Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery
Muhammad Adnan Faisal Saim1, Lubna Bashir1, Shazia Naz1, Sana Ghayas2★, Rabia Bushra2, Zubair Anwar3★, Syed Akif Uddin1, Ubedullah Korai1★ Corresponding author
- 1Department of Pharmaceutics, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Gulshan Campus.
- 2Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Science, Karachi, PAKISTAN.
- 3Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Gadap Road, Karachi, PAKISTAN.
CORRESPONDENCE
Sana Ghayas
Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Science, Karachi, PAKISTAN.
Received: 02-03-2021; Revised: 09-09-2021; Accepted: 04-10-2021.
Volume 56, Issue 1S · pp. S67–S74 · PUBLISHED 2022 · DOI: 10.5530/ijper.56.1s.44
ABSTRACT
The role of Proniosomes in oral controlled drug delivery system is well accepted. Presently, an attempt was made to develop cephradine (CP) Proniosomes to prolong its duration of action with better efficacy. Overall, eighteen formulation trials were developed using variable quantities of sorbitol (F0S-F8S) and maltodextrin (F0M-F8M) carriers along with span60 and cholesterol. Trials were evaluated for powder flowability, drug entrapment efficiency and in vitro drug release. Based on the mentioned characteristics, formulations F4M and F4S were optimized. Stability test was performed on optimized Proniosomes for three months at temperature (2-8°C). Comparison for antimicrobial sensitivity against Staphylococcus aureus was also made between optimized and marketed conventional CP capsule. More than 80% drug release was observed in 22 hr in the trial formulations. The optimized CP Proniosomes were found to be highly stable with % drug entrapment efficiency of 78.60±0.15 and 88.41±0.19 respectively for F4M and F4S. The prepared Proniosomes possessed higher bactericidal activity against S. aureus than reference products (M1 and M2). In conclusion, CP Proniosomes have been successfully prepared using sorbitol/maltodextrin carrier. Sorbitol carrier exhibited marginally better drug entrapment efficiency and bactericidal activity than the maltodextrin trial and marketed brands. This effort offers improved drug delivery with the potential of more effective controlled therapy.
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Saim, M. A. F., Bashir, L., Naz, S., Ghayas, S., Bushra, R., Anwar, Z., Uddin, S. A., & Korai, U. (2022). Development and Characterization of Cephradine Proniosomes for Oral Controlled Drug Delivery. Indian Journal of Pharmaceutical Education and Research, 56(1S), S67–S74. https://doi.org/10.5530/ijper.56.1s.44