Volume 14, Issue 59S

17 January 2019 · pp. 0–657 · 26 articles

Volume: 14
Issue: 59S
Published: 17 January 2019
Pages: 0–657
Articles: 26
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article ORIGINAL ARTICLE

In this issue

Original Article

Article
Characterization of the Secondary Metabolites from Endophytic Fungi Nodulisporium sp. Isolated from the Medicinal Plant Mikania laevigata (Asteraceae) by Reversed‑Phase High‑Performance Liquid Chromatography Coupled with Mass Spectrometric Multistage
Isabella M. A. Reis, Fernanda P. C. Ribeiro, Paulo R. M. Almeida, Larissa C. B. Costa, Hélio M. Kamida, Ana P. T. Uetanabaro, Alexsandro Branco
pp. S495–S498 · DOI: 10.4103/pm.pm_616_17 · Published 17 January 2019
Background: The endophytic fungi are an excellent source of secondary metabolites as a natural product with antimicrobial, insecticidal, cytotoxic, antioxidant, and anticancer activities. No studies on the chemical compo…
Article
Neuropharmacological Effects of Methanolic Extract of Clerodendrum viscosum Leaves on Wistar Albino Rats
Meera Rath, Ayon Bhattacharya, Soumya Santra, Karmajeet Rath, Goutam Ghosh, Bijaya B. Nanda
pp. S507–S514 · DOI: 10.4103/pm.pm_267_18 · Published 17 January 2019
Background: The aim is to study the central nervous system (CNS) depressant, anxiolytic, and antiepileptic activities of methanolic extract of Clerodendrum viscosum (MECV) leaves. Materials and Methods: The study compris…
Article
Inducible Nitric Oxide Synthase Downregulation and Apoptotic Activity of Pleurotus florida (Oyster Mushroom)
Aathishree Vanji Paramasivan, Ramaraj Thirugnanasampandan, Vasantharani Selvaraj, Bhuvaneswari Gunasekaran, Madhusudhanan Gogul Ramnath, Shanmugam Krishnakumari, Subramanian Kathiravan
pp. S515–S519 · DOI: 10.4103/pm.pm_59_18 · Published 17 January 2019
Background: Pleurotus florida is an edible delicious mushroom grown on large scale in different parts of the world. Objective: The objective of this study is to test the hepatoprotective, cytotoxic, and apoptotic activit…
Article
Elucidation of the Molecular Mechanism of Tempol in Pentylenetetrazol‑induced Epilepsy in Mice: Role of Gamma‑aminobutyric Acid, Tumor Necrosis Factor‑alpha, Interleukin‑1β and C‑Fos
Leguo Zhang, Tao Wu, Amit Kandhare, Anwesha Mukherjee, Gang Guo, Subhash L. Bodhankar
pp. S520–S527 · DOI: 10.4103/pm.pm_263_18 · Published 17 January 2019
Background: Epilepsy is a chronic neurological disorder occurred due to periodic neuronal discharge and imbalance in brain electrical activity. 4‑Hydroxy‑TEMPO (Tempol) is a membrane‑permeable radical scavenger moiety. A…
Article
Anti‑Proliferative Activity of Earthworm Coelomic Fluid Using Oral Squamous Carcinoma KB 3‑1 cells: An In vitro Study with Serine Protease Analysis
Dominic Augustine, Roopa S. Rao, Anbu Jayaraman, K. N. Chidambara Murthy
pp. S528–S534 · DOI: 10.4103/pm.pm_412_18 · Published 17 January 2019
Background: Naturally available extracts have gained importance as adjunctive pharmacologic modalities. The earthworm coelomic fluid (ECF) has shown promising in vitro cytotoxic effect in hepatocellular, colorectal, and …
Article
Tropidia Curculioides: Secondary Metabolites and Derivatives with Antimycobacterial and Leishmanicidal Activity
Nandan Sarkar, Biswajit Saha, Sarman Singh, Sabari Ghosal
pp. S535–S538 · DOI: 10.4103/pm.pm_196_18 · Published 17 January 2019
Background: Arunachal Pradesh the north-eastern state of India is a natural habitat of 550 species of orchids including 37 species of medicinal importance. Although these plants are regularly used by ethnic population, v…
