Volume 21, Issue 2

Adib Alam, Papiya Mitra Mazumder

pp. 323–335 · DOI: 10.1177/09731296241281440 · 2025

Background: Neurological diseases represent a pressing global health concern; the World Health Organization reports that neurological conditions rank as the second leading cause of death worldwide. In the last quarter ce…

Qiong Fang, Junjie Wang, Tingting Wu, Yining Cai, Huimin Wang, Jitang Cai

pp. 336–347 · DOI: 10.1177/09731296241286282 · 2025

Background: Nasopharyngeal carcinoma (NPC) is an uncommon type of epithelial carcinoma, characterized by unique features and a higher prevalence in certain populations. Traditional medicines are commonly employed in the …

Lingyuan Kong, Xinyi He, Xiuyang Li

pp. 348–363 · DOI: 10.1177/09731296241246313 · 2025

Background: The relationship between insomnia and depression is complex and two-way. Long-term insomnia may cause, maintain, and aggravate depression, and with the development of the disease, depression patients will als…

Li Wang, Ao-jia Zhou, Yi-dan Zhang, Cheng Fan, Shan-shan Hu, Zhi-yong Zhou, Ding Yuan, Ting Wang

pp. 364–379 · DOI: 10.1177/09731296241259807 · 2025

Background: Panax japonicus (P. japonicus) belongs to the Panax genus of Araliaceae and is used as medicine mainly with the bamboo whiplike rhizome, which has the functions of dispelling blood stasis and hemostasis, atte…

Song Wang, Xinhua Chen, Zuoqiao Shi, Qianqian Shen, Jing Li, Wang Hua, Wang Shujing, Wanjing Wu, Qing Xi, Guowen Li

pp. 380–393 · DOI: 10.1177/09731296241276582 · 2025

Background: Asthma is a chronic respiratory condition by airway inflammation. Traditional Chinese Medicine, is commonly used to treat it. Astragalus is known for its immunoregulation, anti-inflammatory, and antioxidant e…

Ruisu Zhang, Qian Zhang, Dandan Zhang, Ning Zhang, Qingwei Li, Chenyang Li, Long Wang

pp. 394–402 · DOI: 10.1177/09731296241305935 · 2025

Severe depression is the most common mental disorder, with a heavy economic burden and limited treatment. The lifetime prevalence of depression among adults in China is 6.8%, with depression accounting for 3.4%. Currentl…

Ravi Pratap Singh, Ashok Kumar Pattnaik, Mithun Rudrapal, Soumya Bhattacharya

pp. 403–412 · DOI: 10.1177/09731296241281422 · 2025

Nature exhibits a unique beauty that is both recognized and integrated into human practices globally. Annona squamosa Linn., commonly known as “sweet sugar,” is a small medicinal shrub cultivated for its fruits. This spe…

Tianmin Bie, Feng Jia, Yongmei Wang, Zhuoyan Pan

pp. 413–422 · DOI: 10.1177/09731296241262561 · 2025

Background: Stroke is a collection of disorders that develop due to the rapid rupture of blood vessels in the brain or due to the blockage of blood flow. Ischemic stroke (IS) has high mortality as well as morbidity rates…

Ying Wang, Hong Deng, Chuqin Yu, Junfeng Ban, Shu Zhang

pp. 423–432 · DOI: 10.1177/09731296241274884 · 2025

Background: Finding a new promising plant antioxidant to combat or prevent cardiovascular disease remains a major challenge for researchers. Lychee pericarp, which includes a variety of polyphenols, is a prospective sour…

Gang Huang, Nan Zheng, Yinqing Huang

pp. 433–442 · DOI: 10.1177/09731296241275304 · 2025

Background: Ghrelin in the gastric mucosa of rats can improve myocardial cell apoptosis and cardiac remodeling during myocardial ischemia and myocardial infarction, and it has a protective effect on the myocardium, but i…

Haojun Wang, Tao Jin, Yuehan Mao, Yi Wei

pp. 443–453 · DOI: 10.1177/09731296241264617 · 2025

Background: The manifestation of severe sepsis is sepsis-induced myocardial dysfunction (SIMD), which is the chief cause of elevated death in sepsis patients. Sepsis mainly attacks the heart, and the effective switch of …

Ki-Hoon Park, Junyang Jung, Na Young Jeong

pp. 454–466 · DOI: 10.1177/09731296241259226 · 2025

Background: The discovery of new drug targets is a critical and challenging aspect of drug development. Fascaplysin, a marine natural product, has shown potential in various biological applications, but identifying suita…

Qiao Lyu, Yuan Qu, Jianfan Chen, Guo Chen, Zheng Chen, Lijun Qu

pp. 467–479 · DOI: 10.1177/09731296241262075 · 2025

Objectives: The primary aim of this study is to investigate the specific effects and mechanisms of ganoderic acid A (GAA) on castration-resistant prostate cancer (CRPC). Materials and Methods: We successfully established…

Shivangi Kumari, Ashok Kumar Pattnaik

pp. 480–490 · DOI: 10.1177/09731296241264071 · 2025

Background: The rising incidence of obesity and its related health issues demand novel approaches prioritizing safety and effectiveness. In light of concern about the side effects of pharmaceutical therapies, research in…

Abdullah Alqarni, Jagadish Hosmani, Raghad Mohammed, Abdullah Alqahtani, Sarah Alasiri, Nasser Alhamid, Hattan Zaki, Thabet Al Housami, Elumalai Perumal, Imran Khalid, Khurshid Mattoo

pp. 491–506 · DOI: 10.1177/09731296241275740 · 2025

Background: Shilajit a natural phytomineral has a proven record of treating many human body ailments. Objectives: This study aimed to explore the influence of Shilajit on cell proliferation and apoptosis induction in ora…

Tong Yang, Hui Zhao, Xiang Ding, Yiling Hou

pp. 507–520 · DOI: 10.1177/09731296241279087 · 2025

Background: Fungal polysaccharides are an essential active polymer compound in human cells. A clear understanding of the structure of polysaccharides is the foundation for conducting research and utilization of polysacch…

Sanjeev Kumar Kare, Ajay Gupta, Girish H. Rudrappa

pp. 521–535 · DOI: 10.1177/09731296241281438 · 2025

Objectives: To evaluate the efficiency of the turmeric-Boswellia formulation (TBF, Rhuleave-K) in reducing acute low back pain (LBP) among healthy subjects. Materials and Methods: This research aimed to assess the effect…

Zhefeng Xu, Chunshuo Liu, Yuqiu Chen, Jing Fang, Rui Liu, Tao Zhang, Changbao Chen

pp. 536–549 · DOI: 10.1177/09731296231216173 · 2025

Background: Ginseng (Panax ginseng C. A. Meyer) is a type of plant that cannot be continuously cultivated. Continuous cultivation of ginseng can lead to the deterioration of soil properties, affecting the normal growth a…

Jie Zheng, Junyan Hu, Shujun Jiang, Yuhong Wang, Dan Xing

pp. 550–560 · DOI: 10.1177/09731296241281854 · 2025

Background: Breast cancer, originating in the cells of the breast, involves a significant role of oxidative stress and inflammatory reactions in tumor cell proliferation. In this study, we investigate the chemoprotective…

Zimasa Busisiwe Dubeni, Lisa V. Buwa-Komoreng, Siza Mthi

pp. 561–572 · DOI: 10.1177/09731296241288922 · 2025

Background: Chicken meat is vulnerable to contamination during processing and storage, leading to spoilage and economic losses. To find natural alternatives to synthetic preservatives, researchers are exploring plant-bas…