jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Pharmacognosy ReviewsNOW IN
Review

Silymarin: A Historical and Scientific Exploration of its Medicinal Properties

Hebbani Nagarajappa Shivaprasad1, Vinaya Gharabude1, Sravani Thimmannagari1★, Madhu Krishnamani1, Gaurav Soni1★ Corresponding author

  1. 1Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Sravani Thimmannagari

Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad, Telangana, INDIA.

research1@botanichealthcare.net

Received: 17-11-2024; Revised: 05-01-2025; Accepted: 29-04-2025.

Volume 19, Issue 37 · pp. 102–108 · PUBLISHED · DOI: 10.5530/phrev.20250002

View on PR original site ↗

ABSTRACT

Silybum marianum, or milk thistle, has been used medicinally for over 2,000 years, mainly to treat liver conditions. Silymarin, a complex mixture of flavonolignans, is present in the plant, which contributes to its pharmacological properties. Silymarin, especially its active compound silybin used particularly for liver health. This review compiles information from databases such as Google Scholar, PubMed, ScienceDirect, and ResearchGate. It is used in traditional medicine to treat liver conditions like cirrhosis and hepatitis, promoting regeneration, reducing oxidative stress, and enhancing detoxification. It also boosts glutathione levels, lowers liver fibrosis, and has been shown to protect the liver from a number of toxins, including alcohol and environmental pollutants. Various research studies confirm its safety with no serious side effects and it has been proven fairly low in toxicity. Further validating its role as a promising therapeutic agent for liver diseases.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Shivaprasad, H. N., Gharabude, V., Thimmannagari, S., Krishnamani, M., & Soni, G. (). Silymarin: A Historical and Scientific Exploration of its Medicinal Properties. Pharmacognosy Reviews, 19(37), 102–108. https://doi.org/10.5530/phrev.20250002