Volume 18, Issue 79

30 May 2022 · pp. 519–789 · 36 articles

Volume: 18
Issue: 79
Published: 30 May 2022
Pages: 519–789
Articles: 36
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

Original Article ORIGINAL ARTICLE

In this issue

Original Article

Article
Exploring the Topical Gel of Thespesia populnea leaf Extract for in vivo Wound Healing Efficacy
Afzal H. Asif, Salim M. Mulla, Arshia Shariff, Nagaraja Sreeharsha, Girish Meravanige, Predeepkumar N. Shiroorkar, Syed Mohammed Basheeruddin Asdaq, Md. Khalid Anwer, Teeka S. Roopashree, Ranjith K. Karnati
pp. 519–523 · DOI: 10.4103/pm.pm_25_22 · Published 30 May 2022
Aim: Thespesia populnea is a plant known for its polyphenol and flavonoid content, which plays a crucial role in wound healing activity. Traditionally, extracts of various parts of T. populnea plant have been used to tre…
Article
Escin Attenuates Inflammation and Oxidative Stress and Preserves Renal Function in Hyperoxaluric Rats
Qingfei Yu, Peng Qu, Vidya Devanathadesikan Seshadri, Xiaogang Wang
pp. 524–531 · DOI: 10.4103/pm.pm_251_21 · Published 19 September 2022
Background and Objectives: Oxalate is a toxic metabolite, which is predominantly excreted through the kidneys. Hyperoxaluria is a clinical condition characterized by the occurrence of excessive amounts of oxalate in the …
Article
Anticancer Potential of Piper retrofractum on Breast Cancer MCF‑7 Cells Via Induction of Cell Death and Reduction of Cell Migration
Benjaporn Buranrat
pp. 532–539 · DOI: 10.4103/pm.pm_455_21 · Published 19 September 2022
Background: Piper retrofractum (PR) is traditional medicine in the South‑East country. Objectives: This study examined the PR effects on anticancer and anti‑migratory activity in human breast cancer cells. Materials and …
Article
Esculetin Ameliorates Cognitive Impairments in D‑Galactose‑Induced Alzheimer’s Disease Rats by Inhibiting Inflammation and Oxidative Stress
Xinmin Yao, Miao Yu, Yanyan Zhou, Huibo Guan
pp. 540–547 · DOI: 10.4103/pm.pm_524_21 · Published 19 September 2022
Background: Alzheimer disease (AD) is a common form of dementia and is described by memory loss and behavioral disorder. The prevalence of AD is increasing rapidly each year worldwide. Objectives: In this study, we aimed…
Article
GC–MS Metabolomics and Network Pharmacology‑Based Investigation of Molecular Mechanism of Identified Metabolites from Tinospora cordifolia (Willd.) Miers for the Treatment of Kidney Diseases
Gaurav Gaurav, Mohammad Umar Khan, Parakh Basist, Sultan Zahiruddin, Mohammad Ibrahim, Rabea parveen, Anuja Krishnan, Sayeed Ahmad
pp. 548–558 · DOI: 10.4103/pm.pm_582_21 · Published 19 September 2022
Background: Tinospora cordifolia (Willd.) Miers (T. cordifolia) is a well‑known Indian medicinal plant containing several nonpolar and polar constituents that play an important role to mitigate various ailments, such as …
Article
A Comparative Pharmacognostical Evaluation and Simultaneous HPTLC Quantification of Bioactive Alkaloids in Three Species of Gloriosa, Collected from Natural Habitat in India
Ankita Misra, Bhanu Kumar, Sharad Srivastava
pp. 559–564 · DOI: 10.4103/pm.pm_580_21 · Published 19 September 2022
Background: The genus Gloriosa is commercially valued due to its colchicine metabolite, which is clinically used in gout and as an antimitotic agent. Objectives: The study was a comparative pharmacognostical evaluation a…
Article
Apoptosis‑Mediated Inhibition of Human Gastric Cancer Cell Proliferation by Cirsilineol
Mohammed Ali, Ahmed Al-Ghamdi
pp. 565–570 · DOI: 10.4103/pm.pm_75_22 · Published 19 September 2022
