Volume 54, Issue 3

Original Article(continued)

1. Article

   Exploring the Role and Mechanism of Imatinib in Chronic Unpredictable Mild Stress-induced Depression Model of Rats

   Xiaohui Wang, Yajing Li, Yinxue Shen, Dongzi Zhang

   pp. 682–689 · DOI: 10.5530/ijper.54.3.118 · 2020

   Aim: The study was planned to examine the potential effect of imatinib in chronic unpredictable mild stress (CUMS)-induced depression model of rats. Materials and Methods: Male rats were subjected to the 6-week CUMS with…

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2. Article

   Role of Heme Oxygenase- 1(HO-1) and Endothelin-1 (ET-1) in Modulation of Cardioprotective Effect of Ischemic Postconditioning in Diabetic Rat Heart

   Richa Rohilla, Ahsas Goyal, Vibhav Varshney, Bhupesh Chander Semwal, Harlokesh Narayan Yadav

   pp. 690–697 · DOI: 10.5530/ijper.54.3.119 · 2020

   Background: We have recently reported that heme oxygenase-1 (HO-1) is involved in ischemic preconditioning-mediated cardioprotection by promoting nitric oxide (NO) release into diabetic rat heart (DRH). The upregulation …

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3. Article

   Nostocine A Derivatives as Human DNA Topoisomerase II-alpha Inhibitor

   Chita Ranjan Sahoo, Sudhir Kumar Paidesetty, Rabindra Nath Padhy

   pp. 698–704 · DOI: 10.5530/ijper.54.3.120 · 2020

   Introduction: Due to heavy morbidity and mortality from cancer, the designing of newer drugable molecules against breast cancer is the call of day. As, Schiff-base sulfonamides have been widely used in tumor treatments. …

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4. Article

   Bioactivity Guided Antidiabetic Formulation Development of Tridax procumbens Linn Leaves

   Pranali Vijay Bansode, Kiran Shivaji Patil, Ashok Ananda Hajare

   pp. 705–713 · DOI: 10.5530/ijper.54.3.121 · 2020

   Purpose: Diabetes mellitus is a global health problem as it is one of the complex disease and main causes of premature illness and death. The present study was focused to scientifically overcome bioavailability drawbacks…

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5. Article

   Extraction, Identification and Screening of Brassica oleracea var. italica Plenck (Broccoli) Floret to be an Alternative for Nanoparticle Formulations

   Ravindra Chintamani, Kishor Salunkhe, Kiran Kharat, Rudra Pratap Singh, Sonali Diwate

   pp. 724–731 · DOI: 10.5530/ijper.54.3.123 · 2020

   Background: Plant or plant extract act as a source of several abundant natural compounds such as flavonoids, phenolics, alkaloids, steroids, tannins, saponins and other nutritional compounds. The extract not only acts as…

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6. Article

   Mimosa pudica Modulates Neuroactive Ligand- Receptor Interaction in Parkinson’s Disease

   Taaza Duyu, Pukar Khanal, Nayeem Ashrafali Khatib, Basanagouda Mahadevagouda Patil

   pp. 732–739 · DOI: 10.5530/ijper.54.3.124 · 2020

   Introduction: Mimosa pudica is scientifically reported for the enhancement of memory in multiple animal models including Parkinson’s disease (PD); however, the probable molecular mechanism for this effect has not been ex…

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7. Article

   Neuroprotective Effect of Vanda roxburghii Extract in Endothelin-1 (et-1) Induced Hippocampal Ischemic Damage and Ameliorate Cognitive Deficit

   Ravi Mundugaru, Sukrant Sharma, Senthilkumar Sivanesan, Rajesh Thangarajan, Pundalik Rama Naik, Nagesh Raju, Ahmed Alfarhan, Rajakrishnan Rajagopal, Bander AlMunqedhi

   pp. 740–749 · DOI: 10.5530/ijper.54.3.125 · 2020

   Introduction: The concept of neuroprotection gaining considerable interest in search for novel therapy that has potential to preserve brain tissues and improve cognitive functions in ischemic brain damage. In the present…

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8. Article

   New Naphthyl Substituted Phytosterol and Lanostane Type-triterpenic Esters from the Stem Bark of Ficus religiosa L.

