Volume 18, Issue 2

Apr-Jun 2026 · pp. 1–610 · 44 articles

Volume: 18
Issue: 2
Published: Apr-Jun 2026
Pages: 1–610
Articles: 44
Sections: 3
ISSN: Print - 0975-1483 | Online - 0975-1505
Journal: JYP

Original Article Review Article Case Report

In this issue

Original Article

Article
Comparative Analgesic Efficacy of Varying Concentrations of Oxybuprocaine Hydrochloride Gargle Following Adult Tonsillectomy: A Pilot Randomized Controlled Study
Jie Zhang, Rui Jiang, Zhong Bai
pp. 1–4 · DOI: 10.5530/jyp.20260304 · Published Apr-Jun 2026
Objectives Adult tonsillectomy is associated with severe postoperative pain, often leading to readmission. This pilot study evaluates the feasibility, safety, and dose-response relationship of three concentrations of Oxy…
Article
Integrated Standardization of Pergularia daemia (forssk.) Chiov. Using Pharmacognostic and Molecular Techniques
Anitha Singarakani, Prakash Ramakrishnan
pp. 325–350 · DOI: 10.5530/jyp.20260013 · Published Apr-Jun 2026
Background This research paper aims to establish comprehensive pharmacognostical standards and DNA barcode markers for Pergularia daemia (Forssk.) Chiov., a medicinally important plant in traditional medicine systems. Ph…
Article
Antimicrobial Potential of a Raspberry-Sesame Root Herbal Formulation: An in vitro Study Targeting Oral Mucositis
Gomathi Ramalingam, Uma Maheswari T Natarajasundaram, Rajesh Kumar Shanmugam
pp. 351–356 · DOI: 10.5530/jyp.20260339 · Published Apr-Jun 2026
Background Cancer patients frequently experience oral mucositis and oral candidiasis, which are frequently associated with oral pathogens like Candida albicans and Streptococcus mutans. The increasing prevalence of antim…
Article
Systems Pharmacology-Based in silico Decoding of the Polypharmacology Mechanisms of Silymarin against Breast Cancer
Pughazendhi Ravi, Chandrasekaran Velusamy Subbaraman, Muthukumaran Mylasalam, Gowrishankar Jayabalan, Santhiya Gopalsamy, Nivetha Jasmine Edwardraj
pp. 357–368 · DOI: 10.5530/jyp.20260033 · Published Apr-Jun 2026
Background Breast cancer is a biologically heterogeneous disease driven by complex and interconnected molecular pathways, often limiting the efficacy of conventional single-target therapies. Purpose In this study, an int…
Article
Synthesis and in vitro Evaluation of Folic Acid-Functionalized Liquid Crystalline Nanoparticles for Enhanced Cytotoxicity in HCT-116 and HT-29 Colorectal Cancer Cells
Karthikeyan Sathasivam, Subramanian Somaskanthan, S. M. Habibur Rahman
pp. 369–376 · DOI: 10.5530/jyp.2026xxxx · Published Apr-Jun 2026
Background Colorectal Cancer (CRC) therapy is limited by poor tumor selectivity and systemic toxicity associated with 5-Fluorouracil (5-FU). Liquid Crystalline Nanoparticles (LCNs) offer sustained drug release and improv…
Article
Formulation and Optimization of a Rifaximin Solid Dispersion-Based Hydrogel for Topical Delivery
Parag Ashok Pathade, Kalyani Jaywant Bhor, Shivraj Popat Jadhav, Yogesh Suresh Ahire, Vinod Ahshok Bairagi, Bhaskar Onkar Aher, Shakeeb Akhtar Nehal Ahmad
pp. 377–385 · DOI: 10.5530/jyp.20260390 · Published Apr-Jun 2026
Background Rifaximin is a poorly water-soluble antibiotic that limits dissolution, formulation flexibility, and topical delivery. Enhancing its solubility is essential to improve therapeutic performance in localized appl…
Article
Development and Validation of the MBQ-20: A Metacognitive Belief Questionnaire for Delusions in Schizophrenia-A Pilot Study
Varadharajan Sivaraman, Natarajan Shanmugasundaram, Kannan Lakshminarayanan, Thamilselvan Palanichamy, Harshitha Muthu Sundaram, Karthik Sankarbabu
pp. 386–391 · DOI: 10.5530/jyp.20260085 · Published Apr-Jun 2026
