Volume 11, Issue 42

New free radical scavenging neolignans from fruits of Piper attenuatum

S. Divya Reddy, Bandi Siva, B. Poornima, D. Anand Kumar, Ashok K. Tiwari, U. Ramesh

pp. 235–241 · DOI: 10.4103/0973-1296.153063 · Published 12 March 2015

Objective: The aim was to study and identify free radicals scavenging and antihyperglycemic principles in fruit of Piper attenuatum. Materials and Methods: Bioassay guided identification of extracts possessing potent fre…

Anti‑arthritic activity of Fu‑Fang‑Lu‑Jiao‑Shuang on collagen‑induced arthritis in Balb/c mice and its underlying mechanisms

Yanyan Wang, Weiguang Sun, Laxia Chen, Xin Xu, Yunxia Wu, Jinwen Zhang, Yonghui Zhang

pp. 242–249 · DOI: 10.4103/0973-1296.153065 · Published 12 March 2015

Background: Rheumatoid arthritis (RA) is a common, autoimmune disorder characterized by progressive multiple joint destruction, deformity, disability and premature death in most patients. Fu‑Fang‑Lu‑Jiao‑Shuang (FFLJS) i…

Shikonin induces apoptosis in the human gastric cancer cells HGC‑27 through mitochondria‑mediated pathway

Yue Hou, Jinghua Xu, Xia Liu, Xichun Xia, Ning Li, Xiuli Bi

pp. 250–256 · DOI: 10.4103/0973-1296.153074 · Published 12 March 2015

Background: Gastric cancer (GC) is one of the most frequently occurring digestive tract cancers and fewer chemotherapeutic drugs for GC have shown promising results. In this study, we investigated the anti-tumor activity…

The enriched fraction of Elephantopus scaber Triggers apoptosis and inhibits multi‑drug resistance transporters in human epithelial cancer cells

Asmy Appadath Beeran, Naseer Maliyakkal, Chamallamudi Mallikarjuna Rao, Nayanabhirama Udupa

pp. 257–268 · DOI: 10.4103/0973-1296.153077 · Published 12 March 2015

Background: Medicinal plants have played an important role in the development of clinically useful anticancer agents. Elephantopus scaber (Asteraceae) (ES) is widely used in Indian traditional system of medicine for the …

Methyl gallate isolated from Spondias pinnata exhibits anticancer activity against human glioblastoma by induction of apoptosis and sustained extracellular signal‑regulated kinase 1/2 activation

Dipankar Chaudhuri, Nikhil Baban Ghate, Sudhir Shankar Singh, Nripendranath Mandal

pp. 269–276 · DOI: 10.4103/0973-1296.153078 · Published 12 March 2015

Background: Spondias pinnata has been reported for its efficient anticancer effects, but the studies were mostly focused on its extract. Objective: Since its bioactive compounds are largely unknown, this study was design…

Comparative evaluation of standardized alcoholic, hydroalcoholic, and aqueous extracts of Phyllanthus maderaspatensis Linn. against galactosamine‑induced hepatopathy in albino rats

U. K. Ilyas, Deepshikha P. Katare, Vidhu Aeri

pp. 277–282 · DOI: 10.4103/0973-1296.153079 · Published 12 March 2015

Background: Phyllanthus maderaspatensis species (Euphorbiaceae) has been used in folk medicine of many countries as a remedy against several pathological conditions including jaundice and hepatitis. This study is an atte…

Attenuation of reactive oxygen/nitrogen species with suppression of inducible nitric oxide synthase expression in RAW 264.7 macrophages by bark extract of Buchanania lanzan

Shailasree Sekhar, K. K. Sampath-Kumara, S. R. Niranjana, H. S. Prakash

pp. 283–291 · DOI: 10.4103/0973-1296.153080 · Published 12 March 2015

Background: Oxidative stress is one of the most critical factors implicated in disease conditions. Buchanania lanzan Spr. (Anacardiaceae) bark powder preparation has been reported for treating an inflammatory condition i…

Preconditioning with glycyrrhizic, ferulic, paeoniflorin, cinnamic prevents rat hearts from ischemia/reperfusion injury via endothelial nitric oxide pathway

Guo-Qiang Qian, Jingjing Ding, Xiaozhao Zhang, Xiaofeng Yin, Yuqin Gao, Guo-Ping Zhao

pp. 292–296 · DOI: 10.4103/0973-1296.153081 · Published 12 March 2015

Objective: The objective was to investigate the endothelial nitric oxide synthase (eNOS/NO) pathway is involved or not in the protective effects of glycyrrhizic, ferulic, paeoniflorin, cinnamic (GFPC) in myocardial ische…

Simultaneous determination three phytosterol compounds, campesterol, stigmasterol and daucosterol in Artemisia apiacea by high performance liquid chromatography‑diode array ultraviolet/visible detector

