jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacy PracticeNOW IN
Article

Effect of weekly high-dose vitamin D3 supplementation on the association between circulatory FGF-23 and A1c levels in people with vitamin D deficiency: A randomized controlled 10-week follow-up trial

Sara M. Alimam1, Jehad F. Alhmoud2, Heba A. Khader3, Ahmad R. Alsayed1, Mohammad Abusamak4, Beisan A. Mohammad5, Ibrahim Mosleh6, Khaled Abu Khadrah7, Ahmad Aljaberi8, Maha Habash9, Luai Hasoun1, Mahmoud S. Abu-Samak1★★ Corresponding author

  1. 1Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.
  2. 2Department of Medical Laboratory Sciences, Jordan University of Science and Technology, P.O.Box 3030, Irbid, 22110, Jordan.
  3. 3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
  4. 4Department Surgery, School of Medicine, Al-Balqa Applied University, As-Salt 19117, Amman Eye Clinic, Amman 11931, Jordan.
  5. 5Pharmaceutical Sciences Department - PharmD Program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia.
  6. 6Departments of Clinical Laboratory, University of Jordan, Amman, Jordan.
  7. 7Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan.
  8. 8Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science Private University, Amman 11931, Jordan.
  9. 9Michael Sayegh, Faculty of Pharmacy, Aqaba University of Technology, Aqaba 77110, Jordan.

CORRESPONDENCE

Mahmoud S. Abu-Samak

Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, Jordan.

m_abusamak@asu.edu.jo

Received: 17-07-2023; Accepted: 22-11-2023.

Volume 22, Issue 2 · pp. 2934 · PUBLISHED 2 May 2024 · DOI: 10.18549/PharmPract.2024.2.2934

View on PP original site ↗

ABSTRACT

Purpose: This randomized clinical trial (RCT) was designed to assess the effect of vitamin D supplementation (VD3) on the relationship between the levels of fibroblast growth factor-23 (FGF-23) and osteocalcin factor (OSC) with glycated hemoglobin (A1c) values in the blood in a sample of Jordanian males and female adults with vitamin D deficiency. Subjects and methods: This RCT was designed to randomly split (78) eligible participants into two groups: experimental (Group A) and interventional (Group B). Group B was supplemented with a weekly dose of 50,000 IU VD3 for eight weeks. Fasting baseline and follow-up (10 weeks; 8 weeks supplementation plus washout two weeks) of serum 25 hydroxyvitamin D (25OHD), fibroblast growth factor-23 (FGF-23), glycosylated hemoglobin (A1c), parathyroid hormone (PTH), calcium, and phosphorus were assayed. A paired T-test was used to assess the changes in fibroblast growth factor-23, A1c, and OSC levels over the follow-up period. RESULTS: Significant increase in follow-up level of 25OHD (40.04 ± 11.61 vs. 15.35 ± 5.41, PC < 0.001), FGF-23 (114.04 ± 103.8 vs. 87.40 ± 82.21, PA = 0.02) and A1c (5.63 ± 0.33 vs. 5.38 ± 0.32, PA = 0.01). Conclusion: High doses of vitamin D supplementation (50,000 IU/week) may have potentially negative effects on glycemic control, which might be related to changes in serum osteocalcin than in FGF23 levels.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Alimam, S. M., Alhmoud, J. F., Khader, H. A., Alsayed, A. R., Abusamak, M., Mohammad, B. A., Mosleh, I., Khadrah, K. A., Aljaberi, A., Habash, M., Hasoun, L., & Abu-Samak, M. S. (2024). Effect of weekly high-dose vitamin D3 supplementation on the association between circulatory FGF-23 and A1c levels in people with vitamin D deficiency: A randomized controlled 10-week follow-up trial. Pharmacy Practice, 22(2), 2934. https://doi.org/10.18549/PharmPract.2024.2.2934