Volume 18, Issue 77

1 April 2022 · pp. 1–246 · 32 articles

Volume: 18
Issue: 77
Published: 1 April 2022
Pages: 1–246
Articles: 32
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Research Article Original Article

In this issue

Research Article

Article
Phytochemical Profile and Pharmacological Potential of Cissus quadrangularis L.
John Doe, Jane Smith
pp. 1–5 · DOI: 10.4103/pm.pm_123_22 · Published 1 April 2022
Background: The genus <em>Cissus</em> (Vitaceae) is a rich source of bioactive compounds with diverse pharmacological activities. Objective: This study aimed to evaluate the phytochemical profile, antioxidant, and anti-i…

Original Article

Article
Rehmanniae Radix‑Induced Apoptosis via Inhibition of PI3K/ AKT/mTOR Signaling Pathways in Human Hepatocellular Carcinoma Cell Lines SMMC‑7721
Bonian Liao, Fangli Luo, Shu Zhang, Zhengwan Deng, Lin Cai
pp. 4–9 · DOI: 10.4103/pm.pm_147_21 · Published 28 March 2022
Objectives: To inspect RR leaves extracts pro‑apoptotic activities on SMMC‑7721 liver cancer cell lines. Materials and Methods: Anti‑cancer effect of RR extracts in SMMC‑7721 liver cancer cell lines was aged rate of cell…
Article
Evaluation of Cardioprotective Potential of Isolated Swerchirin against the Isoproterenol‑Induced Cardiotoxicity in Wistar albino rats
Rustam Ekbbal, Ashif Iqubal, Mohd Asif Ansari, Sayeed Ahmad, Syed Ehtaishamul Haque
pp. 10–21 · DOI: 10.4103/pm.pm_500_20 · Published 28 March 2022
Objectives: In the present study, we explored the cardioprotective effect of swerchirin (SW) extracted from Swertia chirayita in the ISO model. Materials and Methods: SW was isolated from S. chirayita, characterized by h…
Article
Phyto‑Mediated Green Synthesis of Silver Nanoparticles using Acmella oleracea Leaf Extract: Antioxidant and Catalytic Activity
Sweta Bhardwaj, Suman Lata, Rajni Garg
pp. 22–28 · DOI: 10.4103/pm.pm_586_20 · Published 28 March 2022
Aim: In the current study, an easy, economical and environmentally friendly one‑pot synthesis technique has been proposed to obtain silver nanoparticles (AgNPs) using Acmella oleracea leaf extract. Materials and Methods:…
Article
Anticarcinogenic Effect of Brucine on DMBA‑Induced Skin Cancer via Regulation of PI3K/AKT Signaling Pathway
Jie Wang, Zhenxing He, Juhua Zhao, Wenming Xiao, Lingling Xiong, Wei Chen
pp. 29–35 · DOI: 10.4103/pm.pm_152_21 · Published 28 March 2022
Objectives: The main intention of these hypothesis anticancer effects of brucine on 7,12‑dimethylbenz(a)anthracene (DMBA)‑induced skin cancer in mouse model through phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AK…
Article
Ocotillo‑type Ginsenosides from the Panax vietnamensis Ha et Grushv Protect H9c2 Cardiomyocytes against H2O2‑Induced Apoptosis
Jing Xie, Xiao-Bo Li, Chun-Hua Ma, Wei-Wei Jiang
pp. 36–43 · DOI: 10.4103/pm.pm_253_21 · Published 28 March 2022
Background: The roots of Panax vietnamensis Ha et Grushv. (PV) are used in the preparation of local drugs to treat cardiovascular and cerebrovascular diseases. However, it is still not clear if the saponins extracted fro…
Article
Screening and Characterization of an Acid Polysaccharide with Antioxidant Activity in vitro and in vivo from Dendrobium aurantiacum var. Denneanum (Kerr)