Jiwoo Lee, Jin Bae Weon, Bo‑Ra Yun, Min Rye Eom, Choong Je Ma

pp. 297–303 · DOI: 10.4103/0973-1296.153082 · Published 12 March 2015

Background: Artemisia apiacea is a traditional herbal medicine using treatment of eczema and jaundice in Eastern Asia, including China, Korea, and Japan. Objective: An accurate and sensitive analysis method using high pe…

A new method for identification of natural, artificial and in vitro cultured Calculus bovis using high‑performance liquid chromatography‑mass spectrometry

Yonggang Liu, Peng Tan, Shanshan Liu, Hang Shi, Xin Feng, Qun Ma

pp. 304–310 · DOI: 10.4103/0973-1296.153083 · Published 12 March 2015

Objective: Calculus bovis have been widely used in Chinese herbology for the treatment of hyperpyrexia, convulsions, and epilepsy. Nowadays, due to the limited source and high market price, the substitutes, artificial an…

Effects of Pogostemon cablin Blanco extract on hypoxia induced rabbit cardiomyocyte injury

Chi‑Yeon Lim, Bu‑Yeo Kim, Se‑Hyun Lim, Su‑In Cho

pp. 311–319 · DOI: 10.4103/0973-1296.153084 · Published 12 March 2015

Background: Pogostemonis Herba, the dried aerial part of Pogostemon cablin Blanco, is a well‑known materia medica in Asia that is widely used for syndrome of gastrointestinal dysfunctions. Objective: This study was under…

Quantitative analysis of the eight major compounds in the Samsoeum using a high‑performance liquid chromatography coupled with diode array detection and electrospray ionization mass spectrometer

Jin Bae Weon, Hye Jin Yang, Bohyoung Lee, Jin Yeul Ma, Choong Je Ma

pp. 320–326 · DOI: 10.4103/0973-1296.153085 · Published 12 March 2015

Background: Samsoeum was traditionally used for treatment of a respiratory disease. Objective: The simultaneous determination of eight major compounds, ginsenoside Rg3, caffeic acid, puerarin, costunolide, hesperidin, na…

Sesamol, a lipid lowering agent, ameliorates aluminium chloride induced behavioral and biochemical alterations in rats

Jessy John, Madhavan Nampoothiri, Nitesh Kumar, Jayesh Mudgal, Gopalan Kutty Nampurath

pp. 327–336 · DOI: 10.4103/0973-1296.153086 · Published 12 March 2015

Background: Sesame oil from the seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally in Indian medical practice of Ayurveda in the treatment of central nervous system disorders and insomnia. A few pub…

The influences of inorganic elements in soil on the development of famous ‑ region Atractylodes lancea (Thunb.) DC

Weiwanqi Zhang, Zhen Ouyang, Ming Zhao, Yuan Wei, Huasheng Peng, Qiang Wang, Ling Guo

pp. 337–344 · DOI: 10.4103/0973-1296.153087 · Published 12 March 2015

Background: Atractylodes lancea (Thunb.) DC., is an important medicinal plant in China. Recently, researches of A. Lancea were focused on chemical composition and genetics, only a few were concerned with soil factors. Ob…

Ethyl acetate extract from marine sponge Hyattella cribriformis exhibit potent anticancer activity by promoting tubulin polymerization as evidenced mitotic arrest and induction of apoptosis

Pazhanimuthu Annamalai, Malini Thayman, Sowmiya Rajan, Lakshmi Sundaram Raman, Sankar Ramasubbu, Pachiappan Perumal

pp. 345–355 · DOI: 10.4103/0973-1296.153088 · Published 12 March 2015

Background: Marine sponges are important sources of bioactive compounds. Objective: This study investigated the anticancer properties of Hyattella cribriformis ethyl acetate (EA) fraction in various cancer and normal cel…

Identification of longevity, fertility and growth‑promoting properties of pomegranate in Caenorhabditis elegans

Hasan Kılıçgün, Nazlı Arda, Evren Önay Uçar

pp. 356–359 · DOI: 10.4103/0973-1296.153089 · Published 12 March 2015

Background: Pomegranate (Punica granatum L.) is commonly consumed as fresh fruit and fruit juice. It is also used in the production of jam, wine, food coloring agent, and flavor enhancer. Objective: The aim of this study…

Simultaneous quantification of six alkaloid components from commercial stemonae radix by solid phase extraction‑high‑performance liquid chromatography coupled with evaporative light scattering detector

