Volume 19, Issue 1

Original Article

1. Article

   Acacia Honey-derived Bioactive Compounds Exhibit Induction of p53-dependent Apoptosis in the MCF-7 Human Breast Cancer Cell Line

   Walid Sabri Hamadou, Nouha Bouali, Elham Bader Alhejaili, Zohra Soua, Mitesh Patel, Mohd Adnan, Arif Jamal Siddiqui, Abdel-Muhsin Abdel-Gadir, Abdel Moneim Elhadi Sulieman, Mejdi Snoussi, Riadh Badraoui

   pp. 1–4 · DOI: 10.1177/09731296221145076 · Published 2023

   Background: Research studies have focused on discovering new anti-proliferative and pro-apoptotic agents derived from natural products from which honey constitutes a prominent candidate. The Acacia honey (AH) is known to…

2. Article

   Cognitive Enhancing Activity of Fermented Aloe arborescens Extract on Scopolamine-induced Memory Impairment in Mice

   GiBeom Jeon, Seong Hun Lee, Yong Seong Kwon, Jin Hong Beak, Hyeon Lee, Choong Je Ma

   pp. 5–12 · DOI: 10.1177/09731296221137408 · Published 2023

   Background: Alzheimer’s disease (AD) is a type of dementia that leads to loss of memory and learning ability. Aloe arborescens is a traditional medicinal plant in Europe and Africa. It has been reported that A. arboresce…

3. Article

   Antioxidant, Anti-inflammatory and Cytotoxic Activity of Schinus terebinthifolia Fruit and Isolation of a New Immunomodulatory Polyphenolic Compound

   Aljawharah Alqathama, Mohamed I. S. Abdelhady, Mohsen S. Al-Omar, Mohamed F. Barghash, Aliaa I. Shallan

   pp. 13–22 · DOI: 10.1177/09731296221138632 · Published 2023

   Background: The fruit of Schinus terebinthifolia Raddi is used in ethnomedicine for the treatment of different ailments. Materials and Methods: We studied the phytochemical profile of S. terebinthifolia fruit and evaluat…

4. Article

   Euxanthone Suppresses the Proliferation, Migration and Invasion of Human Medulloblastoma Cells by Inhibiting the RANK/RANKL Pathway

   Chengyan Xu, Zixia He, Zhipeng Shen

   pp. 23–30 · DOI: 10.1177/09731296221138649 · Published 2023

   Background: Euxanthone is a plant-based flavonoid that is mostly isolated from a Chinese medicinal plant, Polygala caudate. This study was designed to evaluate the anticancer effects of euxanthone against human medullobl…

5. Article

   Visnagin Attenuates Gestational Diabetes Mellitus in Streptozotocin-induced Diabetic Pregnant Rats via Regulating Dyslipidemia, Oxidative Stress, and Inflammatory Response

   Xiumei Yang, Cuilian Yang, Wenjing Lu, Xiumei Yang

   pp. 31–40 · DOI: 10.1177/09731296221137440 · Published 2023

   Background: Gestational diabetes mellitus (GDM) is a condition of glucose intolerance and insulin resistance only diagnosed during pregnancy. GDM has exhibited several adverse effects on both mother and offspring. The cu…

6. Article

   Potato Alkaloids α-Solanine and α-Chaconine Promote bFGF and VEGF Expression in Vein and Adjacent Tissues in the Rabbit Model of Phlebitis

   Chunxiu Zhou, Enliang Chen, Daquan Jiang, Nan Wang

   pp. 41–48 · DOI: 10.1177/09731296221137381 · Published 2023

   Objectives: To investigate the therapeutic effect of mashed potato and its alkaloids α-solanine and α-chaconine on basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) expression in ear ven…

7. Article

   Jasminum elongatum Ameliorates Acetaminophen Induced Hepatotoxicity by Modulating Dysregulated Antioxidant Enzyme System

   Sabeena Hussain Syed, Supriya Unavane, Poonam Taru, Bindurani L. G. P. Ram, Sachin Shridhar Sakat, Sonali Manwatkar, Ajay Gajanan Namdeo

   pp. 49–55 · DOI: 10.1177/09731296221137434 · Published 2023

   Objectives: To evaluate the hepatoprotective activity of fractions of Jasminum elongatum methanolic extract against acetaminophen-induced hepatic damage. Materials and Methods: Fractions obtained from methanolic extract …

8. Article

   Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

   Zainab R. Abdelrahman, Yasser K. Bustanji, Shtaywy S. Abdalla

   pp. 56–65 · DOI: 10.1177/09731296221137432 · Published 2023

   Background: Obesity is a serious public health problem contributing to development of several diseases, including hyperlipidemia, hyperglycemia, and hypertension. The plant Eriobotrya japonica (loquat) has been used in t…

9. Article

   Triptonide Ameliorates Middle Cerebral Artery Occlusion-induced Cerebral Ischemic Damage in Rats via Regulation of Inflammatory Response

   Shuai Wang, Hongguang Liu, Tao Chen

   pp. 75–84 · DOI: 10.1177/09731296221137379 · Published 2023

   Background: Cerebral ischemic stroke is the second major cause of mortality worldwide that results in persisting disability and mental agony. Ischemic stroke is induced by the diminished blood circulation to the brain, w…

