Volume 20, Issue 3

Critical Appraisal of Nothapodytes nimmoniana (J. Graham) Mabb. Extraction Methods, Pharmacological Activities, and Future Prospects

Shivani Gayakwad, Amey Shirolkar, Apurva Dixit, Sudesh Gaidhani, Sharad Pawar

pp. 695–703 · DOI: 10.1177/09731296241234113 · Published 2024

Nothapodytes nimmoniana (J. Graham) Mabb., commonly known as Narkya, holds immense potential as a medicinal plant, exhibiting a wide array of pharmacological activities. This review provides a comprehensive overview of t…

Traditional Chinese Medicine Offers New Ideas for the Treatment of Osteoporosis Through Multi-method Interventions in Ferroptosis

Weikang Sun, Zichen Shao, Qipeng Yuan, Huanan Li

pp. 704–711 · DOI: 10.1177/09731296231221610 · Published 2024

Osteoporosis, a chronic metabolic bone disease, has a serious impact on the quality of life of postmenopausal women and elderly men. Its prevalence is on the rise as the population ages worldwide. There are many drawback…

A Review of Traditional Chinese Medicine Syndrome Research on Type 2 Diabetes Mellitus and its Common Chronic Complications

Zhiyuan You, Junhong Lu, Yifeng Xu, Yiqin Wang, Yiming Hao

pp. 712–720 · DOI: 10.1177/09731296241234717 · Published 2024

Type 2 diabetes mellitus is the leading cause of diabetes complications in China, threatening people’s health and quality of life seriously. Over the past few years, with the change in lifestyle and dietary habits, the c…

Research Progress in Regulatory Mechanism of Valproic Acid on Inflammatory Responses to Burns and Trauma

Meidi Zhu, Shu-Ming Wang, Rui Liu

pp. 721–726 · DOI: 10.1177/09731296241234976 · Published 2024

Inflammation plays an important role in the defense of the human body. The inflammatory response can suppress the spread of pathogens, accelerate the removal of necrotic cells, and repair the damaged tissues and organs. …

Assessment of Immunomodulatory Activity of AP-Bio® (KalmCold®), a Standardized Extract of Andrographis paniculata Using in vivo and ex vivo Models

Nehru Sai Suresh Chalichem, Prathiksha Nabhan, Bharathi Bethapudi, Nikita Agarwal, Sasi Kumar Murugan, Mundkinajeddu Deepak

pp. 727–732 · DOI: 10.1177/09731296231222378 · Published 2024

Background: Andrographis paniculata (Burm. f.) Nees is a well-recognized medicinal plant known for its benefits against a multitude of ailments. The intent of the present study was to evaluate the effect of a standardize…

Induction and Characterization of Tetraploids from Astragalus membranaceus (Fisch.) Bge. Seeds

Shu-ling Zhang, Xin Zhang, Meng Wang, Li-jun Dong, Gui-xia Liu

pp. 733–744 · DOI: 10.1177/09731296231198574 · Published 2024

Background: Astragalus membranaceus (Fisch.) Bge., as a Traditional Chinese medicine, not only has ornamental and medicinal value but also plays a role in the effect of sand fixation. At present, the resources of wild A.…

Antihistaminic, Antiarthritic, and Antiobesity Activities of Yellow Horn Poppy Natural Products

Mohamed A. Ashour, Samreen Soomro

pp. 745–754 · DOI: 10.1177/09731296231220981 · Published 2024

Background: Yellow horn poppy (Glaucium flavum, syn. Chelidonium flavum) in the family Papaveraceae, is growing in many geographical areas; it is mostly native to Northern Africa, Western Asia, and Europe. The plant is w…

Investigating the Antioxidant Effect of Deoxyschizandin in Doxorubicin-induced Hepatotoxicity: Role of PTEN Signaling Modulation

Naijing Zhou, Qilian Zhu

pp. 755–763 · DOI: 10.1177/09731296231222671 · Published 2024

Background: The hepatotoxicity of doxorubicin (DOX) is one of its main toxic side effects that cannot be ignored. As an important initiating factor for hepatocyte apoptosis and necrosis, oxidative stress is crucial in DO…

Appearance and Chemical Characteristics of Seeds of Radish with Different Skin Colors

Yumeng Wang, Chunyan Ma, Islam A. Elsehemy, Deqiang Dou

pp. 764–772 · DOI: 10.1177/09731296241226498 · Published 2024

Background: Different parts of radish, such as the roots, leaves, and seeds, can be used in culinary and traditional medicine treatments in East Asia. Objectives: The aim of this study was to explore the difference of Ra…