Background Delusions in schizophrenia are characterized by rigidity and resistance to change; processes potentially linked to metacognitive deficits. However, there is a lack of specific tools to assess metacognitive bel…
Article
Formulation and Evaluation of Phytosomes Loaded Tinospora cordifolia on Ethylene Glycol Induced Urolithiasis: An Experimental Study
Sanjay Ugare, Vinaya Gidaballi, Sachin Gudasi, Tejaswini Chougala, Shweta Myagadeyavar, K.L. Krishna
pp. 392–398 · DOI: 10.5530/jyp.20260240 · Published Apr-Jun 2026
Background Tinospora cordifolia is a renowned traditional medicinal herb known for its diverse therapeutic properties, including antioxidant, neuroprotective, and immunomodulatory effects. Materials and Methods A hydroal…
Article
Development and Optimization of a Nasal in situ Gel for Enhanced Brain Delivery of Safinamide in Parkinson's Disease
Dumpa Rushi Kumar Reddy, Suryaprakash Reddy Chappidi
pp. 399–408 · DOI: 10.5530/jyp.20260307 · Published Apr-Jun 2026
Background Parkinson's Disease (PD) is the second most prevalent neurodegenerative disorder. Currently levodopa along with MAO-B inhibitors remains first line therapy for the management of motor complications. However, i…
Article
A Novel Emulgel-Based Oral Delivery Approach for Amlodipine Besylate: Formulation, Evaluation, and Kinetic Modelling
Pawan Singh, Anuj Kumar, Pankaj Kumar, Arun Kumar, Mohd Fareed, Sunita Gangwar, Mohd Junaid
pp. 409–418 · DOI: 10.5530/jyp.20260404 · Published Apr-Jun 2026
Background Oral drugs like amlodipine besylate commonly have problems such as low water solubility and high first-pass metabolism, leading to changing plasma concentrations. Emulgel formulations offer a great solution as…
Article
Formulation, Compatibility, In vitro, and Stability Studies on Pantoprazole Sodium Enteric Coated Tablets with Super Disintegrants
Chandrasekaran Velusamy Subbaraman, Muthukumaran Mylasalam, Pughazendhi Ravi, Manimegalai Karnan, Gowrishankar Jayabalan
pp. 419–428 · DOI: 10.5530/jyp.20260035 · Published Apr-Jun 2026
Background Pantoprazole sodium is a highly effective proton pump inhibitor that has continued to languish in the therapeutic armory against the acid in the gastrointestinal tract. However, its pharmacokinetic properties …
Article
Development and Optimization of Cholesterol-Coated Phytosomes of Asparagus racemosus Methanolic Extract: Characterization and Antidiabetic Potential
Sandip Sen, Jitendra Debata, Kannan Arumugam, Tandrima Majumder, Soumya Stuti Patnaik, Vakkalagadda Ravi Kumar, Chandan Mohanty
pp. 429–438 · DOI: 10.5530/jyp.20260074 · Published Apr-Jun 2026
Background The presence of potential Phytoconstituents in Asparagus racemosus makes it plant of vital therapeutic importance. Purpose The efficacy of the phytoconstituents is less due to poor aqueous solubility and bioav…
Article
A Systematic Design Of Experiment-Driven High Performance Thin Layer Chromatography Approach for the Quantification of Glimepiride and Linagliptin in Synthetic Blends
Patel Ayushi Shaileshbhai, Hiralben Mehta, Chetan Rathva
pp. 439–449 · DOI: 10.5530/jyp.20260149 · Published Apr-Jun 2026
Background Type 2 Diabetes Mellitus (T2DM) often requires combination therapy for improvement of blood glucose regulation, where Linagliptin (a DPP-4 inhibitor) and Glimepiride (a sulfonylurea) act synergistically. Quali…
Article
Computational Identification of Aggregation-Prone Regions in Brain-Derived Neurotrophic Factor (BDNF)
Muthiah Ramanathan, Radhakrishnan Nithya
pp. 450–456 · DOI: 10.5530/jyp.20260049 · Published Apr-Jun 2026
Background Brain-Derived Neurotrophic Factor (BDNF) is a promising therapeutic protein for neurological disorders; however, its clinical application is limited by aggregation susceptibility, which can compromise stabilit…
Article
