Volume 16, Issue 72

Original Article

1. Article

   Aqueous Leaf Extract of Clinacanthus nutans Inhibits Growth and Induces Apoptosis via the Intrinsic and Extrinsic Pathways in MDA‑MB‑231 Human Breast Cancer Cells

   Marilyn Jane Yong, Ahmad Zaidi Tani, Falah Abass Mohamed Salih, Rahmawati Pare, Rina Norgainathai, Siat Yee Fong

   pp. 689–694 · DOI: 10.4103/pm.pm_121_20 · Published 16 February 2021

   Objectives: The study aimed to assess the anticancer efficacy and associated mechanisms of the crude aqueous extract of C. nutans leaves (cCN) in MDA‑MB‑231 triple‑negative human breast cancer cells. Materials and Method…

2. Article

   Anwulignan from the Fruits of Schisandra chinensis and its Cytotoxicity against Human Cancer Cell Lines

   Yeong‑Geun Lee, Rong Bo Wang, Hyoung‑Geun Kim, Dae‑Young Lee, Yeon‑Ju Kim, Nam‑In Baek

   pp. 695–699 · DOI: 10.4103/pm.pm_208_20 · Published 16 February 2021

   Objectives: We reviewed for the effects of cytotoxic lignans against various human cancer cells. Materials and Methods: Solvent extraction of fruits in aqueous methanol and fractionation of the extract into H2O, n‑BuOH, …

3. Article

   Ethanol Extract of Thuja orientalis L. Seeds Ameliorated Skin Lesions in a Dinitrofluorobenzene‑Induced Mouse Model of Contact Dermatitis

   Kukhwa Kim, Daniel Lee, Yoonhyoung Kang, Seonkyung Jang, Seung‑Jeong Yang, Hyungwoo Kim

   pp. 700–705 · DOI: 10.4103/pm.pm_245_20 · Published 16 February 2021

   Objectives: We investigate the anti‑inflammatory effects of an ethanol extract of the seeds of T. orientalis (EETO) on a dinitrofluorobenzene‑induced mouse model of contact dermatitis (CD). Materials and Methods: We inve…

4. Article

   The Effects of Elateriospermum tapos against Obese Maternal Rat in Mitigating Obesity Development among their Adult Female Offspring

   Hasnah Bahari, Azrina Zainal Abidin, Santhra Segaran Balan, Kokila Vani Perumal, Nurain Syahirah Rosli, Amalia Hazirah Ahamad Lotafi, Sharmmila Danabala, Malarmugila Manimaran, Nurul Husna Shafie, Maizaton Atmadini Abdullah, Azmiza Syawani Jasni

   pp. 706–712 · DOI: 10.4103/pm.pm_142_20 · Published 16 February 2021

   Objectives: This study was aim to investigate the effect of E. tapos supplementation in obese rat prior pregnancy on the female offspring’s body weight, liver and kidney profile, and histological changes of heart, liver,…

5. Article

   Bioactivity‑Guided Isolation, Characterization, and Estimation of Esculetin – A Potential Marker from Launaea pinnatifida Cass.

   Himanshu Makwana, Devang Pandya

   pp. 713–721 · DOI: 10.4103/pm.pm_264_20 · Published 16 February 2021

   Background: Loss of expertise in Sanskrit language and medicinal plant identification as per ayurvedic texts has resulted in the creation of “Controversial Drugs,” i.e., plants with different botanical identities being u…

6. Article

   Preclinical Study on Effects of Acalypha indica on Streptozotocin-induced Liver Damage in Diabetic Rats

   Singamala Hari Prasad, Ganjikunta Venkata Subbaiah, Sahukari Ravi, Boreddy Venu Gopal Reddy, Bhasha Shanmugam

   pp. 722–729 · DOI: 10.4103/pm.pm_272_20 · Published 16 February 2021

   Objective: In this study we investigated the quantifying and profiling of phenols in Acalypha indica polyphenol-rich fraction (PLF) and their therapeutic potential on hepatic tissue damage in streptozotocin (STZ) induced…

7. Article

   Isolation of New Diterpene from Methanolic Extract of Capsicum annuum Linn. Fruits

   Neeraj Kumar Fuloria, Shivkanya Fuloria, Vijay Kumar Sharma, Mohammed Ali, Amit Singh, Pradeep Kumar Sharma

   pp. 730–732 · DOI: 10.4103/pm.pm_250_20 · Published 16 February 2021

   Objectives: The present investigation was intended to explore the CAFME for the presence of any new phytoisolate. Materials and Methods: The study involved the preparation of CAFME, followed by critical isolation through…

8. Article

   Astaxanthin Attenuates Contrast‑Induced Acute Kidney Injury through Silent Mating‑Type Information Regulation 2 Homolog‑1/Peroxisome Proliferator‑Activated Receptor γ Co‑activator–α/NRF1 Signaling Pathway

