Volume 55, Issue 3

Original Article

1. Article

   Gel-forming Mucins in Oviductus Ranae Contribute to Swelling Capacity by iTRAQ Proteomics Analysis

   He Zhang, Yuyao Zhang, Chunhui Yang, Wenjie Su, Daian Pan, Daqing Zhao, Li Jing, Bin Qi

   pp. 638–648 · DOI: 10.5530/ijper.55.3.135 · 2021

   Introduction: Oviductus Ranae (OR) is the dried oviduct of female Rana temporaria chensinensis David, which is one of the best-known and highly valued oriental foods and medicines in China. OR has a unique physiological …

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2. Article

   Model-based Instruction as an Activity in Teaching a Pharmaceutics Course

   May Almukainzi

   pp. 649–654 · DOI: 10.5530/ijper.55.3.136 · 2021

   Objectives: Pharmaceutics is the core component of pharmacy education; the course helps pharmacy students to understand the influence of drugs' physicochemical characteristics and manufacturing parameters on therapeutic …

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3. Article

   Blended Teaching Practices for Active Learning in Higher Pharmacy Education

   Wenyuan Liu, Xinzhu Gao, Lingfei Han, Jing Liu, Feng Feng

   pp. 655–663 · DOI: 10.5530/ijper.55.3.137 · 2021

   Background: Blended adoption of active learning practices improves student achievement on average in college. Nevertheless, there have been few studies to date on the effects of detailed factors on learning outcomes. Obj…

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4. Article

   Self-nanoemulsifying Drug Delivery System of Cilnidipine

   Monica Raghavendra Prasad Rao, Sayali Kulkarni, Ashwini Sonawane, Sayali Sugaonkar

   pp. 664–676 · DOI: 10.5530/ijper.55.3.138 · 2021

   Aim: Self-nanoemulsifying Drug Delivery Systems (SNEDDS) are physically stable, isotropic mixtures of oil, surfactant and co-surfactant. The turbulence generated by peristaltic movements of the GIT causes formation of oi…

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5. Article

   Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate

   Sagar Kumar Mohapatra, Rudra Narayan Sahoo, Subrata Mallick, Rajaram Mohapatra

   pp. 677–684 · DOI: 10.5530/ijper.55.3.139 · 2021

   Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but …

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6. Article

   Development of a Novel Ionic Liquid Based Microemulsion System for Gemcitabine Hydrochloride and in vitro Evaluation in Human Cervical Cancer HeLa Cells

   Yuanyuan Chen, Juan Li

   pp. 685–691 · DOI: 10.5530/ijper.55.3.140 · 2021

   Aim: The aim of this study was to develop novel ionic liquid based microemulsion systems and assessing the in vitro activity against HeLa cancer cell line. Materials and Methods: Four imidazaolium cation based ionic liqu…

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7. Article

   Formulation of Tablets Containing Mesoporous Silica Nanoparticles Loaded with Pramipexole

   Christina Voycheva, Teodora Popova, Marta Slavkova, Diana Tzankova, Borislav Tzankov

   pp. 692–700 · DOI: 10.5530/ijper.55.3.141 · 2021

   Background: In order to develop final pharmaceutical product, the mesoporous silica particles loaded with pramipexole should be further formulated in the applicable solid dosage forms - tablets. The aim of the study was …

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8. Article

   Design of Experiments for Critical Material Attributes Assessment of Linagliptin and Metformin Fixed-dose Combination Tablets

   Kang Min Kim

   pp. 701–708 · DOI: 10.5530/ijper.55.3.142 · 2021

   Aim of work: This study aimed to determine the amount of excipients in the critical material attributes of linagliptin and metformin sustained release (SR) fixed-dose combination (FDC) tablets using design of experiments…

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9. Article

   Oral Delivery of Purple Sweet Potato (Ipomoea batatas L.) Extract-Loaded Carboxymethyl Chitosan and Alginate Nanocapsule in Streptozotocin-induced Diabetic Mice

   Reny I'tishom, Ifan Ali Wafa, David Setyo Budi, Nando Reza Pratama

   pp. 709–714 · DOI: 10.5530/ijper.55.3.143 · 2021

   Background: Insulin therapy is an essential part in diabetes mellitus type 2 treatment, but it has several side effects such as allergy and hypoglycemia. Therefore, alternative treatments are needed, one of which is by u…

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10. Article

    QBD Approach to Predict the in-vivo Performance Based on in-vitro Results using Mucuna pruriens Seed Mucilage as a Novel Tablet Dosage Form Excipient and Dicofenac Sodium as Model drug Candidate

    Gitanjali Sambhajirao Deokar, Harshada Dnyandeo Kakulte, Sanjay Jayprakash Kshirsagar, Dnyaneshwar Ramnath Waghchoure

    pp. 715–727 · DOI: 10.5530/ijper.55.3.144 · 2021

    Background: Aim of the present study was to put forth certain modifications in Quality by design approach to predict the in-auto performance of dosage form based on in-vivo performance parameter simulation using in-vitro…

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11. Article

    Formulation and Evaluation of Sodium Alginate and Guar Gum Based Glycyrrhizin Loaded Mucoadhesive Microspheres for Management of Peptic Ulcer

    Ranjit Kumar Harwansh, Rohitas Deshmukh

    pp. 728–737 · DOI: 10.5530/ijper.55.3.145 · 2021

    Background: Glycyrrhizin (GZ) is a bioactive ingredient of Glycyrrhiza glabra, reported for various therapeutic effects including gastro-protection. It has been associated with low absorption, early elimination, short ha…