Yijun Fan, Xueyan Tan, Juan Zhao, Kaigang Yang, Shengdi Wu, Jiao Zhang, Shangrao Pu, Gang Wang, Aoxue Luo
pp. 44–51 · DOI: 10.4103/pm.pm_580_20 · Published 28 March 2022
Aim: We aimed to monitor an acid polysaccharide with antioxidant activity. Materials and Methods: Three acidic polysaccharides (DAP‑A40, DAP‑A60, and DAP‑A80) were extracted from D. aurantiacum imbricate by alkaline aque…
Article
Polyherbal Formulation Improves Glucose‑Lipid Metabolism and Prevent Hepatotoxicity in Streptozotocin‑Induced Diabetic Rats: Plausible Role of IRS-PI3K-Akt-GLUT2 Signaling
Abdul Haye, Mohd Asif Ansari, Abhinav Saini, Zubair Ahmed, Kavita Munjal, Yasmeen Shamsi, Manju Sharma
pp. 52–65 · DOI: 10.4103/pm.pm_318_21 · Published 28 March 2022
Objectives: The purpose of this research was to find out the plausible mechanisms underlying the synergistic effects of PHF in an experimental setting of diabetes mellitus. Materials and Methods: PHF was evaluated for th…
Article
In vitro Cytotoxic Activity using Fruits of Annona muricata and Aerial Parts of Euphorbia tirucalli against Lung and Oral Cancer Cell Lines
Swapna B, M. Raghavendra Rao, Satvik Kotha, Sagar. S, Ramachandra Siddamsetty Setty
pp. 66–74 · DOI: 10.4103/pm.pm_357_21 · Published 28 March 2022
Aim: Cancer is one of the life‑threatening diseases which cause severe pathological conditions, leading to mortality. The exhaustive data on the vital role of medicinal plants in combating cancer and related diseases are…
Article
Evaluation on the Skin Anti-Aging Potential of an Aqueous Extract from Oenanthe javanica (Blume) DC
Hye‑Won Lim, Yu‑Hua Huang, Minsik Park, Chang‑Jin Lim
pp. 75–81 · DOI: 10.4103/pm.pm_366_21 · Published 28 March 2022
Objectives: This work aimed to primarily assess the skin anti‑aging potential of its aerial parts. Materials and Methods: The dried aerial parts of water dropwort were extracted with water under high pressure and high te…
Article
Effect of Total Flavonoids of Hippophae rhamnoides L. on the Activity and mRNA Expression of CYP450 in Rats
Guodong Wu, Haimei Hao, Le Chang, Xiaofeng Cao, Dong Zhang
pp. 82–88 · DOI: 10.4103/pm.pm_214_21 · Published 28 March 2022
Objectives: In this study, we aimed to study the effect of total flavonoids extracted from Hippophae rhamnoides L. (TFH) on the activity of five CYP450 enzymes in rats by high‑performance liquid chromatography (HPLC). We…
Article
Alteration of Murine Cytochrome P450 Profiles in Fatty Liver Disease by Hesperidin and Myricetin
Nadta Sukkasem, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
pp. 89–93 · DOI: 10.4103/pm.pm_321_21 · Published 28 March 2022
Objectives: This study determined the impacts of hesperidin and myricetin on CYP450 profiles in FLD mice. Materials and Methods: Adult female mice were fed a high fat diet (HFD, 60 kcal % fat of total food) with daily in…
Article
Development and Evaluation of Sesamol-Loaded Self Nanoemulsifying Drug Delivery System for Breast Cancer
Namrata Singh, Poonam Kushwaha, Amresh Gupta, Akash Ved, Shivam Swarup
pp. 94–102 · DOI: 10.4103/pm.pm_248_21 · Published 28 March 2022
Objectives: In the present study, Sesamol‑loaded SNEDDS were developed, identified, and assessed for the enhancement of its in vitro dissolution rate and anticancer efficacy. Materials and Methods: Based on the solubiliz…
