Liver function congruence with contraceptive medical profile in women at child-bearing ages

ABSTRACT

Background: Hormonal contraceptives are among the most widely used medications worldwide, providing effective and reversible contraception for women. However, their use has been associated with potential side effects, including effects on liver function. This article reviews current evidence on the influences of different hormonal contraceptives agents on liver function in women of childbearing age. A cross-sectional study was conducted on 46 women aged 25-45 years using different contraceptive methods. Serum levels of the liver functional parameters were measured and compared between contraceptive-users versus contraceptive-free group, as well as among different age groups, parity, and contraceptive types. The results showed significantly higher levels of the liver functional parameters in women over 45 years old compared to younger age groups. Contraceptive users also had significantly higher levels of these liver enzymes compared to non-users. Among contraceptive types, combined oral contraceptives were associated with the highest elevations in liver enzymes. The results suggest that prolonged use of hormonal contraceptives, especially combined oral contraceptives, may adversely affect liver function. However, the clinical importance of these elevations needs further investigation. Careful screening and monitoring of liver function is advisable for women on long-term hormonal contraception.

KEYWORDS

• contraceptives
• hormones
• liver function
• hepatotoxicity
• reproductive health

Showing references and in-text citations exactly as published.

• DOI10.18549/PharmPract.2025.1.3051Copy

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