Neuroprotective Potential of Thunbergia laurifolia Lindl. Leaf Extracts against Beta Amyloid-induced Neurotoxicity: An in vitro Model of Alzheimer’s Disease

Kritsana Homwuttiwong, Benjaporn Buranrat, Supataechasit Yannasithinon, Parinya Noisa, Nootchanat Mairuae

pp. 773–783 · DOI: 10.1177/09731296241226769 · Published 2024

Background: Beta-amyloid peptide (Aβ) induces oxidative stress, contributing to Alzheimer’s disease (AD) initiation and progression. This study aims to explore Thunbergia laurifolia (T. laurifolia) leaf extract’s protect…

Mechanism Investigation of Tianxiangdan Against Myocardial Ischemia Based on Network Pharmacology, Molecular Docking, and in vitro Experimental

Lin Jiang, Yuan-Jia Yue, Mei Tang, Yu-Che Wu, Xiao Liu, Yu Li

pp. 784–793 · DOI: 10.1177/09731296231220992 · Published 2024

Objectives: Tianxiangdan capsule (TXD) has been clinically used in the treatment of coronary heart disease angina pectoris. This study aimed to evaluate the mechanisms of TXD against myocardial ischemia and provide evide…

Effects of Mineral Chinese Medicine Chloriti Lapis on Gut Microbiota of Small Intestine in PTZ-kindling Epileptic Rats

Peng Yuan, Fengtao Li, Xilong Qian, Yulu Ma, Xiuxiu Wang, Qian Zhao, Xingyu Zhu, Baofei Yan, Liu Zhou, Wei Yang, Yanqiong Pan, Shilin Dai, Fang Fang, Jin Zhao, Shengjin Liu

pp. 802–816 · DOI: 10.1177/09731296231221632 · Published 2024

Background: Epilepsy is a neurological disease, and its clinical treatment presents a significant medical challenge. Nevertheless, Chloriti Lapis (CL), a traditional Chinese Mineral Medicine, has been employed for centur…

Phytochemical Characterization, Antimicrobial Activity, Pharmacokinetic, in silico Molecular Docking and Interaction Analysis of Ajwa (Phoenix dactylifera L.) Palm Date Seeds

Salem Elkahoui, Arzuhan Sihoglu Tepe, Mejdi Snoussi, Abdullah Hamoud Mohsen Alkhiyari, Arshad Jamal, Lassaad Gzara, Najla Haddaji, Abdelmuhsin Abdelgadir, Riadh Badraoui

pp. 817–831 · DOI: 10.1177/09731296231217600 · Published 2024

Background: There is growing evidence that antibiotic resistance is increasing. As a result, the efficacy of these antibiotics is gradually declining. This poses a serious health risk in terms of treatment strategies. Th…

The “Sweat Soaking Method”-processed Radix Wikstroemia indica Extracts Attenuate Liver

Wenjing Wang, Guo Feng, Qin Xu, Wei Li, Lailai Li, Hongmei Su, Guanglin Zhu, Xueli Song, Ju Zhang, Zhengyan He

pp. 832–840 · DOI: 10.1177/09731296241229268 · Published 2024

Background: Radix Wikstroemia indica (RWI) is one of the most commonly used drugs in Miao medicine. However, RWI is characterized by high toxicity. Objectives: In this study, we aimed to observe the effect of the “sweat …

Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.) Gaertn. (Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced Diabetes in Rats

Mai S. Maaliah, Malik Haddadin, Shtaywy Abdalla

pp. 841–852 · DOI: 10.1177/09731296241231104 · Published 2024

Background: Metabolic syndrome (MS) is considered a challenging health problem worldwide. However, the search for alternative treatments to alleviate MS is lacking. Purpose: This study defines Silybum marianum (milk this…

Therapeutic Alleviation and Mechanism of Glabridin Liposome on Histamine-induced Atopic Dermatitis

Yongjie Lu, Lushi Cheng, Lu Ren, Dongqiu Chen, Shumin Guan, Siyang Zhu, Xian Xu, Bing Zhang, Minghui Tang, Chijian Zhang, Yong Ai, Lanyue Zhang, Tinggang He

pp. 853–862 · DOI: 10.1177/09731296231225512 · Published 2024

Background: One of the primary flavonoids found in the Glycyrrhiza glabra is called glabridin, which has anti-inflammatory, anti-bacterial, and antineoplastic effects. However, the insolubility of glabridin in water limi…

