Volume 16, Issue 71

20 October 2020 · pp. 449–688 · 34 articles

Volume: 16
Issue: 71
Published: 20 October 2020
Pages: 449–688
Articles: 34
Sections: 1
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article

In this issue

Original Article

Article
Methanolic Extract of Mitragyna speciosa Korth Leaf Exhibits Place Preference Only at Higher Doses in Mice
Kamini Vijeepallam, Vijayapandi Pandy, Dharmani Devi Murugan, Murali Naidu Kuppusamy
pp. 449–454 · DOI: 10.4103/pm.pm_62_20 · Published 20 October 2020
Objectives: The purpose of this research was to investigate the reinforcing properties of M. speciosa Korth leaf extract obtained via methanol extraction using mouse conditioned place preference (CPP) test. Materials and…
Article
Apigenin attenuated ethylene glycol induced urolithiasis in uninephrectomized hypertensive rats: A possible role of bikunin, BMP‑2/4, and osteopontin
Ke Zhang, Amit Kandhare, Anwesha Mukherjee‑Kandhare, Subhash L. Bodhankar
pp. 455–463 · DOI: 10.4103/pm.pm_83_20 · Published 20 October 2020
Aim: To determine the protective effect of apigenin in experimental ethylene glycol (EG)‑induced urolithiasis in uninephrectomized hypertensive animals. Materials and Methods: EG was administration in uninephrectomized r…
Article
Neuroprotective Effect of the Essential Oil of Lavandula officinalis against Hydrogen Peroxide‑induced Toxicity in Mice
Sarra Akermi, Jackson Roberto Guedes da Silva Almeida, Ahd Khedher, Hafsia Bouzenna, Sabah Dhibi, Anouar Feriania, Afoua Mufti, Amal Daoud, Abdelfattah Elfeki, Najla Hfaiedh
pp. 464–470 · DOI: 10.4103/pm.pm_460_19 · Published 20 October 2020
Background: Brain is the main organ that manages all other organs and has significant oxygen requirements, which makes it vulnerable to reactive oxygen species, thus causing different neurological disorders. The aim of t…
Article
Evaluation of Antioxidant, Anti-inflammatory, and Analgesic Activities of Cissus vitiginea L. Leaves
Beibei Chen, Jinfa Tang, Ming Niu, Ruyuan Zhu, Lin Li, Lili Wang, Yimiao Tian, Rui Li, Qiangqiang Jia, Dandan Zhao, Fangfang Mo, Elena B. Romanenko, Alexander N. Orekhov, Sihua Gao, Dieter Brömme, Dongwei Zhang
pp. 471–478 · DOI: 10.4103/pm.pm_278_19 · Published 20 October 2020
Objective: The objective was to develop a sensitive, rapid, and accurate ultra‑performance liquid chromatography‑mass spectrometry (UPLC‑MS) method for the determination of the pharmacokinetics profile of salidroside aft…
Article
Narirutin Suppresses M1‑Related Chemokine InterferonGamma-Inducible Protein‑10 Production in Monocyte‑Derived M1 Cells via Epigenetic Regulation
Chung‑Hsiang Li, Lin Wang, Chang‑Hung Kuo, Yi‑Ting Chen, Mei‑Lan Tsai, Chih‑Hsing Hung
pp. 479–485 · DOI: 10.4103/pm.pm_105_20 · Published 20 October 2020
Objective: We try to investigate this anti‑inflammatory effect of narirutin in human monocytic THP‑1‑derived M1 macrophage cells. Materials and Methods: To confirm our hypothesis, human THP‑1 cells (1 × 106 cells/mL) wer…
Article
Effect of Diosgenin on T‑Helper 17 Cells in Mice with Collagen‑Induced Arthritis
Yaxian Gao, Yongwei Wang, Hongru Song, Yachun Guo, Enhong Xing, Xiaofei Zhao, Wei Li, Junxia Zhang, Chunyan Yu
pp. 486–492 · DOI: 10.4103/pm.pm_426_19 · Published 26 August 2020
Objective: The objective of this study is to explore the therapeutic effects of diosgenin against collagen‑induced arthritis (CIA) in DBA/1J mice. Materials and Methods: The CIA model was established using chicken type I…
Article
Immunostimulatory Activities of a High Molecular Weight Fraction of Cynanchum auriculatum Royle ex Wight Root Obtained by Ultrafiltration
