Volume 18, Issue 80

23 November 2022 · pp. 791–1216 · 51 articles

Volume: 18
Issue: 80
Published: 23 November 2022
Pages: 791–1216
Articles: 51
Sections: 2
ISSN: Print - 0973-1296, Online - 0976-4062
Journal: PM

INVITED REVIEW Original Article

In this issue

INVITED REVIEW

Article
Exploring the Potential of Flavonoids as Efflorescing Antidiabetic: An Updated SAR and Mechanistic Based Approach
Katharigatta N. Venugopala, Jasmine Chaudhary, Vishal Sharma, Akash Jain, Manish Kumar, Diksha Sharma, Pottathil Shinu, Bandar E. Aldhubiab, PranKishore Deb, Osama I. Alwassil, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Rashmi Venugopala, Mahmoud Kandeel, Christophe Tratrat, Wael El-Deeb, Michelyne Haroun, Mohamad Fawzi Mahomoodally, Viresh Mohanlall, Mohamed A. Morsy
pp. 791–807 · DOI: 10.4103/pm.pm_372_22 · Published 27 September 2022
Diabetes is a metabolic complication distinguished mainly by persistent hyperglycemia and is involved in the formation of reactive oxygen species, thereby causing oxidative stress, which is the major culprit for diabetic…

Original Article

Article
Computer‑aided Box–Behnken Outlook Toward Optimization of Extraction of Baicalin from Oroxylum indicum L. Stem Barks
Syeda Nashvia Adin, Isha Gupta, Mohd. Aqil, Mohd. Mujeeb
pp. 808–814 · DOI: 10.4103/pm.pm_160_22 · Published 23 November 2022
Objectives: The study compares the efficacy of different modern and traditional methods for baicalin extraction. Box–Behnken design (BBD) was availed for optimization of process parameters for the extraction of baicalin …
Article
Immunostimulatory Effects of Complex GPB through Increased TNF‑α Expression and NK Cell Activation
Haeyeop Kim1,+, Laily Rahmawati1,+, Yo Han Hong, Su‑Young Choi, Jae Y. Cho
pp. 815–820 · DOI: 10.4103/pm.pm_40_22 · Published 23 November 2022
Background: Complex Great Powerful Blend (GPB) (a great powerful blend) is a hot water extract of three well‑known dried fruits: goji berry, mulberry, and jujube. These fruits have been used as food for a long time, and …
Article
Isolation of Potential Anti‑Microbial Compounds from Actinomycetes Found in Soil Surrounding Medicinal Plants of Saurashtra, Gujarat, India
Darshit Ram, Devang Pandya
pp. 821–829 · DOI: 10.4103/pm.pm_544_21 · Published 23 November 2022
Objectives: Resistance developed by micro-organisms against antibiotics is now a global threat. There is a need to look at alternate sources from which substances useful against various diseases can be obtained. Soil sur…
Article
In vitro/in vivo Assessment and Cellular Mechanisms of Astragalus spinosus Extract Against Leishmania Major
Hamdan I. Almohammed, Abdullah D. Alanazi
pp. 830–835 · DOI: 10.4103/pm.pm_53_22 · Published 23 November 2022
Background: In recent years, increasing resistance to synthetic agents, their long‑term treatment, and lasting side effects, has faced many problems in treatment of leishmaniasis; so that finding a new high‑efficacy anti…
Article
Assessment of Variation in Shatavarin IV Content in Asparagus racemosus through HPTLC Analysis and Identification of Elite Germplasm from Eastern India
Bibhuti Bhusan Champati, Bhuban Mohan Padhiari, Asit Ray, Sudipta Jena, Ambika Sahoo, Jeetendranath Patnaik, Sujata Mohanty, Pradeep Kumar Naik, Pratap Chandra Panda, Sanghamitra Nayak
pp. 836–843 · DOI: 10.4103/pm.pm_51_22 · Published 23 November 2022
Objectives: Selection of elite germplasm for commercial cultivation was done by studying the variation of Shatavarin IV from different geographical regions. The development of simple and reliable high‑performance thin la…
Article
Globularifolin Exerts Anticancer Effects on Human Lung Cancer Cells Via Regulation of ROS and Suppression of PINK1/Parkin Mitophagy Pathway
