Volume 11, Issue 44S2

2015 · pp. 365–500 · 19 articles

Volume: 11
Issue: 44S2
Published: 2015
Pages: 365–500
Articles: 19
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article ORIGINAL ARTICLE

In this issue

Original Article

Article
Cissus quadrangularis Linn. Stem Ethanolic Extract Liberates Reactive Oxygen Species and Induces Mitochondria Mediated Apoptosis in KB Cells
Saba Sheikh, Sahabjada Siddiqui, Anupam Dhasmana, Safia Safia, Ejazul Haque, Mohammed Kamil, Mohtashim Lohani, Mohammad Arshad, Snober Shabnam Mir
pp. 365–374 · DOI: 10.4103/0973-1296.168972 · Published 2015
Background: Cissus quadrangularis Linn. (CQ) commonly known as Hadjod (Family: Vitaceae) is usually distributed in India and Sri Lanka and contains several bioactive compounds responsible for various metabolic and physio…
Article
Hepatoprotective Effect of A Polyherbal Extract Containing Andrographis Paniculata, Tinospora Cordifolia and Solanum Nigrum Against Paracetamol Induced Hepatotoxicity
Dewasya Pratap Singh, Harshika Awasthi, Suaib Luqman, Saudan Singh, Dayanandan Mani
pp. 375–379 · DOI: 10.4103/0973-1296.168945 · Published 2015
Background: Traditionally, a number of medicinal plants are used to treat various types of hepatic disorders but few of them were pharmacologically evaluated for their safety and efficacy. The combination of Andrographis…
Article
Toxicogenomics of Phenylhydrazine Induced Hematotoxicity and its Attenuation by Plumbagin from Plumbago zeylanica
Pooja Shukla, R. K. Singh
pp. 380–387 · DOI: 10.4103/0973-1296.168983 · Published 2015
Background: High regenerative and proliferative capacity of blood and its components renders it to be at higher risk of adverse drug reactions (ADRs) which are manifested in several treatment regimens against various ail…
Article
Effects of 4‑hydroxyisoleucine from Fenugreek Seeds on Depression‑like Behavior in Socially Isolated Olfactory Bulbectomized Rats
Padmaja B. Kalshetti, Ramesh Alluri, Vishwaraman Mohan, Prasad Arvind Thakurdesai
pp. 388–396 · DOI: 10.4103/0973-1296.168980 · Published 2015
Context: Antidepressant‑like effects of (2S, 3R, 4S)‑4‑hydroxyisoleucine (4‑HI), a major amino acid from fenugreek seeds, has been reported in the animal model of acute depression. Aims: To evaluate effects of subacute a…
Article
Ultraviolet‑B Protective Effect of Flavonoids from Eugenia caryophylata on Human Dermal Fibroblast Cells
Juilee Patwardhan, Purvi Bhatt
pp. 397–406 · DOI: 10.4103/0973-1296.168979 · Published 2015
Background: The exposure of skin to ultraviolet‑B (UV‑B) radiations leads to deoxyribonucleic acid (DNA) damage and can induce production of free radicals which imbalance the redox status of the cell and lead to increase…
Article
Anti‑inflammatory, Anti‑estrogenic, and Anti‑implantation Activity of Bergia suffruticosa (Delile) Fenzl
Sandeep Kumar Bind, Mehul Jivrajani, Sheetal Anandjiwala, Manish Nivsarkar
pp. 407–413 · DOI: 10.4103/0973-1296.168973 · Published 2015
Background: Bergia suffruticosa (Delile) Fenzl (Syn. Bergia odorata Edgew) (Elatinaceae family) is used traditionally to repair bones and is applied as a poultice on sores. It is also used for stomach troubles and as an …
Article
Assessment of Pharmacodynamic and Pharmacokinetic Interaction of Aqueous Extract of Cassia auriculata L. and Metformin in Rats
Hemnath Elango, Sivasankaran Ponnusankar, Sankar Sundaram
pp. 423–426 · DOI: 10.4103/0973-1296.168986 · Published 2015
Background: Cassia auriculata L. (CA) leaf extract might increase the body’s production of insulin thereby suppressing the elevated blood glucose and lipid levels in diabetic rats. CA has been used as dietary supplement …
Article
Toxicological Evaluation of Emblica officinalis Fruit Extract and its Anti‑inflammatory and Free Radical Scavenging Properties
Sushil Kumar Middha, Arvind Kumar Goyal, Prakash Lokesh, Varsha Yardi, Lavanya Mojamdar, Deepthi Sudhir Keni, Dinesh Babu, Talambedu Usha
pp. 427–433 · DOI: 10.4103/0973-1296.168982 · Published 2015
Background: Emblica officinalis (Euphorbiaceae), popularly known as Indian gooseberry or “Amla” in India, is used in Ayurveda as “rejuvenating herb” since ancient times. Objective: This study was carried out to estimate …
Article
The isolation, Characterization and Preclinical Studies of Metal Complex of Thespesia populnea for the Potential Peroxisome Proliferator‑activated Receptors‑γ Agonist Activity
Mohini Ashok Phanse, Manohar Janardhan Patil, Konde Abbulu
pp. 434–438 · DOI: 10.4103/0973-1296.168984 · Published 2015
Background: Diabetes mellitus is an international public health problem since ancient days. The condition is predominantly more severe in developing countries like India where, life is more sedentary due to the even chan…
Article
Morphological and Chemoprofile (Liquid Chromatography‑mass Spectroscopy and Gas Chromatography‑mass Spectroscopy) Comparisons of Cyperus scariosus R. Br and Cyperus rotundus L.
Lavanya Kakarla, Suresh Babu Katragadda, Mahendran Botlagunta
pp. 439–447 · DOI: 10.4103/0973-1296.168975 · Published 2015
Background: Cyperus scariosus (CS) R.Br and Cyperus rotundus (CR) L. belongs to Cyperaceae family which is well‑reputed in the traditional systems of medicine. Although they grow in different agro‑climatic conditions, th…
Article
Culture Conditions for Production of Biomass, Adenosine, and Cordycepin from Cordyceps sinensis CS1197: Optimization by Desirability Function Method
Shashidhar M. Ghatnur, Giridhar Parvatam, Manohar Balaraman
pp. 448–456 · DOI: 10.4103/0973-1296.168946 · Published 2015
Background: Cordyceps sinensis (CS) is a traditional Chinese medicine contains potent active metabolites such as nucleosides and polysaccharides. The submerged cultivation technique is studied for the large scale product…
Article
Synergistic Caseinolytic Activity and Differential Fibrinogenolytic Action of Multiple Proteases of Maclura spinosa (Roxb. ex Willd.) latex
B. K. Venkatesh, Raghu Ram Achar, P. Sharanappa, B. S. Priya, S. Nanjunda Swamy
pp. 457–461 · DOI: 10.4103/0973-1296.168987 · Published 2015
Background: Kollamalayaali tribes of South India use latex of Maclura spinosa for milk curdling. This action is implicated to proteases which exhibit strong pharmacological potential in retardation of blood flow and acce…
Article
Bio Prospecting of Marine‑derived Streptomyces spectabilis VITJS10 and Exploring its Cytotoxicity Against Human Liver Cancer Cell Lines
Jemimah Naine Selvakumar, Subathra Devi Chandrasekaran, Mohanasrinivasan Vaithilingam
pp. 469–473 · DOI: 10.4103/0973-1296.168974 · Published 2015
Background: Recently, numerous pathogens have developed resistance due to the indiscriminate use of commercial therapeutic drugs. Objective: The main aim of the study was to evaluate the bioactive potential of the Strept…
Article
Identity‑based High‑performance thin Layer Chromatography Fingerprinting Profile and Tumor Inhibitory Potential of Anisochilus carnosus (L.f.) wall Against Ehrlich Ascites Carcinoma
Nilesh Gupta, Richard Lobo, Nimmy Kumar, Jay Kumar Bhagat, Jessy Elizabeth Mathew
pp. 474–480 · DOI: 10.4103/0973-1296.168977 · Published 2015
Context: Anisochilus carnosus (L.f.) wall belonging to the family Lamiaceae is a plant that is widely used in folk medicine for treating eczema, cold, cough, and fever. Objective: In the present study, we explored the an…
Article
Selective Cytotoxicity and Pro‑apoptotic Activity of Stem Bark of Wrightia tinctoria (Roxb.) R. Br. in Cancerous Cells
Shilpee Chaudhary, Raviraj Anand Devkar, Deepak Bhere, Manganahalli Manjunath Setty, Karkala Sreedhara Ranganath Pai
pp. 481–487 · DOI: 10.4103/0973-1296.168976 · Published 2015
Background: Wrightia tinctoria (Roxb.) R. Br. is a widely available shrub in India used traditionally in various ailments, including cancer. However, the anticancer activity of the bioactive fractions has not been valida…
Article
Reversed‑phase high‑performance Liquid Chromatography‑ ultraviolet Photodiode Array Detector Validated Simultaneous Quantification of six Bioactive Phenolic Acids in Roscoea purpurea Tubers and their In vitro Cytotoxic Potential against Various Cell Lines
Sharad Srivastava, Ankita Misra, Dharmesh Kumar, Amit Srivastava, Anil Sood, AKS Rawat
pp. 488–495 · DOI: 10.4103/0973-1296.168944 · Published 2015
Background: Roscoea purpurea or Roscoea procera Wall. (Zingiberaceae) is traditionally used for nutrition and in the treatment of various ailments. Objective: Simultaneous reversed‑phase high‑performance liquid chromatog…