In silico Evaluation of Pergularia daemia Steroidal Lactone Phytochemicals as Potential Multi-Target Modulators of PIK3CA and STAT3 Signaling Pathways in Pancreatic Cancer
Muthukumaran Mylasalam, Pughazendhi Ravi, Gowrishankar Jayabalan, Santhiya Gopalsamy
pp. 457–466 · DOI: 10.5530/jyp.20260040 · Published Apr-Jun 2026
Background Pancreatic cancer remains a lethal disease, largely because of its aggressive biology and scant therapeutic options. Central to its progression are dysregulated oncogenic pathways-most notably PI3K/AKT/mTOR an…
Article
Evaluation of Antioxidant Potential and Cytotoxic Effect of Iron Oxide Nanoparticles Synthesized from Red Seaweed Gracilaria corticata
Benshiga Edwin Bennet, Syed Shahid Afridi, Manoj Kumar Karuppan Perumal, Remya Rajan Renuka, Vimalah Devi Gengathurai, Antony Vincent Samrot
pp. 467–472 · DOI: 10.5530/jyp.20260207 · Published Jan-Mar 2026
Background Marine algae have received increasing attention over the past two decades because of their rich nutritional composition and diverse medicinal properties. At the same time, nanoparticles have emerged as promisi…
Article
Explainable Machine Learning for Identifying False-Negative Myocardial Infarction: A SHAP-Based Analysis
Mathesh Anandan, Shirly Sasikumar, Darius Alan Arockiasamy, Aadhithan Dhanasekaran, Joanna Phebe Augustine, Dhivya Kothandan
pp. 473–480 · DOI: 10.5530/jyp.20260004 · Published Apr-Jun 2026
Background The timely and accurate identification of Myocardial Infarction (MI) remains a challenge in clinical practice. Diagnostic inconsistency may result in missed or delayed diagnoses, especially in resource- limite…
Article
Perception and Experience of the Public with Community Pharmacist Services in Hafr Al-Batin, Saudi Arabia
Hajar Alghamdi, Suha Alharbi, Aliah Almutairi, Almaha Almutairi, Anjal Almutairi, Amjad Almutairi, Sarah Aldhafiri, Joud Alfattouh, Ashfaq Ahmad
pp. 481–487 · DOI: 10.5530/jyp.20260005 · Published Apr-Jun 2026
Background Community pharmacists are now evolving from traditional roles to patient-centered healthcare providers, and this is widely acknowledged. This study aimed to assess public opinions and perceptions of pharmacist…
Article
Barriers to Pharmaceutical Care: Insights from Community Pharmacists’ Perspectives
Shalini Rawat, Yogesh Joshi
pp. 488–491 · DOI: 10.5530/jyp.20260180 · Published Apr-Jun 2026
Background Community pharmacists serve as an important link between doctors and patients, helping to ensure that individuals receive the highest quality pharmaceutical care within the healthcare system. Objectives The pu…
Article
Comparative Study of Cradle Hold vs. Football Hold on Maternal Comfort and Breastfeeding Success among Post-Caesarean Mothers
Pinal Darji, Anita Prakasam, Vruti Patel, Shital Patel, Bansi Patel, Bhargavi Patel
pp. 496–501 · DOI: 10.5530/jyp.20260361 · Published Apr-Jun 2026
Background Breastfeeding position technique is very important concerning maternal comfort and infant feeding practice, especially among mothers who gave birth via caesarean section. Although there are many breastfeeding …
Article
General Health and Quality of Life Among Ethnic Minority Elderly with Type 2 Diabetes: A Cross-Sectional Study
Ancelin Wilfy, Arun Sakthi Vijayakumar, Kanthimathi Meenal Chidambaram, Vishwa Athithyan Velayutham, Balasubramaniam Vishwanathan, Ponnusankar Sivasankaran
pp. 502–508 · DOI: 10.5530/jyp.20260396 · Published Apr-Jun 2026
Background Type 2 diabetes significantly impacts physical health and psychological well-being in older adults, particularly affecting their quality of life. However, limited evidence exists regarding these outcomes among…
Article
Evaluating the Awareness of Hospital Pharmacists towards Hospital Pharmacy Services during Pandemic Readiness: A Cross-Sectional Study
Mohammed S. Alshammari
