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Article

Schisandrin A Suppresses Inflammation in DSS-induced IBD Mice and H2O2-induced MODE-K Cells through Wnt/β-Catenin Signaling

Hong Xu1, Xi Chen1, Xinlei Li1, Deqiang Dou1, Zhili Xu1★★ Corresponding author

  1. 1Department of Pharmacology, College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, People’s Republic of China.

CORRESPONDENCE

Zhili Xu

Department of Pharmacology, College of Pharmacy, Liaoning University of Traditional Chinese Medicine, No. 77 Shengming One Road, DD Port, Dalian, Liaoning 116600, People’s Republic of China.

xu_zhili@126.com

Received: 08-12-2022; Accepted: 28-02-2023.

Volume 19, Issue 3 · pp. 667–677 · PUBLISHED 2023 · DOI: 10.1177/09731296231172552

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ABSTRACT

Background: Schisandrin A (SchA) has multiple pharmacological features, and inflammatory bowel disease (IBD) represents a common digestive system disease mainly characterized by inflammation. Objectives: To assess the anti-inflammatory effects and the mechanism of SchA in mice with enteritis and in MODE-K cells representing in vivo and in vitro models of inflammation. Materials and Methods: DSS-induced IBD mouse models and MODE-K cells (an in vitro model of the intestine) were used to assess the effects of SchA on IBD inflammation and to determine the related signaling pathways. Results: Our data showed that SchA exerted anti-inflammatory effects by reducing the general clinical symptoms and the pathological damage to the colonic mucosa in mice with IBD and by promoting the migration of H2O2-induced MODE-K cells, inhibiting apoptotic death, and reducing the release of inflammatory factors. Moreover, SchA downregulated Wnt/β-catenin in both enteritis mice and H2O2-induced cells. Conclusion: SchA inhibits inflammation in DSS-induced IBD mice and H2O2-induced MODE-K cells by repressing Wnt/β-catenin signaling.

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    Xu, H., Chen, X., Li, X., Dou, D., & Xu, Z. (2023). Schisandrin A Suppresses Inflammation in DSS-induced IBD Mice and H2O2-induced MODE-K Cells through Wnt/β-Catenin Signaling. Pharmacognosy Magazine, 19(3), 667–677. https://doi.org/10.1177/09731296231172552