Weijian Li, Changqing Lin, Zhonghong Chen
pp. 844–850 · DOI: 10.4103/pm.pm_87_22 · Published 23 November 2022
Objectives: In the present study, the in vitro anticancer effects of globularifolin were evaluated against human lung cancer and attempts were made to explore the underlying molecular mechanisms. Materials and Methods: C…
Article
Citri Unshius Pericarpium Improves Dexamethasone‑Induced Muscle Atrophy in Mice
Seong‑Wook Seo, Sang‑Cheol Im, Kyoung Kim
pp. 851–858 · DOI: 10.4103/pm.pm_46_22 · Published 23 November 2022
Objectives: Accordingly, the current study was performed to evaluate the effects and the underlying mechanisms of CP on dexamethasone (DEX)‑provoked muscle atrophy in C57BL/6 mice. Materials and Methods: The 8‑week‑old m…
Article
A Combination of Vinorelbine and Oxaliplatin to Restrain the Progression of Non‑Small Cell Lung Cancer via Inhibition of the PI3K/AKT/ABCG2 Axis
Xiang Wang, Qingqing Ding, Tongshan Wang, Weiping Xie, Mao Huang
pp. 859–870 · DOI: 10.4103/pm.pm_439_21 · Published 23 November 2022
Background: This research explored the effects of vinorelbine combined with oxaliplatin on non‑small cell lung cancer (NSCLC). Materials and Methods: NSCLC cells were treated with vinorelbine, oxaliplatin, and insulin‑li…
Article
Aegle marmelos Ameliorates Epilepsy through Suppression of Oxidative Stress and Inflammation
Xiaoyan Wang, Lihong Liu, Huilan Zhang, Xiaoyan Liu, Hui Liu
pp. 871–878 · DOI: 10.4103/pm.pm_173_22 · Published 23 November 2022
Objectives: We induced epilepsy in zebrafish through the administration of pentylenetetrazole as a model organism. Materials and Methods: To assess the anti‑epileptic potency of plant extract, behavioural changes were re…
Article
Mentha piperita Enhances the Antinociceptive and Ameliorates Pain through Antioxidant and Anti‑Inflammation
Wei Ding, Yuan Fang, Fei Fan, Bibo Lei, Mingqiang Zhang, Hui Yong
pp. 879–885 · DOI: 10.4103/pm.pm_215_22 · Published 23 November 2022
Objectives: Pain or nociception is a devastating experience that alters both the physiological and psychological status of individuals. A variety of chemical and physiological tissue damage and physical parameters like t…
Article
Prospecting Indian Barleria Species for their Antioxidants, Anti‑Bronchial, and Anti‑Cancer Compounds
Sandeep R. Pai, Parthraj R. Kshirsagar, Nilesh V. Pawar, Mansingraj S. Nimbalkar
pp. 886–892 · DOI: 10.4103/pm.pm_77_22 · Published 23 November 2022
Aim: The study herein was performed in view of prospecting 15 species and one variety of Barleria in comparison to Adathoda vasica for phytochemical composition, and antioxidant activities. Materials and Methods: In addi…
Article
Abyssomicin W and Neoabyssomicin B are Potential Inhibitors of New Delhi Metallo‑β‑Lactamase‑1 (NDM ‑1): A Computational Approach
Abdulrahman Alsultan, Mohammad Aatif, Ghazala Muteeb
pp. 893–902 · DOI: 10.4103/pm.pm_195_22 · Published 4 November 2022
Background: Antibiotic resistance in bacteria mediated by New Delhi Metallo‑β‑lactamase (NDM) is a global threat to human health with an enormous economic burden. NDM can hydrolyze all the β‑lactam core‑containing antibi…
Article
Steroidal Saponin Dioscin Attenuated Aluminum Chloride– Induced Alzheimer’s‑Like Pathology in Rat Model via Modulation of Oxidative and Inflammatory Markers
Huibo Guan, Miao Yu, Yanyan Zhou, Xinmin Yao
pp. 903–910 · DOI: 10.4103/pm.pm_375_21 · Published 23 November 2022
Background: In this study, we elucidated the neuroprotective effect of dioscin, a plant‑derived steroidal saponin utilized in Chinese medicine to treat various diseases. To achieve this, we established the aluminum chlor…
Article
Synthesis and Evaluation of Grafted Xanthan Gum as a Drug Carrier in Developing Lornoxicam Gel Formulations