Mi Jang, Tae‑Gyu Lim, Eunjung Lee, Hee‑Do Hong, Young Kyoung Rhee, Yun Ji Lee, Jeong Hoon Lee, Chang‑Won Cho
pp. 493–498 · DOI: 10.4103/pm.pm_449_19 · Published 20 October 2020
Objectives: In this study, we explored the immune‑enhancing effect of the high‑molecular weight fraction of C. auriculatum (CAHF) root extracts in RAW 264.7 macrophages and cyclophosphamide (CYP)‑induced immune‑suppresse…
Article
Anticancer Activity of Juniperus procera Grown in Southwestern Region of Saudi Arabia on Human Oral Squamous Cell Carcinoma Cell Lines
Abdulaziz AlShahrani, Ibrahim AlShahrani, Jagadish Hosmani, Rafi Ahmed Togoo, Tasneem Sakinatulain, Tanveer Alam, Mohammad Shahul Hameed
pp. 499–509 · DOI: 10.4103/pm.pm_28_20 · Published 20 October 2020
Objectives: The objective was to evaluate the anticancer properties of JP from Al‑Baha region on SCC‑9 cells. Materials and Methods: Colorimetric assays such as 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyl tetrazolium bromi…
Article
Protective Effects of Gracilaria lemaneiformis Extract against Ultraviolet B‑Induced Damage in HaCaT Cells
Yingnian Lu, Si Mei, Pan Wang, Peipei Ouyang, Xuehua Liao, Hua Ye, Kefeng Wu, Xiaoli Ma
pp. 510–517 · DOI: 10.4103/pm.pm_437_19 · Published 20 October 2020
Background: Gracilaria lemaneiformis is an edible red marine macroalga that contains various active components including phycoerythrin, polysaccharides, and phenolics. In our previous work, crude ethanolic extracts of G.…
Article
Involvement of Toll‑like Receptor 2/Myeloid Differentiation Factor 88/Nuclear Factor kappa B/NLR Family Pyrin Domain‑containing 3 Signaling Pathways in the Hepatoprotective Effect of Lagotis brachystachys in Rats with Alcoholic Liver Disease
Ji Xiao Zhu, Jia Ling Shan, Xiang Ouyang, Hai Yan Yang, Rong Rui Wei, Jin Xiang Zeng, Hong Yu Cheng
pp. 518–523 · DOI: 10.4103/pm.pm_557_19 · Published 20 October 2020
Objectives: The objective of the study was to evaluate the hepatoprotective effect of whole extracts of L. brachystachys against chronic alcohol‑induced ALD in rats. Materials and Methods: Different polar compounds of et…
Article
Honey as a Solvent for the Green Extraction, Analysis, and Bioconversion of Daidzin from Pueraria candollei var. mirifica Root
Suppalak Phaisan, Gorawit Yusakul, Poomraphie Nuntawong, Seiichi Sakamoto, Waraporn Putalun, Satoshi Morimoto, Hiroyuki Tanaka
pp. 524–530 · DOI: 10.4103/pm.pm_74_20 · Published 20 October 2020
Objectives: This study aims to apply honey (H‑NADES) and a sugar‑based NADES (S‑NADES) for the extraction, analysis, and bioconversion of daidzin from Pueraria candollei var. mirifica (PM) root. Materials and Methods: Va…
Article
Chlorogenic Acid in Viscum album Callus is a Potential Anticancer Agent against C6 Glioma Cells
Jinwoo Kim, Suji Baek, Kang Pa Lee, Byung Seok Moon, Hyun-Soo Kim, Seung-Hae Kwon, Dae won Lee, Jisu Kim
pp. 531–537 · DOI: 10.4103/pm.pm_479_19 · Published 20 October 2020
Objective: Our study aimed to explore the anticancer effects of CA obtained from Viscum album callus on C6 glioma cell migration and proliferation. Materials and Methods: Anticancer potency was analyzed by the 2,3‑bis‑(2…
Article
Identification of Polygonatum odoratum Based on Support Vector Machine
Zhong Li, Jie Zheng, Qin Long, Yi Li, Huaying Zhou, Tasi Liu, Bin Han
pp. 538–542 · DOI: 10.4103/pm.pm_410_19 · Published 20 October 2020
Objectives: We aimed to establish a reliable and accurate classification model of P. odoratum based on the support vector machine (SVM) and identify it from different habitats; we also aimed to identify its adulterants. …
Article
