jrnls.org logo
Submit

BROWSE ALL JOURNALS

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: In vitro in vivo Evaluation

Daphisha Marbaniang1★, Ratna Jyoti Das1, Paulami Pal1, Ananta Saikia2, Manash Pratim Pathak1,3, Santa Mandal3,4, Nilutpal Sharma Bora1,3, Anup Kumar Das5, Pronobesh Chattopadhyay3, Subhabrata Ray6, Bhaskar Mazumder1★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.
  2. 2Pratiksha Institute of Pharmaceutical Sciences, Panikhaiti, Assam, INDIA.
  3. 3Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur, Assam, INDIA.
  4. 4School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh, INDIA.
  5. 5Department of Pharmaceutical Technology, Adamas University, Barasat, West Bengal, INDIA.
  6. 6Dr. B.C.Roy College of Pharmacy and Allied Health Sciences, Bidhan Nagar, Durgapur, West Bengal, INDIA.

CORRESPONDENCE

Daphisha Marbaniang

Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, Assam, INDIA.

daphishamarbaniang@gmail.com

Received: 21-12-2018; Revised: 29-03-2019; Accepted: 28-06-2019.

Volume 53, Issue 3S · pp. s246–s254 · PUBLISHED 2019 · DOI: 10.5530/ijper.53.3s.94

View on IJPER original site ↗

ABSTRACT

Aims: Microballoons are floating particulate system comprising of a hollow core, drug being loaded within the polymeric layer. The aim of the study was to prepare microballoons containing extract of Clerodendrum colebrokianum, as bioactive agent. Methods: The microballoons were prepared by solvent diffusion technique, prepared microballoons were physico-chemically characterized (Scanning Electron Microscopy (SEM), buoyancy determination, entrapment efficiency, etc), in vitro drug release study and estimated for its in vivo antihypertensive activity by 2K1C hypertension induction method. Results: SEM confirmed the microballoons to be spherical with porous surfaces and hollow core. The developed formulation showed a buoyancy varying from 70.18%-89.90%. The entrapment efficiency of bioactives in microballoons was found between 52%-69% with a delayed release of maximum 28% in 8 hr as found from in vitro drug release study. In vivo antihypertensive studies carried out in rat model showed C. colebrookianum extract have good antihypertensive activity in both high and low dose with respect to standard propanolol. The formulations containing both doses were further found to be effectual in the treatment of hypertension because of its floating nature. Conclusion: The results suggested that optimized formulation show an effective extended release of Clerodendrum colebrokianum extract for the treatment of hypertension.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Marbaniang, D., Das, R. J., Pal, P., Saikia, A., Pathak, M. P., Mandal, S., Bora, N. S., Das, A. K., Chattopadhyay, P., Ray, S., & Mazumder, B. (2019). Extended Release Floating Microballoons Containing Clerodendrum colebrookianum Extract: In vitro in vivo Evaluation. Indian Journal of Pharmaceutical Education and Research, 53(3S), s246–s254. https://doi.org/10.5530/ijper.53.3s.94