Volume 18, Issue 3

Jul-Sep 2026 · pp. 611–976 · 43 articles

Volume: 18
Issue: 3
Published: Jul-Sep 2026
Pages: 611–976
Articles: 43
Sections: 3
ISSN: Print - 0975-1483 | Online - 0975-1505
Journal: JYP

Review Article Original Article Case Report

In this issue

Review Article

Review
Drug-Resistant Tuberculosis at the Crossroads: Molecular Insights and Next-Generation Therapeutics
Lingaraj Kariyaplar Marulasiddappa, Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju
pp. 611–618 · DOI: 10.5530/jyp.20260061 · Published Jul-Sep 2026
Tuberculosis (TB) growing prevalence of drug-resistant strains Mycobacterium tuberculosis, it continues to major worldwide disease and a major public health concern. Emergence of Extensively Drug-Resistant (XDR-TB), Mult…
Review
The Estrobolome-Epigenetic Inflammatory Axis in Menopause: A Multisystem Mechanistic Link to Chronic Disease
Rina Das, Swati Rana, Dinesh Kumar Mehta, Arush Sharma
pp. 619–625 · DOI: 10.5530/jyp.20260080 · Published Jul-Sep 2026
Menopause is characterized by a progressive decline in ovarian estrogen production, resulting in immune dysregulation and a chronic low-grade inflammatory state known as inflammaging. Beyond hormonal deficiency, emerging…
Review
Nanotechnology-Driven Strategies for Enhanced Brain Drug Delivery: A Review of Bio-Nanoparticle Systems
Suraj Kumar, Pranita Jirvankar
pp. 626–631 · DOI: 10.5530/jyp.20260171 · Published Jul-Sep 2026
The BBB is one of the biggest challenges in the treatment of neurological diseases, as it blocks more than 98% of drugs reaching the brain. In this review, current nanotech approaches to overcoming the BBB are compiled, …
Review
Artificial Intelligence in Pharmacovigilance: A Narrative Review of Global Regulatory Perspectives, Technological Evolution, and Emerging Challenges
Suriya Sundharesan, Sneha Raja, Reshma Suresh, Jayasutha Jayram, Sujatha Kuppusamy, Harini Vinayagam, Someshwaran Surendran, Tanmayee Paladugu
pp. 639–645 · DOI: 10.5530/jyp.20260144 · Published Jul-Sep 2026
Pharmacovigilance plays a key role in public health-it helps us spot, assess, and prevent adverse drug reactions throughout a drug’s life on the market. This review takes a closer look at how AI is reshaping pharmacovigi…
Review
Therapeutic and Dermatological Potential of Ganoderma lucidum (Reishi/Lingzhi) in Cosmeceutical Formulations: A Comprehensive Review
Pankaj Sharma
pp. 646–655 · DOI: 10.5530/jyp.20260426 · Published Jul-Sep 2026
Ganoderma lucidum (Reishi) is a widely utilized medicinal mushroom in Asia, recognized for its hepatoprotective, antioxidant, immunomodulatory, and anticancer properties. The present review aims to systematically evaluat…
Review
Marine Algae-Derived Bioactive Compounds and Biomaterials: Pharmaceutical Applications and Therapeutic Advances in Medical and Dental Sciences
Sahana Shree Muthu, Shivasakthy Manivasakan, Vijayan Venugopal, Arumugam Muthuvel, David Livingstone
pp. 656–661 · DOI: 10.5530/jyp.20260409 · Published Jul-Sep 2026
Marine algae and their derivatives have gained substantial notice in the scientific community because of their rich source of bioactive compounds, which include carbohydrates, lipids, proteins, and pigments. These compou…
Review
Clozapine-Induced Myocarditis: A Systematic Review of Case Reports
Sanat Mahendra Dhoke, Mishthi Prajapati, Meensher Thapa Magar, Bipin Shaji
pp. 662–669 · DOI: 10.5530/jyp.20260255 · Published Jul-Sep 2026
Clozapine-Induced Myocarditis (CIM) is a rare but potentially life-threatening adverse drug reaction linked with the use of clozapine in treatment-resistant. The aim of this systematic review is to recognise the clinical…
Review
