Volume 15, Issue 62S

26 April 2019 · pp. 0–103 · 24 articles

Volume: 15
Issue: 62S
Published: 26 April 2019
Pages: 0–103
Articles: 24
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article Short Communication

In this issue

Original Article

Article
Androgen Receptor (NR3C4) Regulator Potential of Ceratonia siliqua Extract and Its Signaling Pathways
Fehmi Kigili, Fatih Ozen, Tunc Catal, Belkıs Atasever Arslan
pp. S1–S4 · DOI: 10.4103/pm.pm_588_18 · Published 26 April 2019
Background: Androgen receptor (AR/NR3C4) regulates growth, development, reproduction, metabolism, and homeostasis. Since it has multifunctional properties, disrupting of the functions can cause many diseases such as canc…
Article
Antihyperglycemic Activity of the Leaves from Annona diversifolia Safford. and Farnesol on Normal and Alloxan‑Induced Diabetic Mice*
Fernando Calzada, Miguel Valdes, Normand Garcia‑Hernandez, Claudia Velázquez, Elizabeth Barbosa, Celia Bustos‑Brito, Leovigildo Quijano, Emmanuel Pina‑Jimenez, Jesica Elena Mendieta‑Wejebe
pp. S5–11 · DOI: 10.4103/pm.pm_582_18 · Published 26 April 2019
Objective: This study aimed to evaluate the antihyperglycemic properties of the ethanol extract, subsequent fractions, and farnesol obtained from the leaves of Annona diversifolia on alloxan‑induced diabetic and normal m…
Article
Anti‑Tuberculosis Drug‑Induced Oxidative Stress in Kidneys: Role of Brahmi as an Antioxidant Supplement
Sabina Evan Prince, Sherry Joseph Martin, B. Udhaya Lavinya, Kavitha Selvanathan, A. Geetha
pp. S12–S16 · DOI: 10.4103/pm.pm_481_18 · Published 26 April 2019
Purpose: Nephrotoxicity is a known, but rare complication of anti‑tuberculosis (TB) therapy and is known to be due to induction of oxidative stress and immune reaction to the drugs. In the current study, we have made an …
Article
In vivo and in vitro Antidiabetic and Antioxidant Activity of Spirulina
Patrick Nwabueze Okechukwu, Sophia Ogechi Ekeuku, Mridula Sharma, Chong Pei Nee, Hor Kuan Chan, Norazlina Mohamed, Gabriele Ruth Anisah Froemming
pp. S17–S29 · DOI: 10.4103/pm.pm_431_18 · Published 26 April 2019
Objective: This study aims to evaluate the effect of spirulina, a biomass produced by cyanobacteria, on the level of plasma glucose, oxidative stress, and other biochemical parameters in diabetes in streptozocin (STZ) 50…
Article
In vitro Evaluation of the Effects of Lycopene on Caspase System and Oxidative DNA Damage in High‑Glucose Condition
Bunyamin Bazyel, Semiha Dede, Sedat Cetin, Veysel Yuksek, Mehmet Taşpinar
pp. S30–S33 · DOI: 10.4103/pm.pm_488_18 · Published 26 April 2019
Background: The present study was planned to investigate the effects of lycopene, on the caspase‑dependent apoptosis in high‑dose glucose (HG)‑treated PC12 cell line. PC12 cells were cultured in vitro. Materials and Meth…
Article
In vitro Antileishmanial Activity of Methanolic Extracts for Some Selected Medicinal Plants
Ahmed Gomaa Gomaa Darwish, Mamdouh Nabil Samy, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka
pp. S34–S37 · DOI: 10.4103/pm.pm_570_18 · Published 26 April 2019
Objective: The aim of this study is to evaluate the antileishmanial activity of selected medicinal plants; ten well‑known medicinal plants cultivated and growing under African environmental conditions were studied. Mater…
Article
Cloning, Identification, and in silico Analysis of Terpene Synthases Involved in the Competing Pathways of Artemisinin Biosynthesis Pathway in Artemisia annua L
Umara Nissar Rafiqi, Irum Gul, Monica Saifi, Nazima Nasrullah, Javed Ahmad, Prasanta Dash, Malik Zainul Abdin
pp. S38–S46 · DOI: 10.4103/pm.pm_244_18 · Published 26 April 2019
Background: Endoperoxide sesquiterpene lactone, artemisinin, is a widely used antimalarial drug. Artemisia annua L. synthesizes this terpenoid and is the only source of artemisinin. In plants, the content of artemisinin …
Article
Cytoprotective Effect of Cactus cladode (Opuntia ficus-indica) against Chlorpyrifos Induced Reactive Oxygen Species in Rat Hepatocytes: Involvement of Heat Shock Protein 70 and CYP1A1/2 Proteins
Hafiz Antar Makeen, Saida Ncibi, Syam Mohan, Abdullah Farasani, Roger Rahmani, Mohammed Al Bratty, Hassan A. Alhazmi
pp. S47–S53 · DOI: 10.4103/pm.pm_484_18 · Published 26 April 2019
