Volume 53, Issue 3S

2019 · pp. s255–s263 · 28 articles

Volume: 53
Issue: 3S
Published: 2019
Pages: s255–s263
Articles: 28
Sections: 1
ISSN: Online - 0019-5464
Journal: IJPER

Original Article

In this issue

Original Article

Article
Systematic Development with Quality by Design Approach of Effervescent Floating Multiple Unit Minitablets of Metoprolol Succinate using Hydrophobic Grade of Gelucire
Santosh Kumar Panda, Manoranjan Sahu, Kahnu Charan Panigrahi, Chinam Niranjan Patra
pp. s213–s224 · DOI: 10.5530/ijper.53.3s.90 · Published 2019
Objective:The objective of this study was to systematically develop with Quality by Design (QbD) approach of Effervescent Floating Multiple unit Minitablets (EFMM) of metoprolol succinate (MS) for once-a-day dosing using…
Article
Experimental Data of Fabricated Co-crystals of Doxorubicin HCl with Flavonoids
Prasanna Laxmi, Abhishek Varma, Aravind Pai, Muddukrishna Badamane Sathyanarayana
pp. s225–s230 · DOI: 10.5530/ijper.53.3s.91 · Published 2019
Objectives: This current research work aimed for improvement of the solubility and permeability of poorly permeable Doxorubicin HCl through generating co-crystals. The main goal for the preparation of oral drugs is to de…
Article
Solubility Augmentation of Simvastatin by using the Marvelous Carrier Hydroxy Propyl β-cyclodextrin: Compatibility Study, Statistical and Spectral Analysis
Disha Kesharwani, Sandhya Mishra, Swarnali Das Paul, Rishi Paliwal, Trilochan Satapathy
pp. s231–s238 · DOI: 10.5530/ijper.53.3s.92 · Published 2019
Objective:The poor solubility which causes the poor bioavailability of simvastatin is an arduous task for the preparation of oral dosage form, which can be increased by the preparation of solid dispersion. Materials and …
Article
An Innovative Approach in Developing Sustained Release Matrix Tablets using Isolated and Characterized Novel Ceasalpinia sappan L. Seed Galactomannan
Shan Mohanan, Sajan Jose
pp. s239–s245 · DOI: 10.5530/ijper.53.3s.93 · Published 2019
Introduction: The aim of the study is to develop a galactomannan-based drug delivery system. In this work galactomannan, a biocompatible polymer was isolated from a novel plant source. The seeds of the indigenous plant C…
Article
Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: In vitro in vivo Evaluation
Daphisha Marbaniang, Ratna Jyoti Das, Paulami Pal, Ananta Saikia, Manash Pratim Pathak, Santa Mandal, Nilutpal Sharma Bora, Anup Kumar Das, Pronobesh Chattopadhyay, Subhabrata Ray, Bhaskar Mazumder
pp. s246–s254 · DOI: 10.5530/ijper.53.3s.94 · Published 2019
Aims: Microballoons are floating particulate system comprising of a hollow core, drug being loaded within the polymeric layer. The aim of the study was to prepare microballoons containing extract of Clerodendrum colebrok…
Article
Evaluation of Bioactive Metabolites Isolated from Endophytic Fungus Chaetomium cupreum of the Plant Mussaenda luteola
Gunasekaran Shylaja, Arunachalam Sathiavelu
pp. s255–s263 · DOI: 10.5530/ijper.53.3s.95 · Published 2019
Background: Endophytic fungi are one of the most promising resources of natural bioactive products. In the present study, secondary metabolites were isolated from the endophytic fungus Chaetomium cupreum and evaluated in…
Article
Investigations on Apoptotic Activities of Cherry Laurel Extracts in HCT-116 Human Colon Carcinoma Cells
Bilal Çakir, İbrahim Gülseren
pp. s264–s272 · DOI: 10.5530/ijper.53.3s.96 · Published 2019
Background: Cherry laurel fruits are characterized by their dark color and rich phenolic contents. Previously, phenolic extracts from cherry laurel varieties were shown to demonstrate anti-proliferative activities agains…
Article
Pharmacokinetic and Pharmacodynamics Interaction between Syzygium cumini and Glipizide: Role of Cytochrome P450 Enzyme
Sugandha Chaudhari, Shitalkumar Zambad, Mohammed Ali
pp. s273–s279 · DOI: 10.5530/ijper.53.3s.97 · Published 2019
Background: Concomitant administration of herbs and synthetic drugs causes pharmacokinetic and pharmacodynamic interactions. Objectives: To investigate pharmacokinetic and pharmacodynamic interactions between Syzygium cu…
Article
Antibacterial Activity with Bacterial Growth Kinetics and GC-MS Studies on Leaf and Tuber Extracts of Arisaema tortuosum (Wall.) Schott
Kamal Kant, Uma Ranjan Lal, Manik Ghosh
pp. s280–s287 · DOI: 10.5530/ijper.53.3s.98 · Published 2019
Background: Pathogenic bacteria (Gram positive/Gram negative) are serving as a vital precursor for the development of infectious diseases in humans. Arisaema tortuosum (Wall.) Schott (ATWS), a famous folklore medicine of…