   Liang Song, Yang Xu, Yongli Xuan, Di Zheng, Quan Zhang, Wenhua Li

   pp. 733–737 · DOI: 10.4103/pm.pm_81_20 · Published 16 February 2021

   Objectives: In this study, we established a model of contrast‑induced acute kidney injury with iohexol. This model was used to investigate whether astaxanthin (AST) attenuates oxidative stress and apoptosis by activating…

9. Article

   Isolation, Structural Characteristics, and in vitro and in vivo Antioxidant Activity of the Acid Polysaccharide Isolated from Pholiota nameko

   Yijun Fan, Ze Chun, Gang Wang, Shangrao Pu, Yuanzhi Pan, Jie Ma, Rongsu Miao, Aoxue Luo

   pp. 738–744 · DOI: 10.4103/pm.pm_109_20 · Published 16 February 2021

   Objectives: In order to screen a polysaccharide with antioxidant activity from Pholiota nameko. Methods and Materials: A water-soluble acidic P. nameko polysaccharide (PNP) was found from extraction with alkaline water. …

10. Article

    Simultaneous Determination of two Diterpenoids, Continentalic Acid and Kaurenoic Acid, in the Water extract of Aralia continentalis and their Wound‑Healing Activity

    Guijae Yoo, Taek Hwan Lee, Jae Hyuk Lee, Kyo Bin Kang, Heejung Yang, Yong Kon Park, Sun Yeou Kim, Seung Hyun Kim

    pp. 745–749 · DOI: 10.4103/pm.pm_344_20 · Published 16 February 2021

    Objective: Simultaneous determination of two diterpenoids; continentalic acid (CA) and kaurenoic acid, in the water extract of A. continentalis using the high‑performance liquid chromatography (HPLC) was established for …

11. Article

    Chemical Composition and Biological Potential of a Chloroform Fraction from the Leaves of Marine Plant Syringodium filiforme Kützing Kethia González García, David Marrero Delange, Yasnay Hernández Rivera, Yulexi Acosta Suárez, Richard Gutiérrez

    Cuesta Cuesta, Mario Riera‑Romo, Olga Echemendia, Lívia Macedo Dutra, Jackson Roberto Guedes Da Silva Almeida, Dayana Pérez‑martínez, Laurent Picot, Idania Rodeiro Guerra

    pp. 750–756 · DOI: 10.4103/pm.pm_24_20 · Published 16 February 2021

    Background: Seagrasses are an important component of Nearshore marine ecosystems and a rich source of secondary metabolites with important pharmacological properties. Materials and Methods: In this work, crude hydroethan…

12. Article

    Acute Oral Toxicity Studies of Methanolic Extract and Chloroform Fraction of Methanolic Extract of Seeds of Annona muricata

    Bibu John Kariyil, P. T. A. Usha

    pp. 757–763 · DOI: 10.4103/pm.pm_118_20 · Published 16 February 2021

    Objectives: The present study was undertaken to evaluate the acute oral toxicity of methanolic extract of seeds of Annona muricata (MAM) and chloroform fraction of MAM and to derive the lethal dose 50 (LD50) of chlorofor…

13. Article

    Ameliorative Effect of Tinospora tuberculata in Insulin Resistance: Potential Roles of Oxidative Stress Resistance and Heat Shock Protein 70 (Hsp 70) Modulation

    P. K. Lakshmi, Shweta Kumar, Neha Dobriyal, Chandan Sahi, Rajesh Singh Pawar

    pp. 764–773 · DOI: 10.4103/pm.pm_366_20 · Published 16 February 2021

    Background: Tinospora tuberculata Bumee is a climbing vine distributed throughout the South Asian countries and it is known to be a hypoglycaemic agent. However, its role in cytoprotection and cellular oxidation is uncle…

14. Article

    Two New Xeniolide Diterpenes from the Soft Coral Xenia umbellata; Displayed Anti Proliferative Effects

    Walied M. Alarif, Mohamed A. Ghandourah, Ahmed Abdel‑Lateff, Nahed O. Bawakid, Ahmed Abdullah Alotaibi, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi

    pp. 774–779 · DOI: 10.4103/pm.pm_300_20 · Published 16 February 2021

    Objective: Xenia is an octocoral genus of family Xeniidae. It contains 98 species and is rich of xenican‑type diterpenoids. These compounds play an important role in the biological activity of Xenia. Different bioactivit…

15. Article

    Terfezia claveryi and Terfezia boudieri Extracts: An Antimicrobial and Molecular Assay on Clinical Isolates Associated with Eye Infections

    Lorina Ineta Badger-Emeka, Promise Madu Emeka, Saif Aldossari, Hany Ezzat Khalil

    pp. 780–788 · DOI: 10.4103/pm.pm_199_20 · Published 16 February 2021

    Objectives: The antimicrobial effects of Terfezia claveryi and Terfezia boudieri (T. boudieri) against bacteria isolates associated with eye infections and their molecular mechanism were investigated. Materials and Metho…