Preparation, Characteristics, and Antioxidant Activity of the Selenium Nanoparticles Stabilized by Polysaccharides Isolated from Grateloupia filicina
Bilang Cao, Yueling Yang, Chunhua Yue, Yuanyuan Wang, Pengcheng Fu, Yongguang Bi
pp. 543–549 · DOI: 10.4103/pm.pm_405_19 · Published 20 October 2020
Objectives: In this study, we aimed to optimize the extraction parameters of polysaccharides of Grateloupia filicina (GFPs) and investigate the antioxidant activity of SeNPs stabilized by GFPs. Materials and Methods: GFP…
Article
Anticancer Effects of Calotropis procera Latex Extract in MCF‑7 Breast Cancer Cells
Mohammed A. M. Al‑Qahtani, Mohammad Abul Farah, Faisal M. Abou‑Tarboush, Khalid M. Al‑Anazi, Naif O. Al‑Harbi, Mohammad Ajmal Ali, Waleed A. Q. Hailan
pp. 550–556 · DOI: 10.4103/pm.pm_156_20 · Published 20 October 2020
Objectives: The present study was conducted to isolate a cardiac glycosidal (CG) extract from the latex of C. procera and to assess its potential in inducing anticancer effects on breast cancer cells (MCF‑7). Materials a…
Article
Isovitexin, A New Metabolite, Was Found in the Metabolites of Co-cultured Five Flavonoids Isolated from Ziziphus jujuba Mill var. spinosa Seeds by Rat Intestinal Flora
Ying Liu, Junbo Xie, Xusheng Cui, Yanqing Zhang, Kunsheng Zhang
pp. 557–563 · DOI: 10.4103/pm.pm_454_19 · Published 20 October 2020
Objectives: The primary objective of this study was to investigate the mechanism of degradation of co‑cultured flavonoids, namely 6´´´‑feruloyl spinosin, 6´´´‑p‑coumaroyl spinosin, spinosin, swertisin, and isovitexin, in…
Article
Chemical Constituents from Saussurea pachyneura
Shuo Zhang, Xiao‑Man Tu, Wan‑Chang Zhang, Guang‑Bo Xie
pp. 564–567 · DOI: 10.4103/pm.pm_453_19 · Published 20 October 2020
Objectives: Saussurea pachyneura, a plant from genus Saussurea, was studied for its secondary metabolites. Materials and Methods: The air‑dried whole plant material was extracted by ethanol. The compounds from the ethano…
Article
Synthesis, Characterization, and Biological Activity of Silver Nanoparticles Synthesized from Aristolochia bracteolata Lam.
Nagaraja Sreeharsha, Govindarajan Kathiravan, Kalyanaraman Rajagopal, Arvindganth Rajasekar, Bose Rajangam, Bandar E. Aldhubiab, Venugopala Narayanaswamy, Mahesh Attimarad, Anroop B. Nair, Rajith Kumar Karnathi, Girish Meravanige, Uma Chandur, Teeka S. Roopashree, Micheline Haroun, Christophe Tratrat
pp. 568–573 · DOI: 10.4103/pm.pm_313_20 · Published 20 October 2020
The aim of this research is to analyze the antimicrobial activity and cytotoxicity of biologically synthesized silver nanoparticles against A549 cancer cell line. Silver nanoparticles were synthesized from the leaf extra…
Article
Isoliquiritigenin Induces Apoptosis through Caspases and Reactive Oxygen Species Signaling Pathways in Human Bladder Cancer Cells
Minwoo Hwang, Min Ji Kwon, Byung Joo Kim
pp. 574–579 · DOI: 10.4103/pm.pm_21_20 · Published 20 October 2020
Objectives: Mechanisms underlying ISL‑induced cell death were investigated in 5637 human bladder cancer cell line. Materials and Methods: Cell viabilities were measured with 3‑[4,5‑dimethylthiazol‑2‑yl]‑2,5‑diphenyltetra…
Article
Analgesic, Anti‑Inflammatory, and Central Nervous System Depressant Activities of Monochoria hastate (L.) Solms. in Animal Models
Tufael Ahmed, Luthfun Mst. Nesa, D. A. Anwar Al‑Aman, Islam Nazrul Kazi, Md. Eleas Kobir, Md. Ahsan Ullah, Dabanshu Dhali, Mohammad Abdur Rashid
pp. 580–584 · DOI: 10.4103/pm.pm_463_19 · Published 20 October 2020
Objectives: The objective of the study was to investigate the pharmacological effect of crude leaf extracts of M. hastate in mice model, justifying its medicinal use and evaluating its safety and efficacy as a crude drug…