Sandip Ashok Murtale, Prakash S. Goudanavar, N. Raghavendra Naveen, Walaa F. Alsanie, Majid Alhomrani, Abdulhakeem S. Alamri, Syed Mohammed Basheeruddin Asdaq, Md.Khalid Anwer, Nagaraja Sreeharsha, Mazen Al Gharsan, Santosh Fattepur
pp. 911–918 · DOI: 10.4103/pm.pm_161_22 · Published 30 May 2022
Objectives: Natural polymers are chosen over semisynthetic and synthetic excipients due to their lack of toxicity, low cost, availability, soothing action, and nonirritant nature, as well as their ability to undergo a va…
Article
Anticancer Effect of Isoflavone Prunetin on Benzo(a)pyrene Induced Lung Cancer Mice Model
Xiaoping Yang, Vidya Devanathadesikan Seshadri, Jianfei Zhang
pp. 919–925 · DOI: 10.4103/pm.pm_219_22 · Published 23 November 2022
Background: Cancer, a deadly disease seems to be a major concern for the global medical field. Controlling the spread of disease is not only a problem for under developed countries but also the developed countries face a…
Article
Therapeutic and Protective Efficacy of Esculetin on Inflammation and Cartilage Injury by Monosodium Iodoacetate‑Induced Osteoarthritis in a Sprague‑Dawley Rat Model
Jianrui Chen, Wei Liang, Hao Li, Jianzhong Huo
pp. 926–931 · DOI: 10.4103/pm.pm_287_22 · Published 23 November 2022
Background: Osteoarthritis (OA) is a major bone‑related disease, which is characterized by joint deterioration, bone destruction, and whole joint damage, leading to permanent disability. The present study aimed to assess…
Article
Formononetin Inhibits Metastatic Potential of Human Prostate Cancer Cells via Upregulating EGR1
Xue Liang, Ziquan Lan, Yiqiao Huang, Ganggang Jiang, Ting Liu
pp. 932–939 · DOI: 10.4103/pm.pm_296_21 · Published 23 November 2022
Objectives: Formononetin is a natural isoflavone compound and has been reported to have anti‑cancer properties. However, the mechanism by which formononetin inhibits hormone‑resistant prostate cancer (PCa) has not been r…
Article
Response Surface Methodology (RSM) for Optimization of Euphorbia resinifera and Euphorbia officinarum Extracts with Antioxidant and Anti‑Diabetic Activities
Oumaima Boutoub, Smail Aazza, Soukaina El‑Guendouz, Lahsen El Ghadraoui, Maria G. Miguel
pp. 940–952 · DOI: 10.4103/pm.pm_2_22 · Published 23 November 2022
Objectives: The aerial part of two plant samples (Euphorbia resinifera and Euphorbia officinarum) collected in Morocco was examined for the solvent effect, extraction time, and plant concentration in order to determine t…
Article
Green Synthesis‑Mediated Iron Oxide Nanoparticles using Sphagneticola trilobata (L.) for Antibacterial and Anticancer Assessment
Rakesh Pandit Dhavale, Swapnil Sanjay Patil, Sagar Ujwal Jadhav, Rushikesh Pandit Dhavale, Sachin Bharat Agawane
pp. 953–961 · DOI: 10.4103/pm.pm_356_21 · Published 23 November 2022
Objectives: The synthesis of Fe‑NPs using Sphagneticola trilobata leaf extract using ferric chloride solution and its biological assessment. Materials and Methods: The present study involved the synthesis of Fe‑NPs using…
Article
Neuroprotective Effects of Bornyl Acetate against Okadaic Acid–Induced Cytotoxicity in PC12 Cells Via Beclin‑1‑Dependent Autophagy Pathway
Liping Huang, Xiaoqin Zhong, Zhongliu Zhou, NanBu Wang, MinZhen Deng
pp. 962–968 · DOI: 10.4103/pm.pm_565_21 · Published 23 November 2022
Objectives: The purpose of our experiment was to elucidate the mechanism of treatment of AD. Materials and Methods: To explore how BA has therapeutic effects on AD, a model of OA‑induced PC12 cells was established. The O…
Article
Hyphaene thebaica Mart. Extract Attenuates Oxidative Stress and Bax‑ and Bcl‑2‑Mediated Apoptosis in Ethanol‑Induced Gastric Ulcers in Rats