Article
Ameliorative Efficacy of Oxypaeoniflorin, a Traditional Chinese Medicine Monomer against Adjuvant‑Induced Arthritic Inflammation and Pain
Ke Lv, Meng Jiang
pp. 103–111 · DOI: 10.4103/pm.pm_571_21 · Published 28 March 2022
Objectives: The objective of the study is to evaluate the potential of OPA against Freund complete adjuvant (FCA)‑induced inflammatory pain in experimental arthritic rats. Materials and Methods: FCA was administered in f…
Article
Structure Identification and Biological Activities of a New Polysaccharide Isolated from Lyophyllum decastes (Fr.) Sing
Xiang Ding, Ying Liu, Yiling Hou
pp. 112–120 · DOI: 10.4103/pm.pm_185_21 · Published 28 March 2022
Background: Polysaccharide biology, whose core is the structure, function, and edible value of polysaccharides, is regarded as the last great scientific frontier outside the field of protein and nucleic acid research. Ma…
Article
Morphological, Biochemical, Molecular Marker, Gas Chromatography‑Tandem Mass Spectrometer Analysis of Garlic (Allium sativum L.) Landraces in the Rain Shadow High Hills of Kerala, India
Jalaja S. Menon, Berin Pathrose, A. C. Asna, Rukam Singh Tomer, B. Dineshkumar
pp. 121–127 · DOI: 10.4103/pm.pm_435_21 · Published 28 March 2022
Background: In Kerala, dry hill agro ecological zone is famous for the commercial cultivation of hill garlic. Vattavada and Kanthalloor panchayaths in Devikulam block of Idukki district, India, are famous for the cultiva…
Article
Evaluation of the Antidepressant‑like Activity of the Aqueous Extract of Crataegus aronia
Hasan Saeed Alamri
pp. 128–132 · DOI: 10.4103/pm.pm_463_21 · Published 28 March 2022
Background: Crataegus aronia L. Syn: Azarolus (C. aronia) is a hawthorn species and a perennial bush native to Mediterranean regions. It is recognized for its high polyphenol content and potent antioxidant effects. Resea…
Article
Preparation and Anti‑fatigue Effects of Vicatia thibertica Polysaccharide
Weiwei Zhang, Jincheng Duan, Chunyan Ji, Zhengchun He, Guirong Shi, Meixian Guo, Xiaobo Liu
pp. 133–142 · DOI: 10.4103/pm.pm_213_21 · Published 28 March 2022
Objectives: We intended to purify and gauge the anti‑fatigue effects of a polysaccharide isolated from Vicatia thibertica polysaccharide 1 (VTP1). Materials and Methods: First, the exercise fatigue model was recognized i…
Article
Antioxidant, Anti‑proliferative, and Anti‑atherosclerotic Effect of Phytochemicals Isolated from Trachyspermum ammi with Honey in RAW 264.7 and THP‑1 Cells
Hari Priyaa G, Sunil S More
pp. 143–151 · DOI: 10.4103/pm.pm_436_21 · Published 28 March 2022
Background: Trachyspermum ammi is a common spice with vital medicinal properties used in Ayurveda to treat many ailments. Furthermore, natural Honey is said to have high levels of antioxidants and anti‑inflammatory prope…
Article
Protective Effect of Lycium barbarum on Renal Injury Induced by Acute Pancreatitis in Rats
Tugba Dogan, Kadir Batcioglu, Elif Kayhan Kustepe, Ayse Burcin Uyumlu, Yakup Yilmaztekin
pp. 152–159 · DOI: 10.4103/pm.pm_516_21 · Published 28 March 2022
Objectives: The aim of this study was to investigate the protective efficacy of LB, in kidney damage caused by acute pancreatitis (AP). Materials and Methods: In the study, we used 36 female Wistar albino rats (12 in eac…
