Volume 15, Issue 60

Original Article

1. Article

   Picrolemma sprucei Quassinosides Inhibits Breast and Prostate Cell Growth and Impairs Behavioral Phenotype in Mice

   Sinária Rejany Nogaia de Sousa, Ingrit Elida Collantes Díaz, Riad Naim Younes, Sergio Alexandre Frana, Maria Martha Bernardi, Ivana Barbosa Suffredini

   pp. 1–11 · DOI: 10.4103/pm.pm_228_18 · Published 23 January 2019

   Objective: The objective of the study is to bioguide fractionate the organic/aqueous extracts from the aerial organs of Picrolemma sprucei (EB1151 and EB1152) aiming the identification of antitumor compounds and to evalu…

2. Article

   Cytotoxicity and Mitochondrial‑Mediated Apoptosis Induced by Fenugreek Seed Oil in Human Hepatocellular Carcinoma Cells via Reactive Oxygen Species Generation

   Ebtesam S. Al‑Sheddi, Nida N. Farshori, Mai M. Al‑Oqail, Shaza M. Al‑Massarani, Maqsood A. Siddiqui, Javed Ahmad, Abdulaziz A. Al‑Khedhairy

   pp. 12–17 · DOI: 10.4103/pm.pm_163_18 · Published 23 January 2019

   Objective: The present study was aimed to investigate the anticancer activity of Fenugreek seed oil (FSO) against human hepatocellular carcinoma (HepG2) cell line. Materials and Methods: The HepG2 cells were exposed to 1…

3. Article

   Evaluation of Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis Stem Extract

   Xiaoying Chen, Shuangshuang Qin, Cui Li, Qinghua Wu, Chao Jiang, Jian Yang, Xiaoyun Guo, Chunli Ou

   pp. 18–23 · DOI: 10.4103/pm.pm_317_18 · Published 23 January 2019

   Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> (CQ) is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The pr…

4. Article

   Phytochemical Analysis and Cytotoxic Activity of Cnidoscolus quercifolius Pohl (Euphorbiaceae) against Prostate (PC3 and PC3‑M) and Breast (MCF‑7) Cancer Cells

   Raimundo G. Oliveira Júnior, Christiane A. A. Ferraz, Emanuella C. V. Pereira, Pedrita A. Sampaio, Maria Francilene S. Silva, Cláudia O. Pessoa, Larissa A. Rolim, Jackson Roberto Guedes da Silva Almeida

   pp. 24–28 · DOI: 10.4103/pm.pm_6_18 · Published 23 January 2019

   Objective: In this report, it was described the cytotoxic effect of extract and fractions obtained from the leaves of C. quercifolius. It was also reported for the first time the identification of two flavonoids in this …

5. Article

   Comparative Research of the Curative Effects of Pinelliae Rhizoma and Pinelliae Rhizoma Praeparatum cum Alumine on Ovalbumin-induced Allergic Asthma in Rats

   Wei Peng, Da-Neng Wei, Yu-Jie Liu, Meng-Meng Zhang, Mei-Bian Hu, Chun-Jie Wu

   pp. 29–35 · DOI: 10.4103/pm.pm_397_18 · Published 23 January 2019

   Aim: This study was designed to compare the curative effects of Pinelliae Rhizoma (RPT) and Pinelliae Rhizoma Praeparatum cum Alumine (QPT) on ovalbumin (OVA)‑induced allergic asthma in rats. Materials and Methods: Asthm…

6. Article

   Dietary Oils Ameliorate Aluminum Chloride-Induced Memory Deficit in Wistar Rats

   Ayush Kumar, Sanchari Basu Mallik, Samita Rijal, Nilanjan Changdar, Jayesh Mudgal, Rekha R. Shenoy

   pp. 36–42 · DOI: 10.4103/pm.pm_306_18 · Published 23 January 2019

   Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain and is the most common form of dementia. There is no known cure for AD, and therefore, alternate therapies are warranted. Mult…

7. Article

   Ameliorative Effect of Morin, a Plant Flavonoid against Freund’s Complete Adjuvant‑Induced Polyarthritis in Rats

   Guozhi Zhang, Amit D. Kandhare, Anwesha A. Mukherjee, Subhash L. Bodhankar, Hailei Yin

   pp. 43–51 · DOI: 10.4103/pm.pm_351_18 · Published 23 January 2019

   Objective: The aim is to study the anti‑arthritic activity of the morin against adjuvant‑induced polyarthritis in rats. Materials and Methods: Polyarthritis was induced in female Wistar rats (150–180 g) using Freund’s co…

8. Article

   Durio zibethinus Rind Extract Mediated Green Synthesis of Silver Nanoparticles: Characterization and Biomedical Applications