Manal Mohamed Elhassan Taha, Abdullah A. Mobarki, Ayman M. Madkhali, Abdullah Farasani, Emad Sayed Shaheen, Hassan A. Hamali
pp. 969–975 · DOI: 10.4103/pm.pm_557_21 · Published 23 November 2022
Objectives: Hyphaene thebaica Mart. (locally known as Doum) is a well‑known tropical plant and is traditionally used for the treatment of gastrointestinal tract (GIT) ulcers. The current study aimed to investigate the an…
Article
Effects of Drought Stress on the Quality of Licorice
Jian Fan, Ying Shen, Lu-Wen He, Dai-Qian Deng, Xiang-Cai Meng
pp. 976–984 · DOI: 10.4103/pm.pm_84_22 · Published 23 November 2022
Objectives: To establish a method to improve the quality of cultivated licorice by environmental stress. Materials and Methods: The fresh roots of Glycyrrhiza uralensis were soaked in 5%, 10%, and 20% polyethylene glycol…
Article
Taxonomic Implications of Fruit Morphology in Chinese Species of the Genus Bupleurum L. (Apiaceae)
Jialin Sun, Sisi Cao, Zejia Duan, Ye Zhang, Zhonghua Tang, Ann Abozeid
pp. 985–993 · DOI: 10.4103/pm.pm_581_21 · Published 23 November 2022
Background: Because of the certain overlapping of the genus Bupleurum, the identification features are few and the delimitation among species is difficult, Bupleurum taxonomy is under frequent revisions. In this research…
Article
Anticancer Potential of Vernodalin on Diethylnitrosamine Induces Liver Cancer by Inhibition of Cell Proliferation
Yifei Guo, Xuan Li Li, Yao Qu, Lei Yan, Shengping Lei, Chenguang Yang
pp. 994–999 · DOI: 10.4103/pm.pm_599_21 · Published 23 November 2022
Objectives: To investigate the chemopreventive and apoptotic effect of vernodalin in diethylnitrosamine (DEN) induced HCC. Materials and Methods: Rats were distributed into four sets of experimental animals every six rat…
Article
Compounds Isolation and Immunomodulatory Activity of Vicia amoena Fisch. var. Angusta. Freyn Aerial Parts
Yuli Sang, Lei Shi, Hao Pan, Fangyan Guo, Yu Wang, Naizhi Zhang, Guangwen Fan, Yanjun Hao, Li Bai, Jianzhong Qi
pp. 1000–1010 · DOI: 10.4103/pm.pm_24_21 · Published 23 November 2022
Objectives: We aimed to isolate chemical constitutes in aerial parts of V. amoena Fisch. var. Angusta. Freyn and study the immunomodulatory activity of these chemical components via immune cells. Materials and Methods: P…
Article
Comparative Study on the Antitumour Activity of 20(R)‑ginsenoside Rh2 and 20(S)‑ginsenoside Rh2 from Panax ginseng against Non‑small Cell lung Cancer in vitro
Xinze Liu, Xin Jin, Xinmin Wu, Lin Feng, Hongmei Yang, KaiJing Sun, Xue Yang, Ruina Lv, Yuhe Ren, Mengle Xie, Jianhua Lv, Lan Yao, Daiyao Liu, Wei Wu, Shuying Liu, Changbao Chen, Xilin Wan
pp. 1011–1024 · DOI: 10.4103/pm.pm_583_21 · Published 23 November 2022
Background: Non‑small cell lung cancer (NSCLC) is often harmful to human health. It is common in people who smoke or smoke passively, and the affected people are older and find it difficult to recover. The main treatment…
Article
Preparation of Galangin Self‑Microemulsion Drug Delivery System and Evaluation of its Pharmacokinetics in vivo and Antioxidant Activity in vitro
Hao Lu, Cheng Zhang, Yuan Liu, Jie Wang, Hanlin Xu
pp. 1025–1034 · DOI: 10.4103/pm.pm_567_21 · Published 23 November 2022
Objectives: In this study, our primary goal was to prepare a galangin self‑microemulsion drug delivery system (Gal‑SMEDDS) and evaluate the effect of free Gal and Gal‑SMEDDS on the pharmacokinetic parameters of SD rats, …
Article
N‑Acetyl Cysteine Together with Rutin Combats Oxidative Toxicity By Modulating Nrf2 Pathway in Inflammatory Brain–Liver Axis in Scopolamine‑Administered Alzheimer’s Disease Model in Rats
Yongwei Shi, Yujie Yuan, Jing Li, Jun Shen, Qiangguo Ju, Shaoge Gao, Yuxiang Chen, Ibrahim Abdel Aziz Ibrahim, Petchi Iyappan, Ravindran Jaganathan