A Narrative Review on Siddha Dietetics (Pathiyam) and its Pharmacological Relevance in Diabetes Care
Gayatri Raveendran, Ramamurthy Murugan, Suruthi Kanaga Rathina, Priya B Krishnamoorthy, Shanmugapriya Ponnappan, G Senthilvel
pp. 670–675 · DOI: 10.5530/jyp.20260175 · Published Jul-Sep 2026
Diabetes Mellitus has become a global burden with features of hyperglycemia as a result of insulin resistance, impaired insulin secretion or both. Dietetics plays an important role in both the management and prevention o…
Review
APOE ε4 Modifies Stage-Dependent Alterations in Circulating Brain-Derived Neurotrophic Factor Across the Alzheimer’s Disease Continuum: A Systematic Review and Meta-Analysis
BS Sachin, Radhakrishnan Narayanaswamy, Anshu Kumar Yadav, Biswajit Das, V Shree Harsha, Kshama Nadig
pp. 676–685 · DOI: 10.5530/jyp.20260221 · Published Jul-Sep 2026
Circulating Brain-Derived Neurotrophic Factor (BDNF) has been proposed as a blood-based marker of synaptic vulnerability in Alzheimer’s Disease (AD), but published findings vary across disease stages and cohorts. This re…

Original Article

Article
Screening of Bioactive Phytochemicals from Gentiana kurroo for Diabetes Management: An Integrated Molecular Docking and in vitro Enzyme Inhibition Study
Pankaj Sharma
pp. 686–692 · DOI: 10.5530/jyp.20260310 · Published Jul-Sep 2026
Background Diabetes mellitus is a multifactorial metabolic disorder requiring multi-target therapeutic strategies. Medicinal plants rich in bioactive phytochemicals represent promising alternatives to conventional antidi…
Article
Medhya Rasayana Ghrita to Phytosome Approach-Centella asiatica and Bacopa monnieri Bioactive Enriched Fractions
Sharada Deore, Bhushan Arun Baviskar, Ram Chhatrapati Vighne
pp. 693–701 · DOI: 10.5530/jyp.20260039 · Published Jul-Sep 2026
Background Phytosomes overcome solubility, absorption, and stability limitations of crude extracts, leading to enhanced bioavailability, better therapeutic effect, and reduced required dose. Purpose Conventional Ayurvedi…
Article
GC-MS Profiling of Caulerpa lentillifera Hot Water Extract and it’s in vitro Effects on Hepatocellular Carcinoma Cell Progression
Nuranis Syazwani Shaiful Hambry, Mohd Nizam Mordi, Shahrul Bariyah Sahul Hamid
pp. 702–708 · DOI: 10.5530/jyp.20260081 · Published Jul-Sep 2026
Background Hepatocellular Carcinoma (HCC) is a highly resilient cancer associated with poor survival outcomes. Current treatment with sorafenib inhibits Raf kinases but still encounter resistance mediated by alternative …
Article
Design, Synthesis and Molecular Dynamics Simulation of Novel Spiropyran Derivatives as Putative CDK6-Targeting Anticancer Agents for Breast Cancer Treatment
Sagar D. Magar, Shubham P. Mankar, Sanket K. Tambe, Amol S. Dighe, Nilima M. Wani, Mayur S. Bhosale, Rahul K. Godge, Dattaprasad N. Vikhe, Jagdish R. Kudnar
pp. 709–719 · DOI: 10.5530/jyp.20260236 · Published Jul-Sep 2026
Background Breast cancer treatment with current dual CDK4/6 inhibitors is limited by hematological toxicity and acquired drug resistance. CDK6 is overexpressed in specific breast cancer subtypes and represents a validate…
Article
Antimicrobial Evaluation, LC-MS Characterization and Computational Molecular Study of Ethanol Extract of Marine Macro Algae Sargassum tenerrimum J. Agardh
Mohamed Ishal Manningapatt, Muralidharan Palayyan
pp. 720–726 · DOI: 10.5530/jyp.20260274 · Published Jul-Sep 2026
Objectives The current research was aimed to assess the antimicrobial activity and LC-MS characterization, and computational molecular analysis of the ethanolic extract of marine macro algae Sargassum tenerrimum J. Agard…
Article
Biological and Safety Evaluation of Green-Synthesized Calcium Oxide Nanoparticles Using Hedyotis diffusa