Background: Flavonoids constitute one of the best‑characterized groups of plant secondary metabolites with enormous pharmaceutical potential. A flavone type of plant flavonoid, cirsilineol, has been reported to exhibit p…
Article
Alterations in the Pharmacokinetics of Paeoniflorin and Albiflorin in a Collagen‑Induced Arthritis Rat Model
Ya-xin Han, Mu-xin Gong, Jin-e Peng, Yong-song Xu, Feng Qiu, Kai-li Xie, Xue-rong Dong, Bin-bin Wang, Xiao-xin Chai, Zhe Ma, Si-hui Wang, Nan Nan
pp. 571–578 · DOI: 10.4103/pm.pm_539_21 · Published 19 September 2022
Background: Rheumatoid arthritis (RA) is an autoimmune disease that seriously affects the patient’s quality of life. Total glucosides of peony (TGP) have long been used to treat RA in China despite the need for long‑term…
Article
Notoginsenoside R1 Elicits Inhibitory Effects on Keloid Fibroblasts via Downregulation of Vascular Endothelial Growth Factor
Weiping Huang, Jin Chen, Tao Zhu
pp. 579–586 · DOI: 10.4103/pm.pm_359_21 · Published 19 September 2022
Background: Keloid is a fibrotic disease characterized by hyperproliferative fibroblasts. Notoginsenoside R1 (NGR1) possesses inhibitory roles on cell proliferation. Thus, the research sought to assess the mechanism of a…
Article
Anticancer Potential of Brucine against Oral Cancer Cells in vitro through Elevation of Reactive Oxygen Species
Yahya H. Hobani
pp. 587–592 · DOI: 10.4103/pm.pm_126_22 · Published 19 September 2022
Background: Oral cancer is one of the cancers that pose a great threat to life globally. Though a number of chemotherapeutic strategies have been followed to treat oral cancer, a number of adverse effects limit the usage…
Article
Adhatoda vasica is Effective in Relieving Pain through Modulation of Inflammation
Li Gao, Shasha Cui, Zhiqiang Huang, Hailong Cui
pp. 593–599 · DOI: 10.4103/pm.pm_114_22 · Published 19 September 2022
Background: Nociception is an unpleasant experience that has a negative effect on both the physiological and psychological status of individuals. Factors including temperature, and physical damage originating from mechan…
Article
Sinomenine Activates Gut Innate Immune Response through the Aromatic Hydrocarbon Receptor by Regulating the IL‑23/IL‑17 Axis
Weina Zhu, Chunhua Ma, Jie Ruan, Fuqiong Zhou, Yajie Zhang, Hongyan Long
pp. 600–605 · DOI: 10.4103/pm.pm_81_21 · Published 19 September 2022
Background: Sinomenine (SIN) plays a role in regulating intestinal immune inflammation, but its effect on the intestinal immune response is unclear.Objective: To investigate the potential mechanism of SIN in protecting i…
Article
Molecular Mechanisms of Dolichandrone serrulata Flower Ethanolic Extract on Antimigration of Human Cervical Cancer Cell Line
Patcharawan Sujayanont, Ratikorn Chatchanayeunyong
pp. 606–610 · DOI: 10.4103/pm.pm_45_22 · Published 19 September 2022
Background: Dolichandrone serrulata flower has been known for its antioxidation and anti‑inflammation. Its ability to induce cell death and reduce migration on cancer cell lines has been previously demonstrated. Aim: The…
Article
Synthesis of Baicalin Carboxylate Derivatives and their Structure–Activity Relationship Analysis of their Inhibitory Activity on BVDV NS5B Polymerase
Ying Zong, Yu H. Sun, Yi Che, Hui Wang, Kun Shi, Zhong M. He, Rui Du
pp. 611–620 · DOI: 10.4103/pm.pm_561_21 · Published 19 September 2022
Background: Bovine viral diarrhea virus (BVDV) has a serious impact on the global livestock industry; however, there are no specific therapeutic drugs for BVDV, so the development of anti‑BVDV drugs is a research priorit…
Article
Oroxylum indicum (L.) Kurz Seed Extract Prevents LPS‑Mediated BV2 Microglial Activation through NF‑κB Nuclear Translocation and Activation of the Akt/ERK1/2 Signaling Pathways
