Volume 19, Issue 2

Original Article

1. Article

   In vitro Antioxidant and Anti-inflammatory Effects of Erythroxylum cuneatum Leaf Extract on Oxidized Low-density Lipoprotein-stimulated Human Aortic Endothelial Cells

   Siti Khadijah Adam, Nitya Shanmugam, Sharlina Mohamad, Shamima Abd Rahman, Mohamad Aris Mohd Moklas

   pp. 203–213 · DOI: 10.1177/09731296221137401 · Published 2023

   Background: The oxidation of low-density lipoprotein (LDL) by reactive oxygen species (ROS) causes inflammation, which results in the expression of adhesion molecules and monocyte adhesion and migration. This eventually …

2. Article

   Ethacridine Regulation of JAK/STAT/ERK Signaling Pathway in Colon Cancer Cells SW620: In vitro Approach

   Hui Zhang, Hui Yang, Wei Wei, Jing Zhao, Annamalai Vijayalakshmi, Minhong Wang

   pp. 214–221 · DOI: 10.1177/09731296221136906 · Published 2023

   Background: Ethacridine have anticancer effects by inhibiting regulatory transcription factors and cell viability in various cancer cells. To investigate the effect of ethacridine on colorectal cancer cell lines, SW620 w…

3. Article

   LC-MS/MS-based Targeted Metabolomic Profiling of Aqueous and Hydro-alcoholic Extracts of Pistacia integerrima Linn., Quercus infectoria Olivier and Terminalia chebula Retz

   Anil Kumar Saini, Laxman Sawant, Sultan Zahiruddin, Dhiraj Shrivastva, Ranjan Mitra, Rajiva Kumar Rai, Sayeed Ahmad

   pp. 222–230 · DOI: 10.1177/09731296221144809 · Published 2023

   Background: Pistacia integerrima (PI) galls, being rich in polyphenolic compounds, owing to its high restorative worth and restricted assets and exorbitant utilization lead to the overexploitation of the species and avai…

4. Article

   Amelioration of AlCl3-induced Memory Loss in the Rats by an Aqueous Extract of Guduchi, a Medhya Rasayana

   Shrirang B. Jamadagni, Pooja M. Ghadge, Mukul S. Tambe, Marimuthu Srinivasan, Goli Penchala Prasad, Pallavi S. Jamadagni, Shyam Baboo Prasad, Sharad D. Pawar, Arun M. Gurav, Sudesh N. Gaidhani, Y. R. Sanjay Kumar, Narayanam Srikanth

   pp. 231–243 · DOI: 10.1177/09731296221145063 · Published 2023

   Background: In ayurvedic practice, the Guduchi (Tinospora cordifolia (Willd.) Miers) stem is used as a Medhya drug for its beneficial effects on memory improvement. Objectives: The current study was planned to explore th…

5. Article

   Ameliorative Potential of Betanin on Cigarette Smoke Extract-induced Respiratory Mucosal Inflammation and Oxidative Stress in the Adult Zebrafish Model

   Ibrahim Alqasmi

   pp. 244–253 · DOI: 10.1177/09731296221145075 · Published 2023

   Background: Betanin, a natural pigment and glycosidic bioactive compound, possesses anti-inflammatory antioxidant activity. Objectives: In this study, we evaluated the potential effect of betanin on cigarette smoke extra…

6. Article

   TLC-bioautography-MS-based Identification of Antioxidant, α-Amylase and α-Glucosidase Inhibitory Compounds in a Polyherbal Formulation “Sugreen-120”

   Gaurav Gaurav, Nabeel Anwar, Sultan Zahiruddin, Sayeed Ahmad

   pp. 254–268 · DOI: 10.1177/09731296221145064 · Published 2023

   Background: Sugreen-120 is one of the famous Indian polyherbal formulations used for the treatment of diabetes. Due to a lack of scientific evidence, the present study is aimed at investigating the phytopharmacology of S…

