jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy MagazineNOW IN
Article

Salvianolate Ameliorates Renal Damage Induced by C-BSA in Membranous Nephropathy Rats Through Inhibiting Hypercoagulable State and Alleviating Podocyte Injury

Wenjun Chen1, Jinchuan Tan2★, Suzhi Chen2, Fengwen Yang2, Huiming Yan1, Huiling Duo1, Huijie Zhou3★ Corresponding author

  1. 1Department of Nephrology, Shijiazhuang Municipal Hospital of Traditional Chinese Medicine, Shijiazhuang, China.
  2. 2Department of Nephrology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, China.
  3. 3Department of Traditional Chinese Medicine, Affiliated Hospital of Hebei Engineering University, Handan, China.

CORRESPONDENCE

Jinchuan Tan

Department of Nephrology, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China.

dkscofield@126.com

Received: 03-12-2022; Accepted: 28-02-2023.

Volume 19, Issue 3 · pp. 678–688 · PUBLISHED 2023 · DOI: 10.1177/09731296231170082

View on PM original site ↗

ABSTRACT

Background: Membranous nephropathy (MN), one of the primary pathogenic forms of adult nephrotic syndromes, frequently coexists with hypercoagulability and hyperviscosity. MN is prone to thrombosis, embolism, and other complications, leading to the accelerated occurrence of glomerulosclerosis and renal fibrosis. Therefore, it is particularly important to promote blood circulation and remove stasis through anticoagulant therapy. Salvianolate (SAL) is a Chinese patent anticoagulant commonly used in clinical practice to promote blood circulation and remove blood stasis. SAL plays an important role in alleviating urinary protein and renal pathological damage in MN patients. Objectives: In the present study, we aimed to investigate the kidney-protective effect of SAL on MN in a rat model. Materials and Methods: The rat model of MN was established by tail vein injection of cationic bovine serum albumin (C-BSA). After the treatment, urinary proteins, hypercoagulable state index (fibrinogen (Fib), D dimer (D-D)), hepatic and renal functions, renal pathology, and podocyte marker proteins were analyzed to explore the renal protective effect of SAL on MN rats and its underlying mechanism. Results: In the modeled rats, we discovered a significant rise in urinary protein, a hypercoagulable state, and hypoproteinemia. Additionally, the expressions of Wilms’ tumor protein 1 (WT-1), podocalyxin (PCX), and vascular endothelial growth factor (VEGF) in renal tissues were significantly downregulated, indicating remarkable pathological damage to podocytes and renal tissues in MN rats. The expressions of the above-mentioned indices could be greatly reversed by SAL, which could also regulate the hypercoagulable state and suppress podocyte damage and renal pathological harm. Conclusion: Our results suggested that the renal protective effect of SAL on C-BSA-induced MN was related to its ability to inhibit hypercoagulable states, upregulate the expressions of WT-1, PCX, and VEGF in the renal tissue, and repair podocyte injury.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Chen, W., Tan, J., Chen, S., Yang, F., Yan, H., Duo, H., & Zhou, H. (2023). Salvianolate Ameliorates Renal Damage Induced by C-BSA in Membranous Nephropathy Rats Through Inhibiting Hypercoagulable State and Alleviating Podocyte Injury. Pharmacognosy Magazine, 19(3), 678–688. https://doi.org/10.1177/09731296231170082