Volume 21, Issue 4

Wang Jinjin, Jin De, Zhu Qin

pp. 1139–1152 · DOI: 10.1177/09731296251313623 · 2025

Tripterygium wilfordii Hook F. (TwHF), a member of the Celastraceae family and belonging to the genus Tripterygium, is a vine-like shrub. It contains numerous active components, such as Tripterygium glycosides (GTW) and …

Jiajun Huang, Diyou Wu, Yu Zhao, Yun Xue, Junqing Huang, Bin Yang

pp. 1153–1164 · DOI: 10.1177/09731296251313631 · 2025

Osteoclasts are specialized cells responsible for bone resorption, which plays a crucial role in the dynamic processes of bone remodeling and maintenance. Osteolytic skeletal disorders, such as osteoporosis, arise from a…

Wenli He, Lina He

pp. 1165–1175 · DOI: 10.1177/09731296251329683 · 2025

Background: Colon cancer is a significant public health issue, known as a major cause of cancer-associated mortalities globally. Understanding the underlying molecular mechanisms that direct the onset of colon cancer is …

activity of AQP, TLR TLR, Song Liu, Xiaomeng Lv, Dong Wang

pp. 1176–1186 · DOI: 10.1177/09731296241282387 · 2025

Background and Objectives: Stroke threatens neurological function. Salidroside is widely used to treat neurological diseases such as stroke. Previous studies have shown that miR-155 plays an important regulatory role in …

Jiaxing Yu, Shuqin Cheng, Zelin Ye, Ming Zhang, Xinlei Zhao

pp. 1201–1211 · DOI: 10.1177/09731296241294143 · 2025

Background: Beta-sitosterol, a phytosterol similar to cholesterol, is found in various plants and is recognized for its potential anticancer properties; still, the mechanism of breast cancer (BC) remains elusive. Objecti…

Yan Chen, Lu Men

pp. 1212–1219 · DOI: 10.1177/09731296251331682 · 2025

Background: Colon cancer, a prevalent form of gastrointestinal malignancy, poses a significant public health issue globally. The onset of colon cancer is a complex mechanism implicating genetic and environmental factors,…

Jie Liu, Xingde Liu, Xiaoman Xiong, Yuhua Zheng, Rui Rao, Wen Li

pp. 1220–1230 · DOI: 10.1177/09731296241296202 · 2025

Background: 1,8-Cineole is used in traditional folk medicine to treat various diseases. This study evaluates the protective effects of 1,8-cineole on the respiratory system by investigating its impact on inflammatory fac…

Haizhou Yu, Qiaojian Tao, Xianjing Zeng, Jinfeng Zhou

pp. 1231–1243 · DOI: 10.1177/09731296241296599 · 2025

Background: Inflammatory illnesses and severe tissue injuries are frequently accompanied by pain. A widespread global health issue that has a significant negative impact on people’s quality of life everywhere is inflamma…

R. Rezgui, T. Alharazi, K. Alshaghdali, I. Elnaem, M. A. I. Salih, F. Aldakheel, M. Saeed, M. Tasleem, I. Ginawi, A. Saeed

pp. 1244–1256 · DOI: 10.1177/09731296241294132 · 2025

Background: The rising incidence of Major Depressive Disorder (MDD), in conjunction with the inadequate effectiveness and resistance observed in existing therapeutic approaches, emphasizes the urgent need to investigate …

Ching Wong, Siu Kan Law, Xiao Xiao Wu, Christy Wing Sum Tong, Yanping Wang, Wesley Yeuk Lung Chow, Dawn Ching Tung Au

pp. 1257–1266 · DOI: 10.1177/09731296241309430 · 2025

Background: Chinese medicinal ointment was first recorded in the Shan Hai Jing (The Classic of Mountains and Seas). Different formulations of Chinese medicinal ointments have been made based on the traditional Chinese me…

Hongtao Sui, Hai Yang, Zongyuan Huang, Caihua Zhang

pp. 1267–1277 · DOI: 10.1177/09731296251318411 · 2025

Background: Epithelial-mesenchymal transition (EMT) is crucial in liver cancer progression. Developing novel medicines to disrupt the progression of EMT might be a novel approach in managing liver cancer. Objectives: Thi…

Zhiying Huang, Guijun Zhao, Dejun Zeng, Xiaolan Feng, Chenglu Zhang

pp. 1278–1289 · DOI: 10.1177/09731296251313659 · 2025

Background: The Chinese forest musk deer, a solitary ungulate renowned for its musk secretion, is under extinction threat despite its extensive use in traditional Chinese medicine and perfumery. The demand for musk signi…

Yingkui Hou, Wencong Sun, Jing Yang

pp. 1290–1299 · DOI: 10.1177/09731296241311346 · 2025

Background: One of the leading causes of serious liver disease worldwide is drug-induced liver injury, which is brought on by either the direct hepatotoxic effects of a medication or one of its reactive metabolites. One …

XueDong Pan, HongYang Wang, Qian Li, FuLi Zhang

pp. 1300–1312 · DOI: 10.1177/09731296241312488 · 2025

Background: The herbs Baidoukou (the fruit of Amomum compactum Sol. ex Maton), Baijusheng (the fruit of Lactuca sativa L.), and Biba (Piper longum L.) make up the traditional Mongolian medicine known as Sugemule-3 decoct…

Araceli Torres-Martínez, Juan José Acevedo-Fernández, Nelly del Carmen Jiménez-Pérez, Fanny Adabel González-Alejo, Pedro García-Alamilla, Maximiano Antonio Estrada-Botello, Jesús Alfredo Araujo-León, Areli Carrera-Lanestosa

pp. 1313–1322 · DOI: 10.1177/09731296251313843 · 2025

Background: In Mexico, the fruit of the Manilkara zapota (L.) P. Royen (Chicozapote) tree is widely consumed; however, numerous studies have identified bioactive compounds within its leaves. Objectives: To evaluate the b…

Jinghu Liu, Haokun Zhou, Zhitao Hu, Xiangdi Tan, Yujiang Yao

pp. 1323–1333 · DOI: 10.1177/09731296251313634 · 2025

Background: Myocardial fibrosis following myocardial infarction (MI) is linked to decreased cardiac function and heart failure. Astragaloside IV (AST IV), a component of traditional Chinese medicine, has shown promise in…

Liming Wei, Chen Jia, Li Zhang, Jugui Yang, Suqin Zhou, Haisheng Jiao

pp. 1334–1342 · DOI: 10.1177/09731296251323009 · 2025

Background: Epilepsy becomes a prevalent drug-resistant neurological condition, often regarding cognitive impairment. As a traditional Chinese patent medicine, Songling Xuemaikang capsules (SXC) mainly contain Pueraria l…

Jing Li, Qian Jiang

pp. 1343–1355 · DOI: 10.1177/09731296241307433 · 2025

Background: Stroke is a primary global health concern, resulting in substantial mortality and morbidity, with a significant proportion of cases attributed to ischemic stroke. While reperfusion therapies, including thromb…

Fang Wang, Yeqing Su, Xian Zheng, Wenping Li

pp. 1356–1367 · DOI: 10.1177/09731296251333261 · 2025

Background: Gestational diabetes, defined by increased blood glucose levels during pregnancy, impacts a considerable proportion of pregnant women globally. The proper management of gestational diabetes is crucial, as it …

Xianwen Sun, Jun Fei

pp. 1368–1389 · DOI: 10.1177/09731296241312458 · 2025

Background: Osteoporosis is a common condition among the elderly, characterized by reduced bone density and an increased susceptibility to fractures. The efficacy of Cinnamomum cassia in treating osteoporosis is recogniz…