Kaniga Pandi, Binoy Varghese Cheriyan, Jayasri Bantaram, Indhumathi Jagan, Mahalakshmi Sundarraj, Subha Pradhaa Ramachandran, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu, Bhavya Ekambaram
pp. 727–740 · DOI: 10.5530/jyp.20260014 · Published Jul-Sep 2026
Background Dental caries and periodontal diseases are among the most prevalent oral disorders worldwide, necessitating the development of safe and effective therapeutic approaches. Green-synthesized nanoparticles derived…
Article
Poloxamer-Based Thermosensitive Nanoparticle in situ Gel for Sustained Pulmonary Anti-Tubercular Drug Delivery
Pooja Singh, Bhavna Kumar, Santosh Kumar Verma
pp. 741–754 · DOI: 10.5530/jyp.20260381 · Published Jul-Sep 2026
Background Tuberculosis treatment requires prolonged multidrug therapy, often associated with poor patient compliance and systemic side effects. The present study aimed to develop and optimize a Poloxamer 407-based therm…
Article
Systematic Optimization of Tinospora cordifolia Extract Gel Via Box-Behnken Design Using a DoE Framework
Koushik Yetukuri, Sethu Chandra Kanth Annavarapu, Venkata Jaswanth Balla, Vasudeva Bellana, Avinash Chowdary Chirumamilla, Siva Pradeep Raparla
pp. 755–762 · DOI: 10.5530/jyp.20260186 · Published Jul-Sep 2026
Background The design and optimization of a Tinospora cordifolia (Giloy) extract-loaded topical gel was carried out to explore its anti-inflammatory potential using a Box-Behnken Design (BBD). The study focused on improv…
Article
Development, Stability and Safety Evaluation of Lipstick Formulated with Butea monosperma
SVVNSM Lakshmi, S Dinesh Mohan, B Varsha, G Mythri, B Srimukhi
pp. 763–769 · DOI: 10.5530/jyp.20260209 · Published Jul-Sep 2026
Background Increasing safety concerns regarding synthetic colorants have promoted the development of herbal cosmetic formulations. Butea monosperma flowers are rich in natural pigments and bioactive compounds suitable fo…
Article
Optimization of Liposomal Eye Drops Co-Loaded with Triamcinolone Acetonide and Folic Acid for Retinal Vascular Disorders
Deepak Raja Arulmozhi, Pooja Sathishkumar, Subramanian Somaskanthan
pp. 770–778 · DOI: 10.5530/jyp.20260147 · Published Jul-Sep 2026
Background Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) require effective posterior segment drug delivery, challenged by ocular anatomical barriers. Triamcinolone Acetonide (TA) despite its intravitreal eff…
Article
Design and Optimization of Ziziphus mauritiana Fruit Polysaccharide-Based Beads for Controlled Release of Propranolol Hydrochloride Using Response Surface Methodology
Baisnabdas Pathak, Saptarshi Samajdar, Deepshikha Datta, Bimal Das
pp. 779–785 · DOI: 10.5530/jyp.20260332 · Published Jul-Sep 2026
Background Polysaccharides from nature have attracted significant interest as biocompatible and eco-friendly polymers used as carriers in drug delivery systems. ZMBP, which stands for Ziziphus mauritiana fruit pulp polys…
Article
Novel Biopolymeric Microspheres for Colon-Targeted Peptide Drug Delivery: An in vitro Investigation
Mitali Milind Bodhankar, Steffi George, Pooja Nandlal Taori, Nayana Chirag Vora
pp. 786–794 · DOI: 10.5530/jyp.20260276 · Published Jul-Sep 2026
Background Vancomycin (VAN) is used as a model peptide. It has been used extensively to treat severe infections brought on by Gram-positive bacteria. Vancomycin in colon-targeting studies has its therapeutic relevance in…
Article
Formulation and Characterisation of Melatonin in situ Gel for Oral Application
Kaveri Guddada Siddabasappa, Laxman Sureshbabu Vijapur, Swati Setty, Ajay Kumar Oli, Apoorva Jain, Anita Ravi Desai
pp. 795–800 · DOI: 10.5530/jyp.20260174 · Published Jul-Sep 2026
