Volume 53, Issue 4S

Akhilesh Dubey, Bhasini Kotian, Ravi Gundadka Shriram

pp. s451–s459 · DOI: 10.5530/ijper.53.4s.138 · 2019

Background: To fulfil the objective of fast-tracking the accessibility of new drugs and promoting clinical research in India, the Union Ministry of Health and Family Welfare, India has notified the “New Drugs and Clinica…

Abhinav Shrivastava, Shila Jain, Puran Lal Sahu, Sangeeta Shukla, Kapendra Sahu

pp. s460–s465 · DOI: 10.5530/ijper.53.4s.139 · 2019

Background: Androgenic Anabolic Steroids (AAS) are also synthetic derivatives of testosterone, modified to improve its anabolic actions. The misuse of AAS is of particular concern in sports and society. Gas chromatograph…

Kalikrishna Praveen Gadde, Angel Treasa Alex, Alex Joesph

pp. s466–s474 · DOI: 10.5530/ijper.53.4s.140 · 2019

A topical drug-delivery system is the most accepted drug delivery system. One of the pre-requisites for a topical formulation is its ability to penetrate the skin membrane to elicit the intended action. Many in vitro ski…

Job Herman Berkhout, Aswatha Ram HN

pp. s475–s480 · DOI: 10.5530/ijper.53.4s.141 · 2019

The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, usi…

Sreerama Krupanidhi

pp. s481–s486 · DOI: 10.5530/ijper.53.4s.142 · 2019

Background: Phage Display Technology is an advanced version of rDNA and hybridoma technologies with simplicity in its procedure and production of desired therapeutics and biocontrol products. In this context, the filamen…

Yahaya Hassan, Ahmed Alaa Al-Temimi, Rizwan Ramli, Mohd Firdaus M. Saad, Noorizan A. Aziz

pp. s487–s499 · DOI: 10.5530/ijper.53.4s.143 · 2019

Background: Compliance is commonly and always being confused with concordance, which is a process by which a patient and health care provider make discussion and decisions together about treatment and their outcomes. Gen…

Victoria Vladimirovna Fedotova, Dmitry Alexeevich Konovalov

pp. s500–s509 · DOI: 10.5530/ijper.53.4s.144 · 2019

This review presents data on the current propolis research in Russia. The chemical composition, color, aroma and appearance of propolis are influenced by natural and climatic factors, the collection region and the origin…

Rabbani Syed Imam

pp. s510–s517 · DOI: 10.5530/ijper.53.4s.145 · 2019

Monosodium Glutamate (MSG) is a common food additive used in processed foods to enhance the taste. The data available on Google scholar, NCBI, PUBMED, EMBASE, Wang fang databases, meta-analysis and Web of Science were re…

Sai Krishna Gudi, Manik Chhabra, Muhammed Rashid

pp. s518–s521 · DOI: 10.5530/ijper.53.4s.146 · 2019

Hepatitis C Virus (HCV) is a highly diverse and pervasive disease around the globe, with a prevalence ranging from 1.5 to 2.3%. With wide genetic variability, it is classified into seven Genotypes (GT) with 67 subtypes. …

Venkata Deepthi Vemuri, Srinivas Lankalapalli

pp. s522–s538 · DOI: 10.5530/ijper.53.4s.147 · 2019

Pharmaceutical co-crystals have conferred significant recognition in recent past as a new solid form by virtue their capability to modulate physicochemical properties of Active Pharmaceutical Ingredient (API). Neverthele…

Priyanka Sangar, Bandgar Sandip, Shelake Sardar, Patil Pravin, Bhagwat Durgacharan, Patil Shitalkumar

pp. s539–s547 · DOI: 10.5530/ijper.53.4s.148 · 2019

Introduction: At present days there was considerable attention has been taken to develop lipid based pharmaceutical preparation which improves solubility as well as permeability leads to improve oral bioavailability of p…

Shirsath Nitin Rajendra, Jagtap Vaibhavkumar, Goswami Ajaygiri Kamalgiri

pp. s548–s553 · DOI: 10.5530/ijper.53.4s.149 · 2019

Background: Famotidine is BCS class II drug having a low aqueous solubility and low oral bioavailability. It needs to develop into its novel form for solubility and dissolution rate enhancement. Materials and Methods: Th…

Rudra Narayan Sahoo, Ananya De, Vishal Kataria, Subrata Mallick

pp. s554–s562 · DOI: 10.5530/ijper.53.4s.150 · 2019

Background: Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver. Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) techn…

Prabhakar Panzade, Giridhar Shendarkar

pp. s563–s570 · DOI: 10.5530/ijper.53.4s.151 · 2019

Introduction: Pharmaceutical cocrystal is an endowed approach to augment solubility and dissolution of drugs with limited aqueous solubility. Zaltoprofen is a nonsteroidal anti-inflammatory drug with prevailing solubilit…

Vania Rachael Fonseca, Prashant Jivaji Bhide, Madhusudan Purushottam Joshi

pp. s571–s579 · DOI: 10.5530/ijper.53.4s.152 · 2019

Introduction: Etoricoxib is a poorly water-soluble oral NSAID and is associated with a number of complications such as bleeding, ulcers and dyspepsia but these can be overcome by delivering the drug topically. Objectives…

Rasmita Dash, Rudra Narayan Sahoo, Souvik Nandi, Rakesh Swain, Subrata Mallick

pp. s580–s586 · DOI: 10.5530/ijper.53.4s.153 · 2019

Background and Objectives:Ornidazole is widely used as an antiprotozoal and antiamoebic drug and its onset of action is within 2 h. The major extent of the drug is metabolized in the liver and excreted in the urine and f…

Annie Pereira, Anand Panchakshari Gadad, Archana Sidagouda Patil, Panchakshari Mallappa Dandagi

pp. s587–s595 · DOI: 10.5530/ijper.53.4s.154 · 2019

Ramipril, potent anti-hypertensive agent has been used in the treatment of hypertensive disorders. It has low bioavailability of 28-35% and short biological half-life (i.e. 2-4 hr). Thus this study attempts to evaluate c…

Nagaraja SreeHarsha, Jagadeesh G Hiremath, Bimlesh Kumar Rawre, Niranjan Puttaswamy, Bandar E Al-Dhubiab, Katharigatta N. Venugopala, Sabah H Akrawi, Girish Meravanige, Mahesh Attimarad, Anroop B Nair

pp. s596–s606 · DOI: 10.5530/ijper.53.4s.155 · 2019

Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side …

Pushpendra Singh, Mohammad Yasir, Rahul Shrivastava

pp. s607–s618 · DOI: 10.5530/ijper.53.4s.156 · 2019

Aim/Background: Snakebites are generally a neglected tropical disease that have harmful impact on thousands of people globally. Although antiserum therapy is the only management available for snakebites, several side eff…

Vasudeva Murthy Sindgi, Mounika Basani, Pragna Choudary, Kashinath Molugu, Ramesh Malothu

pp. s619–s623 · DOI: 10.5530/ijper.53.4s.157 · 2019

Aim: This paper describes about the new non-invasive method to measure brain waves from the scalp of the rats. The method allows to record good quality Electroencephalogram (EEG) from freely moving rats in the cage. Meth…