Volume 53, Issue 3

Sahil Kumar, Kiran Thakur, Bandna Sharma, Tilak Raj Bhardwaj, Deo Nandan Prasad, Rajesh Kumar Singh

pp. 343–354 · DOI: 10.5530/ijper.53.3.68 · 2019

Background: Malaria, Chikungunya and Dengue are some of the emerging infectious diseases whose incidence has increased in the past 20 years and could increase in the near future. Although many chemotherapeutic agents are…

Swarupanjali Padhi, Rupa Mazumder, Shradha Bisth

pp. 355–365 · DOI: 10.5530/ijper.53.3.69 · 2019

Background: This is an era of inventive technology illuminating fundamental mechanisms of diseases and fabricating drug molecules according to prerequisite condition, but it is still a challenge to target infectious dise…

Ruchi Bhattacharya, Manisha Sahu, Vikash Sharma, Shiv Shankar Shukla, Ravindra Kumar Pandey

pp. 366–375 · DOI: 10.5530/ijper.53.3.70 · 2019

Aim: Ayurvedic formulation consists of natural substance. Many of Ayurvedic formulation consist of heavy metals and some species are poisonous in nature. So it is necessary to determine the toxicity of Ayurvedic formulat…

Halima Sadia, Hina Rehman, Safila Naveed

pp. 376–381 · DOI: 10.5530/ijper.53.3.71 · 2019

Objective: A review has been carried out to understand pharmacoeconomics and its development in the Asian region. Findings: Pharmacoeconomics is a subset of health economics which applies the methodologies and principles…

Priya Virendrakumar Shah, Sadhana Rajput

pp. 382–399 · DOI: 10.5530/ijper.53.3.72 · 2019

Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications o…

Areeba Insaf, Pratap Nath Raju

pp. 400–413 · DOI: 10.5530/ijper.53.3.73 · 2019

Global trend is setting towards improved ‘quality of life’, for that there is considerable evidence of an increase in demand for medicinal plants. According to the WHO report, between 65% and 80% of the populations of de…

Akshatha G, Anoop Narayanan V, Sandeep D S, Narayana Charyulu R

pp. 414–420 · DOI: 10.5530/ijper.53.3.74 · 2019

Background: The Abbreviated New Drug Application commonly referred as ANDA is an application that contains data submitted to US FDA for the review and prospective marketing authorization of generic drugs. The conduct of …

Kaushik Mandal, Hemant Gupta

pp. 421–434 · DOI: 10.5530/ijper.53.3.75 · 2019

Aim/Background: Whether service quality is measured by the gap between expectation and performance or by performance only. In quest of attaining answer of that query, the present research has taken an attempt to compare …

Sudheer Babu Kolla, Madhusudhan Rao Vallabhaneni, Srinivasa Babu Puttagunta, Maharshi Sudulagunta Venkata

pp. 435–445 · DOI: 10.5530/ijper.53.3.76 · 2019

Aim: The study involved design of experiment guided discriminatory dissolution method development for poorly soluble, ezetimibe tablets. Objective: In the current scope of study, ezetimibe tablets are selected as a suita…

Yomna Abdelkarim Aboueisha, Shadeed Gad, Waleed Fathy Khalil, Eman Ali Ahmed Mamdouh Mostafa Ghorab

pp. 446–456 · DOI: 10.5530/ijper.53.3.77 · 2019

Introduction: Fenoprofen calcium (FC) is a non-steroidal anti-inflammatory drug and due to its short half-life, high absorption, extensive metabolism and adverse effect, sustained release formulation of FC is desired. Ob…

Pallavi Argade, Vinita Chandrakant Patole, Ashlesha Pravin Pandit

pp. 457–467 · DOI: 10.5530/ijper.53.3.78 · 2019

Objective:An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Tr…

Chitra Karthikeyini Senthilvel, Kavitha Karuppaiyan, Muthu Mohammed Jamal Moideen

pp. 468–479 · DOI: 10.5530/ijper.53.3.79 · 2019

Introduction: Currently used anticonvulsant drugs are not totally effective to control seizures. Phenytoin is a classic instance where its efficiency is inhibited through high metabolization (90%-95%) and back transport …

Syed Furqan Ahsan, Muhammad Ali Sheraz, Marium Fatima Khan, Zubair Anwar, Sofia Ahmed, Iqbal Ahmad

pp. 480–493 · DOI: 10.5530/ijper.53.3.80 · 2019

Introduction: Among tablets, fast dissolving technology has gained considerable popularity due to their rapid onset of action. Amlodipine besylate (ADB) is a longacting calcium channel blocker that is used in the treatme…

Priyanka Giri, Poonam Jadhav, Udaykumar Patil, Namdeo R. Jadhav

pp. 494–502 · DOI: 10.5530/ijper.53.3.81 · 2019

Aim: The aim of present study deals with preparation and stabilization of Hydrochlorothiazide nanocrystals using silk sericin. Materials and Methods: Nanocrystals of BCS class II drugs were primed by antisolvent precipit…

Fatma Zioud, Viviana Marzaioli, Jamel El-Benna, Rafik Bachoual

pp. 503–510 · DOI: 10.5530/ijper.53.3.82 · 2019

Aim: Plants used in traditional medicine produce diverse active metabolites exhibiting various medicinal properties. For several centuries Citrillus colocynthis and Punica granatum have been used to treat inflammation, c…

Suman Samaddar, Raju Koneri, Joseph Vinod Varre, Deepak Kumar Jha

pp. 511–520 · DOI: 10.5530/ijper.53.3.83 · 2019

Background: Momordica tuberosa, belonging to the family Cucurbitaceae, is a tropical plant that is widely cultivated in the southern states of India. Objectives: Momordica tuberosa possesses a saponin, triterpenoid in na…

Md Azizur Rahman, Juber Akhtar, Sahabjada Sahabjada, Md Arshad, Md Mujahid

pp. 521–526 · DOI: 10.5530/ijper.53.3.84 · 2019

Background: Prostate cancer is the second foremost cause of cancer death in Western males, the progression of which may be a consequence of defect in apoptotic machinery. Objective: Thus, aim of the study was designed to…

Vijay Sharma, Kamla Pathak

pp. 527–536 · DOI: 10.5530/ijper.53.3.85 · 2019

Background: The study investigated the efficacy of Liquisolid Curcumin (LSC) over curcumin for gastroprotective action against ethanol induced acute gastric ulcers and the modulation of endogenous oxidative stress marker…

Gajanand Revanna Siddappa Pujari, Vijayalakshmi Subramanian, Suresh Rangogi Rao

pp. 537–544 · DOI: 10.5530/ijper.53.3.86 · 2019

Aim: The purpose of this study was to behavioral and neuroprotective efficacy of Celastrus paniculatus Willd. and Sida cordifolia Linn on hippocampus of the brain in kainic acid induced neurodegenerative diseases. Materi…

Katharigatta N. Venugopala, Christophe Tratrat, Sandeep Chandrashekharappa, Mahesh Attimarad, Nagaraja Sreeharsha, Anroop B. Nair, Shinu Pottathil, Rashmi Venugopala, Omar Husham Ahmed Al-Attraqchi, Mohamed A. Morsy, Michelyne Haroun, Bharti Odhav

pp. 545–552 · DOI: 10.5530/ijper.53.3.87 · 2019

Background: Several promising compounds against multi-drug-resistant Mycobacterium tuberculosis (MTB) are currently in the drug discovery and development pipeline. While it has yet to establish candidature in this pipeli…