Rong‑Rong Zhang, Dan‑Yi Lu, Zhen‑Ya Yang, Wen Zhao, Paul Pui‑Hay But, Pang‑Chui Shaw, Ren‑Wang Jiang, Zhi‑Guo Ma

pp. 360–367 · DOI: 10.4103/0973-1296.153090 · Published 12 March 2015

Background: Stemonae radix has been applied in traditional Chinese medicine for centuries. Alkaloids are the main active ingredient in stemonae radix, so their composition and concentration levels are directly linked to …

Evaluation of extraction method on the chemical composition in Apeiba tibourbou Aubl’s extracts

Frederico Severino Martins, Edemilson Cardoso da Conceição

pp. 368–373 · DOI: 10.4103/0973-1296.153091 · Published 12 March 2015

Background: The extraction method of bioactive compounds is an important step in the manufacturing of herbal medicines, because secondary metabolites with therapeutic potential are usually found in small quantities in pl…

In vitro regeneration and Agrobacterium tumefaciens‑mediated genetic transformation in asakura‑sanshoo (Zanthoxylum piperitum (L.) DC. F. inerme Makino) an important medicinal plant

Xiaofang Zeng, Degang Zhao

pp. 374–380 · DOI: 10.4103/0973-1296.153092 · Published 12 March 2015

Context: Asakura‑sanshoo (Zanthoxylum piperitum [L.] DC. f. inerme Makino) is an important medicinal plant in East Asia. Transgenic technique could be applied to improve plant traits and analyze gene function. However, t…

Effects of Valerianae Radix et Rhizoma extract on psychological stress in mice

Jeong Suk Kim, Jeong Deok Ahn, Su-In Cho

pp. 381–388 · DOI: 10.4103/0973-1296.153093 · Published 12 March 2015

Background: The aim of this study was to identify the effects of Valerianae Radix et Rhizoma water extract (VRe) originated from Valeriana fauriei Briquet on reducing psychological stress (PS) on mice. Objective: Mice we…

Antiradical and antidiabetic properties of standardized extract of Sunderban mangrove Rhizophora mucronata

Tapas Kumar Sur, Alok Kumar Hazra, Dipankar Bhattacharyya, Avijit Hazra

pp. 389–394 · DOI: 10.4103/0973-1296.153094 · Published 12 March 2015

Background: Mangroves have the ability to grow where no other vascular plants survive. Rhizophora mucronata is a true mangrove and traditionally used to treat diabetes and its allied complications. Objectives: In the pre…

Quercetin induces human colon cancer cells apoptosis by inhibiting the nuclear factor‑kappa B Pathway

Xiang‑An Zhang, Shuangxi Zhang, Qing Yin, Jing Zhang

pp. 404–409 · DOI: 10.4103/0973-1296.153096 · Published 12 March 2015

Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions

Suresh C. Phulara, Virendra Shukla, Sudeep Tiwari, Rakesh Pandey

pp. 410–416 · DOI: 10.4103/0973-1296.153097 · Published 12 March 2015

Background: Bacopa monnieri (L.) Pennell, commonly known as Brahmi is an important medicinal plant traditionally used as memory enhancer and antiepileptic agent. Objective: The present study investigated antioxidant and …

Yin‑Chen‑Hao‑Tang alleviates biliary obstructive cirrhosis in rats by inhibiting biliary epithelial cell proliferation and activation

Bing Wang, Ming‑Yu Sun, Ai‑Hua Long, Hong‑Yan Cao, Shuang Ren, Yan‑Qin Bian, Xiong Lu, Hong‑Tu Gu, Cheng‑Hai Liu, Ping Liu

pp. 417–425 · DOI: 10.4103/0973-1296.153098 · Published 12 March 2015

Background: Yin‑Chen‑Hao‑Tang (YCHT) consists of three aqueous extracts from Artemisia capillaris, Gardenia sp., and prepared Rheum rhabarbarum (rhubarb) (3:2:1). YCHT is characterized by its anti‑inflammatory properties…

In vivo antitumor potential of Ipomoea pes‑caprae on melanoma cancer

Ashish Manigauha, M. D. Kharya, N. Ganesh

pp. 426–433 · DOI: 10.4103/0973-1296.153099 · Published 12 March 2015

Background: The incidence of skin cancers is rising gradually. The treatment of melanoma is also necessary to prevent the spread of cancer to other body organs. Scientific literatures have not documented any evidence of …

Effect of co-administration of Angelicae gigantis radix and Lithospermi radix on rat hepatic injury induced by carbon tetrachloride

Chi-Yeon Lim, Bu-Yeo Kim, Se-Hyun Lim, Su-In Cho

pp. 395–395 · DOI: 10.4103/0973-1296.153095 · Published 12 March 2015

Background: Co‑administration of Angelicae gigantis radix (AGR) and Lithospermi radix (LR) has been commonly applied to patients to treat cardiac and hepatic disorders. Individual bioactivities of these herbal medicines …