Volume 20, Issue 4

Original Research Article(continued)

1. Article

   Astilbin Inhibits the Proliferation and Induces Apoptosis of Gastric Cancer Cells (AGS) by Targeting the Key Inflammatory Markers

   Guoshan Zhang, Xiaoyuan Zhuang, Shen Lin, Yatian Wang

   pp. 1276–1285 · DOI: 10.1177/09731296241264612 · 2024

   Background: The predisposition toward gastrointestinal disease is increasing as a result of dietary changes and overindulgence in food preparation. Ninety percent of stomach cancers are adenocarcinomas, a type of cancer …

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2. Article

   Exploring Melezitose as a Potential Therapeutic Agent in Lung Cancer: Inhibitory Effects on Cell Proliferation and EMT-Mediated Signaling in A549 Cells

   Qihui Zhou, Ziyong Wu, Xi Cheng, Zhigang Zuo, Cunyu Fan

   pp. 1286–1294 · DOI: 10.1177/09731296241251545 · 2024

   Background: Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-related deaths. The study delves into melezitose, a naturally occurring compound known for its biocompatibility. Purpose: …

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3. Article

   Tibetan-Origin Edible Chinese Herbal Prescription C18 Protects H9C2 Cardiomyocytes from Cobalt Chloride-induced Hypoxia Injury through the PI3K/AKT Signaling Pathway

   Guoxin Chang, Hongyi Xie, Shu Chen, Ruixue Wang, Xuxin Zeng, Dingmei Lin, Zixuan Mo, Jingjing Yu, Xindan Liu, Zhaoguang Zheng, Yan Wang

   pp. 1295–1303 · DOI: 10.1177/09731296241252202 · 2024

   Background: Altitude sickness is often prone to occur during tourism or work in high-altitude areas. In China, traditional Tibetan medicines have a long history of preventing or treating altitude sickness, especially alt…

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4. Article

   Kaempferide Inhibits DOX-induced Liver Inflammation by Activating AMPKα/SIRT1

   Qiang Li, Xing Li, Zhenchang Zhou, Pingwei Zhu, Nana Tuo, Jingli Ge, Zhaoyv Liu, Dengke Chen

   pp. 1304–1312 · DOI: 10.1177/09731296241228923 · 2024

   Objectives: DOX can promote liver cell inflammation and lead to liver cell death. Ka protects and stabilizes liver cells for the treatment of hepatitis, cirrhosis, and other diseases. However, there is no evidence to sug…

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5. Article

   Nerolidol Alleviates Oxidative Stress and Inflammation in Diabetic Retinopathy Mediated by High Glucose through Ameliorating Nrf2/HO-1 Pathway

   Changhong Li, Buchao Shi, Dong Li, Hui Li

   pp. 1313–1321 · DOI: 10.1177/09731296241247922 · 2024

   Background: Diabetic retinopathy (DR) is the foremost microvascular problem that causes drastic visual impairment in diabetes patients. Hyperglycemia-triggered reaction cascade of inflammation and oxidative stress consti…

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6. Article

   Anti-myocardial Ischaemia by Bioinformatics of Apocynum venetum L.

   Yuan-Jia Yue, Yu Li, Xing Rong, Zhao Ji, Hui-Min Wang, Lin Jiang

   pp. 1322–1330 · DOI: 10.1177/09731296241242178 · 2024

   Background: In recent years, the number of patients with myocardial ischaemia is rising year by year in China. Objectives: The study uses network pharmacology to predict targets and pathways of action of Apocynum venetum…

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7. Article

   Investigating the Anti-adipogenic Potential of Xanthium strumarium Linn. Leaves Fractions: HPTLC-MS Characterization, Enzymatic Analysis, and 3T3-L1 Adipocyte Differentiation Assay in Oxidative Stress-modulated Adipogenesis Cascade

   Nikita Nayak, Ashok Pattnaik

   pp. 1331–1340 · DOI: 10.1177/09731296241242842 · 2024

   Background: Molecular pathogenesis of obesity is initiated by cellular oxidative stress along with increased adipogenesis. For the search of better alternatives of synthetic molecules in terms of their adverse events, na…

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8. Article

   Effects of Different Administration Cycles of Rhubarb on Fecal Metabolism in Healthy Rats Based on Metabolomics

   Rui Chen, Hongmei Su, Jing Bai, Xueqing Duan, Guo Feng, Weiyi Tian

   pp. 1341–1349 · DOI: 10.1177/09731296241245179 · 2024

   Background: Rhubarb is a common cold-property drug that is commonly used as an effective laxative. It was first recorded in Shen Nong’s Herbal Classic. Purpose: The LC-MS/MS metabolomics technology was used in this study…

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9. Article

   Unraveling the Pharmacological Intricacies of Kurarinone in Osteoporosis: Insights from a Network Pharmacology Approach

   Zhongyu Xiong, Huawen Yang

   pp. 1350–1358 · DOI: 10.1177/09731296241259563 · 2024

   Background: Kurarinone, a compound derived from Sophora flavescens, has been widely studied for its anti-inflammatory properties, as well as its potential in treating autoimmune encephalomyelitis and inflammation-related…

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10. Article

    Huanglian Jiedu Decoction Inhibits LPS-induced Neuroinflammation and Attenuates the Activation of NLRP3 Inflammasome in BV2 Cells

    Junli Wang, Rui Wang, Yaming Du, Xinzi Xu, Xin Liu, Wei Shao, Guohua Chen

    pp. 1359–1366 · DOI: 10.1177/09731296241244575 · 2024

    Background: Huanglian Jiedu decoction (HLJDD) is a classical herbal formula for treating inflammatory diseases with Traditional Chinese Medicine (TCM). However, the impacts of HLJDD on neuroinflammation and the precise m…

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11. Article

    Luteolin Ameliorates Non-alcoholic Fatty Liver Disease via Regulation of Hepatic Lipid Uptake, Autophagy, and Apoptosis in WD/CCl4-induced Mice

    Jingjing Hu, Dongyue Pang, Ning Tian, Rongyin Qin

    pp. 1367–1373 · DOI: 10.1177/09731296241258540 · 2024

    Background and Purpose: Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem with high prevalence and morbidity associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipi…

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12. Article

    Study on UPLC–MS/MS Method for Four Compositions of Cangzhu

    Ren Qiyong, Sun Jikai, Qin Lili, Zhang Min, Ma Junying, Liu Jun, Zhang Honglian

    pp. 1374–1379 · DOI: 10.1177/09731296241251534 · 2024

    Background: The legal quality control of Cangzhu is used the single component as an evaluation indicator, which would not be enough to reflect the authenticity of quality. It is necessary to select several typical chemic…

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