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Pharmacognosy ResearchNOW IN
Article

Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet

Chukwuemeka R. Nwokocha2★, Novie Younger-Coleman2, Magdalene Nwokocha1, Daniel U. Owu3, Moses Iwuala4★ Corresponding author

  1. 1Department of Basic Medical Sciences
  2. 2Tropical Metabolism Research Institute, The University of the West Indies, Mona Campus, Kingston 7, Jamaica, West Indies
  3. 3Department of Physiology, University of Calabar, Calabar, Cross River State
  4. 4Department of Biotechnology, Federal University of Technology, Owerri, Nigeria

CORRESPONDENCE

Chukwuemeka R. Nwokocha

*Address for correspondence: Dr. Chukwuemeka R. Nwokocha, Department of Basic Medical Sciences, University of the West Indies, Mona campus,Kingston 7, Jamaica.

chukwuemeka.nwokocha@uwimona.edu.jm

Revised: 05-01-2014.

Volume 6, Issue 3 · pp. 240–245 · PUBLISHED July-September 2014 · DOI: 10.4103/0974-8490.132604

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ABSTRACT

Context and Objectives Cadmium (Cd) toxicity leads to cell and organ damage, we comparatively examined the protection ability of different medicinal plants on Cd liver accumulation following different treatment interventions and modes of administration. Materials and Methods Rats were fed either 7% w/w Zingiber officinale, 7% w/w Allium Sativum, 10% w/w Lycopersicon esculentum, 5%, w/w Garcinia kola (all in rat chow), while Cd (200 ppm) was given in drinking water. Additives were administered together with (mode 1), a week after (mode 2) or a week before metal exposure (mode 3) for a period of six weeks. Cd liver was determined using AAS and compared using analysis of variance (ANOVA). Results All additives significantly (P <0.5) reduced the accumulation of Cd in the liver. After adjusting for time and mode of administration, mean %protection for week 4 was significantly lower by 14.1% (P=0.02) from that for week 2 but the means did not differ with respect to additive used or mode of administration, no statistically significant interaction between modes of administration and either of additives used or time of administration in their respective relationships to percentage protection from Cd. Conclusion Additives significantly reduced Cd accumulation through a reduction in absorption and enhancement of metal excretion.

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    Nwokocha, C. R., Younger-Coleman, N., Nwokocha, M., Owu, D. U., & Iwuala, M. (2014). Investigation of effects of time of measurement and modes of administration on cadmium accumulation in rat liver under some medicinal plants food supplemented diet. Pharmacognosy Research, 6(3), 240–245. https://doi.org/10.4103/0974-8490.132604