Objective: This investigation focused on CPF‑induced oxidative damage in rat hepatocytes primary culture and the protective effect of Cactus cladode aqueous extract. Materials and Methods: Hepatocytes were treated with C…
Article
Improvement of Sexual Behavior and Ejaculatory Parameters by the Methanolic Extract of Guibourtia tessmannii (Caesalpiniaceae) in High‑Fat‑Diet‑Fed Sexually Sluggish Male Rats
Patrick Brice Defo Deeh, Pierre Watcho, Kamalesh K. Gulia
pp. S54–S61 · DOI: 10.4103/pm.pm_449_18 · Published 26 April 2019
Objective: This study evaluated the effects of the methanolic extract of GT on sexual behavior and fictive ejaculation in high‑fat diet (HFD)‑induced sexually sluggish male rats. Materials and Methods: Male Wistar rats f…
Article
The Contribution of Ionotropic GABAergic and N‑methyl‑D‑Aspartic Acid Receptors in the Antidepressant‑Like Effects of Hispidulin
Abeer Abdelhalim, Imran Khan, Nasiara Karim
pp. S62–S70 · DOI: 10.4103/pm.pm_539_18 · Published 26 April 2019
Background: Salvia triloba, commonly known as sage belongs to Lamiaceae family, is conventionally used as a brain‑enhancing tonic. The purpose of this study was to evaluate hispidulin, a flavonoid isolated from S. trilob…
Article
Wound Healing and Antibacterial Activities of 2‑Pentadecanone in Streptozotocin‑Induced Type 2 Diabetic Rats
Stepfanie N. Siyumbwa, Sophia Ogechi Ekeuku, Farahnaz Amini, Naw May Emerald, Deepali Sharma, Patrick Nwabueze Okechukwu
pp. S71–S77 · DOI: 10.4103/pm.pm_444_18 · Published 26 April 2019
Objective: This study was aimed at evaluating 2‑P wound healing and anti‑bacterial activities. Materials and Methods: Fifteen streptozotocin‑induced type 2 diabetic Sprague Dawley rats were divided into negative (N), pos…
Article
Exploring the Potential of Desmodium gangeticum (L.) DC. Extract against Spatial Memory Deficit in Rats
Nilanjan Changdar, Rajesh Kumar Ganjhu, Samita Rijal, Ayush Kumar, Shanchari Basu Mallik, Madhavan Nampoothiri, Rekha R. Shenoy, Kiran B. Sonawane, Mallikarjuna C. Rao, Jayesh Mudgal
pp. S78–S83 · DOI: 10.4103/pm.pm_501_18 · Published 26 April 2019
Objective: The purpose of the present study was to evaluate the preclinical efficacy of D. gangeticum against chronic dementia when administered prophylactically. Materials and Methods: Chronic spatial memory deficit was…
Article
Anti-inflammatory and Antioxidant Activities of Cissus quadrangularis and Cissus repens
was: NaCl, 118; KCl, 4.7; CaCl2, 2.5; MgSO4, 1.2; KH2PO4, 1.2; NaHCO
pp. S84–S91 · DOI: 10.4103/pm.pm_489_18 · Published 26 April 2019
Objective: The aim of this study is to evaluate the cardiovascular effects of mixture of Hesperidin: Naringenin (mix‑H:N). Materials and Methods: The relaxant effect and the mechanism of action of mix‑H:N were studied on…
Article
Bioautography‑based Identification of Antioxidant Metabolites of Solanum nigrum L. and Exploration Its Hepatoprotective Potential against D‑Galactosamine‑induced Hepatic Fibrosis in Rats
Karishma Chester, Sultan Zahiruddin, Adil Ahmad, Washim Khan, Sarvesh Paliwal, Sayeed Ahmad
pp. S104–S110 · DOI: 10.4103/pm.pm_359_18 · Published 26 April 2019
Objective: A traditional herb Solanum nigrum L. is well known for the management of different ailments including hepatic disorders. The objective of our study is to identify antioxidant metabolites and bioactive fraction…
Article
Bioavailable Curcumin Alleviates Lipopolysaccharide‑Induced Neuroinflammation and Improves Cognition in Experimental Animals
Anu Sunny, Kannan Ramalingam, S. Syam Das, Balu Maliakel, I. M. Krishnakumar, Sibi Ittiyavirah
pp. S111–S117 · DOI: 10.4103/pm.pm_307_18 · Published 26 April 2019
Objective: In the present contribution, we hypothesized that the formulations of curcumin capable of delivering curcuminoids in the brain would provide enhanced cognitive effects. In this regard, we investigated the rela…
Article
Nutritional Value and Nephrotoxicity Effect of Dillenia pentagyna Fruit on Alloxan‑induced Diabetic Rats
Ranjeet Kumar Yadav, Arpit Azad, S. K. Srivastava, B. Sharma, Mahesh Pal
pp. S118–S122 · DOI: 10.4103/pm.pm_494_18 · Published 26 April 2019
Objective: The proximate parameters and high‑performance thin layer chromatography (HPTLC) analysis in the same plant of D. pentagyna of four‑time harvest stage during the maturation of fruits were studied and also the a…
Article
