Rice bran oil has many helath benefit. The biologically active compounds of rice bran oil are fatty acids, squalene, tocopherols, phytosterols, tocotrienols, oryzanol, and polyphenols. Gamma oryzanol is a comb…

Kholid Abdul Hafidz, Nuraini Puspitasari

pp. 559–565 · DOI: 10.5530/jyp.2017.9.107

Objectives: Melinjo (Gnetum gnemon) seeds have been known to have some biological properties. One of them is ant hypercholesterolemia. The present study investigated in vitro and in silico methods to predict potential an…

Ankalikar Aryaa, Agadi Hiremath Viswanathswamy

pp. 566–570 · DOI: 10.5530/jyp.2017.9.108

Objective: The aim of the study was to see the effect of ethanolic extract of Solanum nigrum Linnon Acute and Sub-acute inflammation. Method: Wistar rats weighing 150-200gms were used, divided into four groups Group 1 wa…