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Article

In vitro Antileishmanial Activity of Methanolic Extracts for Some Selected Medicinal Plants

Ahmed Gomaa Gomaa Darwish2,3★, Mamdouh Nabil Samy3,4, Sachiko Sugimoto3, Katsuyoshi Matsunami3, Hideaki Otsuka3,5★ Corresponding author

  1. 1Department of Biochemistry, Faculty of Agriculture, Minia University.
  2. 2Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University.
  3. 3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.
  4. 4Department of Natural Products Chemistry, Faculty of Pharmacy, Yasuda Women’s University, Hiroshima, Japan.

CORRESPONDENCE

Ahmed Gomaa Gomaa Darwish

Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University.

ahmed.darwish@famu.edu

Received: 16-11-2018; Revised: 17-12-2018.

Volume 15, Issue 62S · pp. S34–S37 · PUBLISHED 26 April 2019 · DOI: 10.4103/pm.pm_570_18

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ABSTRACT

Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well‑known medicinal plants cultivated and growing under African environmental conditions were studied. Materials and Methods: The methanolic extracts of these plants were screened for their antileishmanial activity against Leishmania major using 3‑(4.5‑dimethylthiazol‑2yl)‑2.5‑diphenyltetrazolium bromide assay. Results: The methanol extract of Colchicum autumnale and Alpinia officinarum showed potent antileishmanial activity at inhibition% value of 98.29% ± 0.75% and 97.25 ± 1.63%, respectively, while Silybum marianum exhibited inhibition% value of 90.97% ± 1.13%, compared with the standard amphotericin B (89.31% ± 2.08%). Conclusion: Considering these results, medicinal plants from African environment could constitute a developer source for antileishmanial compounds.

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    Darwish, A. G. G., Samy, M. N., Sugimoto, S., Matsunami, K., & Otsuka, H. (2019). In vitro Antileishmanial Activity of Methanolic Extracts for Some Selected Medicinal Plants. Pharmacognosy Magazine, 15(62S), S34–S37. https://doi.org/10.4103/pm.pm_570_18