Background Melatonin in situ gel was formulated and tested to use in the bony defects. Intrabony defects are clinical presentation in some periodontal disease. Materials and Methods In situ gel containing 0.1% w/v Melato…
Article
Assessing the Genotoxic and Cytotoxic Potential of Protein Supplements Using Allium cepa as a Model Bioindicator
C. A. SriRanjani, C. Asha Deepti, K. Bhavya Sri
pp. 801–806 · DOI: 10.5530/jyp.20260084 · Published Jul-Sep 2026
Objectives The increasing consumption of dietary protein supplements raises concerns regarding potential contamination and associated toxicological effects. The present study evaluates the cytotoxic and genotoxic potenti…
Article
Network Pharmacology and Molecular Docking Analysis of Amoora rohituka Roxb. Reveals Bulnesol Modulates ESR1 and CYP2C19 Proteins as Potential Therapeutic Targets for Neuroprotection in the Management of Depression
Manjunatha Pai Chennaithody, Rajesh Kaverikana Shankar, Manappa T Mandalamari, Abdul Fairoz Ahamed
pp. 816–832 · DOI: 10.5530/jyp.20260003 · Published Jul-Sep 2026
Background Depression is a multifactorial neuropsychiatric disorder involving multiple molecular targets and signalling pathways. Amoora rohituka has a variety of pharmacological properties but its antidepressant activit…
Article
Neuroprotective Effects of Resveratrol in STZ-induced Diabetic Neuropathy in Rats by Behavioral and Biochemical Effects
Shafqat Zaidi, Krishana Kumar Sharma
pp. 833–839 · DOI: 10.5530/jyp.20260086 · Published Jul-Sep 2026
Objectives Diabetic neuropathy is one of the major complications, which is characterized by chronic neuropathic pain, oxidative stress, and neuroinflammation related to diabetes. The current research is designed to asses…
Article
Structural and Conformational Landscape of CDK4: The Basis for Next-Generation Kinase Therapeutics
Rashed Mohammed Alghamdi
pp. 840–849 · DOI: 10.5530/jyp.20260334 · Published Jul-Sep 2026
Background CDK4 (303 amino acids) is a serine/threonine kinase that regulates the G1-S transition and which is dysregulated in oncogenesis, and thus is an important target of kinase therapeutics. Structural Profiling aid…
Article
Exploring the Relationship between the Impact of Preoperative Anxiety on Post Operative Recovery of Patients Undergoing Anesthesia - An Observational Study
Sankamithra Sankar, Lavanya Baskaran, Uma Arumbuliyur Natarajan, Mithun Kumar
pp. 850–854 · DOI: 10.5530/jyp.20260009 · Published Jul-Sep 2026
Background Preoperative anxiety is common and may impede surgical recovery, yet it is seldom addressed in routine peri-operative care. Materials and Methods The sample consisted of 100 adult patients (mean age 39.1±12.5 …
Article
Assessment of Fluconazole Utilization: A Prospective Observational Study of Prescribing Patterns, Resistance Trends, and Empirical Therapy Outcomes in Hospitalized Patients at A Tertiary Care Hospital
Sayali Motghare, Tanvi Thakare, Anamika Pramod Bhoyar, Sampada Patwardhan, Komal Nawale
pp. 855–861 · DOI: 10.5530/jyp.20260182 · Published Jul-Sep 2026
Background Fluconazole is a triazole antifungal extensively indicated for the treatment of Candida infections, particularly in hospitalized and immunocompromised patients. It exerts its action by inhibiting lanosterol 14…
Article
Assessment of Awareness and Knowledge of Food-Drug Interactions Among Healthcare Professionals and Patients in India
Punam Kela, Sakshi Latey, Karishma Mainkar, Shreyasi Banerjee, Pratiksha Kulkarni, Nikhil Sathaye
pp. 862–869 · DOI: 10.5530/jyp.20260407 · Published Jul-Sep 2026
Background Food-Drug Interactions (FDIs) can lead to significant changes in drug efficacy and safety and may result in therapeutic failure. Inadequate knowledge and awareness of FDIs among Healthcare Professionals (HCPs)…