pp. 1035–1044 · DOI: 10.4103/pm.pm_108_22 · Published 23 November 2022
Objectives: Current study would demonstrate the healthier effect of N‑acetyl cysteine and rutin against AD in rats. Materials and Methods: Experimental Wistar rats have been grouped appropriately for the administration o…
Article
Application of Sodium Alginate and Chitosan for Compound Volatile Oils From Rimulus cinnamon and Angelica sinensis: Microcapsules Preparation, Evaluation, Characterization, and in vitro Release Study
Wensheng Lai, Yanling Liu, Yanhui Kuang, Sisi Zhang, Chuanping Zhang, Chuyuan Li, Bohong Guo
pp. 1045–1054 · DOI: 10.4103/pm.pm_129_22 · Published 23 November 2022
Objectives: The objective of this study was to prepare and evaluate the CVOs microcapsules. Materials and Methods: Chitosan (CS) and sodium alginate (SA) were used as composite wall materials to encapsulate CVOs using th…
Article
Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway
Tonghao Wang¶, Lijun Tian¶, Lilong Du, Guowang Li, Yongjin Li, BaoShan Xu
pp. 1055–1065 · DOI: 10.4103/pm.pm_282_21 · Published 23 November 2022
Objectives: In this study, we aimed to evaluate the efficacy of ononin against ovariectomy(OVX)‑induced osteoporosis in female rats. Materials and Methods: Ovaries were removed surgically to develop the animal model of O…
Article
Antiplatelet and Anticoagulant Activities of Astragalus sarcocolla Dymock
Muhammad U. Mazhar, Fareeha Anwar, Uzma Saleem, Bashir Ahmad, Muhammad U. Mirza, Sarfraz Ahmad
pp. 1066–1074 · DOI: 10.4103/pm.pm_91_22 · Published 23 November 2022
Background and Aim of the Study: Antiplatelet drugs available on the market have multiple side effects and pose drug interactions, which actuated the researchers to consider better alternatives by using plant extracts. I…
Article
Phytochemical Profiling of Different Processed Products from Atractyloidis Rhizome using UHPLC/Q-TOF-MS
Honglian Zhang, Yumei Wang, Dongmei Wang, Jikai Sun, Zhiguo Zhang, Jinghan Wang, Jun Liu, Qi Liu
pp. 1075–1081 · DOI: 10.4103/pm.pm_70_22 · Published 23 November 2022
Objectives: To unscramble the phytochemical profiling of CZO, CZP, BCZ, and JCZ. Materials and Methods: In this paper, ultra‑high performance liquid chromatography combined with quadrupole time‑of‑flight mass spectrometr…
Article
Water‑Soluble Extract of Safflower Relieved Long‑Term Alcoholic Hepatic Damage through Mitigating Oxidative Stress Within Rat Model
Xiao‑Jing Han, Shuang Rong, Wu‑Ri Han, Bao‑Le Er, LaXi NaMuJiLa Bai, Mei‑Rong Bai
pp. 1082–1088 · DOI: 10.4103/pm.pm_608_21 · Published 23 November 2022
Objective: To study the mechanism of water extract of safflower on chronic alcoholic liver injury. Materials and Methods: The rats were separated in a random manner into five cohorts, namely, the normal control group (NC…
Article
Polydatin Lowers Serum Uric Acid Levels by Increasing its Excretion and Suppressing Production
Shuxie Wu, Gao Wu, Hong Jiang, Hanbin Wu
pp. 1089–1095 · DOI: 10.4103/pm.pm_309_21 · Published 23 November 2022
Background: Polydatin has significant uricosuric effects. This study was conducted to examine the xanthine oxidase inhibition and to detect protein levels of urate transporter 1 (URAT1), organic anion transporters 1 (OAT…
Article
Amygdalin Attenuates Neuroinflammatory Injury via Down-Regulating Toll-Like Receptors-2/Toll-Like Receptors-4- Nuclear Factor Kappa-B Signaling Pathway in BV2
Tong Sun, Jing-Jing Lu, Bi-Xu Wang, Xiao-Qing Ye, Lan Li, Fang-Mei Zhou, Hai-Tong Wan, Zhi-Shan Ding
pp. 1096–1103 · DOI: 10.4103/pm.pm_32_22 · Published 23 November 2022
Objectives: The purpose of this study was to explore the anti‑inflammatory effect of amygdalin on lipopolysaccharide (LPS)‑induced neuron–microglia and its protective mechanism for toll‑like receptors (TLRs) signaling pa…
