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Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins

M. S. Ranjith1★, A. J. A. Ranjitsingh3, S. Gokul Shankar1, G. S. Vijayalaksmi4, K. Deepa2, K. Babu5, Harcharan Singh Sidhu1★ Corresponding author

  1. 1aFaculty of Medicine, Microbiology Unit
  2. 2Anatomy Unit, AIMST University, Kedah, Malaysia
  3. 3Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi
  4. 4Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli
  5. 5R and D Center, Cholayil Private Limited, Chennai, India

CORRESPONDENCE

M. S. Ranjith

*Address for correspondence: Dr. M. S. Ranjith, Associate Professor, Microbiology Unit, Faculty of Medicine, AIMST University, Bedong 08100, Kedah, Malaysia.

msranjith@yahoo.com

Received: 05-10-2009; Revised: 20-11-2009; Accepted: 13-03-2010.

Volume 2, Issue 1 · pp. 10–14 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.60581

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ABSTRACT

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1a and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

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    Ranjith, M. S., Ranjitsingh, A. J. A., Shankar, S. G., Vijayalaksmi, G. S., Deepa, K., Babu, K., & Sidhu, H. S. (2010). Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins. Pharmacognosy Research, 2(1), 10–14. https://doi.org/10.4103/0974-8490.60581