Article
Identifying Prescription Gaps Using WHO Core Indicators: A Pediatric Audit from a Rural Setting
Ayush Khandelwal, Trishala Gurung, Kanishaka Kapoor, Aashish Kumar, Rishabh Chaudhary, Ashwani K Sood, Sumeet Gupta, Rupa Joshi, Seema Bansal
pp. 870–877 · DOI: 10.5530/jyp.20260347 · Published Jul-Sep 2026
Background and Aim Infants and children are especially susceptible to medication errors due to their recurrent illnesses and unique physiological traits. This underscores the significance of rational and evidence-based p…
Article
A Prospective Cost-Utility Analysis of Bevacizumab-Based Combination Therapy Versus Chemotherapy Alone in Ovarian Cancer
Maryam Naseer, Safa Mateen, Mohammed Ziauddin, Mirza Zubair Baig, Anupama Koneru, Mohammed Ashfaq Hussain
pp. 878–884 · DOI: 10.5530/jyp.20260210 · Published Jul-Sep 2026
Background Ovarian cancer remains a leading cause of gynaecologic cancer mortality globally. While chemotherapy is the standard treatment, the addition of targeted therapies such as bevacizumab may improve clinical outco…
Article
Assessment of Response to Therapy and Survival Rate among Pemphigus Patients: A Retrospective Single Centre Study
Linda Clera Gonsalves, B S Girisha, Honnegowda Thittamaranahalli Muguregowda, Preeti Vemula, S Akshatha, Uday Venkat Mateti
pp. 885–891 · DOI: 10.5530/jyp.20260213 · Published Jul-Sep 2026
Background An autoimmune progressive condition called pemphigus causes the immune system to target cells in the mucous membranes and the epidermis unintentionally. In India it has a greater incidence of 4.4 per 100,000 p…
Article
A Community Based Study on Association of Menopausal Stage with Metabolic Health, Anemia, and MENQOL Scores in Postmenopausal Women
Swati Rana, Dinesh Mehta, Rina Das
pp. 892–898 · DOI: 10.5530/jyp.20260111 · Published Jul-Sep 2026
Background Menopause, an early transition in Indian women, impacts well-being and quality of life, with experiences influenced by socioeconomic disparities and phases of reproductive aging. Objectives There is limited co…
Article
Prevalence and Sociodemographic Correlates of Postpartum Depression in the Immediate Postpartum Period: A Cross-sectional Study in a Secondary Care Hospital Setting, India
Sobia Noor, Saritha Chukka
pp. 899–906 · DOI: 10.5530/jyp.20260230 · Published Jul-Sep 2026
Background Postpartum Depression (PPD) is a significant public health concern affecting maternal and infant well-being. Evidence from India remains limited within secondary care settings, where early postpartum contact o…
Article
Prevalence of Complementary and Alternative Medicine Usage in Patients of Diabetes Mellitus in Mumbai Metropolitan Region
Tejal Naik, Pallabika Borah, Dhananjay D. Mankar, Prafulla Parikh, B.M Prasanna Kumar
pp. 907–916 · DOI: 10.5530/jyp.20260030 · Published Jul-Sep 2026
Background We surveyed the prevalence of Complementary and Alternative Medicine (CAM) usage in patients with chronic diseases like DM (Diabetes Mellitus). As CAM usage is very common in patients with chronic diseases lik…
Article
Integrative Network Pharmacology and Molecular Docking Reveal the Multitarget Anti-HGSOC Potential of Pterocarpus marsupium Phytoconstituents via Modulation of HIF-1α-Driven Inflammation-Metabolism Crosstalk
Sambasivam Gopinath, Pavithra Balakrishnan, Yamini Muli, Sabrin Sirajudeen, Pratheesha Vijaya Kumar Rajathi, Mohan Raj Vijayan
pp. 917–930 · DOI: 10.5530/jyp.20260099 · Published Jul-Sep 2026
Background High-Grade Serous Ovarian Cancer (HGSOC) is the most lethal gynaecological malignancy, and its progression is driven substantially by Hypoxia-Inducible Factor-1α (HIF-1α)-centred inflammation-metabolism crosst…