Nootchanat Mairuae, Poonlarp Cheepsunthorn, Benjaporn Buranrat
pp. 621–626 · DOI: 10.4103/pm.pm_122_22 · Published 19 September 2022
Background:Oroxylum indicum (L.) Kurz is an edible plant that is widely consumed in several Asian countries. In our previous study, it was demonstrated that Oroxylum indicum (L.) Kurz seed (OIS) extract attenuated oxidat…
Article
Anti‑inflammatory Effect of luteolin‑7‑O‑glucoside via the JAK1/ STAT6/SOCS1 Pathway in Ulcerative Colitis Treatment
Dajuan Sun, Yan Cheng, Hua Yan, Xiunan Wei, Xinqian Dong, Lili Chi
pp. 627–634 · DOI: 10.4103/pm.pm_506_21 · Published 19 September 2022
Background: Luteolin‑7‑O‑glucoside (Lut‑7‑G) is an effective compound found in plants, such as Patrinia and honeysuckle. It has anti‑inflammatory as well as antioxidant properties; however, its anti‑inflammatory effect o…
Article
Anti‑cancer and Cell Toxicity Effects of Royal Jelly and its Cellular Mechanisms against Human Hepatoma Cells
Sultan F. Alnomasy, Zafer Saad Al Shehri
pp. 635–640 · DOI: 10.4103/pm.pm_18_22 · Published 19 September 2022
Background: This investigation was planned to evaluate the anti‑cancer effects of royal jelly (RJ) obtained from Apis mellifera compared with doxorubicin as an anthracycline with potent anti‑cancer activity and its cellu…
Article
Salvianolic Acid B Delays Hepatolithiasis through Inhibiting the Fibrosis of Intrahepatic Biliary Epithelial Cells
Hao Yao, Wenpin Xu, Zhaoming Liu, Dawei Ma, Hongbin Bao
pp. 641–650 · DOI: 10.4103/pm.pm_162_21 · Published 19 September 2022
Background: Hepatolithiasis (HL) is one of the common diseases in hepatobiliary surgery, and bile duct fibrosis is the key step in the pathogenesis of HL. Salvia miltiorrhiza (S. miltiorrhiza) has an inhibitory effect on…
Article
Terfezia claveryi Chatin: Anti‑Tumor Effects against Ehrlich Solid Tumor in Mice
Norah A. Althobaiti, Reem Hasaballah Alhasani, Mona N. BinMowyna, Aishah E Albalawi, Ifat Alshari
pp. 651–658 · DOI: 10.4103/pm.pm_12_22 · Published 19 September 2022
Background: The genus Crotalaria (Fabaceae) is known for its diverse pharmacological activities. Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of Crotal…
Article
Components with Lifespan‑prolonging Effects in the Fibrous Roots of Anemarrhena asphodeloides Characterized by UltraHigh Performance
Jianhong Li, Qi Huang, Deling Wu, Rumin Zong, Zhiyuan Shao, Yu Meng, Qianqian He
pp. 659–668 · DOI: 10.4103/pm.pm_447_21 · Published 19 September 2022
Background/Context:The fibrous roots of Rhizoma Anemarrhena (FRRA) are produced in the primary processing of Rhizoma Anemarrhena (RA). The lifespan‑prolonging effect and the bioactive compounds of FRRA were rarely report…
Article
Cordyceps militaris Polysaccharide Exerted Anticancer Effect via Activating the Endogenous Apoptosis Pathway
Fenglin Li, Yumiao Ma, Wuyang Hua, Yanxia Liu, Li Li, Zhongkui Lu, Xiaokun Jiang, Chao Liu, Jingxue Liu
pp. 669–674 · DOI: 10.4103/pm.pm_585_21 · Published 19 September 2022
Background: Despite tremendous efforts that have been made, cancer is still the leading cause of death all over the world. Chemotherapy, considered a routine method, always faces severe side effects and drug resistance. …
Article
Anticancer Effect of Benzyl Isothiocyanate on the Apoptosis of Human Gemcitabine‑Resistant Pancreatic Cancer MIA PaCa‑2/ GemR Cells (MIA RG100)
Chao‑Wen Hsueh, Chun Chen, Po‑Yen Chiu, Ni‑Na Chiang, Chi‑Cheng Lu, Jai‑Sing Yang, Fu‑An Chen
pp. 675–678 · DOI: 10.4103/pm.pm_101_22 · Published 19 September 2022
Background: Benzyl isothiocyanate (BITC) is a natural compound found in numerous cruciferous vegetables, and research has indicated that it has diverse biological activities. Isothiocyanate and its derivatives are the ma…