10. Article

    Daidzein Ameliorates Cerebral Ischemic-reperfusion Induced Neuroinflammation in Wistar Rats via Inhibiting NF-κB Signaling Pathway

    Jie Zhang, Ramalingam Kowsalya

    pp. 85–96 · DOI: 10.1177/09731296221137378 · Published 2023

    Background: Cerebral ischemia is a condition of acute brain damage due to the depletion of oxygenated blood supply to cerebral tissues. Daidzein is an isoflavonoid predominantly present in soya, Pueraria species, and red…

11. Article

    Optimization of Microwave-assisted Extraction Technique for Flavonoids and Phenolics from the Leaves of Oroxylum indicum (L.) Kurtz Using Taguchi L9 Orthogonal Design

    Rojalini Samanta, Manik Ghosh

    pp. 97–104 · DOI: 10.1177/09731296221137407 · Published 2023

    Background: An experimental design to obtain bioactive ingredients from Oroxylum indicum (L.) Kurtz was performed applying microwave-assisted extraction (MAE). Recently, tremendous research interest and benefits have bee…

12. Article

    Anti-inflammatory Effect by Cloves Treatment in LPS-induced RAW264.7 Cells

    Seong-Wook Seo, Kyoung Kim, Mi-Rae Shin

    pp. 105–116 · DOI: 10.1177/09731296221137420 · Published 2023

    Background: Cloves mean the dried flower bud harvested from a tree of Syzygium aromaticum L. (SA). Objectives: The current study was to identify the anti-inflammatory effects of SA on lipopolysaccharide (LPS) (0.2 μg/mL)…

13. Article

    Grape Seed Extract and Urolithiasis: Protection Against Oxidative Stress and Inflammation

    Manar Khalid Alomair, Amjad Abdullah Alobaid, Marwah Abdulaziz Ali Almajed, Lama Salman Alabduladheem, Essraa Abdulrahman Alkhalifah, Maged Elsayed Mohamed, Nancy Safwat Younis

    pp. 117–127 · DOI: 10.1177/09731296221145069 · Published 2023

    Background: Grape seed extract (GSE) has demonstrated various pharmacological actions. Urolithiasis is the occurrence of calculus in the renal system. The present study evaluated the anti-urolithic effect of GSE on ethyl…

14. Article

    Morpho-anatomical, Molecular, and Chemical Standardization of Trillium govanianum Wall. ex D. Don: An Endangered Medicinal Herb Native to the Himalayas

    Pankaj Kumar, Kanwaljeet Singh, Javaid Fayaz Lone, Anil Bhushan, Prasoon Gupta, Sumeet Gairola

    pp. 128–143 · DOI: 10.1177/09731296221145070 · Published 2023

    Background: Trillium govanianum Wall. ex D. Don occurring at high altitudes in the Himalayas and known by the common name ‘Nag Chhatri,’ has high medicinal value. Its rhizome samples have substantial therapeutic potentia…

15. Article

    Comparative Phytochemical Profiling (GC-MS and HPLC) and Evaluation of Antioxidant Activities of Wild, In Vitro Cultured and Greenhouse Plants of Kaempferia grandifolia Saensouk and Jenjitt and Kaempferia siamensis Sirirugsa; Rare Plant Species in Thailand

    Sukanya Nonthalee, Suthira Maneechai, Surapon Saensouk, Piyaporn Saensouk

    pp. 156–167 · DOI: 10.1177/09731296221145066 · Published 2023

    Background: Kaempferia grandifolia and Kaempferia siamensis are rare plant species in Thailand used for medicinal, food, and ornamental purposes. Objectives: To compare the phytochemical profiles of leaf and rhizome extr…

16. Article

    Therapeutic Effects of Pinus koraiensis on 1-Fluoro-2,4-Dinitrofluorobenzene-induced Contact Dermatitis in Mice

    Yuntae Kang, Seungyeop Oh, Yoorae Son, Wonjin Yang, Soyeon Kim, Ji-Hyo Lyu, Hyungwoo Kim

    pp. 168–175 · DOI: 10.1177/09731296221144816 · Published 2023

    Background: Korean pine nuts (Semen Pinus koraiensis (P. koraiensis)) have been a valuable ingredient in Korean cuisine since ancient times, and the classical literature on traditional medicine states that pine nuts can …

17. Article

    Procyanidins Ameliorate Acetaminophen-induced Acute Liver Injury via Activating the Nrf-2/SOD-1 Signal Pathway

    Wanting Xu, Yan Liu, Qun Liu, Huan Chen, Langhuan Lei, Xiaojia Shen, Li Liu

    pp. 176–185 · DOI: 10.1177/09731296221144812 · Published 2023

    Background and Objectives: An overdose of acetaminophen (APAP) usually leads to acute liver injury, and oxidative stress is one of the fundamental mechanisms used to characterize it. Procyanidins (PCs) can reduce the oxi…

18. Article

    Nerolidol Attenuates Cerebral Ischemic Injury in Middle Cerebral Artery Occlusion-Induced Rats via Regulation of Inflammation, Apoptosis, and Oxidative Stress Markers

    Jie Zhang, Yanli Li, Tao Zhou

    pp. 186–196 · DOI: 10.1177/09731296221137380 · Published 2023

    Background: Cerebral ischemia is a syndrome that occurs due to the restricted flow of oxygen-rich blood to the brain, causing damage to the brain cells. Globally, ischemia ranks second in causing mortality and third in c…