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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Experimental Data of Fabricated Co-crystals of Doxorubicin HCl with Flavonoids

Prasanna Laxmi1, Abhishek Varma1, Aravind Pai2, Muddukrishna Badamane Sathyanarayana1★★ Corresponding author

  1. 1Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher.
  2. 2Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education.

CORRESPONDENCE

Muddukrishna Badamane Sathyanarayana

Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher.

krishna.mbs@manipal.edu

Received: 18-03-2019; Revised: 14-06-2019; Accepted: 27-06-2019.

Volume 53, Issue 3S · pp. s225–s230 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.3s.91

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ABSTRACT

Objectives: This current research work aimed for improvement of the solubility and permeability of poorly permeable Doxorubicin HCl through generating co-crystals. The main goal for the preparation of oral drugs is to decrease the overall cost of healthcare and route of administration is made easy. Methodology: In this study co-crystals of Doxorubicin HCl with Quercetin hydrate and Naringin has been prepared based on ease of hydrogen bond formation. The co-crystal batches of Doxorubicin HCl-Quercetin hydrate in ratio 1:1, 1:2, 2:1 and Doxorubicin HCl-Naringin in ratio 1:1 are prepared by slow solvent evaporation technique. Results and Discussion: The formation of co-crystal was confirmed by PXRD, DSC and FTIR. Doxorubicin HCl with Naringen crystal batch show improved solubility. The dynamic solubility of Doxorubicin HCl-Naringin co-crystal in the ratios 1:1 increased by approximately 9.2-fold as compared to pure drug and Doxorubicin HCl -Quercetin hydrate cocrystal batches.

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    Laxmi, P., Varma, A., Pai, A., & Sathyanarayana, M. B. (2019). Experimental Data of Fabricated Co-crystals of Doxorubicin HCl with Flavonoids. Indian Journal of Pharmaceutical Education and Research, 53(3S), s225–s230. https://doi.org/10.5530/ijper.53.3s.91