Article
Anticancer Effects of Piper nigrum Extract against Cholangiocarcinoma Cells
Benjaporn Buranrat, Laddawan Senggunprai, Auemduan Prawan, Veerapol Kukongviriyapan
pp. 160–167 · DOI: 10.4103/pm.pm_521_21 · Published 28 March 2022
Objectives: Piper nigrum (PN) is well known for its cytotoxic and pharmacological benefits in several cancer cells. However, there is less documented evidence about its cytotoxic efficacy against cholangiocarcinoma (CCA)…
Article
Syringin Protects against Cerebral Ischemia and Reperfusion Injury via Suppression of Inflammatory Mediators and Toll‑Like Receptor/MyD88 Signaling Pathway in Rats
Yihong Huang, Xiaopeng Wang, Shaobing Guan, Han Lin, Zhizhong Mei, Zhi Huang
pp. 168–174 · DOI: 10.4103/pm.pm_98_21 · Published 28 March 2022
Objectives: In this research work, we envisioned to observe the neuroprotective actions of syringin against ischemic‑reperfusion (I/R)‑provoked ischemic stroke in rats. Materials and Methods: The focal cerebral I/R injur…
Article
Network Pharmacology Analysis with Molecular Docking of Phytochemicals of Panax ginseng against Osteosarcoma
Fahad Hassan Shah, Song Ja Kim
pp. 175–182 · DOI: 10.4103/pm.pm_518_21 · Published 28 March 2022
Background: Panax ginseng is a perennial medicinal herb also known as Korean ginseng or Insam (인삼), commonly found in Korean Peninsula. These herbs are used to treat different types of diseases. Recent studies have shown…
Article
Protective Effect of the Traditional Korean Herbal Prescription, Bojangunbi‑tang, on Non-steroidal Anti‑Inflammatory Drug‑induced Small Bowel Injury
Minji Cho, Jinhyun Bae, Ji‑Hye Park, Youngmin Bu, Beom‑Joon Lee, Jae‑Woo Park, Jinsung Kim, Hye Hyun Yoo
pp. 183–187 · DOI: 10.4103/pm.pm_333_21 · Published 28 March 2022
Background: Bojanggunbi‑tang (BGT) is a well‑known combination of ancient Korean herbal medicines and has been widely used for treating gastrointestinal symptoms. Objectives: This study was aimed at investigating whether…
Article
Anti‑Inflammatory, Antioxidant, Cytotoxic Activities, and Sesquiterpenoid Contents of Paralemnalia thyrsoides
Aya Ali Alassass, Marwa S. Abubakr, Walied M. Alarif, Seif-Eldin N. Ayyad, Abd-Elsalam E. Mohammed
pp. 188–192 · DOI: 10.4103/pm.pm_222_21 · Published 28 March 2022
Objectives: Paralemnalia thyrsoides is an octocoral species of the family Nephtheidae. It has established as platform for the production of a varied array of sesquiterpenoids such as africanane, nardosinane, and neolemna…
Article
Elucidating the Immunomodulatory Effect of Daidzein in Benzo(a)pyrene ‑Induced Lung Cancer Mice Model through Modulation of Proliferating Cell Nuclear Antigen, NF‑κB, CYP1A1, and NRF
Jianyu Feng, Wei Meng, Yandong Liu, Cuiyun Li, Chunnan Zhang, Peng Wang, Hesham S. Almoallim, Velu Manikandan, Hui Guan
pp. 193–200 · DOI: 10.4103/pm.pm_325_21 · Published 28 March 2022
Objectives: In this study, we aimed to understand the immunomodulatory activity of DAZ in the mice model with benzo(a)pyrene (B(a)P)‑induced lung carcinoma. Materials and Methods: The mice were divided into five groups: …
Article
The Ethanol Extract of Caragana sinica Ameliorated Skin Lesions in Mice with Contact Dermatitis
