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Article

Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicity

S. Mohanty1, I. E. Cock1,2★★ Corresponding author

  1. 1Department of Biomolecular and Physical Sciences, Nathan Campus, Griffith University, 170 Kessels Rd., Nathan, Brisbane, Queensland 4111
  2. 2Genomics Research Centre, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, Australia

CORRESPONDENCE

I. E. Cock

*Address for correspondence: I. E. Cock, Biomolecular and Physical Sciences, Nathan Campus, Griffith University, 170 Kessels Rd., Nathan, Brisbane, Queensland 4111, Australia.

i.cock@griffith.edu.au

Received: 23-11-2009; Revised: 08-12-2009; Accepted: 13-03-2010.

Volume 2, Issue 1 · pp. 4–9 · PUBLISHED January 2010 · DOI: 10.4103/0974-8490.60577

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ABSTRACT

Methanol extracts from S. jambos leaves were tested for antimicrobial activity and toxicity. S. jambos leaf extract inhibited the growth of 4 of the 14 bacteria tested (29%). Both gram-positive and gram-negative bacterial growths were inhibited by S. jambos leaf extract, although gram-positive bacteria appeared more susceptible. Two of the 10 gram-negative bacteria (20%) and 2 of the 4 gram-positive bacteria (50%) tested had their growths inhibited by the extract. The leaf extract also proved to be toxic in the Artemia franciscana bioassay, with a 48-h LC50 of 387.9 6 38.8 mg/mL, making it slightly more toxic than Mevinphos (505.3 6 37.7 mg/mL) and approximately 5-fold less toxic than potassium dichromate (80.4 6 4.3 mg/ mL). Whilst potassium dichromate’s LC50 remained constant across the 72-hour test period (24-h LC50, 86.3 6 5.1; 72-h LC50, 77.9 6 4.9), the extract and Mevinphos LC50 values decreased by 72 hours (87.0 6 11.3 mg/mL and 103.9 6 12.8 mg/mL, respectively), indicating their similar levels of toxicity in the assay.

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    Mohanty, S., & Cock, I. E. (2010). Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicity. Pharmacognosy Research, 2(1), 4–9. https://doi.org/10.4103/0974-8490.60577