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Article

Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea

Lilian Carneiro Dos Anjos1, Jacqueline Coimbra Gonçalves1, Bruna Ramos De Araujo1, Marcia Renata Mortari1★★ Corresponding author

  1. 1Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.

CORRESPONDENCE

Marcia Renata Mortari

Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.

mmortari@unb.br

Received: 11-05-2018; Revised: 22-06-2018; Accepted: 12-11-2018.

Volume 15, Issue 61 · pp. 322–326 · PUBLISHED 6 March 2019 · DOI: 10.4103/pm.pm_238_18

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ABSTRACT

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of <em>Crotalaria pallida</em> Aiton. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model. The antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC). Results: The methanolic extract of <em>C. pallida</em> showed significant anti-inflammatory activity in a dose-dependent manner. The extract also exhibited potent antioxidant activity with an IC50 value of 45.23 μg/mL in DPPH assay. The TPC was found to be 124.5 mg gallic acid equivalent/g of extract. Conclusion: The results suggest that <em>C. pallida</em> possesses significant anti-inflammatory and antioxidant properties, which could be attributed to the presence of phenolic compounds.

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    Anjos, L. C. D., Gonçalves, J. C., Araujo, B. R. D., & Mortari, M. R. (2019). Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea. Pharmacognosy Magazine, 15(61), 322–326. https://doi.org/10.4103/pm.pm_238_18