ORIGINAL ARTICLE

Article
Molecular Docking and Molecular Dynamics to Identify a Novel Human Immunodeficiency Virus Inhibitor from Alkaloids of Toddalia asiatica
R. Priya, Rajendrarao Sumitha, C. George Priya Doss, C. Rajasekaran, S. Babu, R. Seenivasan, R. Siva
pp. 414–22 · DOI: 10.4103/0973-1296.168947 · Published 2015
Background: Acquired immunodeficiency syndrome caused by human immunodeficiency virus (HIV) is an immunosuppressive disease. Over the past decades, it has plagued human health due to the grave consequences in its harness…
Article
Dosakaya Juice Assuages Development of Sucrose Induced Impaired Glucose Tolerance and Imbalance in Antioxidant Defense
Dommati Anand Kumar, Pisupati S. R. Sweeya, Srishti Shukla, Sanga Venkata Anusha, Dasari Akshara, Kuncha Madhusudana, Ashok Kumar Tiwari
pp. 462–8 · DOI: 10.4103/0973-1296.168985 · Published 2015
Objective: The objective was to explore the effect of Dosakaya (DK) (Cucumis melo var. chito) juice on sucrose induced dysglycemia and disturbances in antioxidant defense in rats. Materials and Methods: Rats were precond…
Article
Modulatory Role of Shorea robusta Bark on Glucose-metabolizing Enzymes in Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats
A. Kalaiselvan, T. Anand, K. Gokulakrishnan, M. C. Kamaraj, S. Velavan
pp. 496–500 · DOI: 10.4103/0973-1296.168981 · Published 2015
Introduction: The modulations of glucose‑metabolizing enzyme activities play a vital rolein the depletion of energy metabolism and leads to inhibition of cancer growth. Objective: To find the effect of shorearobusta bark…