Volume 14, Issue 58

21 November 2018 · pp. 471–658 · 28 articles

Volume: 14
Issue: 58
Published: 21 November 2018
Pages: 471–658
Articles: 28
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article Original Research Article

In this issue

Original Article

Article
Lactobacillus plantarum Attenuates Oxidative Stress and Liver Injury in Rats with Nonalcoholic Steatohepatitis
Duangporn Werawatganon, Kanjana Somanawat, Somying Tumwasorn, Naruemon Klaikeaw, Prasong Siriviriyakul
pp. 471–476 · DOI: 10.4103/pm.pm_279_18 · Published 21 November 2018
Background: Steatohepatitis is a morphological pattern of liver injury that, in non‑alcoholic patients, may represent a form of chronic liver disease currently known as non‑alcoholic steatohepatitis (NASH). Probiotics, L…
Article
Anticancer Potential of Moringa oleifera Flower Extract in Human Prostate Cancer PC‑3 Cells via Induction of Apoptosis and Downregulation of AKT Pathway
Jiechang Ju, Sivapragasam Gothai, Mohadeseh Hasanpourghadi, Anmar A. Nasser, Ibrahim Abdel Aziz Ibrahim, Naiyer Shahzad, Ashok Kumar Pandurangan, Katyakyini Muniandy, S. Suresh Kumar, Palanisamy Arulselvan
pp. 477–481 · DOI: 10.4103/pm.pm_516_17 · Published 21 November 2018
Background: Moringa oleifera (MO), or the horseradish tree, is a pantropical species that is known by such regional names as benzolive, drumstick tree, kelor, marango, mlonge, mulangay, nébéday, saijhan, and sajna. Over …
Article
Antidiabetic Potential of the Total Flavone Glycoside from Okra Fruit in Type 2 Diabetic Rats
Zhi-Yong Huang, Shan-Shan Jia, An Jia, Jia-Wei Huang, Ke Yuan
pp. 482–488 · DOI: 10.4103/pm.pm_517_17 · Published 21 November 2018
Background: Okra is a commonly consumed healthy vegetable in many countries due to its wide range of pharmacological effects. The present study was designed to investigate in vivo antidiabetic potential of the total flav…
Article
Anti-neuro-inflammatory Effects of the Bioactive Compound Capsaicin through the NF-κB Signaling Pathway in LPS- Stimulated BV2 Microglial Cells
Qin Zheng, Wenjun Sun, Miao Qu
pp. 489–494 · DOI: 10.4103/pm.pm_73_18 · Published 21 November 2018
Background: Inflammation in the central nervous system, resulting from a loss of control involving a network of neuronal cells, is foremost contributors to the instigation and advancement of major neurodegenerative disea…
Article
Effect of Phytohormones on Rapid In vitro Propagation of Dendrobium thyrsiflorum Rchb.f.: An Endangered Medicinal Orchid
Leimapokpam Tikendra, Thoungamba Amom, Potshangbam Nongdam
pp. 495–500 · DOI: 10.4103/pm.pm_155_18 · Published 21 November 2018
Background: Dendrobium thyrsiflorum is highly vulnerable to extinction in its natural habitats due to overexploitation for the medicinal and horticultural purposes. The poor seed germination in a natural condition and sl…
Article
Berberine Protects Against Chronic Social Defeat Stress‑Induced Depressive‑like Behaviors with Upregulation of Neuronal PAS Domain Protein 4/Brain‑Derived Neurotrophic Factor Signaling Pathway
Zhifang Deng, Yan Peng, Wenqi Gao
pp. 501–506 · DOI: 10.4103/pm.pm_268_18 · Published 21 November 2018
Objective: Depression imposes a huge health problem in the world. Recent studies report that berberine has neuroprotective effects. This study was investigated to evaluate the effects of berberine on depression and the p…
Article
Altered Cytochrome P450 Profiles by Plumbago indica Linn. and Plumbagin after Oral Administration in Mice
Nadta Sukkasem, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
pp. 507–512 · DOI: 10.4103/pm.pm_88_18 · Published 21 November 2018