Article
Scutellarin Ameliorated Ovalbumin‑Induced Allergic Rhinitis in Experimental Mice through Potential Attenuation of the GATA3/ p‑STAT6 Pathway
Min Yang, Yanping Shi, Hui Ji
pp. 1104–1110 · DOI: 10.4103/pm.pm_566_21 · Published 23 November 2022
Aim: To determine the effect of SCU against AR induced by Ovalbumin (OVA) in the experimental animal. Materials and Methods: Mice (BALB/c strain) were induced with AR by sensitizing them with OVA (for consecutively 13 da…
Article
Evaluation of Hair Growth Properties of Glycyrrhizic Acid
Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Baoshan Rong, Xiaomin Zheng, Siyang Zhu, Xian Xu, Yong Ai, Lanyue Zhang, Tinggang He
pp. 1111–1117 · DOI: 10.4103/pm.pm_552_21 · Published 23 November 2022
Objectives: The aim of this study was to investigate the potential hair blackening effect and mechanisms of glycyrrhetic acid (GA) extracted from Glycyrrhiza uralensis. Materials and Methods: Different concentrations of …
Article
Metabolomics Analysis of Region‑Specific Polygoni Multiflori Radix Metabolite Profiles
Yonghui Rui, Xiaohua Ou, Jiahui Li, Keke Luo, Wenjing Deng, Xiaoxia Gao, Mengling He, Hongyi Zhang, Hanjing Yan
pp. 1118–1128 · DOI: 10.4103/pm.pm_35_22 · Published 23 November 2022
Objectives: The present comparative metabolite analysis study was conducted in an effort to understand the relationship between the geographical origin of PMR samples and their medicinal properties. Materials and Methods…
Article
Antitumor Potential of Peptides Isolated from Brucea javanica Globulin Fraction on MCF‑7 Cells
Haoyu Shi, Huifang Ji, Fuzhen Zhu, Yi Zhao, Yanyan Yin, Fengjue Shu, Lingzhi Wang
pp. 1129–1136 · DOI: 10.4103/pm.pm_540_21 · Published 23 November 2022
Objectives: To isolate antitumor peptides from B. javanica seeds and research their antitumor activity with MCF‑7 cells. Materials and Methods: Globulin of B. javanica was extracted and enzymatically hydrolyzed by pepsin…
Article
Predicting the Targets of Mangiferin in the Treatment of Diabetes Mellitus on Network Pharmacology and Analysis of its Metabolites in vivo
Ying Wei, Xiaojuan Li, Xiulan Su, Tunhai Xu
pp. 1137–1145 · DOI: 10.4103/pm.pm_5_22 · Published 23 November 2022
Objectives: The purpose of our study was to investigate the targets and mechanism of mangiferin in the treatment of DM and to analyze its metabolites in vivo. Materials and Methods: We predict the targets and mechanism o…
Article
Network Pharmacology Analysis and Experimental Validation of the Antidepression Mechanism of Lactuside B
Bingxuan Niu, Shengying Li, Chunyan Li, Yu Song, Hui Zhang, Huifang Niu, Ruifang Hua, Fulin Yan, Guangfan Hai
pp. 1146–1152 · DOI: 10.4103/pm.pm_79_22 · Published 23 November 2022
Objectives: This study was the first to study the pharmacological effects and mechanisms of LB on depression. Materials and Methods: Network pharmacology method was applied to screen the candidate targets and signaling p…
Article
Anwulignan Attenuates Remote Renal Injury Induced by Intestinal Ischemia/Reperfusion in Rats
Shu Jing, ChunRong Yu, ZiQi Song, HuiJiao Lin, Jia Wei Liu, Chunmei Wang, He Li, Dan Wang, Jianguang Chen
pp. 1153–1159 · DOI: 10.4103/pm.pm_578_21 · Published 23 November 2022
Aim: Intestinal ischemia/reperfusion (II/R) can cause injury of remote organs, including acute renal injury. All of these, in turn, increase the rate of disability and mortality. Anwulignan (Anwu) is an active monomer fr…
Article
Integrating Background Subtraction and Metabolomics Technology to Study the Difference of Serum Chemical Profile Before and After Compatibility of Radix Bupleuri and Radix Paeoniae Alba