Seonkyung Jang, Yoonhyoung Kang, Yuntae Kang, Seungyeop Oh, Soyeon Kim, Ji‑Hyo Lyu, Hyungwoo Kim
pp. 201–206 · DOI: 10.4103/pm.pm_370_21 · Published 28 March 2022
: Background: Caragana sinica (Buc’hoz) Rehd, which belongs to the legume family, is used to treat a variety of diseases such as gout, high blood pressure, neuralgia, arthritis, and eczema. Morden studies reveal that C. …
Article
Genetic Clonal Fidelity Assessment of Rhizome‑Derived Micropropagated Acorus calamus L. – A Medicinally Important Plant by Random Amplified Polymorphic DNA and Inter‑Simple Sequence Repeat Markers
Leimapokpam Tikendra, Oinam Sushma, Thoungamba Amom, Nandeibam Apana Devi, Sonia Paonam, Nongthombam Bidyananda, Angamba Meetei Potshangbam, Abhijit Dey, Rajkumari Sanayaima Devi, Potshangbam Nongdam
pp. 207–215 · DOI: 10.4103/pm.pm_408_21 · Published 28 March 2022
Objectives: Development of fast and reliable in vitro regeneration protocol for A. calamus and clonal fidelity assessment of the regenerants using molecular markers. Materials and Methods: Plants were regenerated on Mura…
Article
Synthesis, Characterization, and Anti‑hepatocellular Carcinoma Effect of Glycyrrhizin‑coupled Bovine Serum Albumin‑loaded Luteolin Nanoparticles
Yongxia Yang, Huaguo Liang, Pei Zeng, Wei Fu, Jingwei Yu, Luxi Chen, Dong Chai, Ying Wen, Ali Chen, Yongli Zhang
pp. 216–225 · DOI: 10.4103/pm.pm_34_21 · Published 28 March 2022
Objectives: Synthesis of glycyrrhizin‑coupled bovine serum albumin‑loaded Lut nanoparticles (GL‑BSA‑Lut‑Nps) to progress the water solubility, anticancer effect, liver targeting, cycle arrest, induction apoptosis, and re…
Article
Anti‑tick Potential and Intra‑Specific Chemical Variations in Ageratum conyzoides L. Collected from Indus Plain and Central India
Bhanu Kumar, Pushpendra Kumar Shukla, Anil Kumar Sharma, Ajay Kumar Singh Rawat, Yashwant Singh Rawat, Srikant Ghosh, Sharad Srivastava
pp. 226–232 · DOI: 10.4103/pm.pm_261_21 · Published 28 March 2022
Objectives: Search for safe and efficacious plant‑based alternatives to the chemical acaricides and to assess chemical variability among intra‑specific germplasms. Materials and Methods: Ageratum conyzoides L. samples we…
Article
Enhanced Synergistic Antitumor Efficacy with Topotecan (Camptothecin Derivative) and Curcumin Analogs Coadministration in Novel Proniosomal Formulations
Afzal Haq Asif, Predeepkumar Narayanappa Shiroorkar, Purna Singh, Pottathil Shinu, Nagaraja Sreeharsha, Md. Khalid Anwer
pp. 233–241 · DOI: 10.4103/pm.pm_588_21 · Published 7 March 2022
Background: In the modern era of therapeutics, the proniosomal system has been identified as the most intriguing one among various novel systems, thus considerably enhancing the bioavailability of low‑soluble drugs. The …
Article
Possible Correction of Thiazide‑Induced Hypokalemia with Co‑Administration of Date Palm Fruits with Hydrochlorothiazide in Rats
Promise Madu Emeka, Kazeem Yusuff Babatunde, Mahesh Attimarad, Abdulaziz K. Al Mouslem
pp. 242–246 · DOI: 10.4103/pm.pm_548_21 · Published 1 February 2022
Background: Thiazide diuretics are one of the most effective, least expensive antihypertensive medicines, however, they are associated with hypokalemia, which can complicate the outcome of care among hypertensive patient…