Article
Protective Effect of Caffeic Acid Phenethyl Ester against Acute and Subchronic Mice Cardiotoxicity Induced by Cyclophosphamide Alone or Plus Naproxen
Promise Madu Emeka, Mohamed A. Morsy, Ibrahim A. Alhaider, Muhammad S. Chohan
pp. 585–591 · DOI: 10.4103/pm.pm_159_20 · Published 20 October 2020
Objectives: This study aims to investigate the possible protective effect of caffeic acid phenethyl ester (CAPE) in the co‑administration of CYP and naproxen (NAP) with acute and subchronic treatments in mice. Materials …
Article
Profiling of Antiviral and Antioxidant Phytochemicals of Pterocephalus frutescens Hochist. using High‑Resolution Ultra‑Performance Liquid Chromatography/Quadrupole Time‑of‑Flight Mass Spectrometer
Atef A. El-Hela, Mostafa M. Hegazy, Marwa S. Abu Bakr, Hatem S. Abbass
pp. 592–599 · DOI: 10.4103/pm.pm_558_19 · Published 20 October 2020
Background: Medicinal plant extracts and herbal preparations are complex mixtures of active and ballast substances, which may contain in frequently up to several hundreds of different constituents, with no exactly define…
Article
Polygonum chinense Water Decoction Lessens Acute Lung Injury in Mice Induced by Influenza Virus
Rongkui Liu, Zhao Zhang, Xueyang Peng, Yueling Su, Yan Xiao, Xiuli Ji
pp. 600–604 · DOI: 10.4103/pm.pm_206_19 · Published 20 October 2020
Background: In traditional Chinese medicine, Polygonum chinense has been used to treat influenza. However, little information is available from current studies regarding the anti‑influenza pharmacological activities of P…
Article
Fisetin Attenuates Gastric Mucosal Lesions through Modulating Nuclear Factor‑Kappa B and Peroxisome Proliferator‑Activated Receptor‑γ in Rats
Jinchen Hu, Li Cai, Zengwu Yao, Zhenbin Zhang, Menglai Zhang, Yifei Zhang, Lixin Jiang, Baohong Hu
pp. 605–612 · DOI: 10.4103/pm.pm_4_20 · Published 20 October 2020
Objective: The objective of this study was to explore the underlying mechanism of action of fisetin on ethanol‑induced gastric ulcer model. Materials and Methods: In this study, gastric mucosal lesions were induced by et…
Article
Rehmannia radix Extract Ameliorates Imiquimod‑Induced Psoriasis‑Like Skin Inflammation in a Mouse Model via the Janus‑Kinase Signal Transducer and Activator of Transcription Pathway
Haixiu Zhang, Minyan Dang, Xuemei Chen, Xin Yan
pp. 613–619 · DOI: 10.4103/pm.pm_218_19 · Published 20 October 2020
Background: Rehmannia glutinosa, commonly known as Dihuang, is a medicinal herb widely used in the formulations of traditional Chinese medicine. Radix or the root of Rehmannia is a vital ingredient used in various orient…
Article
Naringenin Reduced Migration in Osteosarcoma Cells through Downregulation of Matrix Metalloproteinase‑2 and Matrix Metalloproteinase‑9 and Snail
Yuh‑Ming Chang, Ming‑Cheng Lin, Ling‑Zong Hong, Pei‑Ni Chen, Yu‑Hsin Tsai, You‑Cheng Hseu, Ke‑Min Chen, Li‑Sung Hsu, Ting‑Hsien Kao
pp. 620–624 · DOI: 10.4103/pm.pm_31_20 · Published 20 October 2020
Objectives: In this study, we investigate the effects of naringenin on osteosarcoma. Materials and Methods: 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetra zolium bromide (MTT) assay was performed to detect the cell viabi…
Article
A Special Aromatic Chrysanthemum Breed with High Content of Thujone
Ying Zhang, Risheng Cheng, Zijie Xu, Yaoyao She, Keli Chen, Yimei Liu
pp. 625–629 · DOI: 10.4103/pm.pm_382_19 · Published 20 October 2020
Objective: The objective of the study was to determine taxonomic status of the cultivar in genus Dendranthema. Materials and Methods: The differences of morphological characteristics and volatile oil components between t…