   Samuggam Sumitha, Sethu Vasanthi, Sivadasan Shalini, Suresh V. Chinni, Subash C. B. Gopinath, Sathasivam Kathiresan, Periasamy Anbu, Veerasamy Ravichandran

   pp. 52–58 · DOI: 10.4103/pm.pm_400_18 · Published 23 January 2019

   Objective: The present work was aimed to develop green approach for the synthesis of silver nanoparticles (DRAgNPs) using D. zibethinus rind aqueous extract and determination of its antimicrobial and cytotoxic effect aga…

9. Article

   Vasorelaxant Effect of the Ethanol Extract from Valeriana fauriei Briquet Root and Rhizome on Rat Thoracic Aorta

   Bumjung Kim, Shin‑Saeng Ma, Cheolmin Jo, Somin Lee, Hanna Choi, Kyungjin Lee, Inhye Ham, Ho-Young Choi

   pp. 59–65 · DOI: 10.4103/pm.pm_152_18 · Published 23 January 2019

   Background: Valeriana fauriei has been used to treat anxiety and cardiovascular disease in many countries; however, the mechanisms of the vasorelaxant effect of V. fauriei roots and rhizomes have not been elucidated. Pur…

10. Article

    Toxicity Study of Silver Nanoparticles Synthesized from Aqueous Flower Extract of Scrophularia striata on MCF‑7 Human Breast Cancer Cell Line

    Roohangiz Mameneh, Massoumeh Shafiei, Ali Aidy, Elahe Karimi, Behzad Badakhsh, Naser Abbasi

    pp. 66–72 · DOI: 10.4103/pm.pm_78_18 · Published 23 January 2019

    Background: Silver nanoparticles (AgNPs) have been used as an antimicrobial and disinfectant agent. Nevertheless, there is limited data about antitumor potential. This study has focused on investigating cytotoxic effects…

11. Article

    New Formulation Containing Curcuminoids: Method Validation and Dissolution Profile

    Nayara Luiza Oliveira Ferreira, Mariana Cristina Morais Rodrigues, Rejanne Lima Arruda, Pierre Alexandre Santos

    pp. 73–80 · DOI: 10.4103/pm.pm_50_18 · Published 23 January 2019

    Objective: The aim of this work was to obtain capsules using C. longa soft extract, to develop and validate a method for quantification of curcuminoids, and to study the dissolution profile of the capsules. Materials and…

12. Article

    Determination of Isoorientin Levels in Rat Plasma by Ultra‑High Performance Liquid Chromatography Coupled with Diode Array Detector and Its Application to a Pharmacokinetic Study

    Doan Nguyen Kieu Trang, Yu Chul Kim, Seung‑Hwan Kwon, Choon‑Gon Jang, Han‑Joo Maeng

    pp. 81–86 · DOI: 10.4103/pm.pm_68_18 · Published 23 January 2019

    Objective: The aim of this study is to develop a specific and reproducible ultra‑high‑performance liquid chromatography‑diode array detector (UHPLC‑DAD) based method to quantify isoorientin in rat plasma and to apply the…

13. Article

    Clinacanthus nutans Induced Reactive Oxygen Species‑dependent Apoptosis and Autophagy in HCT116 Human Colorectal Cancer Cells

    Kar Suen Wang, Chim Kei Chan, Ahmad Fadhlurrahman Ahmad Hidayat, Yau Hsiung Wong, Habsah Abdul Kadir

    pp. 87–97 · DOI: 10.4103/pm.pm_299_17 · Published 23 January 2019

    Objective: Our study aims to investigate the apoptosis‑ and autophagy‑inducing effects of C. nutans in HCT116 human colorectal cancer cells. Materials and Methods: Cytotoxicity of ethanol extract, hexane, ethyl acetate, …

14. Article

    Evaluation of antioxidant, anti-inflammatory, and cytotoxic activities of Crotalaria pallida Aiton leaves

    Cite this article as: Sato VH, Chewchinda S, Nuamnaichati N, Mangmool S, Sungthong B, Lertsatitthanakorn P, et al. Pharmacological mechanisms of the

    pp. 98–106 · DOI: 10.4103/pm.pm_14_18 · Published 23 January 2019

    Objectives: This study was aimed to evaluate the anti‑inflammatory and hypouricemic effects of L. strychnifolium leaves extract and to investigate the pharmacological mechanisms of these effects. Materials and Methods: T…

15. Article

    Exogenous Intervention with Sodium Hydrosulfite Enhances the Quality of Radix Scutellariae by Modulating Antioxidases and Secondary Metabolites

    Song Qi, Gao Huiru, Wang Jiahui, Zhang Aihua, Meng Xiangcai

    pp. 107–114 · DOI: 10.4103/pm.pm_598_17 · Published 23 January 2019

    Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…

16. Article

    An Ethnobotanical and Ethnomedicinal Survey of Traditionally Used Medicinal Plants in Seymour, South Africa: An Attempt toward Digitization and Preservation of Ethnic Knowledge