7. Article

   Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit

   Swarnali Bhattacharjee, Elancheran Ramakrishnan, Prashanta Kumar Deb, Partha Pratim Sarma, Debopriya Choudhury, Senthamaraikannan Kabilan, Rajlakshmi Devi

   pp. 269–283 · DOI: 10.1177/09731296231158433 · Published 2023

   Background: Garcinia pedunculata (GP) Roxb. is a traditional medicinal plant used for treating gastrointestinal disorders. The fruit is always consumed in dried form in cuisines and as medicine. Objectives: To study the …

8. Article

   Momordica cochinchinensis Suppresses the Human Breast Cancer Cells Growth and Migration by Inhibiting Mevalonate Pathway

   Benjaporn Buranrat, Ratthaphol Kraiklang

   pp. 284–294 · DOI: 10.1177/09731296231157982 · Published 2023

   Background: Momordica cochinchinensis (MC) is shown with high antioxidation and is used as herbal medicine in South-East countries. Objectives: This study aims to determine the four parts (aril, fruit, leaf, and seed) of…

9. Article

   Effects of Tetrandrine on the Apoptosis of Cisplatin-resistant Oral Cancer Cells

   Chin-Wen Chang, Chun Chen, Chih-Wei Chang, Po-Yen Chiu, Jai-Sing Yang, Fu-An Chen

   pp. 295–302 · DOI: 10.1177/09731296231158699 · Published 2023

   Background: Cisplatin, the first-line drug for chemotherapy, often has limited treatment efficacy because of resistance and cancer recurrence mechanisms. Tetrandrine is a unique secondary metabolite of Stephania tetrandr…

10. Article

    Action Mechanism of Extracts from Cerasus serrulata Flower for Hair-Blacking in C57BL/6 Mice

    Bing Zhang, Wenyun Zhang, Jianfang Luo, Jian He, Baoshan Rong, Xiaomin Zheng, Siyang Zhu, Xian Xu, Yong Ai, Lanyue Zhang, Tinggang He

    pp. 303–315 · DOI: 10.1177/09731296231157182 · Published 2023

    Background: Hair color retention and rejuvenation have recently emerged as a new research hot spot, with many studies focused on developing treatments to prevent premature greying. Aim: This study is aimed to explore the…

11. Article

    Effects of Palmijihwang-hwan: A Herbal Formula on the Pharmacokinetics of Tamsulosin in Rats

    Seong Eun Jin, Woo-Young Jeon, Youn-Hwan Hwang, Chang-Seob Seo, Hyeun-Kyoo Shin, Hye Gwang Jeong, Hyekyung Ha

    pp. 316–324 · DOI: 10.1177/09731296231158703 · Published 2023

    Background: Tamsulosin is an α1-adrenoceptor antagonist used to treat lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Palmijihwang-hwan (PMJHH) is a traditional herbal formula for treating pro…

12. Article

    Plumbagin Suppresses Growth, Induces Apoptosis, and Inhibits Migration in Cholangiocarcinoma via Reactive Oxygen Species Generation and Mitochondrial Function

    Benjaporn Buranrat, Maleeruk Utsintong

    pp. 325–335 · DOI: 10.1177/09731296231158221 · Published 2023

    Objectives: Plumbagin has been displayed on growth inhibition in several cancer cells; however, the anticancer effects of plumbagin on cholangiocarcinoma (CCA) cell are still less information. This article will explore t…

13. Article

    Using the UPLC-QTOF-MS Fingerprinting Coupled with Clustering Analysis to Verify the Quality Control of Fritillaria przewalskii Maxim

    Daoguang Song, Jiaxin Guo, Dingai Li, XuanZheng XuanZheng, Hongping Han, Zhi Chen

    pp. 336–345 · DOI: 10.1177/09731296231158227 · Published 2023

    Background: A method is proposed as follows to establish the ultra-performance liquid chromatography quadrupole timeof-flight mass spectrometry (UPLC-QTOF-MS) fingerprinting and content determination for Fritillaria prze…