Article
Pharmacoinformatic Studies on 4-Thiazolyl-phenoxy Tail Containing Indanyl Acetic Acid Derivatives as PPAR-Pan Agonists as Potent Anti-Diabetic Agent
Neha Verma, Usha Chouhan
pp. s288–s298 · DOI: 10.5530/ijper.53.3s.99 · Published 2019
Aim: The increasing incidences of type 2 diabetes mellitus, represents a considerable public health problem and characterized by loss in sensitivity of tissues to insulin which can be restored by activation of Peroxisome…
Article
Fingerprint Based Two-dimensional QSAR Studies on Pyrazolo Quinazolines as CDK2 Inhibitors: A Rational Approach for the Design of Novel Anticancer Agents
Aravinda Pai, Jayashree B.S
pp. s299–s312 · DOI: 10.5530/ijper.53.3s.100 · Published 2019
Aim/Background: Quantitative structure activity relationship studies are important ligandbased methods used in drug discovery process. The development of Quantum mechanics and its application in the study of smaller and …
Article
Design, Synthesis and Biological Evaluation of Novel Piperidinyl Chalcones
Aravinda Pai, B.S. Jayashree
pp. s313–s324 · DOI: 10.5530/ijper.53.3s.101 · Published 2019
Aim/Background: Chalcones are one of the important class of compounds possessing a wide range of biological properties [Dinmock 1999, Go 2005]. One of the extensive area in research on chalcones is expressed in terms of …
Article
Molecular Docking Studies of Novel Furan-azetidinone Hybrids as Potential Inhibitors of Escherichia coli
Judy Jays, Shamanna Mohan, Janardhanan Saravanan
pp. s325–s331 · DOI: 10.5530/ijper.53.3s.102 · Published 2019
Escherichia coli is the predominant gram negative bacteria responsible for a variety of hospital-acquired infections and urinary tract infections. As the bacterial strains are rapidly acquiring resistance to the availabl…
Article
In silico Docking Analysis of Active Biomolecules from Cissus quadrangularis L. against PPAR-γ
Vishal Shivalingappa Patil, Prakash Rajashekhar Biradar, Vasim Attar, Pukar Khanal
pp. s332–s337 · DOI: 10.5530/ijper.53.3s.103 · Published 2019
Introduction: Thiazolidinedione’s are widely used synthetic antidiabetic agents. These agents affect the pumping power of heart muscle due to the formation of edema; limiting their usage in patients with congestive heart…
Article
New Bioanalytical HPLC Method for the Determination of Cyproheptadine Hydrochloride in Human Plasma and its Application to Rat Pharmacokinetic Study
Sadhana Jangbahadur Rajput, Mansi Anuj Sathe
pp. s338–s346 · DOI: 10.5530/ijper.53.3s.104 · Published 2019
Background: Cyproheptadine HCl is a serotonin antagonist and histamine H1 blocker agent. Objective: The objective of the present work was to establish a rapid, sensitive and validated bioanalytical HPLC method using Liqu…
Article
32 Factorial Design for Optimization of HPLC-UV Method for Quantification of Gallic acid in Lohasava and Pippalyasava
Ashiyana Mansuri, Sonal Desai
pp. s347–s355 · DOI: 10.5530/ijper.53.3s.105 · Published 2019
Background: A new, simple, accurate and precise High Performance Liquid Chromatographic method (HPLC-UV) has been developed and validated in accordance with ICH guidelines for the determination of gallic acid in Lohasava…
Article
Development, Optimisation and Validation of RP-HPLC Method for the Quantification of Resveratrol
Aarti Abhishek Shah, Yogendra Nayak
pp. s356–s363 · DOI: 10.5530/ijper.53.3s.106 · Published 2019
Background: Trans-resveratrol is a naturally occurring polyphenolic compound extensively marketed as a nutraceutical. It is highly explored molecule in the research community with vast therapeutic potential. Therefore, m…
Article
Simultaneous Determination of Canagliflozin and Metformin in Human Plasma by LC–MS/MS Assay and its Application to a Human Pharmacokinetic Study
Muralikrishna Ramisetti, Lakshmana Rao Atmakuri, Basaveswara Rao Mandava Venkata, Vinayender Adireddy
pp. s364–s372 · DOI: 10.5530/ijper.53.3s.107 · Published 2019
Objective: The main objective of this work was to develop a simple, rapid and sensitive liquid chromatography/tandem mass spectrometry (LC–MS/MS) method for the simultaneous quantification of Canagliflozin and Metformin.…
Article
Method Development and Validation of Ciprofloxacin HCl and Ornidazole by UFLC in Combined Dosage Form
Palled Mahesh Shivabasappa, Hadaki Diksha, Mahendra Kumar Chouhan, Sunil Satyappa Jalalpure, Shailendra Suryawanshi Sanjay
pp. s373–s379 · DOI: 10.5530/ijper.53.3s.108 · Published 2019
Background: The combination of Ciprofloxacin and Ornidazole is used for the effective treatment of intra-abdominal infections. Many branded and generic combined dosage formulations of Ciprofloxacin and Ornidazole are ava…