Background: Plumbago indica Linn. and its active constituent, plumbagin, are conventionally used in Thai alternative medicines, but information regarding their effects on cytochrome P450 (CYP450) enzymes is limited. Obje…
Article
Polyisoprenoids from Avicennia marina and Avicennia lanata Inhibit WiDr Cells Proliferation
Didi Nurhadi Illian, Mohammad Basyuni, Ridha Wati, Poppy Anjelisa Zaitun Hasibuan
pp. 513–518 · DOI: 10.4103/pm.pm_201_18 · Published 21 November 2018
Objectives: The current investigation was conducted to examine the anticancer effect of polyisoprenoids from Avicennia marina and Avicennia lanata leaves in WiDr cells. Selectivity index (SI), cell cycle inhibition, and …
Article
Molecular Cloning and Expression Analysis of the Circadian Clock for Patchoulol Synthase Gene in Pogostemon Cablin (Blanco) Benth
Xindan Liu, Menghua Wu, Ying Zhang, Hui Cao
pp. 519–524 · DOI: 10.4103/pm.pm_250_18 · Published 21 November 2018
Background: The circadian clock for patchoulol synthase (PTS) gene in Pogostemon cablin remains largely unexplored. Objective: The objective of this study is to clone and to investigate the expression of PTS gene from th…
Article
Secondary Metabolites from Sibiraea angustata
Yang‑Zhirong Hu, Wan‑Chang Zhang, Shuo Zhang, Guang‑Bo Xie
pp. 525–527 · DOI: 10.4103/pm.pm_390_17 · Published 21 November 2018
Background: Sibiraea angustata was used as folk medicine in Tibetan‑inhabited area of Hengduan Mountains, China. Objective: The secondary metabolites from the leaves and twigs of S. angustata were studied. Materials and …
Article
Antioxidant Effect of Royal Jelly on Immune Status of Hyperglycemic Rats
Abdullah G. Al-Kushi, Eslam A. Header, Naser A. ElSawy, Reham A. Moustafa, Nehal A. A. Alfky
pp. 528–533 · DOI: 10.4103/pm.pm_87_18 · Published 21 November 2018
Context: Diabetes mellitus and its increasing effect on endocrine functionality have been widely observed. Aims: The present study aims at investigating the histopathological changes of splenic cells in diabetic rats. Su…
Article
Antioxidant and Anti‑Inflammatory Effects of a Methanol Extract from the Marine Sponge Hyrtios erectus
Ramachandran Muthiyan, Nilkamal Mahanta, Balwin Nambikkairaj, Titus Immanuel, Arun Kumar De
pp. 534–540 · DOI: 10.4103/pm.pm_133_17 · Published 21 November 2018
Background: The marine environment, due to its phenomenal diversity, is a rich natural source of many biologically active compounds. Objective: Marine sponge Hyrtios erectus, collected from North Bay of South Andaman Sea…
Article
Antioxidant and Anticomplement Compounds Isolated from Nitraria sibirica Fruit by High‑Speed Counter‑Current Chromatography
Qian Bo Song, Hua Ding Zhao, Ze Long Fu, Dao Feng Chen, Yan Lu
pp. 541–547 · DOI: 10.4103/pm.pm_207_18 · Published 21 November 2018
Background: Nitraria sibirica fruit is a kind of folk medicine widely used in Northwest China. It contains diverse kinds of bioactive constituents such as flavonoids, alkaloids, and phenols. Objectives: The research was …
Article
Hepatic Immune Response to Environmental Carcinogens
Kawa Amin, Kosar Muhammad Ali, Amanj Saeed, Heshu Sulaiman Rahman, Jonas Bystrom
pp. 548–553 · DOI: 10.4103/pm.pm_242_18 · Published 21 November 2018
Aim: Environmental carcinogenic substances contribute to increasing incidence of hepatocellular carcinoma (HCC). We employed a sensitive method for the detection of DNA damage combined with analysis of the immune respons…
Article
Phytochemical Standardization of Panchavalkala: An Ayurvedic Formulation and Evaluation of its Anticancer Activity in Cervical Cancer Cell Lines