14. Article

    Anti-Plasmodial Activity and Mass Spectrometric Profiling of Peptide-enriched Methanol/Water Extract of Leaves from the Himalayan Viola canescens Wall

    Neha Mann, Pooja Upadhyay, P. Vishnupriya, S. Prabhakar, P.L. Uniyal, Suman Lakhanpaul, Dinkar Sahal, V. Sabareesh

    pp. 346–358 · DOI: 10.1177/09731296231158700 · Published 2023

    Background: Plants belonging to the genus Viola and family Violaceae are well known in Ayurvedic and Unani medicine for their pharmaceutical importance. Viola, commonly known as Banafsha, has been traditionally used as a…

15. Article

    Rhubarb Anthraquinones Ameliorates Inflammatory Lung Injury by Enhancing Alveolar Epithelium Tight Junction Proteins through RhoA/ROCK1 Signalling

    Guiyuan Liu, Yinliang Bai, Guangxian Leng, Hanwei Ma, Yin Kong, Liuqing Guo, Fahong Wu, Fengxian Wei, Yi Pang, Youcheng Zhang

    pp. 359–370 · DOI: 10.1177/09731296231158697 · Published 2023

    Background: Leakage of the alveolar epithelial barrier can lead to pulmonary oedema, leading to organ dysfunction. Objectives: Combination anthraquinone (CA) and free anthraquinone (FA) were extracted from Rhubarb, and t…

16. Article

    Development and Optimization of Phytosome for Enhancement of Therapeutic Potential of Epiyangambin in Tinospora cordifolia Extract Identified by GC–MS and Docking Analysis

    Deivasigamani Senthil Kumar, Karthikeyan Deivasigamani, Biswabara Roy

    pp. 371–384 · DOI: 10.1177/09731296231157192 · Published 2023

    Background: To enhance the therapeutic potential of Tinospora cordifolia phytosomes, a chloroform extract was prepared. Objectives: The goal of this study was to create and test the therapeutic potential of a phytosome c…

17. Article

    Lipid Peroxidation Inhibitory and Cytotoxic Activities of Two Camellia Species Growing Wild in Vietnam

    Nguyen Thi Giang An, Dao Thi Minh Chau, Le Thi Huong, Vu Van Khoa, Nguyen Huy Hung, Do Thi Thao, Vo Thi Quynh Trang, Do Ngoc Dai, William N. Setzer

    pp. 385–399 · DOI: 10.1177/09731296231158437 · Published 2023

    Background: Leaves, flowers and young shoots of yellow Camellia species are often used as a substitute for green tea in Vietnam. Yellow Camellia species contain high levels of polyphenol compounds, and have shown activit…

18. Article

    Nerolidol Attenuates Diabetic Embryopathy in Streptozotocin-induced Diabetic Pregnant Rats by Reducing Embryonic and Maternal Oxidative Stress

    Jingjing Li, Kalaivani Aiyasamy

    pp. 400–409 · DOI: 10.1177/09731296231158479 · Published 2023

    Background: Pregnancy complicated by diabetes leads to congenital disorders, spontaneous abortion, and neonatal morbidity and mortality, which are termed diabetic embryopathy or fetopathy. Objectives: In this work, we pl…

19. Article

    Cytotoxic, in vitro Enzyme Inhibitory Potential and Phytochemical Profiling of Odontonema strictum

    Nida Nadeem, Kashif Maqbool Khan, Moumouni Koala, Muhammad Islam, Tahir Ali Chohan, Shujaat Ali Khan, Nighat Fatima, Kashif Bashir, Shaista Qamar, Sadia Chaman, Muhamamd Azam Tahir, Abdul Mannan

    pp. 410–417 · DOI: 10.1177/09731296221137394 · Published 2023

    Background: Odontonema strictum is an herbaceous plant, indigenous to Central America and Central Africa, and has been used traditionally by the local community against various ailments. The current piece of work was car…