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12. Article

    Coordinated Androgen and Estrogen-receptor microRNA 26 Directive in Breast and Prostate Tumour

    Santosh Fattepur, Kiran Chanabasappa Nilugal, Ibrahim Abdullah, Nagaraja Sreeharsha, Md. Khalid Anwer, Syed Mohammed Basheeruddin Asdaq

    pp. 738–747 · DOI: 10.5530/ijper.55.3.146 · 2021

    MiR-26 is a miRNA tumour suppressor that is frequently dysregulated in many tumour tissues and lines of tumour cells. Androgen and Estrogen receptor (AR & ER) were evolving as a target to examine among hormone proteins s…

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13. Article

    Stimulation of Cell Mediated Immune Response by Protein Hydrolysate from Porphyra yezoensis

    Kalkooru Lakshminarayanan Venkatraman, Azeemullah Azmathullah Syed, Alka Mehta

    pp. 748–755 · DOI: 10.5530/ijper.55.3.147 · 2021

    Aim: To investigate the immunomodulatory effects of the protein hydrolysate from Porphyra yezoensis. Objectives: In this study, the in vitro immunomodulatory effects of protein hydrolysate of Porphyra yezoensis was studi…

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14. Article

    Exploring the Neuroprotective Effects of Mechanosensitive Channel Blocker, GsMTX4 in Intracerebral Hemorrhage Model in Rats

    Wenyan Liu, Guiyu Zhang, Jin Wang, Jing Liu, Yu Yuan, Jun Hong, Yi Ding

    pp. 756–764 · DOI: 10.5530/ijper.55.3.148 · 2021

    Aim: The current study explored the usefulness of a mechanosensitive channel blocker, GsMTX4 in intracerebral hemorrhage (ICH)-associated deleterious effects along with the possible mechanisms. Materials and Methods: Typ…

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15. Article

    Network Pharmacology-based on the Active Components and Molecular Mechanisms of Andrographis paniculata (Burm. f.) Wall. ex Nees in Treating Inflammation

    Wen-ping Xiao, Wan-ju Zhang, Xu-jie Xiong, Lan-ying Xu

    pp. s765–s773 · DOI: 10.5530/ijper.55.3.149 · 2021

    Background: Andrographis paniculata (Burm. f.) Wall. ex Nees (AP) is a medicinal plant traditionally used as anti-inflammation and anti-bacteria. The role of AP in inflammation has been evaluated in several studies. But,…

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16. Article

    Evaluation of in-vitro Immunomodulatory Activity and Thrombolytic Potential of Kabasura Kudineer (KSK): An Official Siddha Polyherbal Formulation

    Sathiyarajeswaran Parameswaran, Shree Devi Munusamy Sampangi Ramulu, Vishnu Kirthi Arivarasan, Kanakavalli Kadarkarai, Ramesh Kumar Dhanakoti, Karthik Loganathan

    pp. 774–781 · DOI: 10.5530/ijper.55.3.150 · 2021

    Aim: Coronavirus disease 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), attacking mainly on the immune system of a body. This has spread mortality and morbidity all over the w…

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17. Article

    Protective Effects of Small Peptides from Periplaneta americana on Cyclophosphamide-induced Oxidative Stress in Rat Ovaries

    Qin Wang, Caihua Kong, Kena Liu, Rong Fu, Huaxin Si, Shiyan Sui

    pp. 782–792 · DOI: 10.5530/ijper.55.3.151 · 2021

    Introduction: Periplaneta americana (P. americana), commonly known as the American cockroach, has shown multiple clinical benefits. Small Peptides from P. americana (SPPA) was found to have promising antioxidative effect…

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18. Article

    Assessment of Antioxidant Activity of Crude and Purified Bio-active Compound, Embelin in Aegiceras corniculatum (L.) Blanco: A Less-explored Mangrove Plant

    Manisha Mohapatra, Uday Chand Basak

    pp. s793–s800 · DOI: 10.5530/ijper.55.3.152 · 2021

    Context: Most of the Mangrove species are vital basically in terms of economic, environmental and medicinal point of view as several Mangrove species are used for preparation of many drug formulations. In this aspect, Ae…

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19. Article

    Biosynthesized Silver Nanoparticles (AgNPs) from Trapa natans Peel Extract Exhibits Anti-Metastasis and Anti-Biofilm Potentials

    Adyasa Samantaray, Debasish Pradhan, Bandana Behera

    pp. 801–811 · DOI: 10.5530/ijper.55.3.153 · 2021

    Background: This study deals with the anti-metastasis and anti-biofilm activities using silver nanoparticles (AgNPs) against human breast cancer cells (MCF-7) via in vitro methods. Different studies have been reported th…

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20. Article

    Phytochemical Profiling and in vitro Screening for Neuritogenic and Antioxidant Activities of Spirulina platensis

    Ee-Ling Ngu, Chen-Lin Ko, Cheng-Yau Tan, Kah-Hui Wong, Siew-Moi Phang, Yoon-Yen Yow

    pp. 812–822 · DOI: 10.5530/ijper.55.3.154 · 2021

    Background: In neurological diseases, neuronal loss is frequently associated with overproduction of free radicals and reduced level of endogenous neurotrophic factors. The blue-green microalga, Spirulina platensis is a w…

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