Article
In vitro and In vivo Hepatoprotective Studies on Methanolic Extract of Aerial Parts of Ludwigia hyssopifolia G. Don Exell
Pallerla Praneetha, Yellu Narsimha Reddy, Bobbala Ravi Kumar
pp. S546–S553 · DOI: 10.4103/pm.pm_85_18 · Published 17 January 2019
Background: Ludwigia hyssopifolia of family Onagraceae is traditionally used in the treatment of jaundice. There were no reports on the plant for both in vivo and in vitro hepatoprotective studies. Objective: The current…
Article
Methyl Elaidate: A Major Compound of Potential Anticancer Extract of Moringa oleifera Seeds Binds with Bax and MDM2
(p53 Inhibitor) In silico Ismail Abiola Adebayo, Hasni Arsad, Mohammed Razip Samian
pp. S554–S557 · DOI: 10.4103/pm.pm_125_18 · Published 17 January 2019
Background: Apoptosis is an energy‑required programmed cell death process that is vital for normal homeostasis. This is because aged, malfunctioning, and genetically deficient cells such as cancer cells are eliminated th…
Article
Acid Stress Reduces the Function of Na+‑K+‑ATPase in Superior Mesenteric Artery of Capra hircus
Subash Chandra Parija, Ipsita Mohanty
pp. S558–S563 · DOI: 10.4103/pm.pm_602_17 · Published 17 January 2019
Context: Extracellular hydrogen ion concentration (pHo) is an important physiological regulator of vascular tone, maintained within 7.35–7.45 and any change in it leads to complex health problem including maintenance of …
Article
Induction Studies of a Novel α‑Glucosidase Purified from Lactobacillus fermentum Grown on Resistant Starch
Mousami Shankar Addala, Muralikrishna Gudipati
pp. S564–S570 · DOI: 10.4103/pm.pm_328_18 · Published 17 January 2019
Aim: The aim of this study is to investigate the induction studies of resistant starch (RS)‑degrading enzyme purified from Lactobacillus fermentum. Background: RS is one of the components of dietary fiber and considered …
Article
Identification of Compounds of Aristolochia tagala and Apoptotic Activity in HeLa Cells
Khetbadei Lysinia Hynniewta Hadem, Arnab Sen
pp. S571–S577 · DOI: 10.4103/pm.pm_145_18 · Published 17 January 2019
Background: Plants contain secondary metabolite used as drugs/medicines for the treatment of various diseases. Aristolochia tagala is used for the treatment of several diseases. Our study reported the chemopreventive pot…
Article
Administration of Roasted Barley and Roasted Horse Gram Powders Pacified Chronic Sucrose‑induced Dysglycemia and Dyslipidemia in Rats and Exerted In Vitro Potent Antioxidative Stress Effect
Ajay Anand, Ukkujuri Priyanka, Kuncha Madhusudana, Vadithe Lakshma Nayak, Amtul Zehra, Katragatta Suresh Babu, Ashok Kumar Tiwari
pp. S578–S590 · DOI: 10.4103/pm.pm_310_18 · Published 17 January 2019
Background: Sugar‑enriched diets/beverages consumption aggravates dysglycemia, dyslipidemia, insulin resistance, glucose intolerance, and weight gain. If unchecked, these disturbances culminate into diabetes. Indian medi…
Article
Evaluation of Cytotoxic Activity of Oil Extract and Fractions from Seeds of Cardiospermum halicacabum L. on Various Human Breast Cancer Cell Lines
Behzad Mohaddesi, Ashvin Dudhrejiya
pp. S591–S595 · DOI: 10.4103/pm.pm_188_17 · Published 17 January 2019
Background: Breast cancer is a common nonskin cancer in females and rarely can happen in males. It is the second leading cause of cancer death among women. In spite of different methods of treatment for cancer, tradition…
Article