Shama Aphale, Savita Pandita, Prerna Raina, J. N. Mishra, Ruchika Kaul‑Ghanekar
pp. 554–560 · DOI: 10.4103/pm.pm_252_18 · Published 21 November 2018
Background: Cervical cancer is the most common malignant disease affecting women worldwide. The currently available therapies for cancer, even though effective, affect the patient’s health severely due to the associated …
Article
Toxicological Studies of Daphnetin
Kuang Nanzhen, Wang Jieying, Zou Wenwei, Zeng Xiaoping, Fu Yingyuan
pp. 561–566 · DOI: 10.4103/pm.pm_523_17 · Published 21 November 2018
Background: Numerous studies have demonstrated that daphnetin (DAP) has anti‑inflammatory, antioxidant, antibacterial, antitumor, anti‑arthritic, and other extensive pharmacological effects. However, its genotoxicity has…
Article
Traditional Chinese Medicine Ingredients Rosa damascena and Poria cocos Promote Phagocytosis and a Dendritic Cell Phenotype in THP‑1 Cells
Samantha J. Roloff, Jeffrey D. Scholten, Jennifer Chuang, Chun Hu, David J. Fast
pp. 567–571 · DOI: 10.4103/pm.pm_564_17 · Published 21 November 2018
Background: Rosa damascena and Poria cocos are ingredients commonly used in Traditional Chinese Medicine. R. damascena is used to promote blood circulation as well as liver and stomach function, while P. cocos is used to…
Article
Anti‑Inflammatory and Anti‑Melanogenic Effects of Major Leaf Components of Alpinia zerumbet var. excelsa
Md Shahinozzaman, Takahiro Ishii, Shinichi Gima, Binh Cao Quan Nguyen, Md Amzad Hossain, Shinkichi Tawata
pp. 578–586 · DOI: 10.4103/pm.pm_136_18 · Published 13 November 2018
Background: The leaves of Alpinia zerumbet var. excelsa (alpinia) are used to prepare traditional food items and folk medicines. Objective: This study was designed with a view to explore the anti‑inflammatory and anti-me…
Article
Elemental Profiling of Smokeless Tobacco Samples Using Inductively Coupled Plasma‑Mass Spectrometry, their Chemometric Analysis and Assessment of Health Hazards
Hassan A. Alhazmi, Waquar Ahsan, Ibraheem M. Attafi, Asaad Khalid, Siddig I. Abdelwahab, Mohammad Al Bratty, Shahnaz Sultana
pp. 587–596 · DOI: 10.4103/pm.pm_262_18 · Published 21 November 2018
Background: Smokeless tobacco (ST), locally called shammah, is a form of tobacco that is widely used in Middle Eastern countries, including Saudi Arabia. Objective: A total of 21 ST samples were collected from the southe…
Article
Ultra‑High Performance Liquid Chromatography/Triple Quadrupole Mass Spectrometry Study of the Stabilities and Transformations of Four Alisols in Alismatis Rhizoma and Proprietary Traditional Chinese Medicine Prescriptions
Chun‑Xin Xiao, Fan He, Miao‑Ting Yang, Fan Xia, Wai‑Jiao Tang, Ben‑Jie Zhou, Hua Zhou
pp. 597–603 · DOI: 10.4103/pm.pm_614_17 · Published 21 November 2018
Background: Alismatis Rhizoma (AR) is a traditional Chinese medicine that is frequently used for the treatment of hyperlipidemia, hypertension, diabetes, and chronic kidney failure. Active alisols contribute to the benef…
Article
Isolation, Elucidation, and Molecular Docking Studies of Active Compounds from Phyllanthus niruri with Angiotensin‑Converting Enzyme Inhibition
Islamudin Ahmad, Abdul Mun’im, Sri Luliana, Berna Elya, Azminah Azminah, Arry Yanuar, Yudithya Artha, Osamu Negishi
pp. 604–610 · DOI: 10.4103/pm.pm_151_18 · Published 21 November 2018
Background: Phyllanthus niruri, in Indonesia, is known as “Meniran” has a long history of use in ethnic or traditional medicine worldwide, mainly as an antihypertensive agent. Objective: The present study was designed to…
Article