   Abuzer Ali, Mohammad Jameel, Mohammed Ali

   pp. 750–754 · DOI: 10.5530/ijper.54.3.126 · 2020

   Background: Ficus religiosa L. (Moraceae) is considered as a holy tree in most of the part of south-eastern Asia. Traditionally, its bark is used in the treatment of burns, diarrhoea, dysentery, gastrohelcosis and gonorr…

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9. Article

   Effect of Apricot Fruit and Kernel Extracts on in-vitro Dissolution of Cholesterol Gallstones: Implication for Development of Potent Anti-cholilithiaticc agent

   Sunita Waila Tiwari, Archana Negi Sah

   pp. 755–760 · DOI: 10.5530/ijper.54.3.127 · 2020

   Prunus armeniaca L. (apricot) belonging to family Rosaceae is an important edible medicinal plant containing many important constituents like polysaccharides, polyphenol, fatty acid and carotenoids. In this study, we att…

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10. Article

    In vivo Anti-diabetic and Anti-hyperlipidemic Activities of ethyl Acetate/Methanol Fractions of Feronia elephantum Fruit in type 2 Diabetic Rats: Via α-amylase and PPAR-γ by using in silico Approach

    Gangavaram Jyothi Reddy, Kesavan Bhaskar Reddy, Gopireddy Venkata Subba Reddy

    pp. 761–770 · DOI: 10.5530/ijper.54.3.128 · 2020

    Background: Obesity and overweight, together with physical inactivity, are projected to cause a huge proportion of the global diabetes burden. Natural products play a key role in the discovery of novel therapeutic agents…

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11. Article

    Novel Quinolone Substituted Imidazol-5(4H)-ones as Anti-inflammatory, Anticancer Agents: Synthesis, Biological Screening and Molecular Docking Studies

    Santosh Kumar, Jignesh C Aghara, Anirudh Manoj, Angel T Alex, Jesil Mathew A, Alex Joesph

    pp. 771–780 · DOI: 10.5530/ijper.54.3.129 · 2020

    Background: Quinolones and imidazolones are important heterocyclic moieties which have been reported to possess potent anti-inflammatory and anticancer properties. The activity of these compounds were related to inhibiti…

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12. Article

    Synthesis, Characterization, Biological and Photoluminescence Study of Co(II) Complexes of Fused Heterocyclic Ring Systems

    Suyambulingam Jone Kirubavathy, Subramanian Chitra

    pp. 781–789 · DOI: 10.5530/ijper.54.3.130 · 2020

    Aim: To synthesize and characterize the transition metal complexes of fused heteroccylic ring systems. Background: Many of the fused ring heterocyclic compounds were found to be biologically active in the literature like…

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13. Article

    Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies

    Shaikh Tanveer Kutubuddin, Shelke Sushil Suresh, Kakde Rajendra Baliram, Lalatsa Aikaterini

    pp. 790–797 · DOI: 10.5530/ijper.54.3.131 · 2020

    Aim: A lucid, rapid and precise stability-indicating method was developed by using HPLC for the estimation of Buparvaquone in bulk as well as pharmaceutical dosage form by forced degradation studies. Materials and Method…

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14. Article

    The Significance of Quality Metrics in a Pharmaceutical Quality Management System – A Case Based Study

    Narayana Charyulu Rompicherla, Edwin Paul, Akshatha Ganesh, Anoop Narayanan V

    pp. 798–808 · DOI: 10.5530/ijper.54.3.132 · 2020

    Background: The pharmaceutical quality management system is a concept of management function that design and implement the “Quality policy”. The pharmaceutical manufacturing industries all over the world have just begun …

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15. Article

    Dynamic Method for Liaison of Community Pharmacists with National Programme for Tuberculosis Control: Efforts to Harness Untapped Opportunities

    Rajeswari Ramasamy, Guru Prasad Mohanta, Shobha Rani R Hiremath, Chandramouli Ramnarayanan, Raman Dang, Manjiri S Gharat

    pp. 809–818 · DOI: 10.5530/ijper.54.3.133 · 2020

    Context: Revised National Tuberculosis Control Program (RNTCP) - Directly Observed Treatment-Short course (DOTS) strategy to involve Community Pharmacist (CPs), was conceived and implemented in India, with the objective …

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16. Article

    Paediatric Focused Triggering Tool (PFTT) To Assess the Harm and its Utilization to Minimize the Levels of Harm among Children at a Tertiary Care Hospital

    Geetanjali Shankarprasad Salimath, Madiwalayya Shivakantayya Ganachari, Manjula Gudhoor

    pp. 819–825 · DOI: 10.5530/ijper.54.3.134 · 2020

    Objectives: Very few paediatric trigger tools have been developed to assess harm in children. Hence, a Paediatric-focused trigger tool has been developed, assess its utility to measure the levels of harm, categorize and …

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17. Article

    Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

    Nagaraja Sreeharsha, Jagadeesh G Hiremath, Bandar E Al-Dhubiab, Girish Meravanige, Ranjith Kumar Karnati, Mahesh Attimarad, Anroop B Nair, Katharigatta N Venugopal, Mohamed A Morsy, Shinu Pottathil, Saleemmulla Khan, Nagashekhara Molugulu

    pp. 826–834 · DOI: 10.5530/ijper.54.3.135 · 2020

    Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer. Methods: The cyl…

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