Gastroprotective Effect of Formononetin against Ethanol‑Induced Gastric Ulceration in Rats via Augmentation of Cytoprotective Markers and Curtailing Apoptotic Gene Expression
Alauddin Alauddin, Swati Chaturvedi, Lubna Azmi, Ila Shukla, Zaiba Naseem, Chandana Venkateswara Rao, Naresh Kumar Agarwal
pp. S605–S612 · DOI: 10.4103/pm.pm_205_18 · Published 17 January 2019
Background: Formononetin (FMN), one of the major isoflavones in red clover, has been shown to possess antioxidant, anti‑inflammatory, antitumor, neuroprotective, and cytoprotective activities. However, there is no report…
Article
Effect of Valeriana wallichii on Alcohol Addiction in Mice
Anusua Biswas, Sugato Banerjee
pp. S613–S618 · DOI: 10.4103/pm.pm_388_18 · Published 17 January 2019
Background: Alcoholism is the most common form of addiction and a worldwide problem. Alcohol addiction primarily leads to alcohol dependence and on abstinence leads to withdrawal effects. Common pharmacological propertie…
Article
Suppression of the Mechanisms of Stone Formation by a Flavonoid‑enriched Ethyl Acetate Fraction of Aerial and Underground Parts of Aerva lanata (Linn.) Juss. Ex Schult
Bitasta Mandal, Swati Madan, Sayeed Ahmad, Sultan Zahiruddin
pp. S630–S637 · DOI: 10.4103/pm.pm_140_18 · Published 17 January 2019
Background: Aerva lanata (Linn.) Juss. ex Schult.(AL), belonging to family Amaranthaceae, is a popular medicinal herb known for its immense antiurolithic properties. Several researchers have reported the antilithiatic ef…
Article
In silico Analysis of Binding Interaction of Phytoconstituents with N‑Methyl‑D‑Aspartate Receptor for Potential Therapeutic Use in Alzheimer’s Disease
Suman Chowdhury, Suresh Kumar
pp. S638–S642 · DOI: 10.4103/pm.pm_214_18 · Published 17 January 2019
Background: Alzheimer’s disease (AD) is an irreversible neurodegenerative disease associated with memory loss and cognition deficit. At present, the drugs which are available in the markets only provide symptomatic relie…
Article
The Positive Intervention Effects of Resveratrol on Acrylamide ‑Induced Cyto‑/Genotoxicity in Primary Lymphocytes of Rat
Ranjini Ankaiah, Nawneet Kumar Kurrey, Manonmani Haravey Krishnan
pp. S643–S648 · DOI: 10.4103/pm.pm_378_18 · Published 17 January 2019
Background: Acrylamide (AA), a product formed from fried foods, has been recognized as a genotoxic agent in animals and humans. Oxidative stress is considered as an indirect cause of AA‑related genotoxicity. Objective: R…
Article
Antithyroidic and Hepatoprotective Properties of High‑Resolution Liquid Chromatography–Mass Spectroscopy‑Standardized Piper betle Leaf Extract in Rats and Analysis of Its Main Bioactive Constituents
Sunanda Panda, Rajesh Sharma, Anand Kar
pp. S658–S664 · DOI: 10.4103/pm.pm_450_18 · Published 17 January 2019
Background: Hyperthyroidism can be a serious health problem, if not treated properly. This investigation primarily aimed to evaluate the thyroid regulatory and hepatoprotective activities of ethyl acetate fraction (EPBL)…
Article
Zanthoxylum alatum Attenuates Lipopolysaccharide-Induced Depressive-like Behavior in Mice Hippocampus
Chandana Choudhury Barua, Beenita Saikia, Xinguo Ren, R. Elancheran, Debesh Chandra Pathak, Shantanu Tamuli, Acheenta Gohain Barua
pp. S673–S682 · DOI: 10.4103/pm.pm_606_17 · Published 17 January 2019
Background: Zanthoxylum alatum (ZA) is used ethnomedicinally for the treatment of various diseases. It is used as a nerve tonic in weak patients and in vertigo. Objective: The beneficial effect of hydroethanolic extract …