Article
The Effect of Curcumin on Aβ, Akt, and GSK3β on the Brain and Retina of APP/PS1 Mice and in the Blood of Alzheimer’s Patients with Early‑stage Disease
Xi Mei, Conglong Qiu, Lingli Shi, Xingxing Li, Mengxiang Yang, Jun Hu, Zhongming Chen, Chenjun Zou
pp. 679–684 · DOI: 10.4103/pm.pm_490_21 · Published 19 September 2022
Background: Curcumin possesses multifunctional pharmacological properties, including antioxidant, anti‑inﬂammatory, and antidiabetic properties. We investigated whether curcumin can improve pathological changes associate…
Article
Protective Effect of 20(R)‑ginsenoside Rg3 on Chemotherapy‑induced Myelosuppression in Mice
Zhengfeng Fu, Nian Sun, Shuqi Li, Jiahong Han, Shiyue Lang, Xiuyong Yue, Enbo Cai
pp. 685–691 · DOI: 10.4103/pm.pm_451_21 · Published 19 September 2022
Background: 20(R)‑ginsenoside Rg3 (R‑Rg3) is a kind of ginseng glycol tetracyclic triterpenoid saponin, which is a recognized traditional Chinese medicine monomer and has the action of inhibiting the proliferation of tum…
Article
In vivo Antitumor and Immune Effects of Paris polyphylla Rhizome and Tinosporae Radix Extracts Administered by Different Modes
Yonghong-Liang Yonghong-Liang, Xiuying-Huang Xiuying-Huang, Xunli-Xia Xunli-Xia, Huiying-Yao Huiying-Yao, Yu-Lu Yu-Lu
pp. 692–698 · DOI: 10.4103/pm.pm_6_22 · Published 19 September 2022
Objectives: To investigate the effects of gavage and transdermal administration on the anti‑tumor activity of QJ623 (extracts of Paris polyphylla rhizome and Tinosporae Radix) on a murine H22 solid tumor transplantation …
Article
Antioxidant and Anti-wrinkle Effects of Orostachys japonicus Extracts as Anti-aging Cosmetic Agents
Dae‑Young Noh, Ji‑Yeon Hyun, Donguk Kim, Dong‑Seok Lee
pp. 699–706 · DOI: 10.4103/pm.pm_497_21 · Published 19 September 2022
Background: Orostachys japonicus has traditionally been used for antifever, anti‑inflammation, and anticancer. O. japonicus has not yet been studied for cosmetic effects. Objectives: In this study, O. japonicus extracts …
Article
Ruta graveolens Linn. (RGLE) Reduces Autophagy and Improves Memory in the Rat Model of Dementia through mTOR Signaling Pathway Regulation
Miao Yu, Huibo Guan, Yanyan Zhou, Xinmin Yao, Yuguang Yang
pp. 707–712 · DOI: 10.4103/pm.pm_202_21 · Published 19 September 2022
Objectives: The present study evaluated Ruta graveolens Linn. extract (RGLE) for its possible role in the treatment of vascular dementia (VD) in the rat model and inhibition of autophagy in hippocampus tissues. Materials…
Article
A Study on the Quality Evaluation of Agarwood of Aquilaria sinensis and Aquilaria malaccensis Induced by Different Inducers Based on Gray Correlation Degree and TOPSIS
Zhiling Zhuang, Shenghong Wu, Shimin Deng, Pengjian Zhu, Xin Zhou, Xiaoying Chen, Weimin Zhang, Xiaoxia Gao
pp. 713–728 · DOI: 10.4103/pm.pm_340_21 · Published 19 September 2022
Background: Agarwood is a resinous heartwood produced in certain Aquilaria species that is often used as a spice and Chinese medicine materials. Objectives: This study aimed to comprehensively evaluate the agarwood quali…
Article
Induction of Cell Death and Apoptosis of Oroxylum Indicum Extract With Gemcitabine On Human Cholangiocarcinoma Cells Through Reducing Epidermal Growth Factor Receptor
Laddawan Senggunprai, Auemduan Prawan, Sarinya Kongpetch, Veerapol Kukongviriyapan, Benjaporn Buranrat
pp. 729–737 · DOI: 10.4103/pm.pm_133_22 · Published 19 September 2022
Background: Cholangiocarcinoma (CCA), epithelial bile duct cancer, is deadly cancer with a very poor prognosis and standard anticancer drugs strategy remains poor and unfavorable outcomes. Objectives: In this study, we e…