PhcogMag 20 3 863

Ravi Pratap Singh, Ashok Kumar Pattnaik

pp. 863–876 · DOI: 10.1177/09731296241228925 · Published 2024

Background: Hyperlipidemia is a common precursor to cardiovascular diseases, necessitating effective intervention. This study explores the potential of a bioactive fraction derived from Kalanchoe pinnata leaf, a less-exp…

Diterpenoids from Scutellaria barbata D. Don Exert the Antiproliferative Effect on Colorectal Cancer Cells Via Hedgehog Signaling Pathway

Wenwen Wang, Zhongyi Tao, Linglan Tu, Wenkang Huang, Yiping Ye, Lijuan Gao, Xiaoyu Li

pp. 877–886 · DOI: 10.1177/09731296241234714 · Published 2024

Background: Scutellaria barbata D. Don, also known as “Banzhilian” in China, the diterpenes of Banzhilian (Bzl-D) is a commonly used herbal medicine for treating various tumors including colorectal cancer (CRC). Objectiv…

The Analgesic Mechanism of Radix Wikstroemia indica “Sweat Soaking Method” Processed Product Based on Metabolomics and Network Pharmacology

Caiyao Han, Guo Feng, Chenchen Ren, Wei Li, Wen Liu, Gang Liu, Xueli Song, Ju Zhang, Yan Lei, Zhengyan He, Tingting Liu, Kexin Ma, Jinxin Hou

pp. 887–897 · DOI: 10.1177/09731296241235450 · Published 2024

Background: Miao medicine Radix Wikstroemia indica (RWI) is derived from the root of W. indica (L.) C. A. Mey. which has an analgesic effect, but its mechanism is not clear. Because of the toxicity of RWI, the research g…

Resveratrol Suppresses “Metabolic Memory” by Inhibiting Inflammation and Apoptosis Through the ROS/TXNIP/NLRP3 Signaling Pathway

Tingting Jiang, 4 Junxiang Gu, Qing Chang

pp. 898–907 · DOI: 10.1177/09731296241229242 · Published 2024

Aim: This research endeavored to explore the impact and underlying mechanisms of resveratrol on the phenomenon of “metabolic memory” in cultured human retinal vascular endothelial cells (HRVECs) under high-glucose (HG) c…

Cannabis sativa L. Fixed Oil and its Nanoemulsion: Effect on Diabetes and Dyslipidemia Induced in Rats

Helison de Oliveira Carvalho, Alicia de Melo Santos, Abrahão Victor Tavares de Lima Teixeira dos Santos, Danna Emanuelle Santos Gonçalves, Karyny Roberta Tavares Picanço, Belmira Silva Faria e Souza, José Carlos Tavares Carvalho

pp. 908–920 · DOI: 10.1177/09731296241234123 · Published 2024

Background: Diabetes Mellitus (DM) is a syndrome that interferes with energy metabolism and is caused by a decrease and dysfunction of insulin, leading to chronic hyperglycemia. DM associated with dyslipidemia is a sever…

Therapeutic Potential of Rosa canina L. Seed Oil and Metformin: Modulation of Bax/Bcl-2/p53/ Caspase-3 Pathways and Improvement of Biochemical and Oxidative Stress Parameters in Estradiol-induced Polycystic Ovary Syndrome Rat Model

Hanping Chen, Xinxin Liang

pp. 921–933 · DOI: 10.1177/09731296241234124 · Published 2024

Background: This study investigated the therapeutic effects of Rosa canina L. seed oil (RCSO) on PCOS using an animal model, focusing on evaluating biochemical factors and the Bax/Bcl-2/p53 and Caspase-3 (Cas-3) pathways…

Protective Effect of Prunella vulgaris L. Whole Plant or Spicas Water Extracts on Hyperthyroidism with Liver-yang Hyperactivity Syndrome

Shuang Li, Zhiguo Gong, Xiangling Hu, Yufan Li, Chao Yan, Liping Cao, Yuhang Chen

pp. 934–944 · DOI: 10.1177/09731296241239160 · Published 2024

Background: Prunella vulgaris L. (Lamiaceae) is a perennial medicinal plant commonly used to treat thyroid dysfunction, infectious hepatitis, and mastitis in north-east Asia and Europe. In China, there has been a histori…