ORIGINAL ARTICLE

Article
Cytotoxicity and Cell Migration Suppression by Noni Fruit Extract on Michigan Cancer Foundation-7 Human Breast Cancer Cells and Development of Topical Microemulsions
Supavadee Boontha, Noppamas Kaewjaiboon, Phitchayut Rattanatanyapat, Wanwalee Nanto, Salisa Taolam, Benjaporn Buranrat, Tasana Pitaksuteepong
pp. S499–506 · DOI: 10.4103/pm.pm_403_18 · Published 17 January 2019
Background: There is limited data about the anti‑breast cancer activity of noni fruit ethanolic extract. Topical route is gaining interest as an alternative route for breast cancer treatment. Objectives: The aims of this…
Article
Hypoglycemic Effect of Ethyl Acetate Fraction of Methanol Extract from Campylandra aurantiaca Rhizome on High-fat Diet and Low-dose Streptozotocin-induced Diabetic Rats
Mainak Chakraborty, Asis Bala, Sanjib Bhattacharya, Pallab Kanti Haldar
pp. S539–45 · DOI: 10.4103/pm.pm_194_17 · Published 17 January 2019
Background: Campylandra aurantiaca (Asparagaceae), commonly known as Nakima in Sikkimese Tibetan, is a plant grown in South‑Central China and Northeast India. Objective: To evaluate the hypoglycemic activity of ethyl ace…
Article
Ameliorative Activity of Ethanolic Flower Extract of Nyctanthes arbor‑tristis (L.) against Scopolamine‑Induced Amnestic Effect and Profiling of Active Compounds Using Gas Chromatography–Mass Spectrometry and Ultra‑Performance Liquid Chromatography‑Quadrupole‑Time‑of‑Flight Mass Spectrometry
Awadhesh Kumar Mishra, Prabhat Upadhyay, Jyoti Dixit, Pradeep Kumar, Kavindra Nath Tiwari, Sunil Kumar Mishra, Raghunath More, Jasmeet Singh
pp. S596–604 · DOI: 10.4103/pm.pm_448_18 · Published 17 January 2019
Background: Amnesia state damages the hippocampus and leads to the loss of short‑term memory. Nyctanthes arbor‑tristis (L.) is used in traditional medicines to treat various ailments. Objective: In the present investigat…
Article
Bioavailability and Stability Enhancement of Natural Isoflavones of Saraca asoca by Cryogenic Encapsulation Technique
Mojeer Hasan, Bibhu Prasad Panda
pp. S619–29 · DOI: 10.4103/pm.pm_468_18 · Published 17 January 2019
Background: The detailed study to overcome the limitations related to oral drug release and better encapsulation efficiency of the Saraca asoca extract has not been reported, despite having so many uses as sacred as well…
Article
Normalization of Insulin Resistance, Glucose Intolerance, and Lipid Profile by Swietenia Mahagoni (L.) Jacq. Leaf Extract in Fructose-Induced Diabetic Rats
Naveen Y. Puttaswamy, Asna Urooj
pp. 649–657 · DOI: 10.4103/pm.pm_358_18 · Published 17 January 2019
Ethanopharmacological Relevance: Swietenia mahagoni (L.) Jacq. is a medicinal plant used in various medicinal practices for the treatment of various human ailments. Materials and Methods: The present study evaluates the …
Article
Comparative Evaluation of Antioxidant Activity and Liquid Chromatography–Mass Spectrometry-based Phytochemical Profiling of Various Biological Parts of Caryota urens
Balaji Sujitha, Kavasseri Ganesan Kripa
pp. S665–72 · DOI: 10.4103/pm.pm_320_18 · Published 17 January 2019
Introduction: Caryota urens belongs to the palm family and is widely distributed in Asia. Conventionally, it is used to treat gastric ulcers, snake bites, migraine, and rheumatic swellings. The objectives of this study w…