pp. 509–515 · DOI: 10.5530/jyp.20260421 · Published Apr-Jun 2026
Background Hospital pharmacists have an essential role to play in maintaining continuity of care, medication safety, and medicine chain management, especially under public health challenges. The COVID-19 pandemic further…
Article
Evaluation of rationality in Prescription Pattern of Antibiotics at A Tertiary Care Centre: An Observational Study
Divya Amaravadi, Sri Karan Uddesh Tangula
pp. 516–520 · DOI: 10.5530/jyp.20260248 · Published Apr-Jun 2026
Background The emergence of resistant microorganisms is caused by the irrational prescription of antibiotics. Despite this, Prescription antimicrobial are on the rise in hospitals. Therefore, this study done with an obje…
Article
Analysis of DENV-2 NS5 Methyltransferase Reveals Structural Features and Potential Epitope Regions
Ghadeer Bukhari
pp. 521–529 · DOI: 10.5530/jyp.20260050 · Published Apr-Jun 2026
Background The NS5 Nterminal Methyltransferase (MTase) of Dengue Virus Serotype2 (DENV2) catalyzes RNA cap methylation. MTase is indispensable for replication and is an attractive target for antivirals and epitopebased v…
Article
Development, Translation and Validation of COPD Awareness Questionnaire (COPD-AQ): A Pilot Study
Tharika Chandramohan, Deivaanai Kasi, Anjaly Thomas, Sama Sruthi Reddy, Hunsur Nagendra Vishwas, Dhivya Chellan
pp. 530–536 · DOI: 10.5530/jyp.20260075 · Published Apr-Jun 2026
Background The current study sought to create, translate, and pilot a culturally relevant COPD Awareness Questionnaire (COPD-AQ) to measure awareness of the disease among Indian patients in the Nilgiris district. Materia…
Article
Impact of Structured Training on Community Pharmacists’ Knowledge, Practice, and Competency in Immunization Services
Gangayya Jagadish Wakkundmath, Madiwalayya Shivakantayya Ganachari, Geetanjali Salimath, Shashikala Chanamallappa Wali
pp. 537–543 · DOI: 10.5530/jyp.20260143 · Published Apr-Jun 2026
Background Immunization is an essential tool of public health, but the coverage in the adult population is not optimal in low- and middle-income countries, such as India. The Community Pharmacists (CPs) are very accessib…
Article
A Cross-Sectional Study of Postmenopausal Women's Clinical Profile, Lifestyle Perspectives, and Knowledge of Osteoporosis in Rural Tamil Nadu
S. Vijayakumar, S Monisha, V Vishnuvarthiniv, S Parimalakrishnan., AR Vijayakumar, TS Shamugarajan, S Megavanan, G Nishalini
pp. 544–551 · DOI: 10.5530/jyp.20260224 · Published Apr-Jun 2026
Background Osteoporosis represents a significant public health issue among postmenopausal women, particularly across developing nations where awareness and prevention efforts remain inadequate. The present research sough…
Article
Enhancing Safety Competence among Nurses: A Pre - Experimental Study on The Impact of an Educational Program on Cytotoxic Drug Management and its Outcomes in Safe Pharmacy Practice
Geetha Chockalingam, Vijayan Venugopal, Chithra Kuppan, Swati Sinha
pp. 552–556 · DOI: 10.5530/jyp.20260036 · Published Apr-Jun 2026
Background Cytotoxic drugs are essential in cancer treatment but pose significant occupational hazards due to their mutagenic, teratogenic, and carcinogenic properties. Nurses are at high risk during drug preparation and…
Article
An Impact of Patient Counselling in Terms of Quality of Life, Knowledge, Attitude and Practice in Subjects with Type 2 Diabetes Mellitus and Hypertension: A Cross-Sectional Study
Rajesh Hadia, Shardul Singh Parihar, Siddharth Patel, Jerin Mariyam Joseph, Sunil Kumar, Hemraj Singh Rajput, Vikas Chandrakar
pp. 557–562 · DOI: 10.5530/jyp.20260034 · Published Apr-Jun 2026