    Lisa Valencia Buwa-Komoreng, Buyisile Mayekiso, Zoleka Mhinana, Ariyo Lateef Adeniran

    pp. 115–123 · DOI: 10.4103/pm.pm_259_18 · Published 23 January 2019

17. Article

    Total Anthocyanins and Cyanidin-3-O-Glucoside Contents and Antioxidant Activities of Purified Extracts from Eight Different Pigmented Plants

    Luo Yang, Cai Rong-Rong, Fang Ji-Li, Yuan Ke

    pp. 124–129 · DOI: 10.4103/pm.pm_162_18 · Published 23 January 2019

    Objective: The objective was to evaluate the contents of total anthocyanin and cyanidin‑3‑O‑glucoside (C‑3‑G) and their contribution to the antioxidant activities in commonly consumed pigmented plants. Materials and Meth…

18. Article

    Immunomodulatory Activity of an Indonesian Herbal Formulation for Respiratory Disorder

    Zullies Ikawati, Triana Hertiani, Fauzia Izzati

    pp. 130–134 · DOI: 10.4103/pm.pm_314_18 · Published 23 January 2019

    Objective: The aim of this study is to determine the activity of an Indonesian herbal formulation, which is specific for respiratory disorders and contains a combination of Curcuma xanthorrhiza rhizome, Vitex trifolia le…

19. Article

    Comparative Studies of Selected Calophyllum Plants for their Anti‑inflammatory Properties

    Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee

    pp. 135–139 · DOI: 10.4103/pm.pm_212_18 · Published 23 January 2019

    Background: Calophyllum (Clusiaceae) plants have been used as traditional medicine for rheumatism, vein problems, hemorrhoids, and gastric ulcers. The traditional uses of this genus prompted us to investigate six Malaysi…

20. Article

    Anti-Inflammatory and Anti-Oxidative Effects of Centella asiatica Extract in Lipopolysaccharide-Stimulated BV2 Microglial Cells

    Nootchanat Mairuae, Poonlarp Cheepsunthorn, Benjaporn Buranrat

    pp. 140–146 · DOI: 10.4103/pm.pm_197_18 · Published 23 January 2019

    Objective: The goal of this study was to investigate the anti‑inflammatory and anti‑oxidative effects of Centella asiatica extract (CA) on lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Methods: BV2 microglial…

21. Article

    Convenient Preparation of 2’’-O-Rhamnosyl Icariside II, a Rare Secondary Flavonol Glycoside, by Recyclable and Integrated Biphase Enzymatic Hydrolysis

    Chunlai Feng, Yi Lu, Yiying Zhou, Hui Pang, Yuping Shen, Huan Yang

    pp. 147–155 · DOI: 10.4103/pm.pm_398_18 · Published 23 January 2019

    Objective: The objective of this study was to establish a novel catalysis system for convenient preparation of this compound based on the recyclable and integrated biphase enzymatic hydrolysis. Materials and Methods: ‑d…

22. Article

    Optimization of Ultrasonic‑Assisted Extraction of Bioactive Compounds from Sargassum henslowianum using Response Surface Methodology

    Yongguang Bi, Yanshan Lu, Hong Yu, Lili Luo

    pp. 156–163 · DOI: 10.4103/pm.pm_347_18 · Published 23 January 2019

    Objective: This study was to optimize the ultrasound‑assisted extraction of polysaccharides and polyphenols from S. henslowianum and test the biological activity of the extract. Materials and Methods: Response surface me…

23. Article

    Metabolic Profiling Analysis of Three Processed Rhizomes of Curcuma wenyujin Y.H. Chen et C. Ling by Ultra‑performance Liquid Chromatography/Time‑of‑Flight Mass Spectrometry

    Min Hao, De Ji, Lin Li, Lianlin Su, Ji Zhang, Qiaohan Wang, Wei Gu, Chengxi Jiang, Tulin Lu, Chunqin Mao

    pp. 164–171 · DOI: 10.4103/pm.pm_399_18 · Published 23 January 2019

    Objective: In order to illustrate the effective substance of the three kinds of rhizome of CW, an ultra‑performance liquid chromatography‑quadrupole time‑of‑flight mass spectrometry (UPLC‑Q/TOF‑MS) method coupled with st…

24. Article

    Protective Effect of Schisandra chinensis Extracts against H2O2‑induced Oxidative Damage in RINm5F Cells

    Lulu Gong, Wei Dong, Xuechun Lu, Guangxin Yuan, Yunpeng Sun, Peige Du, Hui Yang, Meitong Pan, Yingnuo Li

    pp. 172–176 · DOI: 10.4103/pm.pm_478_18 · Published 23 January 2019

    Objective: To study the protective effect of Schisandra chinensis extracts (SCEs) on the RINm5F cells against H2O2‑induced oxidative damage and to provide a basis for the study of the role of SCEs in the prevention and t…