Neuropharmacological Effects of Methanolic Extract of Clerodendrum viscosum Leaves on Wistar Albino Rats
Meera Rath1★, Ayon Bhattacharya1★, Soumya Santra1, Karmajeet Rath1, Goutam Ghosh3, Bijaya B. Nanda4★ Corresponding author
- 1Department of Pharmacology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan University, India.
- 2Department of Pharmacology, KPC Medical College, WBUHS, Kolkata, West Bengal, India.
- 3Department of Pharmacognosy, School of Pharmaceutical Sciences, S‘O’A University, India.
- 4Regional Institute of Planning Applied Economics and Statistics, Government of Odisha, Bhubaneswar, Odisha, India.
CORRESPONDENCE
Meera Rath
Department of Pharmacology, Institute of Medical Sciences, Siksha ‘O’ Anusandhan University, India.
Received: 20-05-2018; Revised: 05-09-2018.
Volume 14, Issue 59S · pp. S507–S514 · PUBLISHED 17 January 2019 · DOI: 10.4103/pm.pm_267_18
ABSTRACT
Background: The aim is to study the central nervous system (CNS) depressant, anxiolytic, and antiepileptic activities of methanolic extract of Clerodendrum viscosum (MECV) leaves. Materials and Methods: The study comprised five groups each with 6 Wistar albino rats. The Group 1 or the positive control (phenytoin 30 mg/kg for the epilepsy model, and diazepam 1 mg/kg for the other models), Group 2 or negative control (0.9% NaCl at 10 ml/kg), and Groups 3–5 or the test drug group (MECV at 200, 400, and 800 mg/kg). Actophotometer test, staircase test, maximal electroshock seizure (MES) test, and the thiopentone sodium‑induced sleep test, were used to study the various parameters. Results: The actophotometer test, MES, and staircase test (steps climbed) were analyzed using parametric tests. The sleep induction and staircase test (number of rears) were evaluated using nonparametric tests. A dose‑dependent significant (P < 0.05) response was observed in the actophotometer test, sleep induction, and MES tests in comparison to control. In the staircase test at 200 and 400 mg/kg, increase in the number of steps climbed, and at 800 mg/kg decrease in both the number of steps climbed and rears were observed in comparison to control. Conclusion: MECV showed a dose‑dependent CNS depressant action in the sleep induction and antiepileptic tests. A CNS stimulant action was observed at low dose (200 mg/kg) and depressant action at a higher dose (800 mg/kg) in the staircase test in comparison to control.
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Rath, M., Bhattacharya, A., Santra, S., Rath, K., Ghosh, G., & Nanda, B. B. (2019). Neuropharmacological Effects of Methanolic Extract of Clerodendrum viscosum Leaves on Wistar Albino Rats. Pharmacognosy Magazine, 14(59S), S507–S514. https://doi.org/10.4103/pm.pm_267_18