Background Diabetes mellitus and hypertension is a significant public health problem globally and is associated with a range of both short- and long-term consequences. The global diabetes prevalence in 2019 is estimated …
Article
A Cross-Sectional Study on the Assessment of Health-Related Quality of Life in Patients with Chronic Liver Disease at Tertiary Care Teaching Hospital
Rajesh Hadia, Kunjal Parmar, Jay Rane, Narayan Saijwani, Pradeep Reddy, Hemraj Singh Rajput, Vikas Raman Chandrakar
pp. 563–568 · DOI: 10.5530/jyp.20260019 · Published Apr-Jun 2026
Background Patients with Chronic Liver Disease (CLD) had large numbers of symptoms which affect their life activities and Health Related Quality of Life (HRQoL). Quality of life measures cover a wide range of aspects of …
Article
Effect of Pharmaceutical Care Interventions on Health-Related Quality of Life (HRQoL) Among Patients with Drug Resistant Tuberculosis: A Prospective Study
Vishwa Rajakumar Byakod, Madiwalayya Shivakantayya Ganachari
pp. 569–577 · DOI: 10.5530/jyp.20260041 · Published Apr-Jun 2026
Introduction Quality of Life (QoL) reflects an individual’s perception of physical, psychological, social, and environmental well-being and is an important indicator of overall health and life satisfaction. Purpose: This…
Article
Characterization of the NS5 Methyltransferase Domain of Dengue Virus Serotype 4: Structural, Functional, and Post-Translational Insights
Afaf Salim Alwabli
pp. 578–586 · DOI: 10.5530/jyp.20260055 · Published Apr-Jun 2026
Background The NS5 Methyltransferase (MTase) domain of Dengue Virus Serotype 4 (DENV-4) plays a central role in viral RNA capping, genome replication, and immune evasion. Understanding its structural and functional prope…
Article
Design, Molecular Docking and ADMET Analysis of Mannich-Base Substituted Benzimidazole Derivatives as Potential Antimicrobial Agents
Nivetha Jasmine Edwardraj, Hemalatha Kuppan, Santhiya Gopalsamy, Manimegalai Karnan
pp. 595–604 · DOI: 10.5530/jyp.20260044 · Published Apr-Jun 2026
Background The growing incidence of antimicrobial resistance demands the development of new therapeutic agents with improved safety and efficacy. Benzimidazole derivatives are considered promising pharmacophores due to t…

Review Article

Review
Thiazolidinediones-A Heterocyclic Scaffold with Versatile Therapeutic Potential
K Joshna, Sandhya M J Nair, S Mathan
pp. 244–250 · DOI: 10.5530/jyp.20260344 · Published Apr-Jun 2026
Thiazolidinediones are a class of five-membered heterocyclic compounds that have gained significant attention in medicinal chemistry due to their diverse therapeutic potential. These compounds, characterized by the prese…
Review
Drug Related Problems in Geriatric Critical Care: Challenges, Clinical Implications and Future
M K Soumya, R. Margret Chandira, Sujith S Nair
pp. 251–259 · DOI: 10.5530/jyp.20260328 · Published Apr-Jun 2026
Drug Related Problems (DRP) represent a significant and often under-recognised challenge in the care of elderly patients admitted to Intensive Care Units (ICU). Epidemiological data reveal a high prevalence of DRP among …
Review
Monoclonal Antibody Therapy in Rheumatoid Arthritis: A Paradigm Shift Toward Precision Immunotherapy
Kannaiyan Suria Prabha, Joshua Albert, Daniel Catherine Grace, Selva Kumar Gokul, Sankar Kalai Kumar, Ganesan Shyam Sundar, Ravichandran Udaya Kumar
pp. 260–266 · DOI: 10.5530/jyp.20260217 · Published Apr-Jun 2026
Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory condition that is marked by sustained synovial inflammation, joint destruction, and extra-articular complications. While methotrexate and other conventional …
Review
Tiny Droplets Big Impact: Emerging Nanoemulsion Strategies for Enhanced Nail Penetration in Onychomycosis Therapy
Kausendra Singh, Anurag Verma
pp. 267–274 · DOI: 10.5530/jyp.20260403 · Published Apr-Jun 2026