Cytotoxicity and Antitumoral Activity by Apoptosis Induction of AC13: A Brominated Curcumin Analogue
Ana Beatriz Bortolozo Oliveira, Renata Prandini Adum de Matos, Bruna Stuqui, Guilherme Silva Torrezan, Carlos Roberto Polaquini, Luis Octávio Regasini, Marilia de Freitas Calmon, Paula Rahal
pp. 611–616 · DOI: 10.4103/pm.pm_272_17 · Published 21 November 2018
Background: Natural compounds with therapeutic potential have been explored as antitumoral agents, as curcumin (CUR), a substance which has activity against various tumor types and a tool used to improve the action of th…
Article
Ophiopogon Japonicus Herbal Tea Ameliorates Oxidative Stress and Extends Lifespan in Caenorhabditis Elegans
Xuesong Yu, Dake Gao, Bing Qi, Xiaochun Xiao, Xufeng Zhai, Chung Wah Ma, Qiangqiang Wang, Zebo Huang
pp. 617–623 · DOI: 10.4103/pm.pm_313_18 · Published 21 November 2018
Background: Ophiopogon japonicus is a medicinal and edible plant widely used in China. Despite a long history of O. japonicus tea (OJT) in health promotion, however, the mechanistic studies on its actions are lacking. Ob…
Article
Systematic Understanding the Mechanisms of Tripterygium wilfordii on Atherosclerosis and Pharmacodynamics Research in Apo E‑/‑mice Model
Jingyan Liang, Lu Chen, Yang Pan, Yayun Qian, Lifu Wei, Yumeng Zhang, Kaiming He, Yanqing Liu, Yingge Wang
pp. 624–633 · DOI: 10.4103/pm.pm_556_17 · Published 21 November 2018
Background: Atherosclerosis (AS) is a chronic arterial disease and a major cause of vascular death, with multiple pathogenesis including chronic inflammatory. Tripterygium wilfordii (TGW) had a good effect on an anti‑inf…
Article
Frankincense Administration Antagonizes Adenine‑induced Chronic Renal Failure in Rats
Entsar A. Saad, Hussam A. El‑Gayar, Reda S. El‑Demerdash, Kholoud H. Radwan
pp. 634–640 · DOI: 10.4103/pm.pm_271_18 · Published 12 September 2018
Background: Chronic renal failure (CRF) treatment through kidney transplantation or dialysis is restricted because of economic and medical resources deficiency. Thus, demand for using dietary supplements that can delete …
Article
Osthole Promote Differentiation and Inhibit Proliferation of Osteoblast by Activating Wnt Signaling and Endoplasmic Reticulum Stress
Suyang Zheng, Yong Ma, Yang Guo, Lining Wang, Yalan Pan
pp. 641–646 · DOI: 10.4103/pm.pm_591_17 · Published 4 July 2018
Background: Osthole is extracted from Fructus Cnidii and is proved to be effective in the treatment of osteoporosis in rats. However, data are still scarce and the mechanism remains elusive. Objective: To investigate the…
Article
Development and Evaluation of Sea Buckthorn (Hippophae rhamnoides L.) Seed Oil Nanoemulsion Gel for Wound Healing
Tanurajvir Kaur, Deepak N. Kapoor
pp. 647–658 · DOI: 10.4103/pm.pm_375_18 · Published 21 November 2018
Background: Sea buckthorn (SBT) seed oil is reported to have significant wound‑healing activity. However, the oil presents with problems such as poor skin permeation and retention in the deeper layers of skin, as well as…

Original Research Article

Article
Polyherbal Formulation Containing Antioxidants may Serve as a Prophylactic Measure to Diabetic Cataract: Preclinical Investigations in Rat Model
Nilesh M. Mahajan, Bhushan B. Lokhande, Raju R. Thenge, Purushottam S. Gangane, Nitin G. Dumore
pp. 572–577 · DOI: 10.4103/pm.pm_622_17 · Published 21 November 2018
Background: Cataract is a major cause of visual impairment in diabetic patients. Due to increasing numbers of type 1 and type 2 diabetics worldwide, the incidence of diabetic cataracts steadily rises. Cataract surgery is…