Article
Comparative Antifungal Study of Methanolic Extracts of Senna auriculata and Lawsonia inermis
Shanmugapriya Ekambaram, Saravanan Devarajan, Seetharaman Rathinam, Vanitha Rani Nagasubramanian, Padmavathy Jagannathan
pp. 931–937 · DOI: 10.5530/jyp.20260208 · Published Jul-Sep 2026
Background Fungal infections pose a serious threat to human health. Infections commonly known as mycoses, particularly those caused by Candida pose a remarkable challenge, especially in immunosuppressed patients. These f…
Article
Knowledge-Practice Gap in Household Medication Safety: Insights from Pharm. D Academia in South India
Pavan Kumar Yanamadala, Sai Krishna Reddy Konda, Hari Shankar Kantati, Jahnavi Kanaparthi, Chatana Lakshmi Sai Sravanthi Malisetty, Deepika Jinka, Guru Lakshmi Bolisetty, Gnaneswari Madineni, Rama Rao Nadendla, Pallavi Vadlamudi
pp. 938–944 · DOI: 10.5530/jyp.20260083 · Published Jul-Sep 2026
Background The safety of medications used in households and the problem of polypharmacy are becoming increasingly important public health issues in India, especially in environments where informal practices, a lack of aw…
Article
In vitro Cytotoxic Effect of Green Synthesized Hydroxyapatite Nanoparticles and Nanocomposites using Fibroblast Cell Line
Lakshmi Ajithan Sreelatha, Dhanraj Muthuveera Ganapathy, Rajeshkumar Shanmugam, Pradeep Chandralekha Dathan, Nikhil Soma Rajan
pp. 945–954 · DOI: 10.5530/jyp.20260295 · Published Jul-Sep 2026
Introduction Hydroxy apatite nanoparticles are a material of choice for biomedical application owing to its properties like biocompatibility and bioactivity. But there are concerns regarding the safety of these nanoparti…
Article
Targeting NF-κB Signaling with Naringenin: Molecular Docking and Cellular Insights into Asthma Therapy
Abdulrahman Alzahrani
pp. 955–960 · DOI: 10.5530/jyp.20260325 · Published Jul-Sep 2026
Background Asthma is a chronic inflammatory lung disease where the airways are affected by immune dysregulation, eosinophilic inflammation and activation of NF-κB signaling pathways. Integrated in silico and in vitro ana…

Case Report

Article
Management of Chronic Contact Eczema (Stravi Vicharchika) through Ayurvedic Therapy: A Case Study
Aishwarya Sureshrao Kadam, Sourabh Gyanranjan Deshmukh
pp. 961–966 · DOI: 10.5530/jyp.20260008 · Published Jul-Sep 2026
Ayurveda, the traditional Indian medical science, broadly identifies skin ailments under the umbrella term Kushtharoga, which covers a diverse range of dermatological issues. These disorders are categorized into two grou…
Article
Ebstein Anomaly in a Term Neonate Complicated by Burkholderia cepacia Culture-Proven and Multiorgan Failure: A Rare Case Report of Late-Onset Sepsis
Mandava Mahima Swaroopa, Meghana Regulapati, Reha Bhavani Chennu, Blessy Chittelu, Lalasa Sri Tulasi Royyuru
pp. 967–971 · DOI: 10.5530/jyp.20260021 · Published Jul-Sep 2026
Ebstein anomaly is a rare congenital malformation of the tricuspid valve that can present in the neonatal period with severe cyanosis, heart failure, and cardiopulmonary instability. Neonates with complex congenital hear…
Article
A Fatal Case of Phenobarbital-Induced Stevens-Johnson Syndrome with Erythroderma Associated with Sepsis, Drug-Induced Liver Injury and Normocytic Normochromic Anaemia
N K Keerthana, G M Monika, M Kumaraswamy, A Hafis, Pavan Kumar Chikkavalli Muddanna, J P Darshan, G Likhith, B Yuktha
pp. 972–976 · DOI: 10.5530/jyp.20260165 · Published Jul-Sep 2026
Stevens-Johnson syndrome is a potentially fatal condition characterized by severe adverse drug reactions involving the mucosal surfaces and skin. This study describes an SJS case with erythroderma induced by the medicati…