Background As the nail plate is not very permeable and has a high density of keratinization, onychomycosis is one of the most common types of mycological nail contamination and is characterized by high recurrence. Despit…
Review
The Molecular Signature of Diabetic Kidney Disease: A Scoping Review of Emerging Biomarker Classes
Biswajit Das, Radhakrishnan Narayanaswamy, KR Shruthi, Wilma Delphine Silvia Chickballapur Rayappa, BS Sachin, Arbind Kumar Choudhary
pp. 275–285 · DOI: 10.5530/jyp.20260318 · Published Jan-Mar 2026
Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease worldwide, yet routine clinical biomarkers-albuminuria and creatinine-based estimated Glomerular Filtration Rate (eGFR)-often change only afte…
Review
Wound Healing Potential of Ehretia laevis Roxb.: A Comprehensive Review of Phytochemical, Preclinical, and Clinical Studies
Pawan Banduji Itankar, Gaurav Rajendra Sawarkar, Punam Gaurav Sawarkar, Vaishnavi Banduji Itankar, Kamlesh Surendra Choudhary
pp. 286–292 · DOI: 10.5530/jyp.20260324 · Published Apr-Jun 2026
Ehretia laevis Roxb., a medicinal tree from the Boraginaceae family, has been a cornerstone of traditional medicine across Asia for treating a multitude of ailments, particularly those involving inflammation and tissue d…
Review
Association of ESR1 and ESR2 Gene Polymorphisms with Metabolic Syndrome in Peri- and Postmenopausal Women: A Systematic Review
S Sindhu, K. Sujatha, S Bhuvana, C. D. Mohanapriya, M. G. Rajanandh
pp. 293–299 · DOI: 10.5530/jyp.20260343 · Published Apr-Jun 2026
Metabolic Syndrome (MetS) encompasses central obesity, insulin resistance, dyslipidemia, and hypertension, collectively increasing risks of cardiovascular disease and type 2 diabetes. Menopause exacerbates susceptibility…
Review
Pharmacological Targeting of Cellular Senescence: Molecular Mechanism and Anti-Ageing Strategies in Chronic Diseases Pathophysiology
Sekhar Sharma, Bhumika Chettri, R Keerthi Shree, G Namana, N P Rakshitha, Benson Babu Thomas, B Sreya Krishna, V V Suryan, Rajendra Dhakal
pp. 300–309 · DOI: 10.5530/jyp.20260026 · Published Apr-Jun 2026
Background Cellular senescence is a condition in which the cells permanently stop dividing due to various conditions like DNA damage, shortening of telomeres, oxidative stress, and mitochondrial problems. Initially this …
Review
Aquasomes as Smart Nanocarriers: A Review on Drug Delivery Potential
Piyali Khamkat, Vivek Barik, Soudip Das, Rupam Maiti, Soumen Singh, Sangita Banerjee, Siddheswar Maiti, Prasenjit Mondal
pp. 310–314 · DOI: 10.5530/jyp.20260032 · Published Apr-Jun 2026
Aquasomes, a novel Vesicular Drug Delivery (VDD) technology in the pharmaceutical industry, are composed of a three-layered self-assembled nanoparticle (NP) such as a ceramic core, carbohydrate coating, and drug. It adso…
Review
Marine Bioactive Compounds and Pollution Impacts on Human Health: Ocean Education in the New Era
Kavitha Chrisnasamy, Nur Jahan Ahmad
pp. 315–324 · DOI: 10.5530/jyp.20260282 · Published Apr-Jun 2026
Ocean education has become an increasingly important field in addressing global environmental and sustainability challenges. A comprehensive analysis is presented of its current landscape, exploring recent innovations, p…

Case Report

Article
Ileocolic Intussusception in a 7-Month-Old Infant: Early Diagnosis through Ultrasonography: A Case Report
Mandava Mahima Swaroopa, Meghana Regulapati, Reshma Gayathri Kassetti, Mohammad Karishma, Kurra Varun
pp. 605–610 · DOI: 10.5530/jyp.20260288 · Published Apr-Jun 2026
Ileocolic intussusception is one of the most common causes of intestinal obstruction in infancy and represents a paediatric surgical emergency. Early diagnosis is essential to prevent bowel ischemia, necrosis, and perfor…