16. Article

    Anti-arthritic Effect of Neferine on Adjuvant‑Induced Experimental Arthritis in Rats via Nuclear Factor Kappa B Signaling Pathway

    Guoxi Gao, Chao Zhang

    pp. 789–796 · DOI: 10.4103/pm.pm_538_19 · Published 16 February 2021

    Background: Inflammation plays an important role in the progression of arthritis. The imbalance between pro‑inflammatory and anti‑inflammatory mediators regulates the induction and progression of arthritis. Nuclear facto…

17. Article

    Juglanin Attenuated Adjuvant‑Induced Arthritis via Inactivating NF‑κB/IκBα and A Disintegrin‑Like and Metalloproteinase Domain with Thrombospondin‑1 Repeat Pathways in Experimental Rats

    Chao Ning, Shaoqi Ning, Heng Luo, Lei Yan

    pp. 803–811 · DOI: 10.4103/pm.pm_106_20 · Published 16 February 2021

    Objective: The present study was undertaken to evaluate their possible mechanism of action against adjuvant‑induced arthritis (AIA), i.e., Freund’s complete adjuvant (FCA)‑induced arthritis, in experimental rats. Materia…

18. Article

    Two New Flavonoid Glycosides Isolated from the Fruits of Catalpa ovata

    Liu‑Qiang Zhang, Hai‑Bing Xue, Wei‑Liang Zhu, Yi‑Ming Li, Kai‑Xian Chen

    pp. 812–816 · DOI: 10.4103/pm.pm_91_20 · Published 16 February 2021

    Objectives: This communication report presents the results of chemical investigation and antioxidant capacity of the fruits of C. ovata. Materials and Methods: The polar fraction from the fruits of C. ovata was isolated …

19. Article

    Synergistic and Toxicity‑Attenuating Effects of Periplaneta americana Extract CII‑3 Combined with Cisplatin on Lewis Lung Cancer‑Bearing Mice

    Qiaoling Yang1+, Mili Shi1+, Guangming Liu, Fang Peng, Xiaobo Liu, Meixian Guo

    pp. 817–829 · DOI: 10.4103/pm.pm_499_19 · Published 16 February 2021

    Objective: The objective was to study the synergistic and attenuating effects of CII‑3 combined with cisplatin. Materials and Methods: A Lewis tumor‑bearing mouse model was established. After 15 days of continuous admini…

20. Article

    Factorial Design-Guided Optimization of Extraction of Therapeutically Active Furanocoumarin Khellin from Ammi majus L. Fruits

    Hina Kausar, Lubna Abidin, Mohd. Mujeeb, Mohd. Aqil, Ozair Alam

    pp. 830–835 · DOI: 10.4103/pm.pm_295_20 · Published 16 February 2021

    Objectives: The study objective was to analyze the optimization of extraction parameters of khellin from A. majus L. by response surface methodology (RSM). Materials and Methods: Box–Behnken Design (BBD) of RSM was used …

21. Article

    Inhibitory Effects of Triterpenoid Betulin on Inflammatory Mediators Inducible Nitric Oxide Synthase, Cyclooxygenase‑2, Tumor Necrosis Factor‑Alpha, Interleukin‑6, and Proliferating Cell Nuclear Antigen in 1,2‐Dimethylhydrazine‐Induced Rat Colon Carcinogenesis

    Jinfeng Yu, Min Li, Dong Zhan, Chang Shi, Le Fang, Chunmei Ban, Weifeng Zheng, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Xiaoling Tang

    pp. 836–842 · DOI: 10.4103/pm.pm_516_19 · Published 16 February 2021

    Objectives: In this study, we explored the anticancer, antiproliferative, and anti‑inflammatory effects of BE on 1,2‑dimethylhydrazine (DMH)‑treated rat model of colon cancer. Materials and Methods: Colon cancer was indu…

22. Article

    Antineoplastic Potential of Eupatilin against Benzo[a] pyrene‑Induced Lung Carcinogenesis

    Yanzhou Han, Zhiqing Zheng, Fanping Liu, Yanqing Tian, Lixin Bi, Sujuan Zhang

    pp. 843–850 · DOI: 10.4103/pm.pm_162_20 · Published 16 February 2021

    Background: Most of the conservative therapies used to treat lung cancer show serious side effects. In addition, the prevalence and death rates due to lung cancer have been increasing alarmingly across the globe. Eupatil…

23. Article

    Anti‑Inflammatory and Anti‑Cell Proliferative Effects of Dieckol in the Prevention and Treatment of Colon Cancer Induced by 1,2‑Dimethyl Hydrazine in Experimental Animals

    Baoxiu Yang, Ying Li, Zhengbo Yang, Legang Xue, Minqin Zhang, Guoliang Chen, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Xu Liu

    pp. 851–858 · DOI: 10.4103/pm.pm_165_20 · Published 16 February 2021

    Objectives: Colon carcinogenesis is a major cause of mortality and morbidity in developing and developed countries, and its etiology is familiar to be a grouping of environmental and nutritional factors, hereditary facto…