Article
Effect and Mechanism of Ginsenoside Rg1 on Synaptic Plasticity of Oxygen‑Glucose Deprivation/Reoxygenation‑Induced Neuronal Injury
Chen Yan, Yan Ma, Lin Li, Meng Zhang, Junhua Zhan, Xiang Fan
pp. 630–636 · DOI: 10.4103/pm.pm_541_19 · Published 20 October 2020
Objective: In this study, we aim to establish the model of oxygen–glucose deprivation/reoxygenation (OGD/ R)‑injured primary cortical neurons to mimic ischemia/reperfusion injury and investigate the mechanisms of action …
Article
Sagittaria sagittifolia Polysaccharide, a Chinese Herbal Extract, Protects against Isoniazid‑ and Rifampicin‑induced Hepatotoxicity in in-vitro Model
Yibo Tang, Junping Lv, Jing Wang, Bing Li, Qiaohui Zhang, Zhenquan Liu, Xiuhui Ke, Weizao Luo, Yin Lin, Yan Liao
pp. 637–643 · DOI: 10.4103/pm.pm_542_19 · Published 20 October 2020
Objectives: In this study, we aimed to investigate the protective effect and the underlying mechanisms of SSP in cultured HepG2 cells after induction with INH and RFP. Materials and Methods: The study was designed as fol…
Article
Methanolic Extracts of Capparis ecuadorica Iltis Inhibit the Inflammatory Response in Lipopolysaccharide‑Stimulated RAW 264.7 Macrophage Cells
Bo Ram Song, Ji Eun Kim, Jin Ju Park, Mi Rim Lee, Jun Young Choi, Jin Kyung Noh, Hyun Keun Song, Dae Youn Hwang
pp. 644–653 · DOI: 10.4103/pm.pm_464_19 · Published 20 October 2020
Objectives: In this study, we investigated the anti‑inflammatory activity of a methanolic extract of C. ecuadorica leaves (MCE) in macrophages. Materials and Methods: Anti‑inflammatory responses and mechanisms were asses…
Article
Distinguishing the Rhizomes of Atractylodes japonica, Atractylodes chinensis, and Atractylodes lancea by Comprehensive Two‑Dimensional Gas Chromatography Coupled with Mass Spectrometry Combined with Multivariate Data Analysis
Jie Lu, WenTing Chen, BoWen Zhou, Yang Chen, XinHong Wang, Rui An, Ming Yang
pp. 654–661 · DOI: 10.4103/pm.pm_33_20 · Published 20 October 2020
Background: In clinical practice, the species of Atractylodes are difficult to identify based on their morphological and chemical features which often leads to confusion. In addition, the composition of volatile componen…
Article
Content Determination and Anti-fatigue Effect of the Purified Anthocyanin from Purple Daucus carota
Fang-Rong Cheng, Yue-Yue Mao, Song-Heng Jin, Rong-Rong Cai, Ke Yuan
pp. 670–674 · DOI: 10.4103/pm.pm_452_19 · Published 20 October 2020
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present…
Article
Glabridin Downregulates Lipopolysaccharide‑Induced Oxidative Stress and Neuroinflammation in BV‑2 Microglial Cells via Suppression of Nuclear Factor‑κB Signaling Pathway
Yan Wu, Jia Geng, Xiaoguang Lei, Qian Wu, Tao Chen, Lianmei Zhong
pp. 675–680 · DOI: 10.4103/pm.pm_497_19 · Published 20 October 2020
Background: Microglia initially undergoes chronic activation in response to the damages caused by stressful stimuli, such as bacterial infection and hypoxia. Inflammatory responses, as well as oxidative stress, perform c…
Article
Fucoxanthin Modulates the Development of 7, 12-dimethyl benz (a) anthracene-induced Skin Carcinogenesis in Swiss Albino Mice in vivo
Pengtao Kou, Najat Marraiki, Abdallah M. Elgorban, Yaowu Du
pp. 681–688 · DOI: 10.4103/pm.pm_292_19 · Published 20 October 2020
Background: Fucoxanthin (Fx), an distinctive carotenoid occurs on brown seaweed, contains several benefits including anti‑cancer effects. To investigate the chemopreventive effectual of Fx on 7,12‑dimethylbenz[a] anthrac…