Formulation and Evaluation of Wound Healing Activity of Sophorolipid-Sericin Gel in Wistar Rats
Snehal V. More, Santosh S. Koratkar, Navnath Kadam, Sachin Agawane, Asmita Prabhune
pp. S123–S127 · DOI: 10.4103/pm.pm_392_18 · Published 26 April 2019
Sericin is a useful by‑product of silk processing and is resistant to oxidation and ultraviolet and can absorb and release moisture easily. Sericin has biological activities such as antibacterial, antioxidant, and tyrosi…
Article
Quantitative Assessment of Tactile Allodynia and Protective Effects of flavonoids of Ficus carica Lam. Leaves in Diabetic Neuropathy
Khan Dureshahwar, Mohammed Mubashir, Aman Upaganlwar, Jaiprakash N. Sangshetti, Chandrashekhar D. Upasani
pp. S128–S134 · DOI: 10.4103/pm.pm_553_18 · Published 26 April 2019
Objective: Ficus carica Lam. leaves were studied for the conformation of flavonoids in ethyl acetate fraction of methanolic extract (FCEA) using GC‑HRMS for the identification of flavonoids. It was analyzed for antioxida…
Article
14‑Deoxy‑11,12‑Didehydroandrographolide: A Novel Compound Isolated from Andrographis paniculata Nees. Induces Robust Apoptosis in Leukemic Cells
Swadesh Sarkar, Priya K. Gopal, Biswajit Chakraborty, Mausumi Paul, Chinmay Chowdhury, Santanu Paul
pp. S135–S143 · DOI: 10.4103/pm.pm_466_18 · Published 26 April 2019
Objective: Andrographis paniculata is widely cultivated in South and Southeast Asian countries and popularly used in “Ayurveda” medicine. We attempted to investigate antileukemic activity of the biomolecules extracted fr…
Article
Bioactive Compound of Ocimum sanctum Carvacrol Supplementation Attenuates Fluoride Toxicity in Sodium Fluoride Intoxicated Rats: A Study with Respect to Clinical Aspect
Kondeti Ramudu Shanmugam, Mavulapati Siva, Sahukari Ravi, Bhasha Shanmugam, Kesireddy Sathyavelu Reddy
pp. S144–S149 · DOI: 10.4103/pm.pm_436_18 · Published 26 April 2019
Objective: The present study was carried out to know the anti‑oxidant activity of carvacrol bioactive compound of OS in sodium fluoride (NaF) rats and free‑radical scavenging activities of OS. Materials and Methods: Supe…
Article
Phytochemical Evaluation and Cytotoxic Potential of Chloroform Soluble Fraction of Methanol Extract of Thespesia populnea in Human Breast Cancer Cell Lines
Anu Gopalakrishnan, Bibu John Kariyil, Reni John, P. T. A. Usha
pp. S150–S154 · DOI: 10.4103/pm.pm_329_18 · Published 26 April 2019
Objective: The present study was undertaken to find out different phytochemical principles of chloroform- soluble fraction of T. populnea (CSFTP) using gas chromatography mass spectrometry-mass spectrometry (GCMS-MS) and…
Article
Physicochemical Standardization of Mucilage Obtained from Althaea officinalis Linn – Root
Mazhar Husain, Abdul Wadud, Hamiduddin Hamiduddin, Gulamuddin Sofi, Shaista Perveen, Khadeeja Abdul Hafeez
pp. S155–S161 · DOI: 10.4103/pm.pm_506_18 · Published 26 April 2019
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the anti…
Article
Ultra High Performance Liquid Chromatography‑Electrospray Ionization‑Mass Spectroscopy Quantification, Xanthine Oxidase Inhibitory, and Antioxidant Activity Profile of some Medicinal Plants from Albaha Region
Nasser A. Awadh Ali, Iman Mansi, Nafees Ahmed, Saleh Alghamdi, Rajab Abu Alhalawah, Abdulwali Al-Khulaidi, Sirajudheen Anwar
pp. S162–S167 · DOI: 10.4103/pm.pm_514_18 · Published 26 April 2019
Objective: Screening of Saudi medicinal plants for XO inhibitory activity, to quantify the polyphenol–flavonoid content and to study ultra high performance liquid chromatography‑electrospray ionization‑mass spectroscopy …

Short Communication

Communication
Inducible Nitric Oxide Synthase Downregulation and Cellular Antioxidant Enzyme Enhancing Potential of Oleanolic Acid from Isodon wightii (Bentham) H. Hara against Lipopolysaccharide‑induced Liver Damage in Bagg Albino Strain C Mice
Madhusudhanan Gogul Ramnath, Ramaraj Thirugnanasampandan, Sadasivam Mathusalini, Gunasekaran Bhuvaneswari, Selvaraj Vasantharani, Palathurai Subramaniam Mohan
pp. S168–S172 · DOI: 10.4103/pm.pm_533_18 · Published 26 April 2019
Objective: The objective of the study is to evaluate in vivo anti‑inflammatory activity of oleanolic acid from I. wightii against lipopolysaccharide‑induced liver inflammation in Bagg albino strain C mice. Materials and …