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Article

Anti‑tick Potential and Intra‑Specific Chemical Variations in Ageratum conyzoides L. Collected from Indus Plain and Central India

Bhanu Kumar1,2, Pushpendra Kumar Shukla1, Anil Kumar Sharma3, Ajay Kumar Singh Rawat1, Yashwant Singh Rawat2, Srikant Ghosh3, Sharad Srivastava1★★ Corresponding author

  1. 1Division of Pharmacognosy, CSIR- National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India.
  2. 2Department of Botany, Kumaun University, Nainital, Uttarakhand, India.
  3. 3Division of Parasitology, ICAR- Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.

CORRESPONDENCE

Sharad Srivastava

Division of Pharmacognosy, CSIR- National Botanical Research Institute, Rana Pratap Marg, Lucknow 226 001, India.

sharad_ks2003@yahoo.com

Received: 11-06-2021; Revised: 07-07-2021; Accepted: 14-12-2021.

Volume 18, Issue 77 · pp. 226–232 · PUBLISHED 28 March 2022 · DOI: 10.4103/pm.pm_261_21

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ABSTRACT

Objectives: Search for safe and efficacious plant‑based alternatives to the chemical acaricides and to assess chemical variability among intra‑specific germplasms. Materials and Methods: Ageratum conyzoides L. samples were collected from different locations and pharmacognostic analysis was performed. The plant extract was subjected to chromatographic profiling and quantification of three bioactive markers precocene I, precocene II, and caryophyllene oxide followed by in vitro anti‑tick activity through the adult immersion test. Results: Precocene I content ranged from 0.001% to 0.019% while precocene II and caryophyllene oxide content varied from 0.003% to 0.11%. In the Indus plain samples, adult tick mortality (%) ranged from 15.0 ± 2.9 to 78.5 ± 4.1, whereas in the Central India, it ranged from 30.0 ± 12.9 to 81.4 ± 7.7 at 8% concentration of plant extract. Precocene II showed weak positive correlation (r = 0.11) with tick mortality. The results indicate that there is considerable variation in the marker compounds content and anti- tick potential of the plant extracts analyzed. There is significant (P < 0.05) variation in marker compound content as well as anti-tick potential of A. conyzoides. Conclusion: The results indicate there apart from the analyzed marker compounds there might be some other phytomolecules playing a role in the tick mortality which needs further investigation.

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    Kumar, B., Shukla, P. K., Sharma, A. K., Rawat, A. K. S., Rawat, Y. S., Ghosh, S., & Srivastava, S. (2022). Anti‑tick Potential and Intra‑Specific Chemical Variations in Ageratum conyzoides L. Collected from Indus Plain and Central India. Pharmacognosy Magazine, 18(77), 226–232. https://doi.org/10.4103/pm.pm_261_21