Congcong Chen, Ruihong Hou, Qicai Yin, Junshen Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou
pp. 1160–1169 · DOI: 10.4103/pm.pm_139_22 · Published 23 November 2022
Objectives: Here, an effective strategy has been developed for screening differences of constituents in vivo before and after compatibility by integrating background subtraction and metabolomics technology. Materials and…
Article
Anti‑cancer effect Shikonin on Ferric Nitrilotriacetate‑induced Renal Cancer Rats Apoptosis Mediating PEG2/NF‑κB Signaling Pathway
Dong Wang, Yahong Lu, Wenjing Meng, Tao Shu, Zengyue Yang
pp. 1170–1176 · DOI: 10.4103/pm.pm_517_21 · Published 23 November 2022
Objectives: The research aimed to study the anti‑cancer effect of SKN in diethylnitrosamine (DEN) and ferric nitrilotriacetate (Fe‑NTA)‑induced renal carcinoma in rats. Materials and Methods: The experimental animal grou…
Article
Cardioprotective Effect of Gedunin on Isoproterenol‑Induced Cardiotoxicity through the Attenuation of NF-κB‑Mediated Inflammatory Pathway in Rats
Yongle Sun, Hongwen You
pp. 1177–1182 · DOI: 10.4103/pm.pm_29_22 · Published 23 November 2022
Background: There is an increasing interest in new natural compounds for the treatment of myocardial infarction (MI). Gedunin is a tetranortriterpenoid extracted from the Indian neem tree (Azadirachta indica). The main o…
Article
Apoptosis‑Mediated Anticancer Activity of Geraniol Inhibits NF‑κB, MAPK, and JAK‑STAT‑3 Signaling Pathways in Human Thyroid Cancer Cells
Hongli Yang, Yonggang Zhang, Jianying Cui, Zhi Hao
pp. 1183–1189 · DOI: 10.4103/pm.pm_223_21 · Published 23 November 2022
Aim: Thyroid cancer accounts for 3.8% of the total endocrine cancer and is the fifth most diagnosed cancer among Indian women. Geraniol possesses pharmacological properties, including anti‑inflammatory, anti‑cancer, and …
Article
Withaferin A Attenuates Epithelial-Mesenchymal Transition and Cancer Stem Cells Properties in Hepatocellular Carcinoma Cells by Inhibiting the PI3K/AKT Pathway through miR-200c
Hui Tian
pp. 1190–1195 · DOI: 10.4103/pm.pm_86_22 · Published 23 November 2022
Objectives: The present study was aimed at elucidating the mechanism of action of withaferin A against hepatocellular carcinoma (HCC) cells via the PI3K/AKT signaling pathway. Materials and Methods: MTT (tetrazolium dye)…
Article
HPLC Determination of Anti‑cancer Components Isolated from Rabdosia rubescens
Hong-Xin Cui, Fang-Rong Cheng, Ke Yuan
pp. 1196–1201 · DOI: 10.4103/pm.pm_30_22 · Published 23 November 2022
Background: Rabdosia rubescens is a traditional herbal medicine, commonly known as an anti‑cancer plant. A large number of literatures have reported that the diterpenoids in R. rubescens have strong anti‑tumor effects. T…
Article
Degalactotigonin Inhibits Invasion and Induce Apoptosis by Targeting TGF‑β Signalling in Oral Cancer Cells
Yang Li, Chengnan Gu
pp. 1202–1210 · DOI: 10.4103/pm.pm_7_22 · Published 23 November 2022
Objectives: The study aimed to investigate the anti‑invasion and apoptotic induction effect of DGT in oral squamous cell carcinoma (OSCC) cells through inhibiting non‑canonical TGF‑β signalling. Materials and Methods: Hu…
Article
miR‑223‑3p Promotes Ulcerative Colitis Progression in Rhubarb Decoction‑Induced Rats with the Spleen‑Kidney‑Yang Deficiency
Model by Regulating the TGF‑β/Smad3 Pathway Shiju Liu, Huijian Zhang, Junhong Liu, Xinchun Zhang, Xiang Liu, Yapeng Sun, Yan Li, Jie Wang, Dianwen Liu
pp. 1211–1216 · DOI: 10.4103/pm.pm_266_21 · Published 23 November 2022
Background: Ulcerative colitis (UC) is a prevalent case which needs more detailed exploration. We attempted to illustrate how miR‑223‑3p acted in the development of UC. Materials and Methods: The level of miR‑223‑3p in s…