20. Article

    Chemical Composition, in vitro, and in vivo Antiparasitic Effects of Curcuma zedoaria Rhizome Essential Oil Against Giardia lamblia

    Aishah E Albalawi, Abdullah D Alanazi

    pp. 418–426 · DOI: 10.1177/09731296231166055 · Published 2023

    Background: The present experimental work aimed to evaluate the chemical composition and in vitro and in vivo effects of Curcuma zedoaria essential oil (CZEO) compared with metronidazole (MTZ) for Giardia lamblia infecti…

21. Article

    Ameliorative Effects of Ponicidin Against the Isoproterenol‑induced Acute Myocardial Infarction in Rats

    Xuemei Zhang, Vidya Devanathadesikan Seshadri, Qihua Jiang

    pp. 427–438 · DOI: 10.1177/09731296221139010 · Published 2023

    Background: Cardiovascular disease (CVD) is a group of heart disorders, which is a major cause of non-communicable disease-related mortalities worldwide. Myocardial infarction (MI) is an acute disorder due to the poor su…

22. Article

    Deoxyschizandrin Inhibits PTEN to Regulate Inflammation in Doxorubicin-induced Hepatotoxicity

    Jinhai Wang, Naijing Zhou

    pp. 439–447 · DOI: 10.1177/09731296231165593 · Published 2023

    Aim: Doxorubicin (DOX) has long been criticized for its cardiotoxicity, yet one cannot overlook its hepatotoxicity. Deoxyschizandrin (Deo) is a type of monomer used in traditional Chinese medicine that has a powerful ant…

23. Article

    Anti-osteoporosis Effect of Cynaropicrin against Ovariectomy-induced Osteoporosis in Rats

    Hanlu Ye, Ke Wang, Kai Li

    pp. 448–460 · DOI: 10.1177/09731296221137415 · Published 2023

    Background: Osteoporosis is a progressive bone disease, which is characterized by high bone resorption, and low bone density and mass. Osteoporosis elevates the risk of bone fragility and fracture, which leads to signifi…

24. Article

    Purpurin, a Natural Anthroquinone Ameliorates Streptozotocin-induced Diabetic Nephropathy via Attenuating Hyperglycemia, Dyslipidemia, and Inflammation in Rats

    Yan Shang, Abubucker Peer Mohideen

    pp. 461–472 · DOI: 10.1177/09731296231158477 · Published 2023

    Background: Throughout the world, diabetic nephropathy has been treated by managing hyperglycemia and hypertension with antidiabetic and antihypertensive drugs, but the potency of reversing the diabetic nephropathy-induc…

25. Article

    Baicalin Magnesium Salt Exerts an Antitumor Effect in HepG2 Hepatoma Cells

    Xia Dongshuai, You Yong, Gao Yaxian, Wang Shuo, Guo Yachun, Jiang Tao, Liu Cuizhe, Song Hongru

    pp. 473–481 · DOI: 10.1177/09731296231158698 · Published 2023

    Background: Scutellaria baicalensis is an important medicinal plant used in China. Several compounds have been extracted from S. baicalensis using modern techniques. Baicalin, an active ingredient of S. baicalensis, is w…

26. Article

    Phytochemical Profile, Antioxidant and Antiproliferative Activity from Leaves and Seeds of Bixa orellana L. from the Yucatán Peninsula, Mexico

    Dora Valencia, Dolores Isela Aguilar-González, Jesús Ortega-García, Gregorio Godoy-Hernández, Mario Alberto Leyva-Peralta, Víctor Manuel Moo-Huchín, Rayn Clarenc Aarland, Jael Quintero-Vargas, José Alberto Mendoza-Espinoza, Addy Leticia Zarza-García

    pp. 482–490 · DOI: 10.1177/09731296231158492 · Published 2023

    Background: In Mexico, there is an ancestral custom about the knowledge of the medicinal use of plants. Bixa orellana L. is a plant species that represents one of the main crops used in traditional medicine in southeaste…