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Article

Natural agents’ role in cancer chemo-resistance prevention and treatment: molecular mechanisms and therapeutic prospects

Anas Abed1, Malek Zihlif2, Heba A Khader3, Luai Hasoun4, Amniyah Al-Imam4, Mahmoud J Al Shawabkeh5, Leen B Fino4, Alhareth A. Alsa’d1, Mustafa Al-Shajlawi6, Ahmad R. Alsayed4★★ Corresponding author

  1. 1Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
  2. 2Department of Pharmacology, The University of Jordan, Amman, Jordan.
  3. 3Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, PO Box 330127, Zarqa 13133, Jordan.
  4. 4Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11937, Jordan.
  5. 5Department of Basic Dental Sciences, Faculty of Dentistry, Applied Science Private University, Amman, Jordan.
  6. 6, Iraq.

CORRESPONDENCE

Ahmad R. Alsayed

Associate Professor in Clinical Pharmacy, Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11937, Jordan. , a.alsayed.phd@gmail.com

a_alsayed@asu.edu.jo

Received: 07-08-2023; Accepted: 04-09-2023.

Volume 22, Issue 2 · pp. 2950 · PUBLISHED Apr-Jun 2024 · DOI: 10.18549/PharmPract.2024.2.2950

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ABSTRACT

Cancer is a leading cause of morbidity and mortality worldwide, necessitating exploring novel preventive and therapeutic strategies. Over the years, the potential of natural agents in cancer prevention and treatment has garnered considerable attention. This review highlights the current understanding of the molecular mechanical bases underlying the role of natural agents and their therapeutic potential in combating cancer. The molecular mechanisms through which these natural agents exert their anti-cancer activities are elucidated, encompassing modulation of signaling pathways involved in cell proliferation, apoptosis, angiogenesis, metastasis, and immune response. Additionally, the review delves into the emerging research on the epigenetic modifications induced by natural agents, providing a deeper insight into their anti-cancer properties.

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    Abed, A., Zihlif, M., Khader, H. A., Hasoun, L., Al-Imam, A., Shawabkeh, M. J. A., Fino, L. B., Alsa’d, A. A., Al-Shajlawi, M., & Alsayed, A. R. (2024). Natural agents’ role in cancer chemo-resistance prevention and treatment: molecular mechanisms and therapeutic prospects. Pharmacy Practice, 22(2), 2950. https://doi.org/10.18549/PharmPract.2024.2.2950