Article
Fracture Healing in SD Rats’ Bioactivities of Cucumber Seed Polysaccharides
Zhihong Zhang, Yuanning Zeng, Donghui Peng, Na Xing, Haodong Bai, Yuxin Li, Na Cui, Huilin Su, Tingting Qiao, Congjing Shi, Haixue Kuang, Qiuhong Wang
pp. 738–745 · DOI: 10.4103/pm.pm_14_22 · Published 19 September 2022
Background: We investigated the composition and structure of intracellular polysaccharides in cucumber seeds (CSs) and their effect on Sprague-Dawley (SD) rats and potential activity for fracture healing. Materials and M…
Article
Pinocembrin Shows Antithrombotic Activity on the Thrombosis‑Induced Experimental Rats
Haifeng Zhu, Qian Xia, Hong Jiang, Furong Wang, Long Yu, Liwei Zhang
pp. 746–751 · DOI: 10.4103/pm.pm_535_21 · Published 19 September 2022
Background: Thrombosis is a major complication and is responsible for cardiovascular diseases (CVDs). The majority of CVDs like stroke, coronary syndrome, and vascular ailments are tightly connected to venous/arterial bl…
Article
UPLC-TQ/MS Determination and Pharmacokinetic Study of Eight Compounds in Normal and Lps-primed Rat Plasma after Oral Administration of Psoralea Fructus ethanol Extract
Wei‑xia Li, Xiao‑yan Wang, Hui Zhang, Ming‑liang Zhang, Ya‑li Wu, Lu Niu, Shu‑qi Zhang, Xiao‑fei Chen, Jin‑fa Tang
pp. 758–765 · DOI: 10.4103/pm.pm_332_21 · Published 19 September 2022
Background: Psoralea Fructus (PF) is one of the most frequently applied tonic Chinese herbs with various bioactivities, while recently, the idiosyncratic drug‑induced liver injury (IDILI) nature of PF was addressed, and …
Article
Schisandrin A Ameliorates Erectile Dysfunction and Regulates RhoA/ROCK1 Pathway in Rats with Streptozotocin‑induced Type 1 Diabetes
Hao Huiyao, Zhang Rongjin, Guo Pengpeng, Zhang Fang, Xu Yi, Li Chunhui, Hao Yongmei
pp. 766–772 · DOI: 10.4103/pm.pm_454_21 · Published 19 September 2022
Background: The genus Crotalaria (Fabaceae) is known for its diverse pharmacological activities. Crotalaria pallida Aiton is a medicinal plant used in traditional medicine for various ailments. Objectiv…
Article
Lapachol and (α/β)‑Lapachone as Inhibitors of SARS‑CoV‑2 Main Protease (Mpro) and hACE‑2: ADME Properties, Docking and Dynamic Simulation Approaches
Mejdi Snoussi, Iqrar Ahmad, Harun Patel, Emira Noumi, Rafat Zrieq, Mohd Saeed, Shadi Sulaiman, Nasrin E. Khalifa, Fakher Chabchoub, Vincenzo De Feo, Mohamed A. M. Gad-Elkareem, Kaïss Aouadi, Adel Kadri
pp. 773–782 · DOI: 10.4103/pm.pm_251_22 · Published 15 September 2022
Background: Tabebuia impetiginosa is an important medicinal plant rich in lapachol, α‑lapachone, and β‑lapachone known to possess several biological activities. Objective: In this study, we investigated the drug potentia…
Article
Angelica gigas Nakai Attenuated Inflammatory Response on Monosodium Iodoacetate‑Induced Osteoarthritis
Jin A. Lee, Min Ju Kim, Mi-Rae Shin, Hae-Jin Park, Seong-Soo Roh
pp. 783–789 · DOI: 10.4103/pm.pm_422_20 · Published 19 September 2022
Background: Angelica gigas Nakai (AGN) is well‑known for anti‑ inflammatory and anti‑oxidative effects; however, the mechanism underlying the protective effects of AGN on monosodium iodoacetate (MIA)‑induced osteoarthrit…

ORIGINAL ARTICLE

Article
The Total Flavones of Abelmoschus manihot Inhibit Reactive Proliferation of Astrocytes Following Cerebral Ischemia
Weizhuo Lu, Jingru Tong, Miaomiao Zhou, Jiyue Wen
pp. 752–7 · DOI: 10.4103/pm.pm_572_21 · Published 19 September 2022
Objective: The aim of this study was to demonstrate the role of the total flavones of Abelmoschus manihot (TFA) in the reactive proliferation of astrocytes after cerebral ischemia in mice. Materials and Methods: The expr…