Phytochemical and Anti-inflammatory Activities of Oxytropis aciphylla

Hao Qian, Jiaqiong Liu, Xianqi Meng, Xiaoqin Wang

pp. 945–955 · DOI: 10.1177/09731296241240236 · Published 2024

Background: The objective of this research is to explore the phytochemical constituents and the potential anti-inflammatory properties of the herb Oxytropis aciphylla. Materials and Methods: From the ethyl acetate and n-…

Effect of Cryptotanshinone on BDNF/TrkB Pathway in Hippocampus of Chronic Stress-induced Depression Rats

Shaomei Lin, Shuifa Wu, Wanting Liao, Wanqiong Chen, Congyi Cai, Yin Zhang, Mingzhu Chen

pp. 956–964 · DOI: 10.1177/09731296241236034 · Published 2024

Background: Cryptotanshinone (CTS) is a monomer possessing a diverse array of pharmacological properties, primarily derived from Salvia miltiorrhiza. CTS was examined for its impact on rats with depression subjected to c…

Baicalin Inhibits VSMC Phenotypic Transition and Ameliorates Atherosclerosis via GSK3β- TCF21 Signaling Pathway

Meng Huo, Jingjing Lin, Qiaoqiao Xu, Haina Zhang, Qizhen Ye

pp. 965–972 · DOI: 10.1177/09731296241239152 · Published 2024

Background: Atherosclerosis (AS) is the pathological basis of acute myocardial infarction, acute stroke, and other acute critical illnesses. Vascular smooth muscle cell (VSMC) phenotypic transformation plays a remarkable…

Pyrogallol Suppresses the Tumor Progression

Hao Liu, Yanxiang Chang, Lei Jin

pp. 973–982 · DOI: 10.1177/09731296241242542 · Published 2024

Background: Pyrogallol, a bioactive compound derived from natural sources, is the focus of this study, aiming to investigate its anti-cancer properties against A549 lung cancer cells and uncover the underlying mechanisms…

Shikonin Attenuate Behavioral Defects, Oxidative Stress, and Neuroinflammation During Aluminum Chloride-induced Alzheimer’s Disease Condition in an in-vivo Experimental Model

Danni Li, Min Wang

pp. 983–995 · DOI: 10.1177/09731296241239153 · Published 2024

Background: Aluminum chloride (AlCl3) is an environmental neurotoxin that affects cerebral functions and causes health complications. However, the role of AlCl3 in arbitrating glia homeostasis and pathophysiology remains…

The Vasodilator Effect and Mechanism of 18β-glycyrrhetinic Acid on Isolated Pulmonary Artery Rings in Rats

Huijuan Yang, Hailong Li, Yuxin Liu, Jinrui Jiang, Mei Hai, Cong Li, Zhiqiang Hu, Ru Zhou

pp. 996–1004 · DOI: 10.1177/09731296241241115 · Published 2024

Background: The purpose of this study was to evaluate the effect of 18β-glycyrrhetinic acid (18β-GA) on isolated rat pulmonary artery vascular rings as well as the mechanism that lies behind the diastolic effects of this…

The Beneficial Effects of Topical Cream Containing 17% of Herbal Extract on Skin Barrier Function: A Randomized Four-week Trial

Ji-Hyo Lyu, Soyeon Kim, Kang Kwon, Yongkuk Kim, Chanhun Choi, Hyunwoo Jeong, Hyungwoo Kim

pp. 1005–1012 · DOI: 10.1177/09731296241243129 · Published 2024

Background: Skin moisture management is important for maintaining healthy skin and treating inflammatory skin diseases, and skin barrier function can be assessed by measuring trans-epidermal water loss (TEWL) and skin mo…

Study on the Mechanism of Anti-atopic Dermatitis by Herba Siegesbeckiae Based on System Pharmacology

Xiaowei Chen, YingYue Wang, Xin Zhang, Chang Liu, Chunxue You, Yubin Xu

pp. 1013–1022 · DOI: 10.1177/09731296241242172 · Published 2024

Background: Atopic dermatitis (AD) is a common but complex chronic inflammatory skin condition characterised by intense pruritus, severely impacting patients’ quality of life. At present, there is no specific drug for AD…

Taraxacum officinale Extracts Alleviate Anhedonia and Depression by Inhibiting UPRmt and Mitophagy in the Hippocampi of T2DM Rats

Meng Wang, Zhen’an Gao, Leilei Ma, Xiuping Wang, Zhaojia Li, Ji’an Li

pp. · DOI: 10.1177/09731296231226067 · Published