Article
Method Development and Validation for Quantitative Estimation of Calcium Acetate in Calcium Acetate Capsules by RP-HPLC using Indirect UV Method
Rajesh Kumar Chawla, Subhranshu Panda, Kulandaivelu Umasankar, Siva Prasad Panda, Dalu Damayanthi
pp. s380–s386 · DOI: 10.5530/ijper.53.3s.109 · Published 2019
Objective:A simple, accurate and economical method has been developed by Reverse Phase High Performance Liquid Chromatography (RP-HPLC) using indirect UV (Ultra Violet) method. The Principle behind the indirect UV method…
Article
Evaluation of Alpha Glucosidase Inhibitor (Miglitol) for its Efficacy in Constipation Associated with Diabetes
Yogesh Kumar, Ajit Kumar Thakur, Ramesh Kishorilal Goyal
pp. s387–s391 · DOI: 10.5530/ijper.53.3s.110 · Published 2019
Objectives: Recently, miglitol emerged as effective α-glucosidase inhibitor for the treatment of diabetic mellitus with specific advantages over currently available class of antidiabetic drugs. The aim of the present stu…
Article
Neuroprotective Effect of Carica papaya Leaf Extract against Aluminium Toxicity: An Experimental Study on Cognitive Dysfunction and Biochemical Alterations in Rats
Kalluri Hima Bindhu, Arumugam Vijayalakshmi
pp. s392–s398 · DOI: 10.5530/ijper.53.3s.111 · Published 2019
Objective:To study the protective role of alcoholic leaf extract of Carica papaya in aluminium induced cognitive dysfunction and oxidative damage in albino rats and to explore the neuroprotective effect of Carica papaya …
Article
The Role of Lifestyle Choices among Female Patients for Prevention of Coronary Artery Disease
Vinay Krishna, Pranay Wal, Umeshwar Pandey, Ankita Wal, Pinki Rawat, Vivek Kumar
pp. s399–s403 · DOI: 10.5530/ijper.53.3s.112 · Published 2019
Objectives: There was limited data available regarding the effect of daily lifestyle choices in female patients suffering from Coronary Artery Disease (CAD). It had been found that lifestyle played a critical role in the…
Article
Thyroid Health and its Correlation to Female Fertility: A Pilot Study
Havagiray Revanappa Chitme, Eman Al Azawi, Maryam Khamis Al Farsi, Dahlia Mohammed Abdul Jalil, Muzna Salim Al Hadhrami
pp. s404–s415 · DOI: 10.5530/ijper.53.3s.113 · Published 2019
Background: Most of the problems in female reproductive system are due to dysfunction in hypothalamic-pituitary-ovarian axis. Our study is evaluating thyroid profile in the presence and absence of autoantibodies and how …
Article
Wound Healing Activity of Gel Formulated Leaves Extract of Neolamarckia cadamba (Roxb) Bosser
Shruti Nayan, Chanchal Kumar Mishra, Divya Priyadarshini, Kishanta Kumar Pradhan, Manik Ghosh, Ashok Pattnaik
pp. s416–s422 · DOI: 10.5530/ijper.53.3s.114 · Published 2019
Background: Wound occurs when integrity of the skin is compromised. Healing of wounds occur in various phases namely hemostasis, inflammation, proliferation, granulation, contracture remodelling. Neolamarckia cadamba lea…
Article
Synthesis and Evaluation of Insecticidal Activity of Bis-Semicarbazones and Bis-(5-Aryl Substituted-1, 3, 4-Oxadiazole)
Veerabhadraswamy Maruthyunjaya, Bhimashankar B Molkere, Prashantha Karunakar
pp. s423–s432 · DOI: 10.5530/ijper.53.3s.115 · Published 2019
Background: Various substituted semicarbazones and oxadiazols have been widely investigated for their insecticidal and pharmacological activities. Heterocyclic analogs of these types were extensively studied for their bi…
Article
Pharmacological Modulation of Flavivirus Methyltransferase Activity of Dengue Virus (DEV)
Afaf Salim Alwabli, Sana Ghazi Alattas, Alawiah Mohammad Alhebshi, Nidal Mohammed Zabermawi, Fatima Kaneez, Esam Ibraheem Azhar, Naseer Alkenani, Khalid Al-Ghmady, Ishtiaq Qadri
pp. s433–s436 · DOI: 10.5530/ijper.53.3s.116 · Published 2019
Background: The occurrence of dengue fever plagues has expanded significantly in the course of the most recent couple of decades. Be that as it may, no immunization or antiviral treatments are accessible. In this manner,…
Article
In-silico Designing, Synthesis, SAR and Microbiological Evaluation of Novel Amide Derivatives of 2-(3-methylbenzo[b]thiophen-6-yl)-1- (3-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylic Acid
Tanuj Hooda, Sunil Sharma, Naveen Goyal
pp. s437–s450 · DOI: 10.5530/ijper.53.3s.117 · Published 2019
Aim/Background: Due to this increasing problem of antibiotic resistance, the number of different antibiotics available is dwindling and there are only a handful of new antibiotics in the drug development pipeline. Theref…